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Article ; Online: Bandgap prediction of non-metallic crystals through machine learning approach.

Barman, Sadhana / Dua, Harkishan / Sarkar, Utpal

Journal of physics. Condensed matter : an Institute of Physics journal

2024

Abstract: The determination of bandgap is the heart of electronic structure of any material and is a crucial factor for thermoelectric performance of it. Due to large amount to data (features) that are related to bandgap are now a days available, it is possible to ...

Abstract	The determination of bandgap is the heart of electronic structure of any material and is a crucial factor for thermoelectric performance of it. Due to large amount to data (features) that are related to bandgap are now a days available, it is possible to make use of machine learning approach to predict the bandgap of the material. The study commences by selecting the feature through Pearson correlation study between bandgap and various thermoelectric parameters in non-metallic crystals. Among the forty two parameters available in the dataset, the seebeck coefficient and its corresponding temperatures show high correlation with the bandgap. With these three selected features we have used different machine learning models like multilinear regression, polynomial regression, random forest regression, support vector regression to predict the bandgap. Amongst the different machine learning models considered, random forest regression outperforms the other models to predict the bandgap with R2 value of 97.55 % between actual bandgap and predicted bandgap.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ad3873
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Are Retropharyngeal Parathyroid Adenomas Associated with Retropharyngeal Carotid Arteries?

Kadam, G H / Dua, S G

AJNR. American journal of neuroradiology

2021 Volume 42, Issue 10, Page(s) E74

MeSH term(s)	Carotid Artery, Internal ; Humans ; Neck ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/diagnostic imaging
Language	English
Publishing date	2021-09-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7248
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Article: Outcomes after chronic isolated epididymal pain: A retrospective study.

Chung, David / Dua, Suvig / Bal, Dhiraj / Dhillon, Harliv / Patel, Premal

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2024

Abstract: Introduction: Chronic epididymitis imposes significant physical and psychosocial distress on affected patients. Despite being a commonly encountered urologic condition, there remains a paucity of understanding and literature surrounding the management ... ...

Abstract	Introduction: Chronic epididymitis imposes significant physical and psychosocial distress on affected patients. Despite being a commonly encountered urologic condition, there remains a paucity of understanding and literature surrounding the management and natural history of isolated epididymal pain. Typically, patients who do not respond to conservative management undergo an epididymectomy.; however, the literature on its efficacy is also scarce, with success rates varying widely from 10-90% in existing studies. Our goal was to better describe the etiology, and natural history of isolated epididymal pain. Furthermore, we aimed to describe the rates of success associated with epididymectomy. Methods: A retrospective case-control study was conducted at the Manitoba Men's Health Clinic, with the approval of the University of Manitoba Research Ethics Board. All patients presenting with chronic epididymitis, defined as discomfort or pain localized to the epididymis for at least three months, were identified. Information regarding patient demographics, past medical and surgical history, duration of pain, localization of pain, findings on previous ultrasounds, prior conservative therapies trialed and response rates, as well as response rates to surgical therapy were collected. Results: From April 2022 to 2023, a total of 275 patients with chronic orchialgia were identified, and among them, 74 patients specifically presented with chronic isolated epididymal pain. The average duration of symptoms was as follows: 22.9% of patients experienced symptoms for 3-6 months, 10% for 6-12 months, and 67.1% for over 12 months; 13.5% (n=10) had associated ejaculatory pain, 8.1% (n=6) had lower urinary tract symptoms, and 4.1% (n=3) had erectile dysfunction. Ultrasound findings were observed in 68.9% of patients, with 31.1% having an epididymal cyst, 27.1% having a varicocele, 5.4% having a spermatocele, and 4.1% having a hydrocele. Among those who underwent conservative therapy, only 36.2% of patients reported a positive response. Surgical intervention was performed on 23 patients, including 16 who underwent an epididymectomy, three who underwent cord denervation, and two who underwent vasovasostomy and spermatocelectomy each. Most (81.3%, n=13) patients who underwent an epididymectomy had a positive response to the surgical intervention, defined as no pain on followup, while all patients undergoing other surgical interventions experienced a positive response. Conclusions: Chronic epididymal pain is a condition with limited data surrounding its management. Prior to referral, a large proportion of patients did not undergo any conservative treatment, and of those that did, there was limited response. For those who underwent surgical intervention, all were pain-free on followup, except three patients who underwent epididymectomy.
Language	English
Publishing date	2024-02-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.8701
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Article: Editorial: Recent trends and spotlight on nucleotide-based drugs: novel targets, their design, delivery, and clinical potential.

Chander, Subhash / Bhatt, Shvetank / Dua, Kamal / Jadhav, Hemant

Frontiers in pharmacology

2023 Volume 14, Page(s) 1245809

Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1245809
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Article ; Online: Pharmacogenomic biomarkers in coronary artery disease: a narrative review.

Dua, Pamila / Seth, Sandeep / Prasher, Bhavana / Mukerji, Mitali / Maulik, Subir Kumar / Reeta, K H

Biomarkers in medicine

2024 Volume 18, Issue 5, Page(s) 191–202

Abstract: Coronary artery disease (CAD) has a high mortality rate. Despite various therapeutic targets, non-responsiveness to drugs remains a prevalent issue. Pharmacogenomics assesses the way an individual's genetic attributes affect their likely response to drug ...

