LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article: Herpesviruses and autoimmunity.

Posnett, David N

Current opinion in investigational drugs (London, England : 2000)

2008 Volume 9, Issue 5, Page(s) 505–514

Abstract: Herpesvirus infection, in particular EBV infection, has been implicated in several major autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS) and rheumatoid arthritis (RA). Herpesvirus infection has potential roles ... ...

Abstract	Herpesvirus infection, in particular EBV infection, has been implicated in several major autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS) and rheumatoid arthritis (RA). Herpesvirus infection has potential roles in both initiating the autoimmune process and exacerbating disease progression. In particular, EBV has a proposed role in initiating the anti-nucleoprotein antibodies that are characteristic of SLE through molecular mimicry. There is also evidence to suggest that there is productive infection with EBV in the brain lesions of MS patients and in the synovium of RA patients. Research has been conducted in a mouse gamma-herpesvirus model, as it serves as a useful model for productive infection within autoimmune target tissues. The novel mechanisms by which EBV could contribute bystander effects by amplification of innate immune responses, along with preclinical and epidemiological studies into the role of herpesviruses in SLE, MS and RA, and clinical studies into the potential benefit of antiviral therapy, are discussed in this review.
MeSH term(s)	Animals ; Antiviral Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/virology ; Autoimmunity ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/epidemiology ; Epstein-Barr Virus Infections/immunology ; Herpesvirus 4, Human/immunology ; Humans ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/virology ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Multiple Sclerosis/virology
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2027913-9
ISSN	2040-3429 ; 1472-4472 ; 0967-8298
ISSN (online)	2040-3429
ISSN	1472-4472 ; 0967-8298
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5305: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Amplification of autoimmune disease by infection.

Posnett, David N / Yarilin, Dmitry

Arthritis research & therapy

2005 Volume 7, Issue 2, Page(s) 74–84

Abstract: Reports of infection with certain chronic persistent microbes (herpesviruses or Chlamydiae) in human autoimmune diseases are consistent with the hypothesis that these microbes are reactivated in the setting of immunodeficiency and often target the site ... ...

Abstract	Reports of infection with certain chronic persistent microbes (herpesviruses or Chlamydiae) in human autoimmune diseases are consistent with the hypothesis that these microbes are reactivated in the setting of immunodeficiency and often target the site of autoimmune inflammation. New experimental animal models demonstrate the principle. A herpesvirus or Chlamydia species can be used to infect mice with induced transient autoimmune diseases. This results in increased disease severity and even relapse. The evidence suggests that the organisms are specifically imported to the inflammatory sites and cause further tissue destruction, especially when the host is immunosuppressed. We review the evidence for the amplification of autoimmune inflammatory disease by microbial infection, which may be a general mechanism applicable to many human diseases. We suggest that patients with autoimmune disorders receiving immunosuppressing drugs should benefit from preventive antiviral therapy.
MeSH term(s)	Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Autoimmune Diseases/complications ; Autoimmune Diseases/immunology ; Biological Transport ; Chlamydia Infections/complications ; Chlamydia Infections/immunology ; Chlamydia Infections/prevention & control ; Chlamydophila Infections/complications ; Chlamydophila Infections/immunology ; Chlamydophila Infections/prevention & control ; Encephalomyelitis, Autoimmune, Experimental/complications ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Herpesviridae Infections/complications ; Herpesviridae Infections/immunology ; Herpesviridae Infections/prevention & control ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Inflammation ; Mice ; Models, Immunological ; Organ Specificity ; Parvoviridae Infections/complications ; Parvoviridae Infections/immunology ; Parvoviridae Infections/prevention & control ; Parvovirus B19, Human ; Rhadinovirus ; Tumor Virus Infections/complications ; Tumor Virus Infections/immunology ; Viremia/complications ; Viremia/immunology ; Viremia/prevention & control ; Virus Diseases/complications ; Virus Diseases/immunology ; Virus Diseases/prevention & control ; Virus Replication
Chemical Substances	Antiviral Agents ; Immunosuppressive Agents
Language	English
Publishing date	2005
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/ar1691
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 5490: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Antiviral T cell responses: phalanx or multipronged attack?

