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  1. Article ; Online: Risk Profiles and Treatment Patterns in Atrial Fibrillation Patients with Chronic Kidney Disease Receiving or not Receiving Anticoagulation Therapy.

    Kreutz, Reinhold / Deray, Gilbert / Floege, Jürgen / Gwechenberger, Marianne / Hahn, Kai / Luft, Andreas R / Persson, Pontus / Axthelm, Christoph / Beer, Juerg Hans / Bergler-Klein, Jutta / Lellouche, Nicolas / Taggeselle, Jens / Beyer-Westendorf, Jan

    TH open : companion journal to thrombosis and haemostasis

    2024  Volume 8, Issue 1, Page(s) e106–e113

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0044-1780529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Clinical Nephrotoxins

    Broe, Marc E. / Bennett, William M. / Deray, Gilbert / Porter, George A.

    Renal Injury from Drugs and Chemicals

    2008  

    Author's details edited by Marc E. Broe, George A. Porter, William M. Bennett, Gilbert Deray
    Keywords Nephrology
    Language English
    Publisher Springer Science+Business Media, LLC
    Publishing place Boston, MA
    Document type Book ; Online
    HBZ-ID TT050386994
    ISBN 978-0-387-84842-6 ; 978-0-387-84843-3 ; 0-387-84842-8 ; 0-387-84843-6
    DOI 10.1007/978-0-387-84843-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Toxicité rénale des anticancéreux.

    Aloy, Blandine / Janus, Nicolas / Isnard-Bagnis, Corine / Deray, Gilbert / Launay-Vacher, Vincent

    Nephrologie & therapeutique

    2021  Volume 17, Issue 7, Page(s) 553–563

    Abstract: The renal toxicity of anticancer drugs is a clinical challenge because of the intrinsic toxicity of some anticancer drugs and because the cancer itself. Indeed, cancer patients are exposed to all types of renal disorders (obstructive, functional, organic ...

    Title translation Renal toxicity of anticancer drugs.
    Abstract The renal toxicity of anticancer drugs is a clinical challenge because of the intrinsic toxicity of some anticancer drugs and because the cancer itself. Indeed, cancer patients are exposed to all types of renal disorders (obstructive, functional, organic because of radiotherapy, paraneoplastic glomerulopathy, thrombotic microangiopathy…). The therapeutic index of anticancer drugs is often narrow and the doses used for optimal efficacy are high. Improving safety requires a better dose adjustment, which depends on the correct evaluation of the renal function. Prevention remains important as the mortality associated with acute renal failure is very high.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Antineoplastic Agents/adverse effects ; Humans ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents
    Language French
    Publishing date 2021-11-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2021.09.001
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  4. Article ; Online: Clarification de la méthode utilisée pour adapter la posologie des médicaments chez les patients insuffisants rénaux : étude CLEAR.

    Berdougo, Jessica / Delorière, Émilie / Deray, Gilbert / Launay-Vacher, Vincent

    Nephrologie & therapeutique

    2020  Volume 16, Issue 1, Page(s) 59–64

    Abstract: Introduction: The French National Authority for health recommends that the adjustment of the dosage of drugs in patients with renal insufficiency be carried out on the basis of an estimate of renal function using the Cockcroft-Gault formula, while the ... ...