Abstract	Coronary artery disease (CAD) has a high mortality rate. Despite various therapeutic targets, non-responsiveness to drugs remains a prevalent issue. Pharmacogenomics assesses the way an individual's genetic attributes affect their likely response to drug therapy. Single-nucleotide polymorphisms play a crucial role in determining these outcomes. This review offers an overview of single-nucleotide polymorphisms investigated in clinical studies and their associations with drug response/nonresponse in the treatment of CAD. A total of 104 studies of whole sets of chromosomes and several genes were explored. A total of 161 polymorphisms exhibited associations with drug response/nonresponse in CAD across diverse ethnic populations. This pool can serve as a pharmacogenomic biomarker for predicting response to drug therapy in patients with CAD.
MeSH term(s)	Humans ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/genetics ; Pharmacogenetics ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2023-0476
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Article: Curious Case of Acoustic Schwannoma of Middle Cranial Fossa: A Case Report.

Singh, Hershdeep / Dua, Sanjeev / Dhar, Anil / Katyar, Vikrant

Brain tumor research and treatment

2022 Volume 10, Issue 1, Page(s) 43–47

Abstract: Acoustic neuromas are the most common lesion in the cerebellopontine angle. The authors report a unique case of acoustic schwannoma, presenting in middle cranial fossa masquerading as meningioma in a 24-year-old man, presenting with headache and focal ... ...

Abstract	Acoustic neuromas are the most common lesion in the cerebellopontine angle. The authors report a unique case of acoustic schwannoma, presenting in middle cranial fossa masquerading as meningioma in a 24-year-old man, presenting with headache and focal seizures. Contrast-enhanced MRI of the brain revealed a mass lesion of the right middle cranial fossa consistent with features of meningioma. Intraoperatively a well-defined tumor with attachment to anterior petrous bone was excised. In the immediate postoperative period, the patient developed right-sided hearing loss, which was proven to be retrochoclear hearing loss on brainstem evoked response audiometry. Histopathology findings were consistent with benign schwannoma. Acoustic schwannoma originating in an unusual location middle cranial fossa is a plausible explanation of such unusual occurrence. Such a case has never been reported in the literature.
Language	English
Publishing date	2022-02-03
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	3018737-0
ISSN	2288-2413 ; 2288-2405
ISSN (online)	2288-2413
ISSN	2288-2405
DOI	10.14791/btrt.2022.10.e21
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Article: Isolated Intramedullary Lumbar Spine Neurocysticercosis: A Rare Occurrence and Review of Literature.

Dhar, Anil / Dua, Sanjeev / Singh, Hershdeep

Surgery journal (New York, N.Y.)

2021 Volume 7, Issue 4, Page(s) e327–e336

Abstract: Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system. Spinal cysticercosis is a rather rare clinical occurrence. Intramedullary (IM) spinal NCC is rarer still. Furthermore, cases of IM-NCC at lumbar levels are few ...

Abstract	Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system. Spinal cysticercosis is a rather rare clinical occurrence. Intramedullary (IM) spinal NCC is rarer still. Furthermore, cases of IM-NCC at lumbar levels are few and far between. We present a case of a 35-year-old male patient who was diagnosed to have IM-NCC at L2-3 level and was managed surgically with no recurrence at 2 years of follow-up. A systematic literature review (1992-2020) highlights it to be only the third case reported with exclusive lumbar involvement.
Language	English
Publishing date	2021-12-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2864275-2
ISSN	2378-5136 ; 2378-5128
ISSN (online)	2378-5136
ISSN	2378-5128
DOI	10.1055/s-0041-1739118
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Article ; Online: Recent Trends and Applications of Nanostructure-based Drug Delivery in Alleviating Chronic Obstructive Pulmonary Disease (COPD).

Nagar, Lokesh / Gulati, Nisha / Saini, Annu / Singh, Sachin / Gupta, Gaurav / MacLoughlin, Ronan / Chellappan, Dinesh Kumar / Dua, Kamal / Dureja, Harish

Current drug delivery

2024

Abstract: Chronic Obstructive Pulmonary Disease (COPD), a chronic lung disease that causes breathing difficulties and obstructs airflow from the lungs, has a significant global health burden and affects millions of people worldwide. The use of pharmaceuticals in ... ...

Abstract	Chronic Obstructive Pulmonary Disease (COPD), a chronic lung disease that causes breathing difficulties and obstructs airflow from the lungs, has a significant global health burden and affects millions of people worldwide. The use of pharmaceuticals in COPD treatment is aimed to alleviate symptoms, improve lung function, prevent exacerbations, and enhance the overall quality of life for patients. Nanotechnology holds great promise to alleviate the burden of COPD. The main goal of this review is to present the full spectrum of therapeutics based on nanostructures for the treatment and management of COPD, including nanoparticles, polymeric nanoparticles, polymeric micelles, solid-lipid nanoparticles, liposomes, exosomes, nanoemulsions, nanosuspensions, and niosomes. Nanotechnology is just one of the many areas of research that may contribute to the development of more effective and personalized treatment modalities for COPD patients in the future. Future studies may be focused on enhancing the therapeutic effectiveness of nanocarriers by conducting extensive mechanistic investigations to translate current scientific knowledge for the effective management of COPD with little or no adverse effects.
Language	English
Publishing date	2024-03-05
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/0115672018289883240226113353
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Article ; Online: Chitosan based sorafenib tosylate loaded magnetic nanoparticles: Formulation and in-vitro characterization.

