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  1. Book ; Online ; E-Book: Phytocannabinoids

    Kinghorn, A. Douglas / Falk, Heinz / Gibbons, Simon / Kobayashi, Jun'ichi / Chandra, S.

    unraveling the complex chemistry and pharmacology of Cannabis sativa

    (Progress in the chemistry of organic natural products ; 103)

    2017  

    Author's details A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors ; with contributions by S. Chandra [und 13 weiteren]
    Series title Progress in the chemistry of organic natural products ; 103
    Collection
    Language English
    Size 1 Online-Ressource (vii, 131 Seiten)
    Publisher Springer International Publishing
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019352492
    ISBN 978-3-319-45541-9 ; 9783319455396 ; 3-319-45541-9 ; 3319455397
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Search for New Bioactive Marine Natural Products and Application to Drug Development.

    Kobayashi, Jun'ichi

    Chemical & pharmaceutical bulletin

    2016  Volume 64, Issue 8, Page(s) 1079–1083

    Abstract: Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) ...

    Abstract Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.
    MeSH term(s) Animal Shells/chemistry ; Animals ; Bacteria/chemistry ; Biological Products/chemistry ; Dinoflagellida/chemistry ; Drug Discovery ; Fungi/chemistry ; Porifera ; Urochordata
    Chemical Substances Biological Products
    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c16-00281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 770: Show issues Location:
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  3. Article ; Online: Zamamiphidins B and C, Manzamine-Related Alkaloids from an

    Kurimoto, Shin-Ichiro / Suzuki, Shoichi / Ueno, Mayumi / Fromont, Jane / Kobayashi, Jun'ichi / Kubota, Takaaki

    Journal of natural products

    2022  Volume 85, Issue 9, Page(s) 2226–2231

    Abstract: Zamamiphidins B ( ...

    Abstract Zamamiphidins B (
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Animals ; Cell Line, Tumor ; Molecular Structure ; Porifera/chemistry
    Chemical Substances Alkaloids
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00395
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  4. Article ; Online: Efficacy of KPR-5714, a selective transient receptor potential melastatin 8 antagonist, on chronic psychological stress-induced bladder overactivity in male rats.

    Watanabe, Shinjiro / Miyazaki, Shingo / Yumoto, Yu / Kobayashi, Jun-Ichi / Fujimori, Yoshikazu

    Neurourology and urodynamics

    2023  Volume 42, Issue 8, Page(s) 1812–1821

    Abstract: Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this ... ...

    Abstract Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this report, the effects of KPR-5714, which is a selective transient receptor potential melastatin 8 (TRPM8) antagonist, on bladder overactivity induced by water avoidance stress were examined.
    Methods: Male rats were subjected to water avoidance stress for 2 h per day for 10 consecutive days. The effects of water avoidance stress on voiding behavior using metabolic cages and histological bladder changes were investigated in rats. The involvement of bladder C-fiber afferent on voiding frequency in rats exposed to water avoidance stress was assessed using capsaicin. The effects of KPR-5714 on storage dysfunction in rats subjected to water avoidance stress were examined.
    Results: In voiding behavior measurements, water avoidance stress-induced storage dysfunction, causing a decrease in the mean voided volume and increasing voiding frequency. A comparison of bladders from normal rats and rats exposed to water avoidance stress showed no histological differences. Water avoidance stress-induced bladder overactivity was completely inhibited by pretreatment with capsaicin. KPR-5714 showed a tendency to increase the mean voided volume and significantly decreased the voiding frequency without affecting the total voided volume in these rats.
    Conclusion: The results suggest that KPR-5714 is a promising option for treating chronic psychological stress-induced bladder overactivity.
    MeSH term(s) Rats ; Male ; Animals ; Urinary Bladder ; Rats, Sprague-Dawley ; Capsaicin/pharmacology ; Disease Models, Animal ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/chemically induced ; Stress, Psychological/complications ; Water
    Chemical Substances Capsaicin (S07O44R1ZM) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Updating view of membrane transport proteins by simulation studies.

