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Article ; Online: Mayer-Rokitansky-Küster-Hauser Syndrome: MR Manifestations Of Typical And Atypical Cases.

Khan, Nasir / Khaliq, Maria / Azam, Madiha Maryam / Raja, Riffat

Journal of Ayub Medical College, Abbottabad : JAMC

2022 Volume 33Suppl 1, Issue 4, Page(s) S711–S716

Abstract: Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a group of congenital malformations arising due to agenesis or arrest of the growth of paired Mullerian ducts leading to absence of uterus, fallopian tubes and upper part of vagina. MRI ... ...

Abstract	Background: The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a group of congenital malformations arising due to agenesis or arrest of the growth of paired Mullerian ducts leading to absence of uterus, fallopian tubes and upper part of vagina. MRI has an unmatched role in diagnosing MRKH syndrome. The aim of the present study is to elaborate MRI manifestations of typical and atypical MRKH syndrome and its common and rare associations. Methods: It was a cross sectional analysis of 19 cases in the Radiology Department of a public sector tertiary health care hospital of Rawalpindi over a period of one year. All patients clinically diagnosed as MRKH syndrome were included in the study. MRI pelvis of the study patients was performed and evaluated by two experienced radiologists. Results: The mean age of study patients was 22.2 years. Out of 19 study patients, 16 (84%) had type I while 3 (16%) had type II MRKH syndrome. None of the patients had normally cited uterus of normal morphology. Bilateral ovaries with follicular activity were identified in all patients. A well-defined leiomyoma was identified arising from the left uterine bud in one of these patients. All three patients with MRKH II syndrome had ectopic pelvic kidneys. One of the patients showed a neoplastic mass lesion arising from ectopic left kidney. Conclusion: MRI is an excellent imaging modality for accurate diagnosis and evaluation of other system anomalies in MRKH syndrome. Rudimentary uterine buds are commonly seen in these patients and may have functioning endometrium. Ovaries are of normal appearance but frequently ectopic.
MeSH term(s)	46, XX Disorders of Sex Development/diagnostic imaging ; Adult ; Congenital Abnormalities/diagnostic imaging ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Mullerian Ducts/abnormalities ; Mullerian Ducts/diagnostic imaging ; Vagina/diagnostic imaging ; Young Adult
Language	English
Publishing date	2022-01-25
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
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Article: Physicians' attitude, belief and practice of complementary alternative medication use.

Shoaib, Maria / Khaliq, Muhammad Farhan

Patient preference and adherence

2017 Volume 11, Page(s) 1091–1092

Language	English
Publishing date	2017-06-27
Publishing country	New Zealand
Document type	Journal Article ; Comment
ZDB-ID	2455848-5
ISSN	1177-889X
ISSN	1177-889X
DOI	10.2147/PPA.S141767
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Article: An Analysis of High-Resolution Computed Tomography Chest Manifestations of COVID-19 Patients in Pakistan.

Khaliq, Maria / Raja, Riffat / Khan, Nasir / Hanif, Hina

Cureus

2020 Volume 12, Issue 7, Page(s) e9373

Abstract: Objective The objective of the present study is to describe high-resolution CT (HRCT) chest manifestations of coronavirus disease 2019 (COVID-19) patients presenting to a tertiary healthcare facility in Punjab, Pakistan, and to analyze the distribution ... ...

Abstract	Objective The objective of the present study is to describe high-resolution CT (HRCT) chest manifestations of coronavirus disease 2019 (COVID-19) patients presenting to a tertiary healthcare facility in Punjab, Pakistan, and to analyze the distribution of the disease in lung fields. Additionally, we assess the role of chest CT severity scoring (CT-SS) in determining the severity of pneumonia. Methods In this cross-sectional descriptive study conducted from March 30, 2020, to May 30, 2020, 87 confirmed COVID-19 patients undergoing HRCT scan in a tertiary care facility in Punjab, Pakistan were included. The HRCT chest was performed on the patients using a standard protocol. Each study was evaluated for the presence of ground-glass opacities (GGOs), consolidation, mixed pattern, distribution, crazy paving, reverse halo sign, nodules, pleural effusion, and other findings. Additionally, CT-SS was calculated by dividing each lung into 20 zones. Each zone was scored as 0, 1, and 2, representing no involvement, <50% involvement, and >50% involvement of one zone respectively (total score: 0-40 for each patient). The patients were classified into mild, moderate, and severe cases (mild: CT-SS of <20, moderate: CT-SS of 20-30, and severe: CT-SS of >30). Results GGO was the most common finding, as seen in 88.5% of the patients, followed by consolidations (52.8%) and crazy paving (33.3%). The majority of the patients showed the bilateral and peripheral distribution of the disease process. Vascular dilatation and bronchiectasis were seen in 10 patients; pleural effusions were observed in only two study patients, while no patient exhibited reverse halo sign or pulmonary nodules. The superior segment of lower lobes was the most commonly involved segment bilaterally. According to CT-SS, 78 (89.6%), six (6.9%), and three (3.45%) patients had mild, moderate, and severe disease respectively. Conclusion The typical imaging findings of COVID-19 on HRCT are GGOs with multilobe involvement and bilateral, peripheral, and basal predominance. CT-SS is helpful in categorizing pneumonia into mild, moderate, and severe types, thereby helping to identify patients with severe disease. This is particularly helpful in settings where fast triage is required.
Keywords	covid19
Language	English
Publishing date	2020-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.9373
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Article ; Online: A novel study for producing complexed and encapsulated nutrients at nanometric scale to enhance plant growth.