    Title translation Clarification of the method used for drug dosage adjustment in patients with renal failure: The CLEAR study.
    Abstract Introduction: The French National Authority for health recommends that the adjustment of the dosage of drugs in patients with renal insufficiency be carried out on the basis of an estimate of renal function using the Cockcroft-Gault formula, while the estimation of the glomerular filtration rate using the Modification of Diet in Renal Disease or CKD-EPI formula is recommended for the diagnosis and monitoring of renal insufficiency. The argument put forward is that the recommendations for dosage adjustment of the summaries of product characteristics would have been established on the basis of the use of this formula. Service ICAR aimed at verifying the evidence supporting this argument.
    Methods: In all, 2447 summaries of product characteristics were analyzed to identify the renal function criterion specified for dose adjustment recommendations. When no formulas were found in the summary of product characteristics, the firms were contacted to obtain information on renal function estimation methods used in developmental studies. Their responses were analyzed.
    Results: Of the 2447 summaries of product characteristics studied, 438 (17.9%) propose a dosage adjustment in case of renal insufficiency. No formula is mentioned in the summarie of product characteristics for 90.0% of them. The Cockcroft-Gault and Modification of Diet in Renal Disease/CKD-EPI formulas are found in 8.7% and 0.7% respectively of these 438 summaries of product characteristics. After contacting pharmaceutical companies and analysis of the data available in the studies on which the summaries of product characteristics were based, the information cannot be found for 63.0% of the summaries of product characteristics, in spite they mention the need to adjust the dosage in case of renal insufficiency.
    Conclusion: The majority of summaries of product characteristics do not mention the Cockcroft-Gault formula and in the majority of cases it is not possible to identify the formula or technique used in the studies on which is based the reference to dosage adjustment in the summarie of product characteristics. In addition, there are discrepancies between the wording of the summaries of product characteristics and the data from development studies. The use of Cockcroft-Gault for dosage adjustment is to be questioned, especially since the Isotope-dilution mass spectrometry, or IDMS, standardization of creatinine dosage makes obsolete studies based on Cockcroft-Gault formula and a non-standardized dosage, and thus the use of Cockcroft-Gault not transposable to current clinical practice.
    MeSH term(s) Drug Dosage Calculations ; Humans ; Practice Guidelines as Topic ; Renal Insufficiency
    Language French
    Publishing date 2020-01-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2019.09.003
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  5. Article: La variabilité de l'hémoglobine chez le patient dialysé

    Deray, Gilbert

    Nephrologie & therapeutique

    2008  Volume 4, Issue 7, Page(s) 549–552

    Abstract: Several recent articles have examined the time-dependent effects of epoetin therapy and the variability of hemoglobin (HGb) levels and what epoetin does in hemodialysis patients. A recent preliminary report also found that HGG cycling was common among ... ...

    Title translation Hemoglobin variability in patients with chronic renal insuffiency.
    Abstract Several recent articles have examined the time-dependent effects of epoetin therapy and the variability of hemoglobin (HGb) levels and what epoetin does in hemodialysis patients. A recent preliminary report also found that HGG cycling was common among hemodialysis patients, with only 10% of patients remaining within their initial HGb range (less than 11 g/dl, 11 to 12.5 g/dl, greater than 12.5 g/dl) during a six-month period. Factors associated with HGb cycling were changes in epoetin dose, intravenous-iron administration or a change in dose and hospitalization. What is not known is whether there are adverse clinical outcomes associated with HGb variability, although preliminary data indicate, perhaps predictably, that a decreasing HGb level is associated with a higher mortality risk. This is certainly an area that merits further study.
    MeSH term(s) Epoetin Alfa ; Erythropoietin/therapeutic use ; Hematinics/therapeutic use ; Hemoglobins/drug effects ; Hemoglobins/metabolism ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Recombinant Proteins ; Renal Dialysis
    Chemical Substances Hematinics ; Hemoglobins ; Recombinant Proteins ; Erythropoietin (11096-26-7) ; Epoetin Alfa (64FS3BFH5W)
    Language French
    Publishing date 2008-12
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2008.04.010
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  6. Article ; Online: Toxicité rénale des produits de contraste non iodés.

    Janus, Nicolas / Launay-Vacher, Vincent / Deray, Gilbert

    Nephrologie & therapeutique

    2018  Volume 14, Issue 6, Page(s) 484–490

    Abstract: The development of interventional radiology techniques regularly exposes patients to the potential renal toxocity of iodinated contrast media. Faced with this risk of nephrotoxicity, gadolinium-based contrast agents have long been considered as a safe ... ...

