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  1. Article ; Online: In Memorium: Jun Kimura, MD.

    Eisen, Andrew

    Muscle & nerve

    2022  Volume 65, Issue 5, Page(s) 487–488

    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27536
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  2. Article: The Dying Forward Hypothesis of ALS: Tracing Its History.

    Eisen, Andrew

    Brain sciences

    2021  Volume 11, Issue 3

    Abstract: The site of origin of amyotrophic lateral sclerosis (ALS), although unsettled, is increasingly recognized as being cortico-fugal, which is a dying-forward process primarily starting in the corticomotoneuronal system. A variety of iterations of this ... ...

    Abstract The site of origin of amyotrophic lateral sclerosis (ALS), although unsettled, is increasingly recognized as being cortico-fugal, which is a dying-forward process primarily starting in the corticomotoneuronal system. A variety of iterations of this concept date back to over 150 years. Recently, the hallmark TAR DNA-binding protein 43 (TDP-43) pathology, seen in >95% of patients with ALS, has been shown to be largely restricted to corticofugal projecting neurons ("dying forward"). Possibly, soluble but toxic cytoplasmic TDP-43 could enter the axoplasm of Betz cells, subsequently causing dysregulation of nuclear protein in the lower brainstem and spinal cord anterior horn cells. As the disease progresses, cortical involvement in ALS becomes widespread, including or starting with frontotemporal dementia, implying a broader view of ALS as a brain disease. The onset at the motor and premotor cortices should be considered a nidus at the edge of multiple cortical networks which eventually become disrupted, causing failure of a widespread cortical connectome.
    Language English
    Publishing date 2021-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11030300
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  3. Article ; Online: Role of the paediatrician in dental health.

    Hurry, K Julia / Eisen, Sarah / Ward, Allison

    Archives of disease in childhood

    2024  

    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325873
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  4. Article ; Online: Central nervous system in motor neuron disease.

    Eisen, Andrew

    Journal of neurology, neurosurgery, and psychiatry

    2018  Volume 89, Issue 9, Page(s) 901–902

    MeSH term(s) Central Nervous System Diseases/history ; History, 20th Century ; Humans ; Motor Neuron Disease/history ; Neuropathology/history ; United Kingdom
    Language English
    Publishing date 2018-04-21
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2018-318186
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  5. Article: Corrigendum: Development of a quadruplex PCR amplicon next generation sequencing assay for detection and differentiation of

    Bai, Ying / Osikowicz, Lynn M / Hojgaard, Andrias / Eisen, Rebecca J

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1360286

    Abstract: This corrects the article DOI: 10.3389/fmicb.2023.1243471.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmicb.2023.1243471.].
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1360286
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  6. Article ; Online: The glymphatic system and Amyotrophic lateral sclerosis.

    Eisen, Andrew / Nedergaard, Maiken / Gray, Emma / Kiernan, Matthew C

    Progress in neurobiology

    2024  Volume 234, Page(s) 102571

    Abstract: The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is applicable for TDP-43 and glutamate, both major elements in disease ...

    Abstract The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is applicable for TDP-43 and glutamate, both major elements in disease pathogenesis. Flow is propelled by arterial pulsation, respiration, posture, as well as the positioning and proportion of aquaporin-4 channels (AQP4). Non-REM slow wave sleep is the is key to glymphatic drainage which discontinues during wakefulness. In Parkinson's disease and Alzheimer's disease, sleep impairment is known to predate the development of characteristic clinical features by several years and is associated with progressive accumulation of toxic proteinaceous products. While sleep issues are well described in ALS, consideration of preclinical sleep impairment or the potential of a failing glymphatic system in ALS has rarely been considered. Here we review how the glymphatic system may impact ALS. Preclinical sleep impairment as an unrecognized major risk factor for ALS is considered, while potential therapeutic options to improve glymphatic flow are explored.
    MeSH term(s) Humans ; Glymphatic System/metabolism ; Glymphatic System/pathology ; Amyotrophic Lateral Sclerosis/metabolism ; Brain/metabolism ; Alzheimer Disease/metabolism ; Sleep
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2024.102571
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  7. Article ; Online: A next generation sequencing assay combining Ixodes species identification with pathogen detection to support tick surveillance efforts in the United States.

    Osikowicz, Lynn M / Maes, Sarah E / Eisen, Rebecca J / Hojgaard, Andrias

    Ticks and tick-borne diseases

    2024  Volume 15, Issue 4, Page(s) 102343

    Abstract: The burden of tick-borne diseases continues to increase in the United States. Tick surveillance has been implemented to monitor changes in the distribution and prevalence of human disease-causing pathogens in ticks that frequently bite humans. Such ... ...

