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  1. Article: Chromosome Rearrangement in

    Jiang, Chengzhi / Liu, Xiaodan / Yang, Zujun / Li, Guangrong

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: As a perennial herb in Triticeae, ...

    Abstract As a perennial herb in Triticeae,
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12183268
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  2. Article: Sexual Dimorphism in the Limb Bones of Asiatic Toad (

    Yan, Chengzhi / Ma, Hui / Yang, Yuejun / Mi, Zhiping

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 16

    Abstract: Sexual dimorphism is often considered to be the result of differences in the intensity of sexual selection between sexes. From this point of view, the sexual dimorphism of the limb bones of ... ...

    Abstract Sexual dimorphism is often considered to be the result of differences in the intensity of sexual selection between sexes. From this point of view, the sexual dimorphism of the limb bones of the
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13162638
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  3. Article: Visible Light-Driven Micromotors in Fuel-Free Environment with Promoted Ion Tolerance.

    Jiang, Huaide / He, Xiaoli / Yang, Ming / Hu, Chengzhi

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to ...

    Abstract Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to complex external environments are particularly attractive. In this study, we have fabricated visible light-driven micromotors that could swim in an environment with relatively high salinity. To achieve this, we first tuned the energy bandgap of rutile TiO
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13121827
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  4. Article ; Online: Metabolic Adaption of Flexor Carpi Radialis to Amplexus Behavior in Asiatic Toads (

    Yan, Chengzhi / Ma, Hui / Yang, Yuejun / Mi, Zhiping

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Amplexus is a type of mating behavior among toads that is essential for successful external fertilization. Most studies have primarily focused on the behavioral diversity of amplexus, and less is known regarding the metabolic changes occurring in ... ...

    Abstract Amplexus is a type of mating behavior among toads that is essential for successful external fertilization. Most studies have primarily focused on the behavioral diversity of amplexus, and less is known regarding the metabolic changes occurring in amplectant males. The aim of this study was to compare the metabolic profiles of amplectant Asiatic toad (
    MeSH term(s) Animals ; Male ; Adaptation, Physiological ; Amino Acids/analysis ; Amino Acids/metabolism ; Bufonidae/metabolism ; Carbohydrate Metabolism ; Carbohydrates/analysis ; Energy Metabolism ; Forelimb ; Lipid Metabolism ; Metabolome ; Muscle, Skeletal/metabolism ; Sexual Behavior, Animal
    Chemical Substances Amino Acids ; Carbohydrates
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210174
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  5. Article ; Online: Catalytic hairpin assembly triggering amplified DNAzyme-feedback for sensitive detection of hepatitis C virus genotype 1b.

    Xu, Yuting / Li, Lili / Yang, Yumeng / Huang, Chengzhi / Zou, Hongyan

    Talanta

    2024  Volume 271, Page(s) 125754

    Abstract: Developing a simple, reliable, and sensitive hepatitis C virus (HCV) genetic sensing platform is of great significance for diagnosing diseases and selecting appropriate antiviral treatments. Herein, a tandem nucleic acid amplification strategy for ... ...

    Abstract Developing a simple, reliable, and sensitive hepatitis C virus (HCV) genetic sensing platform is of great significance for diagnosing diseases and selecting appropriate antiviral treatments. Herein, a tandem nucleic acid amplification strategy for sensitive detection of HCV genotype 1b (HCV-1b) was developed by stringing the catalytic hairpin assembly (CHA) and the triggered DNAzyme amplifier. The hairpin reactants were initiated by the target to produce lots of triggering double-stranded DNA sequences which can efficiently activate the subsequent blocked DNAzyme. Thereby, the continuous cleavage of substrate was realized, resulting in the fluorescence signal amplification. The DNA-based isothermal CHA-DNAzyme (CDz) sensing platform was successfully applied for sensitive detection of HCV-1b with the limit of detection (84 pM) and showed good selectivity. Moreover, the practical detection of target DNA in the complex biologic matrix indicated that the developing strategy had good potential for early HCV infection diagnosis.
    MeSH term(s) Humans ; DNA, Catalytic/genetics ; Hepacivirus/genetics ; Feedback ; Biosensing Techniques/methods ; DNA/genetics ; Hepatitis C/diagnosis ; Genotype ; Limit of Detection
    Chemical Substances DNA, Catalytic ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125754
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  6. Article ; Online: A Lightweight Semantic Segmentation Algorithm Based on Deep Convolutional Neural Networks.

