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  1. Article ; Online: Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice.

    Kakuta, Hiroki / Ohsawa, Fuminori / Yamada, Shoya / Makishima, Makoto / Tai, Akihiro / Yasui, Hiroyuki / Yoshikawa, Yutaka

    Biological & pharmaceutical bulletin

    2011  Volume 35, Issue 4, Page(s) 629–633

    Abstract: ... which have different heterodimer-activating patterns, in KKA(y) type 2 diabetes model mice. We found that NEt ...

    Abstract Retinoid X receptor (RXR) agonists are reported to exhibit blood glucose-lowering action owing to peroxisome proliferator-activated receptor (PPAR)/RXR or liver X receptor (LXR)/RXR activation, but may also cause adverse effects such as blood triglyceride elevation. In order to examine the feasibility of separating the glucose-lowering action from the adverse effects, we examined the effects of RXR agonists (NEt-TMN), NEt-3IB, and NEt-3IP, which have different heterodimer-activating patterns, in KKA(y) type 2 diabetes model mice. We found that NEt-3IB induced lower degrees of hepatomegaly and blood triglyceride (TG) elevation than the other RXR agonists, even though all of them showed similar blood glucose-lowering action on repeated administration. These findings indicate that structural modification of RXR agonists is a potentially effective strategy to reduce adverse effects while retaining desired activities.
    MeSH term(s) Animals ; Blood Glucose/analysis ; COS Cells ; Cercopithecus aethiops ; Cholesterol/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Disease Models, Animal ; Hypoglycemic Agents/therapeutic use ; Liver/pathology ; Liver X Receptors ; Male ; Mice ; Organ Size ; Orphan Nuclear Receptors/metabolism ; PPAR gamma/metabolism ; Retinoid X Receptors/agonists ; Retinoid X Receptors/metabolism ; Triglycerides/blood
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Liver X Receptors ; Orphan Nuclear Receptors ; PPAR gamma ; Retinoid X Receptors ; Triglycerides ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2011-08-12
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.35.629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Autolysis of Chlorella variabilis in Starving Paramecium bursaria Help the Host Cell Survive Against Starvation Stress.

    Kodama, Yuuki / Miyazaki, Shoya

    Current microbiology

    2021  Volume 78, Issue 2, Page(s) 558–565

    Abstract: The endosymbiosis between Paramecium bursaria and Chlorella spp. is mutualistic. Symbiotic algae localize beneath the host Paramecium cell cortex compete for their attachment sites with preexisting organelle trichocysts. To examine the relationship ... ...

    Abstract The endosymbiosis between Paramecium bursaria and Chlorella spp. is mutualistic. Symbiotic algae localize beneath the host Paramecium cell cortex compete for their attachment sites with preexisting organelle trichocysts. To examine the relationship between P. bursaria trichocysts and their symbiotic algae, algae-bearing or alga-free P. bursaria were starved for several days and the changes in the number of Chlorella sp. and presence or absence of trichocysts were evaluated. We conducted an indirect immunofluorescence microscopy with an anti-trichocyst monoclonal antibody against P. bursaria cells. Indirect immunofluorescence microscopy demonstrated that under starvation and darkness conditions, the immunofluorescence of trichocysts in alga-free P. bursaria decreased much faster than that in the normal algae-bearing P. bursaria. In the latter case, our observations proposed the possibility that the nutrition obtained from symbiotic algal digestion may promote trichocysts synthesis. This algal digestion mechanism may permit host P. bursaria cells to survive for a longer time under starvation condition. To the best of our knowledge, this may be a new benefit that host P. bursaria gain from harboring symbiotic algae.
    MeSH term(s) Chlorella ; Darkness ; Microscopy, Fluorescence ; Paramecium ; Symbiosis
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-020-02304-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: [The Need for Lens Radiation Protection for Healthcare Provider in Open and Internal Fixation of the Hip Joint].

    Matsumoto, Hiroki / Tokushige, Shoya / Takei, Yasutaka / Uyama, Yuji / Mura, Masakatsu / Hitomi, Go

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2024  Volume 80, Issue 3, Page(s) 287–295

    Abstract: Increased occupational exposure of radiation workers is a major problem during open reduction and internal fixation (ORIF) of the hip joint, as the surgeon's eye lens is in close proximity to the patient and the X-ray tube. The purposes of this study ... ...