    Abstract The burden of tick-borne diseases continues to increase in the United States. Tick surveillance has been implemented to monitor changes in the distribution and prevalence of human disease-causing pathogens in ticks that frequently bite humans. Such efforts require accurate identification of ticks to species and highly sensitive and specific assays that can detect and differentiate pathogens from genetically similar microbes in ticks that have not been demonstrated to be pathogenic in humans. We describe a modification to a next generation sequencing pathogen detection assay that includes a target that accurately identifies Ixodes ticks to species. We show that the replacement of internal control primers used to ensure assay performance with primers that also act as an internal control and can additionally differentiate tick species, retains high sensitivity and specificity, improves efficiency, and reduces costs by eliminating the need to run separate assays to screen for pathogens and for tick identification.
    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2024.102343
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  8. Article ; Online: Susceptibility to stress and nature exposure: Unveiling differential susceptibility to physical environments; a randomized controlled trial.

    Eisen, Aaron M / Bratman, Gregory N / Olvera-Alvarez, Hector A

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301473

    Abstract: Background: Emerging epidemiological evidence indicates nature exposure could be associated with greater health benefits among groups in lower versus higher socioeconomic positions. One possible mechanism underpinning this evidence is described by our ... ...

    Abstract Background: Emerging epidemiological evidence indicates nature exposure could be associated with greater health benefits among groups in lower versus higher socioeconomic positions. One possible mechanism underpinning this evidence is described by our framework: (susceptibility) adults in low socioeconomic positions face higher exposure to persistent psychosocial stressors in early life, inducing a pro-inflammatory phenotype as a lifelong susceptibility to stress; (differential susceptibility) susceptible adults are more sensitive to the health risks of adverse (stress-promoting) environments, but also to the health benefits of protective (stress-buffering) environments.
    Objective: Experimental investigation of a pro-inflammatory phenotype as a mechanism facilitating greater stress recovery from nature exposure.
    Methods: We determined differences in stress recovery (via heart rate variability) caused by exposure to a nature or office virtual reality environment (10 min) after an acute stressor among 64 healthy college-age males with varying levels of susceptibility (socioeconomic status, early life stress, and a pro-inflammatory state [inflammatory reactivity and glucocorticoid resistance to an in vitro bacterial challenge]).
    Results: Findings for inflammatory reactivity and glucocorticoid resistance were modest but consistently trended towards better recovery in the nature condition. Differences in recovery were not observed for socioeconomic status or early life stress.
    Discussion: Among healthy college-age males, we observed expected trends according to their differential susceptibility when assessed as inflammatory reactivity and glucocorticoid resistance, suggesting these biological correlates of susceptibility could be more proximal indicators than self-reported assessments of socioeconomic status and early life stress. If future research in more diverse populations aligns with these trends, this could support an alternative conceptualization of susceptibility as increased environmental sensitivity, reflecting heightened responses to adverse, but also protective environments. With this knowledge, future investigators could examine how individual differences in environmental sensitivity could provide an opportunity for those who are the most susceptible to experience the greatest health benefits from nature exposure.
    MeSH term(s) Male ; Adult ; Humans ; Glucocorticoids ; Stress, Psychological/psychology ; Environment ; Disease Susceptibility ; Social Class
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301473
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  9. Article ; Online: A novel approach to post-acute myocardial infarction care.

    Porter, Avital / Eisen, Alon / Kheifets, Mark

    Kardiologia polska

    2023  Volume 81, Issue 2, Page(s) 103–104

    MeSH term(s) Humans ; Myocardial Infarction/therapy
    Language English
    Publishing date 2023-02-05
    Publishing country Poland
    Document type Editorial ; Comment
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2023.0031
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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  10. Book: Clinical neurophysiology of motor neuron diseases

    Eisen, Andrew

    (Handbook of clinical neurophysiology ; 4)

    2004  

    Author's details vol. ed. Andrew Eisen
    Series title Handbook of clinical neurophysiology ; 4
    Collection
    Keywords Motor Neuron Disease / diagnosis ; Motor Neuron Disease / physiopathology ; Motorik ; Nervensystem ; Krankheit
    Subject Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS ; Motorisches System ; Anthropomotorik
    Language English
    Size XV, 724 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014197493
    ISBN 0-444-51359-0 ; 978-0-444-51359-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 5676 order for loan Magazin

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