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Article: Visceral leishmaniasis in the island of Margarita, Venezuela: a neglected parasitic infection in the Caribbean.

García Oronoz, Gerardine / Pedraza-Arévalo, Laura C / Henao-Martínez, Andrés F / Franco-Paredes, Carlos / Suarez, José A

Therapeutic advances in infectious disease

2021 Volume 8, Page(s) 20499361211031714

Abstract: ... Herein, we describe an autochthonous case of visceral leishmaniasis in the Caribbean Island of Margarita ...

Abstract	Visceral leishmaniasis carries a significant burden of disease in the Americas with up to 7000 cases reported annually. There are several reports of autochthonous visceral leishmaniasis cases in the Caribbean, including the Dominican Republic, Guadalupe, Martinique, and Trinidad and Tobago. However, we lack recent clinical description and epidemiologic data of visceral leishmaniasis in other islands in the Caribbean. Herein, we describe an autochthonous case of visceral leishmaniasis in the Caribbean Island of Margarita in Venezuela. This index case of visceral leishmaniasis highlights the need for further regional surveillance efforts to identify animal reservoirs and to monitor the occurrence of further clinical cases. Additionally, there is an urgent need for implementing vector control strategies.
Language	English
Publishing date	2021-07-27
Publishing country	England
Document type	Case Reports
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/20499361211031714
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Adapting to changing poaching intensity of yellow-shouldered parrot (Amazona barbadensis) nestlings in Margarita Island, Venezuela

Briceño-Linares, José Manuel / Rodríguez, Jon Paul / Rodríguez-Clark, Kathryn M / Rojas-Suárez, Franklin / Millán, Pablo Antonio / Vittori, Eleonora G / Carrasco-Muñoz, Mar

Biological conservation. 2011 Apr., v. 144, no. 4

2011

Abstract: The yellow-shouldered parrot (Amazona barbadensis) is listed in Venezuela as Endangered and internationally as Vulnerable, primarily due to poaching for the illegal pet trade. Various interventions have been implemented to reduce poaching (increasing the ...

Abstract	The yellow-shouldered parrot (Amazona barbadensis) is listed in Venezuela as Endangered and internationally as Vulnerable, primarily due to poaching for the illegal pet trade. Various interventions have been implemented to reduce poaching (increasing the population from 700 in 1989 to 1600 in 2009), but poaching pressure is still high, and is ever-changing, requiring an evolving response. Between 2000 and 2003, our only intervention was environmental education in schools: in the short term, unsurprisingly, it had no impact on poaching, which reached 100% of nestlings in monitored nests. From 2004 onwards, we implemented a set of new field interventions. In 2004, 24h field surveillance decreased poaching to 56%. In 2005, the addition of foster nests and a pilot test of “assisted breeding” brought the figure down to 18%. In 2006, assisted breeding was expanded, achieving 0% poaching. In 2007, poachers raided our “secure” site, and took 34 nestlings, bringing poaching up to 60%. A pilot study of artificial nests offered promising results. In 2008 and 2009, the addition of patrolling by local police reduced poaching to 16% and 1%, respectively. During 2004-2009, nestling poaching averaged 25%. Ensuring parrot recruitment in the future will require a combination of the strategies employed to date; in the short term, expanding the use of artificial nests to increase availability of nesting sites in easily-patrolled areas has the most potential to build on past successes.
Keywords	Amazona ; environmental education ; islands ; nesting sites ; nests ; parrots ; population growth ; recruitment ; schools ; Venezuela
Language	English
Dates of publication	2011-04
Size	p. 1188-1193.
Publishing place	Kidlington, Oxford: Elsevier Science Ltd.
Document type	Article
ISSN	0006-3207
DOI	10.1016/j.biocon.2010.12.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Transjugular Intrahepatic Portosystemic Shunt Creation in Children Weighing <10 kg Using an Unconventional Technique.

Sanín, Emilio / Suárez-Galvis, Margarita / Álvarez, Sergio / Santamaría, Alfredo

Journal of vascular and interventional radiology : JVIR

2023 Volume 34, Issue 6, Page(s) 1070–1074

Abstract: Transjugular intrahepatic portosystemic shunt (TIPS) creation is a standard therapeutic procedure for the management of complications of portal hypertension. However, in small children, this procedure is infrequently performed because of technical ... ...

Abstract	Transjugular intrahepatic portosystemic shunt (TIPS) creation is a standard therapeutic procedure for the management of complications of portal hypertension. However, in small children, this procedure is infrequently performed because of technical difficulties owing to their small size and scarce information on outcomes. This article presents the results of treatment of variceal bleeding with TIPS creation in 8 children weighing <10 kg, along with the description of the unconventional techniques and materials required. Technical and clinical success rates were 100%. Although this was a small cohort of patients, the results obtained suggest that this is a safe and technically and clinically effective treatment option for complications of portal hypertension in this age group.
MeSH term(s)	Humans ; Child ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Esophageal and Gastric Varices/diagnostic imaging ; Esophageal and Gastric Varices/etiology ; Esophageal and Gastric Varices/surgery ; Gastrointestinal Hemorrhage/diagnostic imaging ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/surgery ; Hypertension, Portal/diagnostic imaging ; Hypertension, Portal/surgery ; Hypertension, Portal/complications ; Treatment Outcome
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2023.01.037
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Article: Impetigo Leishmaniasis Previously Diagnosed as Crusty Impetigo: A Case Study.

