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  1. Article ; Online: Reply.

    Singh, Aastha / Murthy, Somasheila I / Gandhi, Arpan / Sangwan, Virender S

    Cornea

    2022  Volume 41, Issue 7, Page(s) e16

    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000003045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mini-Review: Regenerating the Corneal Epithelium With Simple Limbal Epithelial Transplantation.

    Singh, Aastha / Sangwan, Virender S

    Frontiers in medicine

    2021  Volume 8, Page(s) 673330

    Abstract: Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, ... ...

    Abstract Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, the technique has been performed in a variety of cases of limbal stem cell deficiency (LSCD) and has underwent several innovative modifications. Published literature on SLET has progressively increased over time and successful outcomes in various clinical scenarios have been reported. This concise review attempts to present a crisp account of SLET covering the indications and contraindications of performing the procedure; detailed account of pre-operative work up and preparation; surgical technique and its modifications; post-operative course, care and possible complications as well as published outcomes of surgery from across the world. Comparative analysis of various techniques of LSCT have been discussed and common concerns of surgeons practising or those who are planning to start practising SLET have been addressed. The authors hope that the pragmatic insights and pearls given at the end of the review will aid the surgeons in performing this technique to provide maximum benefit to patients suffering from the potentially blinding condition of LSCD.
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.673330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mini-Review

    Aastha Singh / Virender S. Sangwan

    Frontiers in Medicine, Vol

    Regenerating the Corneal Epithelium With Simple Limbal Epithelial Transplantation

    2021  Volume 8

    Abstract: Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, ... ...

    Abstract Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, the technique has been performed in a variety of cases of limbal stem cell deficiency (LSCD) and has underwent several innovative modifications. Published literature on SLET has progressively increased over time and successful outcomes in various clinical scenarios have been reported. This concise review attempts to present a crisp account of SLET covering the indications and contraindications of performing the procedure; detailed account of pre-operative work up and preparation; surgical technique and its modifications; post-operative course, care and possible complications as well as published outcomes of surgery from across the world. Comparative analysis of various techniques of LSCT have been discussed and common concerns of surgeons practising or those who are planning to start practising SLET have been addressed. The authors hope that the pragmatic insights and pearls given at the end of the review will aid the surgeons in performing this technique to provide maximum benefit to patients suffering from the potentially blinding condition of LSCD.
    Keywords limbal stem cells ; limbal stem cell deficiency ; limbal stem cell transplantation ; simple limbal epithelial transplantation ; corneal regeneration ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Commentary: Impact of COVID-19 on ocular surface health.

    Singh, Aastha / Acharya, Manisha / Sangwan, Virender S

    Indian journal of ophthalmology

    2021  Volume 69, Issue 5, Page(s) 1066–1067

    MeSH term(s) COVID-19 ; Communicable Disease Control ; Eye ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-04-29
    Publishing country India
    Document type Journal Article ; Comment
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_720_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Management of cataract in dry eye disease: Preferred practice pattern guidelines.

    Donthineni, Pragnya R / Deshmukh, Rashmi / Ramamurthy, Chitra / Sangwan, Virender S / Mehta, Jodhbir S / Basu, Sayan

    Indian journal of ophthalmology

    2023  Volume 71, Issue 4, Page(s) 1364–1372

    Abstract: Cataract surgery is one of the most commonly performed ophthalmic surgeries in the world. Dry eye disease (DED) is found to coexist in most patients with cataracts due to the overlapping age groups of both these conditions. Preoperative evaluation for ... ...

    Abstract Cataract surgery is one of the most commonly performed ophthalmic surgeries in the world. Dry eye disease (DED) is found to coexist in most patients with cataracts due to the overlapping age groups of both these conditions. Preoperative evaluation for DED is important to improve outcomes. A pre-existing DED affecting the tear film is likely to affect biometry. Moreover, special intraoperative considerations are needed in eyes with DED to reduce complications and improve postoperative outcomes. Dry eye disease (DED) is known to occur following an uneventful cataract surgery or a pre-existing DED is likely to worsen following cataract surgery as well. In these situations, despite a good visual outcome, patient dissatisfaction is common owing to the distressing DED symptoms. This review aims to summarize the preoperative, intraoperative, and postoperative considerations when performing cataract surgery in the presence of a coexisting DED.
    MeSH term(s) Humans ; Cataract/complications ; Cataract Extraction ; Dry Eye Syndromes/complications ; Postoperative Period ; Tears
    Language English
    Publishing date 2023-03-09
    Publishing country India
    Document type Practice Guideline ; Review ; Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2807_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Surgical Management of Peripheral Ulcerative Keratitis: Update on Surgical Techniques and Their Outcome.

    Sabhapandit, Swapnali / Murthy, Somasheila I / Sharma, Namrata / Sangwan, Virender S

    Clinical ophthalmology (Auckland, N.Z.)

    2022  Volume 16, Page(s) 3547–3557

    Abstract: Peripheral ulcerative keratitis (PUK) is an inflammatory, necrotic condition in the peripheral cornea which may end in corneal perforation and visual morbidity if not treated adequately. PUK can occur due to infectious or non-infectious causes. Early ... ...

    Abstract Peripheral ulcerative keratitis (PUK) is an inflammatory, necrotic condition in the peripheral cornea which may end in corneal perforation and visual morbidity if not treated adequately. PUK can occur due to infectious or non-infectious causes. Early cases need medical therapy, both locally and systemically (for some cases). However, advanced PUK may necessitate surgical removal of inciting cause of the pathology and maintaining tectonic stability. Such surgical treatment, including corneal transplantations, may be used in an emergency setting or for visual rehabilitation following preliminary stabilization of the affected cornea. The outcome of these surgeries need to be analyzed to understand the long-term visual prognosis of such eyes. This is an attempt to analyze surgical modalities in the management of PUK and their outcomes.
    Language English
    Publishing date 2022-10-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S385782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prevention, diagnosis & management of dry eye in South Asia.