Khaliq, Marium / Hanif, Muhammad Asif / Bhatti, Ijaz Ahmad / Mushtaq, Zahid

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11100

Abstract: Complexation of micronutrients with complexing agents reduce undesirable reactions of fertilizers in soil water system. In the form of complex structure nutrients remain available to plants in the useable form. Nanoform fertilizer enhances the surface ... ...

Abstract	Complexation of micronutrients with complexing agents reduce undesirable reactions of fertilizers in soil water system. In the form of complex structure nutrients remain available to plants in the useable form. Nanoform fertilizer enhances the surface area of particles and less amount of fertilizer contact with large area of plant roots which reduce fertilizer cost. Controlling release of fertilizer using polymeric material like sodium alginate makes agriculture practices more efficient and cost effective. Several fertilizers and nutrients are used at a large scale to improve crop yields globally and almost more than half goes to waste. Therefore, there is a dire need to improve plant-available nutrients in soil, using feasible, environmentally friendly technologies. In the present research, complexed micronutrients were successfully encapsulated using a novel technique at nanometric scale. The nutrients were complexed with proline and encapsulated using sodium alginate (polymer). Sweet basil was subjected to seven treatments over three months in a moderately controlled environment (25 °C of temperature and 57% of humidity) to study the effects of synthesized complexed micronutrient nano fertilizers. The structural modifications of the complexed micronutrient nanoforms of fertilizers were examined, through X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The size of manufactured fertilizers was between 1 and 200 nm. Fourier transform infrared (FTIR) spectroscopy stretching vibration peaks at 1600.9 cm
MeSH term(s)	Fertilizers ; Soil/chemistry ; Agriculture/methods ; Micronutrients ; Trace Elements ; Polymers ; Alginates
Chemical Substances	Fertilizers ; Soil ; Micronutrients ; Trace Elements ; Polymers ; Alginates
Language	English
Publishing date	2023-07-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37607-x
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Article ; Online: The role of thermal tolerance in determining elevational distributions of four arthropod taxa in mountain ranges of southern Asia

Khaliq, Imran / Shahid, Muhammad Junaid / Kamran, Haseeb / Sheraz, Muhammad / Awais, Muhammad / Shabir, Mehtab / Asghar, Muhammad / Rehman, Abdul / Riaz, Maria / Braschler, Brigitte / Sanders, Nathan J. / Hof, Christian

Journal of Animal Ecology. 2023 Oct., v. 92, no. 10 p.2052-2066

2023

Abstract: Understanding the role of thermal tolerances in determining species distributions is important for assessing species responses to climate change. Two hypotheses linking physiology with species distributions have been put forward—the climatic variability ... ...

Abstract	Understanding the role of thermal tolerances in determining species distributions is important for assessing species responses to climate change. Two hypotheses linking physiology with species distributions have been put forward—the climatic variability hypothesis and the climatic extreme hypothesis. The climatic variability hypothesis predicts the selection of individuals with broad thermal tolerance in more variable climatic conditions and the climatic extreme hypothesis predicts the selection of individuals with extreme thermal tolerance values under extreme climatic conditions. However, no study has tested the predictions of these hypotheses simultaneously for several taxonomic groups along elevational gradients. Here, we related experimentally measured critical thermal maxima, critical thermal minima and thermal tolerance breadths for 15,187 individuals belonging to 116 species of ants, beetles, grasshoppers, and spiders from mountain ranges in central and northern Pakistan to the limits and breadths of their geographic and temperature range. Across all species and taxonomic groups, we found strong relationships between thermal traits and elevational distributions both in terms of geography and temperature. The relationships were robust when repeating the analyses for ants, grasshoppers, and spiders but not for beetles. These results indicate a strong role of physiology in determining elevational distributions of arthropods in Southern Asia. Overall, we found strong support for the climatic variability hypothesis and the climatic extreme hypothesis. A close association between species' distributional limits and their thermal tolerances suggest that in case of a failure to adapt or acclimate to novel climatic conditions, species may be under pressure to track their preferred climatic conditions, potentially facing serious consequences under current and future climate change.
Keywords	animal ecology ; arthropods ; climate change ; geography ; heat tolerance ; physiology ; temperature ; Pakistan
Language	English
Dates of publication	2023-10
Size	p. 2052-2066.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	3024-7
ISSN	1365-2656 ; 0021-8790
ISSN (online)	1365-2656
ISSN	0021-8790
DOI	10.1111/1365-2656.13996
Database	NAL-Catalogue (AGRICOLA)

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Article: Performance of a Norfentanyl Immunoassay in Specimens with Low Concentrations of Fentanyl and/or Norfentanyl.