Dahiya, Mandeep / Awasthi, Rajendra / Yadav, Jaya Parkash / Sharma, Shammi / Dua, Kamal / Dureja, Harish

International journal of biological macromolecules

2023 Volume 242, Issue Pt 2, Page(s) 124919

Abstract: Biocompatible magnetic nanoparticles are used for various biomedical applications. This study reported the development of nanoparticles with magnetic properties by embedding magnetite particles in the drug-loaded, crosslinked matrix of chitosan. ... ...

Abstract	Biocompatible magnetic nanoparticles are used for various biomedical applications. This study reported the development of nanoparticles with magnetic properties by embedding magnetite particles in the drug-loaded, crosslinked matrix of chitosan. Sorafenib tosylate-loaded magnetic nanoparticles were prepared by a modified ionic-gelation method. Particle size, zeta potential, polydispersity index, and entrapment efficiency of nanoparticles were in the range of 95.6 ± 3.4 nm to 440.9 ± 7.3 nm, 12.8 ± 0.8 mV to 27.3 ± 1.1 mV, 0.289 ± 0.011 to 0.571 ± 0.011, and 54.36 ± 1.26 % to 79.67 ± 1.40 %, respectively. The XRD spectrum of formulation CMP-5 confirmed the amorphous nature of the loaded drug in nanoparticles. TEM image confirmed the spherical shape of nanoparticles. Atomic force microscopic image of formulation CMP-5 indicated a mean surface roughness of 10.3597 nm. The magnetization saturation of formulation CMP-5 was 24.74 emu/g. Electron paramagnetic resonance spectroscopy revealed that formulation CMP-5's g-Lande's factor was 4.27, which was extremely near to the 4.30 (usual for Fe
MeSH term(s)	Humans ; Sorafenib ; Chitosan/chemistry ; Magnetite Nanoparticles ; Nanoparticles/chemistry ; Ferrosoferric Oxide ; Microscopy, Atomic Force ; Particle Size ; Drug Carriers/chemistry
Chemical Substances	Sorafenib (9ZOQ3TZI87) ; Chitosan (9012-76-4) ; Magnetite Nanoparticles ; Ferrosoferric Oxide (XM0M87F357) ; Drug Carriers
Language	English
Publishing date	2023-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.124919
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Article ; Online: Pre-Descemets endothelial keratoplasty: the PDEK clamp for successful PDEK.

Dua, H S / Said, D G

Eye (London, England)

2017 Volume 31, Issue 7, Page(s) 1106–1110

Abstract: PurposeTo design and produce a clamp that enables good handling of donor sclera-corneal disks, allows air to be injected in the corneal stroma and consistently provides pre-Descemets endothelial keratoplasty (PDEK) tissue by creation of a type-1 big ... ...

Abstract	PurposeTo design and produce a clamp that enables good handling of donor sclera-corneal disks, allows air to be injected in the corneal stroma and consistently provides pre-Descemets endothelial keratoplasty (PDEK) tissue by creation of a type-1 big bubble (BB) avoiding a type-2BB by shutting the fenestrations in the periphery of the pre-Descemets layer and preventing escape of air.Patients and methodsA clamp with spring loaded handles attached to two rings of 9 mm diameter and 1 mm width with a side port for insertion of a needle for air injection was designed and produced. The clamp was tested in 20 human donor sclera-corneal disks and refined over three prototypes. The final design was used for PDEK in 8 patients.ResultsThe clamp was able to prevent any escape of air or the formation of a type-2BB. By preventing air leak, it provided better control over the volume of air injected allowing for consistent formation of a type-1BB, which could be expanded to its full diameter by advancing the tip of the needle into the bubble cavity. Centration of tissue in the clamp was important. The clamp was used successfully to obtain PDEK tissue from 8 donor sclara-corneal disks for transplant in three eyes with pseudophakic bullous keratopathy and five eyes with pseudophakia and Fuchs' endothelial dystrophy.ConclusionThe PDEK clamp is a simple and useful instrument that will give surgeons the confidence of consistently obtaining PDEK tissue with ease and without the risk of separating the Descemets membrane in a type-2BB.
MeSH term(s)	Aged ; Aged, 80 and over ; Corneal Endothelial Cell Loss/diagnosis ; Corneal Endothelial Cell Loss/surgery ; Descemet Stripping Endothelial Keratoplasty/methods ; Endothelium, Corneal/pathology ; Female ; Graft Survival ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Tissue Donors ; Visual Acuity
Language	English
Publishing date	2017-02-17
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/eye.2017.10
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Zs.MO 603: Show issues

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