    Title translation Non-iodinated contrast media nephrotoxicity.
    Abstract The development of interventional radiology techniques regularly exposes patients to the potential renal toxocity of iodinated contrast media. Faced with this risk of nephrotoxicity, gadolinium-based contrast agents have long been considered as a safe alternative to iodinated contrast media, especially in sensitive or at risk patients. However, these gadolinium-based contrast agents are not devoid of nephrotoxicity and present another risk, a complication related to renal failure, the nephrogenic systemic fibrosis. European and US recommendations from health agencies have recently come closer, defining groups of patients at risk of nephrogenic systemic fibrosis according to their level of renal function and the type of gadolinium-based contrast agent used. What are the real renal risks for these products? How to evaluate the benefit-risk balance of the patient to choose a radiological examination in an informative, effective and safe way? This article focuses on the description of the risks of gadolinium-based contrast agents, reviews existing recommendations and best practices to guide the choice of clinicians.
    MeSH term(s) Contrast Media/adverse effects ; Gadolinium/adverse effects ; Humans ; Kidney/drug effects ; Kidney/pathology ; Practice Guidelines as Topic ; Radiography, Interventional/adverse effects ; Renal Insufficiency/chemically induced ; Risk Assessment/methods ; Risk Factors
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language French
    Publishing date 2018-10-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2018.09.002
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  7. Article ; Online: Visipaque (iodixanol) and hexabrix (ioxaglate) in renal insufficiency.

    Deray, Gilbert

    Journal of the American College of Cardiology

    2007  Volume 49, Issue 15, Page(s) 1668

    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Contrast Media/adverse effects ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Coronary Disease/complications ; Coronary Disease/diagnostic imaging ; Humans ; Incidence ; Ioxaglic Acid/adverse effects ; Prognosis ; Renal Insufficiency, Chronic/complications ; Risk Assessment ; Triiodobenzoic Acids/adverse effects
    Chemical Substances Contrast Media ; Triiodobenzoic Acids ; iodixanol (HW8W27HTXX) ; Ioxaglic Acid (Z40X7EI2AF)
    Language English
    Publishing date 2007-04-02
    Publishing country United States
    Document type Comparative Study ; Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2007.02.005
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  8. Article ; Online: Rationale and design of XARENO: XA inhibition in RENal patients with non-valvular atrial fibrillation. Observational registry.

    Kreutz, Reinhold / Deray, Gilbert / Floege, Jürgen / Gwechenberger, Marianne / Hahn, Kai / Luft, Andreas R / Persson, Pontus / Beyer-Westendorf, Jan

    Kardiologia polska

    2021  Volume 79, Issue 11, Page(s) 1265–1267

    MeSH term(s) Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Factor Xa Inhibitors/therapeutic use ; Humans ; Registries ; Stroke
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors
    Language English
    Publishing date 2021-10-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2021.0134
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  9. Article ; Online: Iodixanol and chronic kidney disease.

    Deray, Gilbert

    The Journal of invasive cardiology

    2006  Volume 18, Issue 2, Page(s) 84

    MeSH term(s) Chronic Disease ; Contrast Media/administration & dosage ; Contrast Media/adverse effects ; Diabetic Nephropathies/diagnosis ; Humans ; Kidney Diseases/chemically induced ; Triiodobenzoic Acids/administration & dosage ; Triiodobenzoic Acids/adverse effects
    Chemical Substances Contrast Media ; Triiodobenzoic Acids ; iodixanol (HW8W27HTXX)
    Language English
    Publishing date 2006-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
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    Zs.MO 272: Show issues
    Zs.MG 31: Show issues

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  10. Article: Infections urinaires au cours de la grossesse.

    Bagnis, Corinne Isnard / Deray, Gilbert

    La Revue du praticien

    2014  Volume 64, Issue 7, Page(s) 983–985

    Title translation Urinary tract infections during pregnancy.
    MeSH term(s) Bacteriuria/diagnosis ; Bacteriuria/epidemiology ; Female ; Humans ; Monitoring, Physiologic ; Pregnancy ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Complications, Infectious/urine ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/microbiology ; Urinary Tract Infections/therapy ; Urinary Tract Infections/urine
    Language French
    Publishing date 2014-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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