    Rathi, Varsha M / Sangwan, Virender S

    Community eye health

    2018  Volume 30, Issue 99, Page(s) S3–S4

    Language English
    Publishing date 2018-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036859-0
    ISSN 0953-6833
    ISSN 0953-6833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of dry eyes in children with vernal kerato-conjunctivitis using clinical tests and ocular surface analysis.

    Gupta, Shalini / Rahman, Mahmooda / Tibrewal, Shailja / Gaur, Abha / Ganesh, Suma / Sangwan, Virender Singh

    Indian journal of ophthalmology

    2023  Volume 71, Issue 4, Page(s) 1488–1494

    Abstract: ... Collaborative Longitudinal Evaluation of Keratoconus (CLEK) scoring, and OSA. Children with a TBUT of < 10 s ... 3.8 and 5.9 ± 1.9 s in non-dry and dry eye groups, respectively (P < 0.001). The mean value ... of non-invasive break-up time (NIBUT) was 8.3 ± 3.2 s in non-dry eye group and 6.4 ± 2.9 s in dry eye ...

    Abstract Purpose: To evaluate dry eyes in children with vernal kerato-conjunctivitis (VKC) and correlate it with symptoms, clinical findings, and ocular surface analysis (OSA) parameters.
    Methods: Children with clinically diagnosed VKC underwent complete ophthalmological examination, Schirmer's testing, modified ocular surface disease index (OSDI) scoring, Bonini grading, fluorescein tear-film break-up time (TBUT), VKC - Collaborative Longitudinal Evaluation of Keratoconus (CLEK) scoring, and OSA. Children with a TBUT of < 10 s were defined to have dry eyes. The above-mentioned parameters were compared between dry eye and non-dry eye VKC children.
    Results: The mean age of the 87 children included in the study was 9.1 ± 2.9 years. Dry eyes were seen in 60.9% [95% confidence interval (CI); 51% to 71%]. The mean TBUT was 13.4 ± 3.8 and 5.9 ± 1.9 s in non-dry and dry eye groups, respectively (P < 0.001). The mean value of Schirmer's test was 25.9 ± 9.8 and 20.8 ± 8.6 mm in the non-dry and dry eye groups, respectively (P = 0.01). The two groups did not differ in their OSDI scores, Bonini grading, and CLEK scores. The OSA parameter of non-invasive break-up time (NIBUT) was 8.3 ± 3.2 s in non-dry eye group and 6.4 ± 2.9 s in dry eye group, P = 0.008. The lower lid Meibomian gland (MG) loss was 7.4% in non-dry eye group and 12.2% in dry eye group, P = 0.028. Other OSA parameters did not differ significantly among the two groups.
    Conclusion: Dry eyes are seen in two-thirds of pediatric VKC. Evaluation of dry eyes should be incorporated in their clinical evaluation. Among OSA parameters, NIBUT and lower lid MG loss are associated with dry eyes in pediatric VKC patients.
    MeSH term(s) Child ; Humans ; Conjunctivitis, Allergic/diagnosis ; Dry Eye Syndromes/diagnosis ; Fluorescein ; Keratoconus ; Tears
    Chemical Substances Fluorescein (TPY09G7XIR)
    Language English
    Publishing date 2023-04-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2836_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Vernal Keratoconjunctivitis spectrum in two generations of a family.

    Singh, Garima / Mathur, Umang / Sangwan, Virender S

    Indian journal of ophthalmology

    2020  Volume 68, Issue 8, Page(s) 1644–1645

    MeSH term(s) Conjunctivitis, Allergic/diagnosis ; Conjunctivitis, Allergic/genetics ; Humans
    Language English
    Publishing date 2020-07-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1716_19
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  10. Article ; Online: Allograft rejection after living-related simple limbal epithelial transplantation.

    Vazirani, Jayesh / Basu, Sayan / Sangwan, Virender S

    Indian journal of ophthalmology

    2021  Volume 69, Issue 2, Page(s) 433–435

    Abstract: A 23-year-old man presented with congestion, peripheral corneal vascularization, an elevated ridge-like epithelial line and cellular infiltration around limbal transplants, 15 months after undergoing living-related simple limbal epithelial ... ...

    Abstract A 23-year-old man presented with congestion, peripheral corneal vascularization, an elevated ridge-like epithelial line and cellular infiltration around limbal transplants, 15 months after undergoing living-related simple limbal epithelial transplantation (SLET) for total limbal stem cell deficiency. A diagnosis of acute allograft rejection was made and he was treated with intravenous methylprednisolone, topical and oral prednisolone as well as systemic cyclosporine and azathioprine, leading to reversal of the signs. Similar findings were noted during a later rejection episode. An epithelial rejection line and cellular infiltration of limbal transplants are easily identifiable clinical signs of allograft rejection post SLET.
    MeSH term(s) Adult ; Allografts ; Corneal Diseases/diagnosis ; Corneal Diseases/etiology ; Corneal Diseases/surgery ; Corneal Transplantation ; Epithelium, Corneal ; Graft Rejection/diagnosis ; Humans ; Limbus Corneae ; Male ; Stem Cell Transplantation ; Transplantation, Autologous ; Transplantation, Homologous ; Young Adult
    Language English
    Publishing date 2021-01-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_1952_20
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