    Sumikama, Takashi / Corry, Ben / Ono, Junichi / Kobayashi, Chigusa / Okazaki, Kei-Ichi

    Biophysics and physicobiology

    2023  Volume 20, Issue 4, Page(s) e200041

    Language English
    Publishing date 2023-11-02
    Publishing country Japan
    Document type Journal Article
    ISSN 2189-4779
    ISSN 2189-4779
    DOI 10.2142/biophysico.bppb-v20.0041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The manzamine alkaloids.

    Kubota, Takaaki / Kurimoto, Shin-Ichiro / Kobayashi, Jun'ichi

    The Alkaloids. Chemistry and biology

    2020  Volume 84, Page(s) 1–124

    Abstract: The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine ...

    Abstract The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/metabolism ; Alkaloids/pharmacology ; Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Carbazoles/chemistry ; Carbazoles/metabolism ; Carbazoles/pharmacology ; Humans ; Indole Alkaloids/chemistry ; Indole Alkaloids/metabolism ; Indole Alkaloids/pharmacology ; Molecular Structure
    Chemical Substances Alkaloids ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Carbazoles ; Indole Alkaloids ; manzamine B ; manzamine A (104196-68-1)
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 7577-2
    ISSN 1099-4831 ; 0099-9598
    ISSN 1099-4831 ; 0099-9598
    DOI 10.1016/bs.alkal.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp

    Kurimoto, Shin-ichiro / Okamoto, Ayano / Seino, Satsuki / Fromont, Jane / Kobayashi, Jun'ichi / Kubota, Takaaki

    Tetrahedron letters. 2022 Aug. 03, v. 103

    2022  

    Abstract: Two new bromotyrosine alkaloids, ma'edamines E (1) and F (2), were isolated from an Okinawan marine sponge Suberea sp., and their structures were elucidated by the analyses of spectroscopic (UV, IR, and NMR) and spectrometric (MS) data. Ma'edamines E (1) ...

    Abstract Two new bromotyrosine alkaloids, ma'edamines E (1) and F (2), were isolated from an Okinawan marine sponge Suberea sp., and their structures were elucidated by the analyses of spectroscopic (UV, IR, and NMR) and spectrometric (MS) data. Ma'edamines E (1) and F (2) are the second and third examples of natural products possessing an N-alkyl-3,5-diethyl-2-propylpyridinium moiety. Ma'edamine F (2) is the first bromotyrosine alkaloid having both pyridinium and quaternary ammonium moieties. Ma'edamines E (1) and F (2) showed moderate cytotoxicity against L1210 murine leukemia cells in vitro.
    Keywords Suberea ; alkaloids ; cytotoxicity ; leukemia ; mice ; moieties ; quaternary ammonium compounds
    Language English
    Dates of publication 2022-0803
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.153985
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2837: Show issues Location:
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  8. Article: [Attempt to Calculate the Efficiency of Methylation Using

    Ogawa, Asamoe / Iwakoshi, Keiko / Nakajima, Jun'ichi / Takahashi, Natsumi / Sakamaki, Narue / Kobayashi, Chigusa

    Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan

    2021  Volume 62, Issue 2, Page(s) 51–55

    Abstract: We studied the efficiency of methylation for analyzing brominated vegetable oil (BVO). In this report, we investigated ... ...

    Abstract We studied the efficiency of methylation for analyzing brominated vegetable oil (BVO). In this report, we investigated whether
    MeSH term(s) Chromatography, Gas ; Methylation ; Plant Oils ; Proton Magnetic Resonance Spectroscopy ; Protons
    Chemical Substances Plant Oils ; Protons
    Language Japanese
    Publishing date 2021-04-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604314-8
    ISSN 1882-1006 ; 0015-6426
    ISSN (online) 1882-1006
    ISSN 0015-6426
    DOI 10.3358/shokueishi.62.51
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  9. Article: Formation of Amino Acids and Carboxylic Acids in Weakly Reducing Planetary Atmospheres by Solar Energetic Particles from the Young Sun.