Uljon, Sacha / Tolan, Nicole V / Mahowald, Grace K / Khaliq, Tahira / Urwiller, Elizabeth D / Fernandes, Maria Daluz / Basu, Sankha S / Kang, Phillip / Erickson, Timothy B / Hayes, Bryan D / Chai, Peter R / Melanson, Stacy E F

The journal of applied laboratory medicine

2024

Abstract: Background: Many fentanyl immunoassays are limited in their ability to detect norfentanyl. Urine specimens collected from individuals who have been exposed to fentanyl frequently have detectable concentrations of norfentanyl (≥2 ng/mL) but low ... ...

Abstract	Background: Many fentanyl immunoassays are limited in their ability to detect norfentanyl. Urine specimens collected from individuals who have been exposed to fentanyl frequently have detectable concentrations of norfentanyl (≥2 ng/mL) but low concentrations of fentanyl (<2 ng/mL) by LC-MS/MS. The Lin-Zhi Fentanyl II Immunoassay (Lin-Zhi) claims 100% cross-reactivity with norfentanyl and therefore may detect exposure missed by other assays. Methods: In addition to verifying the manufacturer's analytical sensitivity claims, we selected 92 urine specimens with low-positive Lin-Zhi results (1-99 absorbance units, lowest 10%) for analysis by the Immunalysis Health Equity Impact Assessment and ARK II fentanyl methods. The accuracy of the 3 immunoassays was compared to LC-MS/MS as the reference method. Results: Spiking studies using purified fentanyl and norfentanyl and a set of 100 consecutive specimens confirmed the manufacturer's claims of limit of detection for fentanyl (3.8 ng/mL) and norfentanyl (5.0 ng/mL). However, the 92 low-positive patient specimens demonstrated concentrations of norfentanyl and fentanyl below 2.0 ng/mL by LC-MS/MS, with 47 (51%) having only norfentanyl detected. When comparing Lin-Zhi to the Immunalysis and ARK II immunoassays, only 27 (29%) of the 92 specimens were concordant. Fifty-two (57%) of the specimens were positive by LC-MS/MS and Lin-Zhi but false negative by one or both other immunoassays. Seven specimens (8%) were positive by Lin-Zhi but negative by the other immunoassays and had undetectable concentrations (<2 ng/mL) of fentanyl and norfentanyl by LC-MS/MS. Conclusions: The clinical sensitivity of the Lin-Zhi exceeds the manufacturer's claims, providing results comparable to LC-MS/MS methods.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfae036
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Article ; Conference proceedings: Pictorial Review of Currently Available IR-Guided Procedures in Treating Portal Hypertension

Khan, Zahid Amin / Rauf, Maria / Bhinder, Khurram Khaliq / Khalid, Namrah / Rana, Atif / Anwar, Jamshaid

The Arab Journal of Interventional Radiology

2024 Volume 08, Issue S 01

Event/congress	PAIRS 2024 Annual Congress, World Trade Center, Dubai, UAE, 2024-02-10
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ISSN	2542-7083 ; 2542-7075
ISSN (online)	2542-7083
ISSN	2542-7075
DOI	10.1055/s-0044-1785917
Database	Thieme publisher's database

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Article ; Online: Warming underpins community turnover in temperate freshwater and terrestrial communities.

Khaliq, Imran / Rixen, Christian / Zellweger, Florian / Graham, Catherine H / Gossner, Martin M / McFadden, Ian R / Antão, Laura / Brodersen, Jakob / Ghosh, Shyamolina / Pomati, Francesco / Seehausen, Ole / Roth, Tobias / Sattler, Thomas / Supp, Sarah R / Riaz, Maria / Zimmermann, Niklaus E / Matthews, Blake / Narwani, Anita

Nature communications

2024 Volume 15, Issue 1, Page(s) 1921

Abstract: Rising temperatures are leading to increased prevalence of warm-affinity species in ecosystems, known as thermophilisation. However, factors influencing variation in thermophilisation rates among taxa and ecosystems, particularly freshwater communities ... ...