    Yang, Chengzhi / Guo, Hongjun

    publication RETRACTED

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 5339664

    Abstract: With the development of deep learning theory and the decrease of the cost of acquiring massive data, the image semantic segmentation algorithm based on Convolutional Neural Networks (CNNs) is gradually replacing the conventional segmentation algorithm by ...

    Abstract With the development of deep learning theory and the decrease of the cost of acquiring massive data, the image semantic segmentation algorithm based on Convolutional Neural Networks (CNNs) is gradually replacing the conventional segmentation algorithm by its high accuracy segmentation performance. By increasing the amount of training data and stacking more convolutional layers to form Deep Convolutional Neural Networks (DCNNs), a neural network model with higher segmentation accuracy can be obtained, but it faces the problems of serious memory consumption and long latency. For some special application scenarios, such as augmented reality and mobile interaction, real-time processing cannot be performed. To improve the speed of semantic segmentation while obtaining the most accurate segmentation results as possible, this paper proposes a semantic segmentation algorithm based on lightweight convolutional neural networks. Taking the computational complexity and segmentation accuracy into account, the algorithm starts from the perspective of extracting high-level semantic features and introduces a position-attention mechanism with richer contextual information to model the relationship between different pixels, avoiding the convolutional local perceptual field to be too small. To recover clearer target boundaries, a channel attention mechanism is introduced in the decoding part of the model to mine more useful feature channel information and effectively improve the fusion of low-level features with high-level features. By verifying the effectiveness of the above model on a publicly available dataset and comparing it with the more popular semantic segmentation methods, the model proposed in this paper has higher semantic segmentation accuracy and reflects certain advantages in objective evaluation.
    MeSH term(s) Algorithms ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Semantics ; Time Perception
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/5339664
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  7. Article ; Online: Metabolic Adaption of Flexor Carpi Radialis to Amplexus Behavior in Asiatic Toads ( Bufo gargarizans )

    Chengzhi Yan / Hui Ma / Yuejun Yang / Zhiping Mi

    International Journal of Molecular Sciences, Vol 24, Iss 10174, p

    2023  Volume 10174

    Abstract: Amplexus is a type of mating behavior among toads that is essential for successful external fertilization. Most studies have primarily focused on the behavioral diversity of amplexus, and less is known regarding the metabolic changes occurring in ... ...

    Abstract Amplexus is a type of mating behavior among toads that is essential for successful external fertilization. Most studies have primarily focused on the behavioral diversity of amplexus, and less is known regarding the metabolic changes occurring in amplectant males. The aim of this study was to compare the metabolic profiles of amplectant Asiatic toad ( Bufo gargarizans ) males in the breeding period (BP group) and the resting males in the non-breeding period (NP group). A metabolomic analysis was conducted on the flexor carpi radialis (FCR), an essential forelimb muscle responsible for clasping during courtship. A total of 66 differential metabolites were identified between the BP and NP groups, including 18 amino acids, 12 carbohydrates, and 8 lipids, and they were classified into 9 categories. Among these differential metabolites, 13 amino acids, 11 carbohydrates, and 7 lipids were significantly upregulated in the BP group compared to the NP group. In addition, a KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis identified 17 significant metabolic pathways, including ABC transporters, aminoacyl-tRNA biosynthesis, arginine biosynthesis, pantothenate and CoA biosynthesis, and fructose and mannose metabolism. These results suggest that amplectant male toads are metabolically more active than those during the non-breeding period, and this metabolic adaptation increases the likelihood of reproductive success.
    Keywords amphibian ; metabolomic ; reproduction ; adaption ; energy demands ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 590
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Visible Light-Driven Micromotors in Fuel-Free Environment with Promoted Ion Tolerance

    Huaide Jiang / Xiaoli He / Ming Yang / Chengzhi Hu

    Nanomaterials, Vol 13, Iss 1827, p

    2023  Volume 1827

    Abstract: Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to ...

    Abstract Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to complex external environments are particularly attractive. In this study, we have fabricated visible light-driven micromotors that could swim in an environment with relatively high salinity. To achieve this, we first tuned the energy bandgap of rutile TiO 2 that was hydrothermally synthesized, enabling it to generate photogenerated electron-hole pairs under visible light rather than solely under UV. Next, platinum nanoparticles and polyaniline were decorated onto the surface of TiO 2 microspheres to facilitate the micromotors swimming in ion-rich environments. Our micromotors exhibited electrophoretic swimming in NaCl solutions with concentrations as high as 0.1 M, achieving a velocity of 0.47 μm/s without the need for additional chemical fuels. The micromotors’ propulsion was generated solely by splitting water under visible light illumination, therefore offering several advantages over traditional micromotors, such as biocompatibility and the ability to operate in environments with high ionic strength. These results demonstrated high biocompatibility of photophoretic micromotors and high potential for practical applications in various fields.
    Keywords micromotors ; visible light ; ion-tolerant ; biocompatibility ; Chemistry ; QD1-999
    Subject code 535
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Generalizing factors of COVID-19 vaccine attitudes in different regions