Posnett, David N / Engelhorn, Manuel E / Houghton, Alan N

The Journal of experimental medicine

2005 Volume 201, Issue 12, Page(s) 1881–1884

Abstract: Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the ...

Abstract	Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?
MeSH term(s)	Antigens, CD ; Antigens, Differentiation/immunology ; CD8-Positive T-Lymphocytes/immunology ; CTLA-4 Antigen ; Cytomegalovirus Infections/immunology ; Humans ; Immediate-Early Proteins/immunology ; Immunity, Cellular ; Neoplasms/immunology ; Phosphoproteins/immunology ; Receptors, Antigen, T-Cell/immunology ; Viral Matrix Proteins/immunology ; Viral Proteins/immunology
Chemical Substances	Antigens, CD ; Antigens, Differentiation ; CTLA-4 Antigen ; CTLA4 protein, human ; IE1 protein, cytomegalovirus ; Immediate-Early Proteins ; Phosphoproteins ; Receptors, Antigen, T-Cell ; Viral Matrix Proteins ; Viral Proteins ; cytomegalovirus matrix protein 65kDa
Language	English
Publishing date	2005-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20050928
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

Order via subito

Details ▾

Article: Apoptosis of T cells in peripheral blood and cerebrospinal fluid is associated with disease activity of multiple sclerosis.

Okuda, Yoshinobu / Apatoff, Brian R / Posnett, David N

Journal of neuroimmunology

2006 Volume 171, Issue 1-2, Page(s) 163–170

Abstract: Apoptotic elimination of pathogenic T cells is considered to be one of regulatory mechanisms in multiple sclerosis (MS). To explore the potential relationship between Fas-mediated apoptosis and the disease course of MS, we examined apoptosis, defined by ... ...

Abstract	Apoptotic elimination of pathogenic T cells is considered to be one of regulatory mechanisms in multiple sclerosis (MS). To explore the potential relationship between Fas-mediated apoptosis and the disease course of MS, we examined apoptosis, defined by annexin V (AV) binding, and Fas (CD95) expression in CD4+ and in CD8+ T cells in MS patients by using five-color flow cytometry. The percentage of AV+CD4+CD3+ cells and CD95+AV+CD4+CD3+ cells in peripheral blood and cerebrospinal fluid (CSF) were significantly decreased in active MS patients compared with inactive MS patients. A significantly lower proportion of CD95+AV+CD8+CD3+ cells in CSF was observed in active MS patients compared with inactive MS patients, but not in peripheral blood. These results indicate that the resistance of T cells to Fas-mediated apoptosis is involved in exacerbation of MS and/or that Fas-mediated apoptosis of T cells is associated with remission of MS.
MeSH term(s)	Adult ; Annexin A5/metabolism ; Antigens, CD/metabolism ; Apoptosis/physiology ; Case-Control Studies ; Cerebrospinal Fluid/metabolism ; Female ; Flow Cytometry/methods ; Humans ; Lymphocyte Activation/physiology ; Male ; Middle Aged ; Multiple Sclerosis/blood ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/pathology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/pathology ; T-Lymphocytes/physiology ; fas Receptor/metabolism
Chemical Substances	Annexin A5 ; Antigens, CD ; fas Receptor
Language	English
Publishing date	2006-02
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2005.09.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1646: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A mouse herpesvirus induces relapse of experimental autoimmune arthritis by infection of the inflammatory target tissue.

Yarilin, Dmitry A / Valiando, Jennifer / Posnett, David N

Journal of immunology (Baltimore, Md. : 1950)

2004 Volume 173, Issue 8, Page(s) 5238–5246

Abstract: It is not known what is required for successive relapses in autoimmune diseases or evolution to a progressive chronic disease. Autoimmune arthritis caused by passive transfer of autoantibodies against glucose 6-phosphate isomerase is transient and ... ...