    Kobayashi, Kensei / Ise, Jun-Ichi / Aoki, Ryohei / Kinoshita, Miei / Naito, Koki / Udo, Takumi / Kunwar, Bhagawati / Takahashi, Jun-Ichi / Shibata, Hiromi / Mita, Hajime / Fukuda, Hitoshi / Oguri, Yoshiyuki / Kawamura, Kimitaka / Kebukawa, Yoko / Airapetian, Vladimir S

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Life most likely started during the Hadean Eon; however, the environmental conditions which contributed to the complexity of its chemistry are poorly known. A better understanding of various environmental conditions, including global (heliospheric) and ... ...

    Abstract Life most likely started during the Hadean Eon; however, the environmental conditions which contributed to the complexity of its chemistry are poorly known. A better understanding of various environmental conditions, including global (heliospheric) and local (atmospheric, surface, and oceanic), along with the internal dynamic conditions of the early Earth, are required to understand the onset of abiogenesis. Herein, we examine the contributions of galactic cosmic rays (GCRs) and solar energetic particles (SEPs) associated with superflares from the young Sun to the formation of amino acids and carboxylic acids in weakly reduced gas mixtures representing the early Earth's atmosphere. We also compare the products with those introduced by lightning events and solar ultraviolet light (UV). In a series of laboratory experiments, we detected and characterized the formation of amino acids and carboxylic acids via proton irradiation of a mixture of carbon dioxide, methane, nitrogen, and water in various mixing ratios. These experiments show the detection of amino acids after acid hydrolysis when 0.5% (
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051103
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  10. Article ; Online: Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma

    Nyein Nyein Chan / Manabu Yamazaki / Satoshi Maruyama / Tatsuya Abé / Kenta Haga / Masami Kawaharada / Kenji Izumi / Tadaharu Kobayashi / Jun-ichi Tanuma

    International Journal of Molecular Sciences, Vol 24, Iss 6035, p

    2023  Volume 6035

    Abstract: Cholesterol plays an important role in cancer progression, as it is utilized in membrane biogenesis and cell signaling. Cholesterol-lowering drugs have exhibited tumor-suppressive effects in oral squamous cell carcinoma (OSCC), suggesting that ... ...

    Abstract Cholesterol plays an important role in cancer progression, as it is utilized in membrane biogenesis and cell signaling. Cholesterol-lowering drugs have exhibited tumor-suppressive effects in oral squamous cell carcinoma (OSCC), suggesting that cholesterol is also essential in OSCC pathogenesis. However, the direct effects of cholesterol on OSCC cells remain unclear. Here, we investigated the role of cholesterol in OSCC with respect to caveolin-1 (CAV1), a cholesterol-binding protein involved in intracellular cholesterol transport. Cholesterol levels in OSCC cell lines were depleted using methyl-β-cyclodextrin and increased using the methyl-β-cyclodextrin-cholesterol complex. Functional analysis was performed using timelapse imaging, and CAV1 expression in cholesterol-manipulated cells was investigated using immunofluorescence and immunoblotting assays. CAV1 immunohistochemistry was performed on surgical OSCC samples. We observed that cholesterol addition induced polarized cell morphology, along with CAV1 localization at the trailing edge, and promoted cell migration. Moreover, CAV1 was upregulated in the lipid rafts and formed aggregates in the plasma membrane in cholesterol-added cells. High membranous CAV1 expression in tissue specimens was associated with OSCC recurrence. Therefore, cholesterol promotes the migration of OSCC cells by regulating cell polarity and CAV1 localization to the lipid raft. Furthermore, membranous CAV1 expression is a potential prognostic marker for OSCC patients.
    Keywords caveolin-1 ; cell polarization ; cholesterol ; migration ; oral squamous cell carcinoma ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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