    Yang Liu / Jiale Shi / Chenxu Zhao / Chengzhi Zhang

    Digital Health, Vol

    A summary generation and topic modeling approach

    2023  Volume 9

    Abstract: Objective The goal of this study is to use summary generation and topic modeling to identify factors contributing to vaccine attitudes for three different vaccine brands, with the aim of generalizing these factors across different regions. Methods A ... ...

    Abstract Objective The goal of this study is to use summary generation and topic modeling to identify factors contributing to vaccine attitudes for three different vaccine brands, with the aim of generalizing these factors across different regions. Methods A total of 5562 tweets about three vaccine brands (Sinovac, AstraZeneca, and Pfizer) were collected from 14 December 2020 to 30 December 2021. BERTopic clustering is used to group the tweets into topics, and then contrastive learning (CL) is adopted to generate summaries of each topic. The main content of each topic is generalized into three factors that contribute to vaccine attitudes: vaccine-related factors, health system-related factors, and individual social attributes. Results BERTopic clustering outperforms Latent Dirichlet Allocation clustering in our analysis. It can also be found that using CL for summary generation helped to better model the topics, particularly at the center-point of the clustering. Our model identifies three main factors contributing to vaccine attitudes that are consistent across different regions. Conclusions Our study demonstrates the effectiveness of deep learning methods for identifying factors contributing to vaccine attitudes in different regions. By determining these factors, policymakers and medical institutions can develop more effective strategies for addressing concerns related to the vaccination process.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 006
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Traditional Chinese Medicine is Associated with the Reduction in Endpoint Events in Patients with Gouty Arthritis: Cohort Study and Association Rule Analysis.

    Chen, Yiming / Liu, Jian / Cong, Chengzhi / Li, Yang / Hu, Yuedi

    International journal of general medicine

    2024  Volume 17, Page(s) 525–539

    Abstract: Objective: This study aimed to evaluate the effect of traditional Chinese medicine (TCM) on endpoint events in patients with gouty arthritis (GA).: Methods and materials: A total of 2091 hospitalized GA patients were followed up by telephone, and ... ...

    Abstract Objective: This study aimed to evaluate the effect of traditional Chinese medicine (TCM) on endpoint events in patients with gouty arthritis (GA).
    Methods and materials: A total of 2091 hospitalized GA patients were followed up by telephone, and propensity score matching (PSM) was used to reduce potential bias in the study design. Cox proportional risk model and Kaplan-Meier survival curve were utilized to analyze the impact and time effect of factors on the readmission of GA patients. The differences of laboratory indexes before and after treatment between the low and high exposure groups were compared, and the types and frequencies of medicines in all patients were counted. Association rule analysis was performed to investigate the association between TCM and test indexes or endpoint events.
    Results: After 1:1 PSM, 187 patients were enrolled in the TCM group and 187 patients in the non-TCM group. The incidence of readmission, new tophus, and all-cause death was lower in the TCM group than that in the non-TCM group (P < 0.05). Cox proportional risk regression analysis showed that TCM, NSAIDs and uric acid lowering drug were independent protective factors for GA readmission. The protective effect was enhanced by the prolongation of TCM treatment and the drug combinations. Kaplan-Meier survival curves indicated a significantly lower readmission rate in the high exposure group than in the low exposure group (P < 0.01). Compared with before treatment, NLR, hs-CRP, UA, TC and other laboratory indexes of the low and high exposure groups were improved after treatment (P < 0.01); The improvement of TG and TC in the high exposure group was more significant than the low exposure group (P < 0.01). The analysis of medicines used by all patients identified the top 20 Chinese herbal medicines and the top 2 Chinese patent medicines. The core drugs identified through association rule analysis that can improve test index and reduce the incidence of endpoint events include Yiyiren, Danshen, and HQC, among others. The network diagram of association rule analysis intuitively shows the relationship between core drugs and "improvement of indicators" and "the absence of endpoint events".
    Conclusion: TCM is associated with a reduced incidence of endpoint events in patients with GA.
    Language English
    Publishing date 2024-02-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S451097
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