Abstract	Rising temperatures are leading to increased prevalence of warm-affinity species in ecosystems, known as thermophilisation. However, factors influencing variation in thermophilisation rates among taxa and ecosystems, particularly freshwater communities with high diversity and high population decline, remain unclear. We analysed compositional change over time in 7123 freshwater and 6201 terrestrial, mostly temperate communities from multiple taxonomic groups. Overall, temperature change was positively linked to thermophilisation in both realms. Extirpated species had lower thermal affinities in terrestrial communities but higher affinities in freshwater communities compared to those persisting over time. Temperature change's impact on thermophilisation varied with community body size, thermal niche breadth, species richness and baseline temperature; these interactive effects were idiosyncratic in the direction and magnitude of their impacts on thermophilisation, both across realms and taxonomic groups. While our findings emphasise the challenges in predicting the consequences of temperature change across communities, conservation strategies should consider these variable responses when attempting to mitigate climate-induced biodiversity loss.
MeSH term(s)	Animals ; Ecosystem ; Biodiversity ; Body Size ; Climate ; Fresh Water
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46282-z
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Article ; Online: Correlating CT Chest with RT-PCR in Diagnosing COVID-19

Riffat Raja / Maria Khaliq / Muhammad Imran Khan / Nasir Khan / Khoala Riaz / Sadaf Arooj

Journal of Rawalpindi Medical College, Vol 1, Iss

Experience at a Tertiary Health Care Hospital in Pakistan

2022 Volume 1

Abstract: Objective: To establish the accuracy of computed tomography(CT) chest in the diagnosis of COVID-19 pneumonia by taking reverse transcriptase-polymerase chain reaction(RT-PCR) as a reference standard and to analyze discordant CT chest and RT-PCR results. ... ...

Abstract	Objective: To establish the accuracy of computed tomography(CT) chest in the diagnosis of COVID-19 pneumonia by taking reverse transcriptase-polymerase chain reaction(RT-PCR) as a reference standard and to analyze discordant CT chest and RT-PCR results. Materials and Methods: A retrospective cross-sectional study of patients presented to a tertiary health care hospital in Punjab, Pakistan for CT examination with suspicion of COVID-19 from April 1, to June 30, 2020. Each CT chest was categorized as positive/negative for COVID-19 pneumonia and the results were compared with the RT-PCR test. Discordant CT chest and PCR results were also investigated. Results: The study population had a mean age of 48 years ± 6.6 years with 54.5% males and 45.4% females. Sensitivity(Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of CT in diagnosing COVID-19 pneumonia taking RT- PCR as the gold standard was 92.5%, 46.6%%, 82.2%, 70%, and 80% respectively. Conclusion: CT chest has high sensitivity but modest specificity in the diagnosis of COVID-19 pneumonia. It can be employed as an adjunctive screening and diagnostic test for early diagnosis of disease in places where disease prevalence is high.
Keywords	COVID-19 ; CT chest ; RT-PCR ; ground glass opacities ; diagnostic accuracy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Rawalpindi Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Left atrial remodelling among Turner syndrome patients: novel insights from non-invasive 3D echocardiography.

Abd El Rahman, Mohamed / Jung, Anna-Maria / Zemlin, Michael / Rohrer, Tilman R / Schuck, Rita / Oberhoffer, Felix Sebastian / Abdul-Khaliq, Hashim

Quantitative imaging in medicine and surgery

2022 Volume 12, Issue 5, Page(s) 2634–2648

Abstract: Background: To assess (I) the left atrial (LA) size, function and (II) the impact of excess weight on the LA and left ventricular (LV) performance in Turner syndrome (TS) patients.: Methods: Twenty-five TS patients without congenital heart disease ( ... ...

Abstract	Background: To assess (I) the left atrial (LA) size, function and (II) the impact of excess weight on the LA and left ventricular (LV) performance in Turner syndrome (TS) patients. Methods: Twenty-five TS patients without congenital heart disease (CHD) and 19 healthy, age-matched controls underwent three-dimensional echocardiography (3DE) for LA volume measurements and two-dimensional speckle tracking echocardiography (2DSTE) for LA strain measurements. LV performance was measured through LV Tei-index, indexed isovolumetric contraction (ICT/√RR interval), indexed relaxation (IVRT/√RR interval) and indexed filling time (FT/√RR interval). Results: Compared to healthy controls, normal-weight TS patients (n=16) displayed significantly increased heart rate (92.88±16.66 Conclusions: Normal-weight TS patients with increased heart rate and reduced LV filling time display subtle LV diastolic dysfunction in the form of reduced LA reservoir and pump function. Manifested systolic and diastolic LV dysfunction among overweight TS patients is partially compensated through an increase in LA active pump function.
Language	English
Publishing date	2022-04-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-21-515
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