Abstract	It is not known what is required for successive relapses in autoimmune diseases or evolution to a progressive chronic disease. Autoimmune arthritis caused by passive transfer of autoantibodies against glucose 6-phosphate isomerase is transient and therefore lends itself well to test for what might extend the disease. Herpesviruses have long been suspected of contributing to human autoimmune disease. We infected mice with a murine gamma-herpesvirus (MHV-68). In immunodeficient mice, transient arthritis was followed by a relapse. This was due to lytic viral infection of synovial tissues demonstrated by PCR, immunohistochemistry, and electron microscopy. Latent infection could be reactivated in the synovium of normal mice when treated with Cytoxan and this was associated with increased clinical arthritis. We conclude that herpesviruses may play an ancillary pathogenic role in autoimmune arthritis by infection of the inflammatory target tissue.
MeSH term(s)	Animals ; Antigens, Viral/analysis ; Arthritis, Experimental/etiology ; Autoimmune Diseases/etiology ; CD8-Positive T-Lymphocytes/immunology ; DNA, Viral/analysis ; Joints/virology ; Mice ; Mice, Inbred C57BL ; Recurrence ; Rhadinovirus/physiology ; Virus Activation ; Virus Replication
Chemical Substances	Antigens, Viral ; DNA, Viral
Language	English
Publishing date	2004-11-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.173.8.5238
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The activation of memory CD4(+) T cells and CD8(+) T cells in patients with multiple sclerosis.

Okuda, Yoshinobu / Okuda, Misa / Apatoff, Brian R / Posnett, David N

Journal of the neurological sciences

2005 Volume 235, Issue 1-2, Page(s) 11–17

Abstract: To reevaluate whether an association exists between the clinical course of multiple sclerosis (MS) and the activation of memory T cells, we investigated the phenotype of T cells in peripheral blood and cerebrospinal fluid (CSF) of patients with MS using ... ...

Abstract	To reevaluate whether an association exists between the clinical course of multiple sclerosis (MS) and the activation of memory T cells, we investigated the phenotype of T cells in peripheral blood and cerebrospinal fluid (CSF) of patients with MS using five-color flow cytometry. A cross-sectional study with 39 relapsing-remitting MS patients demonstrated that the percentage of CD25(+)CD45RO(+)CD4(+)CD3(+) cells was significantly increased in peripheral blood as well as in CSF of active MS patients compared with inactive MS patients. A longitudinal study with 11 relapsing-remitting MS patients also showed a higher percentage of CD25(+)CD45RO(+)CD4(+)CD3(+) cells in peripheral blood at the phase of exacerbation than during remission. On the other hand, regardless of the disease activity, the percentage of CD25(+)CD45RO(+)CD8(+)CD3(+) cells in peripheral blood was significantly higher in patients with MS than in healthy control subjects. A lower percentage of CD25(+)CD45RO(+)CD8(+)CD3(+) cells in CSF was observed in active MS patients compared with inactive MS patients. These results suggest that the activation of memory CD4(+) T cells is associated with the exacerbation of MS and activation of memory CD8(+) T cells reflects systemic immunological dysregulation in MS patients. Transient as well as continuous activation of T cells by recall antigens may be involved in the disease course of MS.
MeSH term(s)	Adult ; Antigens, CD/analysis ; Antigens, CD/classification ; Antigens, CD/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross-Sectional Studies ; Female ; Flow Cytometry ; Humans ; Immunologic Memory ; Immunophenotyping ; Longitudinal Studies ; Lymphocyte Activation/physiology ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/blood ; Multiple Sclerosis, Relapsing-Remitting/cerebrospinal fluid ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Statistics, Nonparametric
Chemical Substances	Antigens, CD
Language	English
Publishing date	2005-08-15
Publishing country	Netherlands
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2005.02.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 308: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Allelic variations of human TCR V gene products.

Posnett, D N

Immunology today

1990 Volume 11, Issue 10, Page(s) 368–373

Abstract: ... V gene allelic variation. In this article David Posnett summarizes evidence in favour ...