Suarez, José / Rios, Margarita / Estripeaut, Dora / Reina, Adelys

Cureus

2022 Volume 14, Issue 2, Page(s) e22492

Abstract: Cutaneous leishmaniasis is a zoonotic disease caused by several species of protozoa of the ... ...

Abstract	Cutaneous leishmaniasis is a zoonotic disease caused by several species of protozoa of the genus
Language	English
Publishing date	2022-02-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22492
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bisphenol A exposure affects specific gut taxa and drives microbiota dynamics in childhood obesity.

Lopez-Moreno, Ana / Cerk, Klara / Rodrigo, Lourdes / Suarez, Antonio / Aguilera, Margarita / Ruiz-Rodriguez, Alicia

mSystems

2024 Volume 9, Issue 3, Page(s) e0095723

Abstract: Cumulative xenobiotic exposure has an environmental and human health impact which is currently assessed under the One Health approach. Bisphenol A (BPA) exposure and its potential link with childhood obesity that has parallelly increased during the last ... ...

Abstract	Cumulative xenobiotic exposure has an environmental and human health impact which is currently assessed under the One Health approach. Bisphenol A (BPA) exposure and its potential link with childhood obesity that has parallelly increased during the last decades deserve special attention. It stands during prenatal or early life and could trigger comorbidities and non-communicable diseases along life. Accumulation in the nature of synthetic chemicals supports the "environmental obesogen" hypothesis, such as BPA. This estrogen-mimicking xenobiotic has shown endocrine disruptive and obesogenic effects accompanied by gut microbiota misbalance that is not yet well elucidated. This study aimed to investigate specific microbiota taxa isolated and selected by direct BPA exposure and reveal its role on the overall children microbiota community and dynamics, driving toward specific obesity dysbiosis. A total of 333 BPA-resistant isolated species obtained through culturing after several exposure conditions were evaluated for their role and interplay with the global microbial community. The selected BPA-cultured taxa biomarkers showed a significant impact on alpha diversity. Specifically,
MeSH term(s)	Female ; Pregnancy ; Humans ; Child ; Overweight ; Pediatric Obesity/epidemiology ; Dysbiosis/chemically induced ; Xenobiotics ; Microbiota ; Clostridiaceae ; Benzhydryl Compounds ; Phenols
Chemical Substances	bisphenol A (MLT3645I99) ; Xenobiotics ; Benzhydryl Compounds ; Phenols
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.00957-23
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Article ; Online: Steroids Conjugated to Carbon Nanoforms as Potential Inhibitors of Viral Proteases, Synthesis, DFT Calculations, and Molecular Docking

Reinier Lemos / Kamil Makowski / Margarita Suárez

Medical Sciences Forum, Vol 14, Iss 53, p

2022 Volume 53

Abstract: Steroid [60]fullerene hybrids have been synthesized by the Bingel−Hirsch reaction as a contribution to the chemistry of carbon nanoforms. The hybrids were characterized by different spectroscopic experiments and analytical techniques. Theoretical ... ...

Abstract	Steroid [60]fullerene hybrids have been synthesized by the Bingel−Hirsch reaction as a contribution to the chemistry of carbon nanoforms. The hybrids were characterized by different spectroscopic experiments and analytical techniques. Theoretical calculations using the Density functional theory and the PBE functional were performed to predict the most stable conformations for the synthesized compounds and the frontier molecular orbitals energy. Some properties, such as polarizability, dipole moment, lipophilicity, solvent-accessible surface area, and topological polar surface area, were calculated. Fullerenes and their derivatives have potential antiviral activity due to their specific binding interactions with biological molecules. The ability of fullerene derivatives to interact with the active site of HIV and SARS-Cov-2 proteases was studied by the Autodock Vina program. The C 60 cage exhibited an interaction with the phenyl group of phenylalanine residues through π–π and T-shape interactions. Furthermore, it was observed that the steroid moieties formed H-bonds with the amino acid residues in the active sites of proteins. In addition, van der Waals contacts with the nonpolar protease surface, thereby improving the binding relative to the tested compound. Protein-ligand docking revealed several important molecular fragments that are responsible for the interaction, thus paving the way to study the possible application of these hybrids in medicinal chemistry.
Keywords	steroid hybrids ; antivirals ; theoretical calculations ; fullerenes ; Medicine ; R
Subject code	540
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ChatGPT performance in prosthodontics: Assessment of accuracy and repeatability in answer generation.

Freire, Yolanda / Santamaría Laorden, Andrea / Orejas Pérez, Jaime / Gómez Sánchez, Margarita / Díaz-Flores García, Víctor / Suárez, Ana

The Journal of prosthetic dentistry

2024 Volume 131, Issue 4, Page(s) 659.e1–659.e6

Abstract: Statement of problem: The artificial intelligence (AI) software program ChatGPT is based on large language models (LLMs) and is widely accessible. However, in prosthodontics, little is known about its performance in generating answers.: Purpose: The ... ...