    Abstract Increased occupational exposure of radiation workers is a major problem during open reduction and internal fixation (ORIF) of the hip joint, as the surgeon's eye lens is in close proximity to the patient and the X-ray tube. The purposes of this study were to clarify the occupational exposure of radiation workers during ORIF of the hip joint and to examine the need for radiation protection measures. The radiation exposure of radiation workers was evaluated by making an airborne dose distribution map using phantom experiments. The radiation goggles attached with a small optically stimulated luminescence dosimeter were used in clinical practice to measure the lens dose received by the surgeon, and the necessity of radiation goggles was examined. The airborne dose distribution in ORIF of the hip joint showed a wider area of high dose rate during axial fluoroscopy of the femoral neck than during posterior-anterior fluoroscopy. In axial fluoroscopy of the femoral neck, the surgeon was always in the high dose rate range of 10 µGy/min or higher, the nurses were in the dose rate range of 4 to 10 µGy/min, and the radiologic technologists were in the dose rate range of 0.5 µGy/min or lower. The maximum 3 mm dose equivalent to the surgeon per case was 0.38 mSv. In contradiction, radiation goggles were useful in ORIF because they provided approximately 60% shielding. It is advisable to work with radiation goggles to avoid cataracts.
    MeSH term(s) Humans ; Radiation Protection ; Lens, Crystalline ; Radiation Exposure/prevention & control ; Hip Joint ; Health Personnel ; Occupational Exposure/prevention & control ; Radiation Dosage ; Fluoroscopy
    Language Japanese
    Publishing date 2024-01-30
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2024-1422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of the Clinical Specimen Information Management System for Multicenter Clinical Studies.

    Okada, Katsuki / Sugimoto, Kento / Wada, Shoya / Konishi, Shozo / Manabe, Shirou / Matsumura, Yasushi / Takeda, Toshihiro

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 119–123

    Abstract: Some multicenter clinical studies require the acquisition of clinical specimens from patients, and the centralized management and analysis of clinical specimens at a research institution. In such cases, it is necessary to manage clinical specimens with ... ...

    Abstract Some multicenter clinical studies require the acquisition of clinical specimens from patients, and the centralized management and analysis of clinical specimens at a research institution. In such cases, it is necessary to manage clinical specimens with anonymized patient information. In addition, clinical specimens need to be managed in connection with clinical information in clinical studies. In this study, we have developed a clinical specimen information management system that works with electronic data capture system for efficient specimen information management and the system workflow has verified at Osaka University Hospital. In addition, by combining this system with medical image collection system that we have developed previously, the integrated management of clinical information, medical image, and clinical specimen information will become possible. This specimen information management system may be expected to provide the platform for integrated analysis utilizing clinical information, medical image, and data from clinical specimens in multicenter clinical studies.
    MeSH term(s) Humans ; Information Management ; Health Facilities ; Hospitals, University ; Workflow
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Multicenter Study ; Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Classification of Diagnostic Certainty in Radiology Reports with Deep Learning.

    Sugimoto, Kento / Wada, Shoya / Konishi, Shozo / Okada, Katsuki / Manabe, Shirou / Matsumura, Yasushi / Takeda, Toshihiro

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 569–573

    Abstract: A radiology report is prepared for communicating clinical information about observed abnormal structures and clinically important findings with referring clinicians. However, such observations and findings are often accompanied by ambiguous expressions, ... ...

    Abstract A radiology report is prepared for communicating clinical information about observed abnormal structures and clinically important findings with referring clinicians. However, such observations and findings are often accompanied by ambiguous expressions, which can prevent clinicians from accurately interpreting the content of reports. To systematically assess the degree of diagnostic certainty for each observation and finding in a report, we defined an ordinal scale comprising five classes: definite, likely, may represent, unlikely, and denial. Furthermore, we applied a deep learning classification model to determine its applicability to in-house radiology reports. We trained and evaluated the model using 540 in-house chest computed tomography reports. The deep learning model achieved a micro F1-score of 97.61%, which indicated that our ordinal scale was suitable for measuring the diagnostic certainty of observations and findings in a report.
    MeSH term(s) Deep Learning ; Radiography ; Radiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inhibition of Ironic Errors and Facilitation of Overcompensation Errors Under Pressure: An Investigation Including Perceived Weakness.

    Nakamoto, Hiroki / Hashimoto, Shoya / Kamei, Mio / Murata, Munenori / Ikudome, Sachi / Karakida, Kenta / Tanaka, Yoshifumi

    Journal of sport & exercise psychology

    2024  , Page(s) 1–13

    Abstract: The conflicting predictions of ironic process theory and the implicit overcompensation hypothesis have been presented as a framework to explain the characteristics of errors that occur when a certain behavior is prohibited. The former predicts that ... ...

    Abstract The conflicting predictions of ironic process theory and the implicit overcompensation hypothesis have been presented as a framework to explain the characteristics of errors that occur when a certain behavior is prohibited. The former predicts that instructions prohibiting a particular behavior will increase the likelihood of an outcome that should be avoided (ironic error), whereas the latter predicts that the likelihood of an outcome opposite of that to be avoided (overcompensation error) will increase. We examined how these errors, which negatively affect performance, are influenced by pressure and perceived weakness. Participants performed a tennis-stroke task, aiming to hit a ball toward a target zone while avoiding a discouraged zone. The results indicate that pressure decreases the ironic errors but increases the overcompensation errors that occur when a particular behavior is discouraged, while an increase in perceived weakness induces random errors.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 1543-2904
    ISSN (online) 1543-2904
    DOI 10.1123/jsep.2023-0042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism.