Abstract	A central problem confronting the immune system is how to discriminate among vast numbers of antigens. Novel genetic ploys that aid the discriminative process, including complex gene rearrangements (in antibody and T-cell receptor (TCR) genes) and extensive allelic polymorphism (in major histocompatibility complex (MHC) genes), have been described. Recent evidence has suggested a further level of diversity; TCR V gene allelic variation. In this article David Posnett summarizes evidence in favour of this possibility and speculates on the possible functional consequences of TCR allelism.
MeSH term(s)	Alleles ; Humans ; Introns/genetics ; Major Histocompatibility Complex/genetics ; Polymorphism, Genetic ; Receptors, Antigen, T-Cell/genetics ; Recombination, Genetic
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	1990-10
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	283214-8
ISSN	1355-8242 ; 0167-5699 ; 0167-4919
ISSN (online)	1355-8242
ISSN	0167-5699 ; 0167-4919
DOI	10.1016/0167-5699(90)90143-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 2: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Development of effective vaccines for old mice in a tumor model.

Posnett, David N / Engelhorn, Manuel E / Lin, Yun / Merghoub, Taha / Duan, Fei / Wolchok, Jedd D / Houghton, Alan N

Vaccine

2008 Volume 27, Issue 7, Page(s) 1093–1100

Abstract: Vaccines are often inefficient in old people and old mice. Few studies have focused on testing vaccines in old populations. Here we used DNA tumor antigen vaccines against melanoma and showed that old mice were not protected. Vaccines incorporating ... ...

Abstract	Vaccines are often inefficient in old people and old mice. Few studies have focused on testing vaccines in old populations. Here we used DNA tumor antigen vaccines against melanoma and showed that old mice were not protected. Vaccines incorporating fusions of the tumor antigen with microbial adjuvant proteins OmpA (E. Coli) or Vp22 (Herpes simplex virus-1) dramatically improved protection of old mice. The mechanisms by which these adjuvant proteins act are distinct. TLR2 was not required for either OmpA or Vp22. Antigen processing and presentation were not boosted by these fusion constructs. However, fusion constructs with Vp22 gave a strong CD4 response to B16 melanoma and the OmpA response is MHC-II dependent. Both adjuvant fusion constructs stimulated CD4 and CD8 responses otherwise diminished in old mice.
MeSH term(s)	Adjuvants, Immunologic/genetics ; Adjuvants, Immunologic/pharmacology ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/immunology ; Female ; Interferon-gamma/metabolism ; Melanoma/immunology ; Melanoma/prevention & control ; Mice ; Mice, Inbred C57BL ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/pharmacology ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology ; Viral Structural Proteins/genetics ; Viral Structural Proteins/pharmacology
Chemical Substances	Adjuvants, Immunologic ; Antigens, Neoplasm ; Bacterial Outer Membrane Proteins ; Cancer Vaccines ; Recombinant Fusion Proteins ; Vaccines, DNA ; Viral Structural Proteins ; herpes simplex virus type 1 protein VP22 ; OMPA outer membrane proteins (149024-69-1) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2008-12-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2008.11.112
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mechanisms of immunization against cancer using chimeric antigens.

Engelhorn, Manuel E / Guevara-Patiño, José A / Merghoub, Taha / Liu, Cailian / Ferrone, Cristina R / Rizzuto, Gabriele A / Cymerman, Daniel H / Posnett, David N / Houghton, Alan N / Wolchok, Jedd D

Molecular therapy : the journal of the American Society of Gene Therapy

2008 Volume 16, Issue 4, Page(s) 773–781

Abstract: Successful approaches to tumor immunotherapy must overcome the physiological state of tolerance of the immune system to self-tumor antigens. Immunization with appropriate variants of syngeneic antigens can achieve this. However, improvements in vaccine ... ...