Abstract	Statement of problem: The artificial intelligence (AI) software program ChatGPT is based on large language models (LLMs) and is widely accessible. However, in prosthodontics, little is known about its performance in generating answers. Purpose: The purpose of this study was to determine the performance of ChatGPT in generating answers about removable dental prostheses (RDPs) and tooth-supported fixed dental prostheses (FDPs). Material and methods: Thirty short questions were designed about RDPs and tooth-supported FDP, and 30 answers were generated for each of the questions using ChatGPT-4 in October 2023. The 900 generated answers were independently graded by experts using a 3-point Likert scale. The relative frequency and absolute percentage of answers were described. Accuracy was assessed using the Wald binomial method, while repeatability was evaluated using percentage agreement, Brennan and Prediger coefficient, Conger generalized Cohen kappa, Fleiss kappa, Gwet AC, and Krippendorff alpha methods. Confidence intervals were set at 95%. Statistical analysis was performed using the STATA software program. Results: The performance of ChatGPT in generating answers related to RDP and tooth-supported FDP was limited. The answers showed a reliability of 25.6%, with a confidence range between 22.9% and 28.6%. The repeatability ranged from substantial to moderate. Conclusions: The results show that currently ChatGPT has limited ability to generate answers related to RDPs and tooth-supported FDPs. Therefore, ChatGPT cannot replace a dentist, and, if professionals were to use it, they should be aware of its limitations.
MeSH term(s)	Prosthodontics ; Artificial Intelligence ; Reproducibility of Results ; Research Design ; Software
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2024.01.018
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Article ; Online: Unveiling the ChatGPT phenomenon: Evaluating the consistency and accuracy of endodontic question answers.

Suárez, Ana / Díaz-Flores García, Víctor / Algar, Juan / Sánchez, Margarita Gómez / de Pedro, María Llorente / Freire, Yolanda

International endodontic journal

2023 Volume 57, Issue 3, Page(s) 371–372

Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Letter
ZDB-ID	603734-3
ISSN	1365-2591 ; 0143-2885
ISSN (online)	1365-2591
ISSN	0143-2885
DOI	10.1111/iej.13998
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Article ; Online: Isolation of local strains of the yeast Metschnikowia for biocontrol and lipid production purposes.

Tatay-Núñez, Josep / Albi-Puig, Joana / Garrigós, Víctor / Orejas-Suárez, Margarita / Matallana, Emilia / Aranda, Agustín

World journal of microbiology & biotechnology

2024 Volume 40, Issue 3, Page(s) 88

Abstract: The bioprospection of indigenous microorganism strains with biotechnological potential represents a prominent trend. Metschnikowia yeasts exhibit diverse capabilities, such as ethanol reduction in winemaking, biocontrol potential, and lipid production. ... ...

Abstract	The bioprospection of indigenous microorganism strains with biotechnological potential represents a prominent trend. Metschnikowia yeasts exhibit diverse capabilities, such as ethanol reduction in winemaking, biocontrol potential, and lipid production. In this work, local Metschnikowia strains were isolated from different fruits by their ability to produce pulcherrimic acid, a molecule that has been linked to biocontrol activity and that binds iron giving colored colonies. Five strains were selected, each from one of five distinct sources. All of them were identified as M. pulcherrima. All five were able inhibit other yeasts and one M. pulcherrima, called M7, inhibited the growth of Aspergillus nidulans. The selected strains accumulated lipid bodies in stationary phase. Certain non-conventional yeasts like Hanseniaspora vineae are very sensitive to biomass drying, but cell extracts from M. pulcherrima added to the growth media as a source of antioxidant lipids increased their tolerance to drying. All strains isolated showed good stress tolerance (particularly to heat) and have nutrient requirements similar to a commercial M. pulcherrima strain. In addition, the M7 strain had a good growth in sugarcane and beet molasses and behaved like Saccharomyces cerevisiae in a growth medium derived from agricultural waste, a persimmon hydrolysate. Therefore, the isolation of local strains of Metschnikowia able to grow in a variety of substrates is a good source of biocontrol agents.
MeSH term(s)	Saccharomyces cerevisiae/metabolism ; Metschnikowia/metabolism ; Wine/analysis ; Fruit ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-024-03918-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Synthesis of [60]Fullerene Hybrids Endowed with Steroids and Monosaccharides: Theoretical Underpinning as Promising anti-SARS-CoV-2 Agents.

Lemos, Reinier / Makowski, Kamil / Almagro, Luis / Tolón, Blanca / Rodríguez, Hortensia / Herranz, M Ángeles / Molero, Dolores / Martín, Nazario / Suárez, Margarita

European journal of organic chemistry

2023 , Page(s) e202201301

Abstract: Cyclopropanation reactions between ... ...

Abstract	Cyclopropanation reactions between C
Language	English
Publishing date	2023-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475010-7
ISSN	1099-0690 ; 1434-193X
ISSN (online)	1099-0690
ISSN	1434-193X
DOI	10.1002/ejoc.202201301
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