    Urano, Yasuomi / Osaki, Shoya / Chiba, Ren / Noguchi, Noriko

    Cell death discovery

    2022  Volume 8, Issue 1, Page(s) 406

    Abstract: Perturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol-i.e., 24(S)-hydroxycholesterol (24S-OHC)- ...

    Abstract Perturbation of proteostasis triggers the adaptive responses that contribute to the homeostatic pro-survival response, whereas disruption of proteostasis can ultimately lead to cell death. Brain-specific oxysterol-i.e., 24(S)-hydroxycholesterol (24S-OHC)-has been shown to cause cytotoxicity when esterified by acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in the endoplasmic reticulum (ER). Here, we show that the accumulation of 24S-OHC esters caused phosphorylation of eukaryotic translation initiator factor 2α (eIF2α), dissociation of polysomes, and formation of stress granules (SG), resulting in robust downregulation of global protein de novo synthesis in human neuroblastoma SH-SY5Y cells. We also found that integrated stress response (ISR) activation through PERK and GCN2 activation induced by 24S-OHC treatment caused eIF2α phosphorylation. 24S-OHC-inducible SG formation and cell death were suppressed by inhibition of ISR. These results show that ACAT1-mediated 24S-OHC esterification induced ISR and formation of SG, which play crucial roles in 24S-OHC-inducible protein synthesis inhibition and unconventional cell death.
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-022-01197-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Stereoselective Synthesis of Volicitin and 9-D1-Volicitin

    Mamada, Shunki / Niwa, Kosuke / Toyoshima, Shoya / Seto, Yoshiya / Ogawa, Narihito

    Synlett

    2024  

    Abstract: The synthesis of volicitin involved the condensation of l -(+)-glutamine with 17( S )-hydroxylinolenoic acid, derived from a Wittig reaction between the C10–C18 phosphonium salt and the C1–C9 aldehyde. The phosphonium salt was prepared through the ... ...

    Abstract The synthesis of volicitin involved the condensation of l -(+)-glutamine with 17( S )-hydroxylinolenoic acid, derived from a Wittig reaction between the C10–C18 phosphonium salt and the C1–C9 aldehyde. The phosphonium salt was prepared through the alkynylation of a ( Z )-allylic phosphate with an alkyne derived from (2 S )-but-3-yn-2-ol. The deuterated aldehyde was derived with a 96% deuteration ratio by reduction of the C1–C9 methyl ester with NaBD 4, followed by oxidation. Subsequently, 9- D 1 -volicitin was synthesized from the monodeuterated aldehyde by using the Wittig reaction and condensation with l -(+)-glutamine.
    Keywords volicitin ; deuteration ; alkynylation ; Wittig reaction ; condensation
    Language English
    Publishing date 2024-01-15
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0042-1751547
    Database Thieme publisher's database

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  9. Article ; Online: Implementation of a Multilingual Electronic Medical Questionnaire: For Use Inside or Outside the Hospital.

    Konishi, Shozo / Manabe, Shirou / Shimai, Yoshie / Namiuchi, Yoshiki / Sugimoto, Kento / Wada, Shoya / Okada, Katsuki / Matsumura, Yasushi / Takeda, Toshihiro

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 1360–1361

    Abstract: We implemented a multilingual medical questionnaire system, which allows patients to answer questionnaires both in and out of the hospital. The response data are sent to and stored as structured data on the server in hospital information system, and ... ...

    Abstract We implemented a multilingual medical questionnaire system, which allows patients to answer questionnaires both in and out of the hospital. The response data are sent to and stored as structured data on the server in hospital information system, and could be converted to Japanese and quoted as part of progress notes in the electronic medical record.
    MeSH term(s) Humans ; Hospitals ; Hospital Information Systems ; Electronic Health Records ; Multilingualism ; Electronics
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: High utilization efficiencies of alkylbenzokynones hybridized inside the pores of activated carbon for electrochemical capacitor electrodes.

    Itoi, Hiroyuki / Matsuura, Miku / Tanabe, Yuichiro / Kondo, Shoya / Usami, Takanori / Ohzawa, Yoshimi

    RSC advances

    2023  Volume 13, Issue 4, Page(s) 2587–2599

    Abstract: Benzoquinone derivatives (BQDs) are hybridized inside activated carbon (AC) ... ...

    Abstract Benzoquinone derivatives (BQDs) are hybridized inside activated carbon (AC) pores
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06634c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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