Abstract	Successful approaches to tumor immunotherapy must overcome the physiological state of tolerance of the immune system to self-tumor antigens. Immunization with appropriate variants of syngeneic antigens can achieve this. However, improvements in vaccine design are needed for efficient cancer immunotherapy. Here we explore nine different chimeric vaccine designs, in which the antigen of interest is expressed as an in-frame fusion with polypeptides that impact antigen processing or presentation. In DNA immunization experiments in mice, three of nine fusions elevated relevant CD8(+) T-cell responses and tumor protection relative to an unfused melanoma antigen. These fusions were: Escherichia coli outer membrane protein A (OmpA), Pseudomonas aeruginosa exotoxin A, and VP22 protein of herpes simplex virus-1. The gains of immunogenicity conferred by the latter two are independent of epitope presentation by major histocompatibility complex class II (MHC II). This finding has positive implications for immunotherapy in individuals with CD4(+) T-cell deficiencies. We present evidence that antigen instability is not a sine qua non condition for immunogenicity. Experiments using two additional melanoma antigens identified different optimal fusion partners, thereby indicating that the benefits of fusion vectors remain antigen specific. Therefore large fusion vector panels such as those presented here can provide information to promote the successful advancement of gene-based vaccines.
MeSH term(s)	ADP Ribose Transferases/genetics ; ADP Ribose Transferases/immunology ; Animals ; Antigen Presentation ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/immunology ; Bacterial Toxins/genetics ; Bacterial Toxins/immunology ; CD8-Positive T-Lymphocytes/immunology ; COS Cells ; Cancer Vaccines/genetics ; Cancer Vaccines/immunology ; Cancer Vaccines/therapeutic use ; Chlorocebus aethiops ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/immunology ; Exotoxins/genetics ; Exotoxins/immunology ; Female ; Histocompatibility Antigens Class II/immunology ; Humans ; Melanoma, Experimental/immunology ; Melanoma, Experimental/therapy ; Mice ; Mice, Inbred C57BL ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Vaccination ; Vaccines, DNA/genetics ; Vaccines, DNA/immunology ; Vaccines, DNA/therapeutic use ; Viral Structural Proteins/genetics ; Viral Structural Proteins/immunology ; Virulence Factors/genetics ; Virulence Factors/immunology ; Pseudomonas aeruginosa Exotoxin A
Chemical Substances	Antigens, Neoplasm ; Bacterial Outer Membrane Proteins ; Bacterial Toxins ; Cancer Vaccines ; Escherichia coli Proteins ; Exotoxins ; Histocompatibility Antigens Class II ; Recombinant Fusion Proteins ; Vaccines, DNA ; Viral Structural Proteins ; Virulence Factors ; herpes simplex virus type 1 protein VP22 ; OMPA outer membrane proteins (149024-69-1) ; ADP Ribose Transferases (EC 2.4.2.-)
Language	English
Publishing date	2008-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1038/mt.2008.8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5640: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Staphylococcus aureus express unique superantigens depending on the tissue source.

Banks, Michael C / Kamel, Nabil S / Zabriskie, John B / Larone, Davise H / Ursea, Dana / Posnett, David N

The Journal of infectious diseases

2003 Volume 187, Issue 1, Page(s) 77–86

Abstract: A comprehensive analysis of Staphylococcus aureus superantigen (SAG) genes was undertaken in isolates from a major hospital and compared with isolates from patients with toxic shock syndrome (TSS). Polymerase chain reaction (PCR) analysis included ... ...

Abstract	A comprehensive analysis of Staphylococcus aureus superantigen (SAG) genes was undertaken in isolates from a major hospital and compared with isolates from patients with toxic shock syndrome (TSS). Polymerase chain reaction (PCR) analysis included recently discovered SAGs. Staphylococcal enterotoxin (SE) G and SEI were uniquely expressed in genital isolates. Genital isolates were similar to TSS isolates, although the latter frequently expressed TSS toxin 1. Both had a high frequency of SEG/SEI and a high number of SAG genes per bacterium. Detection of an SAG gene by PCR correlated with positive results in functional assays for SAG activity. Levels of serum antibodies to SEG and SEI, but not to other superantigens, were higher in healthy women than in men and served as an independent measure of the higher frequency of exposure to SEG/SEI among women. Together, the data suggest a role for SEG/SEI or closely linked genes in the adaptation of S. aureus to the genital mucosa environment.
MeSH term(s)	Adolescent ; Adult ; Enterotoxins/genetics ; Female ; Humans ; Male ; Middle Aged ; Mucous Membrane/microbiology ; Polymerase Chain Reaction ; Shock, Septic/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/immunology ; Staphylococcus aureus/pathogenicity ; Superantigens/genetics ; Vagina/microbiology
Chemical Substances	Enterotoxins ; Superantigens ; enterotoxin G, staphylococcal ; enterotoxin I, staphylococcal
Language	English
Publishing date	2003-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1086/345874
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito