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Article ; Online: LysZX4-NCA, a new endolysin with broad-spectrum antibacterial activity for topical treatment.

Li, Ping / Shen, Mangmang / Ma, Wenjie / Zhou, Xin / Shen, Jiayin

2023 Volume 340, Page(s) 199296

Abstract: The prevalence of multidrug-resistant highly virulent Klebsiella pneumoniae (MDR-hvKP) requires the development of new therapeutic agents. Herein, a novel lytic phage vB_KpnS_ZX4 against MDR-hvKP was discovered in hospital sewage. Phage vB_KpnS_ZX4 had a ...

Abstract	The prevalence of multidrug-resistant highly virulent Klebsiella pneumoniae (MDR-hvKP) requires the development of new therapeutic agents. Herein, a novel lytic phage vB_KpnS_ZX4 against MDR-hvKP was discovered in hospital sewage. Phage vB_KpnS_ZX4 had a short latent period (5 min) and a large burst size (230 PFU/cell). It can rapidly reduce the number of bacteria in vitro and improve survival rates of bacteremic mice in vivo from 0 to 80 % with a single injection of 10
MeSH term(s)	Mice ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacteriophages ; Endopeptidases/pharmacology ; Klebsiella pneumoniae
Chemical Substances	endolysin (EC 3.4.99.-) ; Anti-Bacterial Agents ; Endopeptidases (EC 3.4.-)
Language	English
Publishing date	2023-12-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2023.199296
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Article ; Online: A nano-copper particle-modified zinc anode as a protective coating enables dendrite-free aqueous zinc-ion batteries.

Zhu, Hongchuan / Zhao, Mingshu / Shi, Mangmang / Yuan, Chenjie / Li, Feng / Su, Zhou / Jiao, Lidong / Li, Min / Yang, Sen

Dalton transactions (Cambridge, England : 2003)

2024 Volume 53, Issue 8, Page(s) 3855–3864

Abstract: Aqueous zinc-ion batteries (AZIBs) have become one of the hotspots in large-scale energy storage due to their advantages of high safety, low cost, and environmental friendliness. However, the metallic Zn anode is prone to dendritic growth and ... ...

Abstract	Aqueous zinc-ion batteries (AZIBs) have become one of the hotspots in large-scale energy storage due to their advantages of high safety, low cost, and environmental friendliness. However, the metallic Zn anode is prone to dendritic growth and electrochemical corrosion on the surface during cycling, posing a serious challenge to the cycling life of AZIBs. Herein, a simple, low-cost and suitable for mass production method is reported to construct an anti-corrosive nano-copper particle protective coating on the surface of a metallic zinc (Cu-Zn) anode. The prepared nano-copper particles are evenly distributed on the surface of Zn, providing a uniform electric field distribution and successfully suppressing electrochemical corrosion on the surface. Importantly, it is confirmed microscopically that the Cu-Zn anode maintains homogeneous stripping and plating processes, effectively alleviating dendrite formation. Additionally, the resulting Cu-Zn anode exhibits a lower overpotential, which offers a lower interfacial transfer resistance of the battery. The symmetric battery test results show that the unmodified bare Zn anode fails after 58 h at 1 mA cm
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt03975g
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Article: Neck Circumference Is Associated With Poor Outcome in Patients With Spontaneous Intracerebral Hemorrhage.

Li, Yujian / Zhou, Huiqing / Yang, Xiang / Zheng, Jun / Zhang, Fan / Xu, Mangmang / Li, Hao

Frontiers in neurology

2021 Volume 11, Page(s) 622476

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2020.622476
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Article ; Online: Burden of heart failure in Asia, 1990-2019: findings from the Global Burden of Disease Study 2019.

Zhang, Chi / Xie, Bo / Wang, Xin / Pan, Mangmang / Wang, Jia / Ding, Huamin / Li, Tiejun / Lin, Houwen / Gu, Zhichun

Public health

2024 Volume 230, Page(s) 66–72

Abstract: Objectives: Heart failure (HF) is on the rise as a global health problem, but information on its burden in Asia is limited. This study aimed to assess the burden, trends, and underlying causes of HF in the Asian region.: Study design and methods: ... ...

Abstract	Objectives: Heart failure (HF) is on the rise as a global health problem, but information on its burden in Asia is limited. This study aimed to assess the burden, trends, and underlying causes of HF in the Asian region. Study design and methods: Data on HF in Asia from 1990 to 2019, including prevalence, years lived with disability (YLD), and underlying causes, were extracted from the Global Burden of Diseases 2019. The cases, the age-standardized prevalence, and the YLD were compared between the age groups, the sexes, the sociodemographic index, and the locations. The proportion of age-standardized prevalence rates of HF attributable to 16 underlying causes was also analyzed. Results: In 2019, the age-standardized prevalence rate of HF per 100,000 persons in Asia was 722.45 (95% uncertainty interval [UI]: 591.97-891.64), with an estimated 31.89 million cases (95% UI: 25.94-39.25). From 1990 to 2019, the prevalence of age-standardized HF in Asia decreased by 4.51%, reflecting the global trend (-7.06%). Age-standardized YLD rates of HF exhibited patterns similar to prevalence rates. Among Asian countries, China had the highest age-standardized prevalence rate, followed by Kuwait and Jordan. Hypertensive heart disease was the leading cause of HF, followed by ischemic heart disease and rheumatic heart disease. Conclusions: Although the burden of HF in Asia showed a gradual decline between 1990 and 2019, it remains a significant health challenge that requires increased attention. Regional disparities in HF burden are evident, emphasizing the need for urgent prevention and control measures at the regional and national levels.
MeSH term(s)	Humans ; Global Burden of Disease ; Asia/epidemiology ; Prevalence ; Disabled Persons ; Global Health ; Heart Failure/epidemiology ; Quality-Adjusted Life Years ; Incidence
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	427333-3
ISSN	1476-5616 ; 0033-3506
ISSN (online)	1476-5616
ISSN	0033-3506
DOI	10.1016/j.puhe.2024.02.015
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Article ; Online: Spatial Distribution Characteristics and Influencing Factors of Pro-Poor Tourism Villages in China

Lei Zhu / Jing Hu / Jiahui Xu / Yannan Li / Mangmang Liang

Sustainability, Vol 14, Iss 15953, p

2022 Volume 15953

Abstract: This paper aims to contribute to the effectiveness of pro-poor tourism in rural areas. We use 5770 pro-poor tourism villages in China as the research objects; the spatial distribution characteristics of pro-poor tourism villages in China are analyzed ... ...

Abstract	This paper aims to contribute to the effectiveness of pro-poor tourism in rural areas. We use 5770 pro-poor tourism villages in China as the research objects; the spatial distribution characteristics of pro-poor tourism villages in China are analyzed using a combination of disequilibrium index, kernel density analysis, and spatial autocorrelation; their influencing factors are detected using a geographical detector and overlay analysis. The study results show the following: (1) The distribution of pro-poor tourism villages is exceptionally uneven in three zones, eight regions, and inter-provincial levels, forming a high-density cluster belt that includes Hebei, Henan, Anhui, and Hubei, and five high-density cluster cores that include southern Gansu, Sichuan–Gansu–Shaanxi border area; Guizhou, Hunan, and Chongqing border area; southern Sichuan; and southwest Guizhou. (2) Regarding spatial correlations, the pro-poor tourism villages in central and western regions are in hot spots, while those in eastern regions are in cold spots. The hot spots gradually increase, while cold spots gradually decrease, and the clustering trend of the distribution of the pro-poor tourism villages is increasingly apparent. (3) Pro-poor tourism villages are affected by social, economic, industrial, and other human factors as well as natural geographical factors such as terrain, precipitation, river, and climate, among which the industrial factors have a more significant impact. Pro-poor tourism villages are concentrated in humid mountainous areas with an altitude of about 1000 m and an annual precipitation of more than 800 mm, and they are mostly distributed in the subtropical monsoon climate zone closer to the river and more suitable climate. (4) It is suggested that pro-poor tourism villages can be divided into four types: the resource underutilization type, mountain environment restriction type, traffic location non-optimization type, and industrial development lagging type, and the sustainable development strategies of different ...
Keywords	rural tourism ; pro-poor tourism villages ; spatial distribution characteristics ; geographic detector ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An "AND" Molecular Logic Gate as a Super-Enhancers for De Novo Designing Activatable Probe and Its Application in Atherosclerosis Imaging.

Sang, Mangmang / Huang, Yibo / Wang, Lu / Chen, Lei / Nawsherwan / Li, Gang / Wang, Yan / Yu, Xiu / Dai, Cuilian / Zheng, Jinrong

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 12, Page(s) e2207066

Abstract: Developing activatable fluorescent probes with superlative fluorescence enhancement factor (F/ ... ...

Abstract	Developing activatable fluorescent probes with superlative fluorescence enhancement factor (F/F
MeSH term(s)	Mice ; Animals ; Atherosclerosis/diagnostic imaging ; Fluorescent Dyes ; Plaque, Atherosclerotic ; Diagnostic Imaging ; Fluorescence
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2023-02-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202207066
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Article: Echocardiographic correlates of MRI imaging markers of cerebral small-vessel disease in patients with atrial-fibrillation-related ischemic stroke.

Ye, Kaili / Tao, Wendan / Wang, Zhetao / Li, Dayan / Xu, Mangmang / Liu, Junfeng / Liu, Ming

Frontiers in neurology

2023 Volume 14, Page(s) 1137488

Abstract: Background and objectives: Atrial fibrillation (AF) has been linked to dementia risk, partly explained by cerebral small vessel disease (CSVD). Since AF and cardiovascular comorbidities were associated with cardiac dysfunction, we aimed to determine the ...

Abstract	Background and objectives: Atrial fibrillation (AF) has been linked to dementia risk, partly explained by cerebral small vessel disease (CSVD). Since AF and cardiovascular comorbidities were associated with cardiac dysfunction, we aimed to determine the association between echocardiographic parameters and neuroimaging markers of CSVD in patients with AF-related ischemic stroke. Methods: This cross-sectional study enrolled patients with AF-related ischemic stroke from March 2013 to December 2019 who underwent transthoracic echocardiography and brain 3T MRI, including T1, T2, Flair, and SWI imaging sequences. We assessed the presence of lacunes and cerebellar microbleeds (CMBs), the severity of white matter hyperintensity (WMH) scored by the Fazekas scale (0-6), and the severity of enlarged perivascular spaces (EPVS) in basal ganglia (BG) and centrum semiovale (CSO) classified into three categories (0-10, 10-25, and >25). CSVD burden was rated on a 0-to-4 ordinal scale. Generalized linear regression analysis and post hoc comparisons with Bonferroni correction were performed to assess the association between various echocardiographic parameters and these lesions, adjusted for demographics and potential confounders. Results: 119 patients (68.38 ± 12.692 years; male 45.4 %) were included for analysis, of whom 55 (46.2%) had lacunes, 40 (33.6%) had CMBs, and median severity for WMH, BG-EPVS, CSO-EPVS, and CSVD burden were 2 (IQR: 1-3), 1 (IQR: 1-2), 1 (IQR: 0-1), and 1 (IQR: 1-2) respectively. In multivariable, fully adjusted models, left ventricular posterior wall thickness (LVPW) was associated with a higher risk of lacunes (RR 1.899, 95% CI: 1.342-2.686) and CSVD burden (RR = 2.081, 95%CI: 1.562-2.070). Right atrial diameter (RAD) was associated with greater CSO-EPVS (RR = 2.243, 95%CI: 1.234-4.075). No echocardiographic parameters were revealed to be associated with CMBs and WMH. Conclusion: In patients with AF-related ischemic stroke, LVPW is associated with a higher risk of lacunes and CSVD burden, while RAD was associated with greater CSO-EPVS. Larger studies are required to determine these associations and to elucidate if these associations can help facilitate cognitive evaluation and brain MRI screening.
Language	English
Publishing date	2023-03-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1137488
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Article ; Online: Enzyme Catalysis Biomotor Engineering of Neutrophils for Nanodrug Delivery and Cell-Based Thrombolytic Therapy.

Zheng, Jinrong / Qi, Ruiqiang / Dai, Cuilian / Li, Gang / Sang, Mangmang

ACS nano

2022 Volume 16, Issue 2, Page(s) 2330–2344

Abstract: Utilizing neutrophils (NEs) to target and deliver nanodrugs to inflammation sites has received considerable attention. NEs are involved in the formation and development of thrombosis by transforming into neutrophil extracellular traps (NETs); this ... ...

Abstract	Utilizing neutrophils (NEs) to target and deliver nanodrugs to inflammation sites has received considerable attention. NEs are involved in the formation and development of thrombosis by transforming into neutrophil extracellular traps (NETs); this indicates that NEs may be a natural thrombolytic drug delivery carrier. However, NEs lack an effective power system to overcome blood flow resistance and enhance targeting efficiency. Herein, we report the application of a urease catalysis micromotor powered NEs nanodrug delivery system to promote thrombolysis and suppress rethrombosis. The urease micromotor powered Janus NEs (UM-NEs) were prepared by immobilizing the enzyme asymmetrically onto the surface of natural NEs and then loading urokinase (UK) coupled silver (Ag) nanoparticles (Ag-UK) to obtain the UM-NEs (Ag-UK) system. Urease catalytic endogenous urea is used to generate thrust by producing ammonia and carbon dioxide, which propels NEs actively targeting the thrombus. The UM-NEs (Ag-UK) can be activated by enriched inflammatory cytokines to release NETs at the thrombosis site, resulting in a concomitant release of Ag-UK. Ag-UK induces thrombolysis to restore vascular recanalization. This urease micromotor-driven NEs drug delivery system can significantly reduce the hemorrhagic side effects, promote thrombolysis, and inhibit rethrombosis with high bioavailability and biosafety, which can be used for the treatment of thrombotic diseases.
MeSH term(s)	Catalysis ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Humans ; Neutrophils ; Thrombolytic Therapy ; Thrombosis/drug therapy
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.1c08538
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Article ; Online: Peroxynitrite/Lipid Droplet Sequence-Activated Dual-Lock Fluorescent Probes Enable Precise Intraoperative Imaging of Atherosclerotic Plaques.

Sang, Mangmang / Huang, Yibo / Liu, Zhiwei / Li, Gang / Wang, Yan / Yuan, Zhenwei / Dai, Cuilian / Zheng, Jinrong

ACS sensors

2023 Volume 8, Issue 2, Page(s) 893–903

Abstract: The formation of atherosclerotic plaques is the root cause of various cardiovascular diseases (CVDs). Effective CVD interventions thus call for precise identification of the plaques to aid clinical assessment and treatment of such diseases. In this study, ...

Abstract	The formation of atherosclerotic plaques is the root cause of various cardiovascular diseases (CVDs). Effective CVD interventions thus call for precise identification of the plaques to aid clinical assessment and treatment of such diseases. In this study, we introduced a dual-analyte sequentially activated logic fluorescence reporting system CNN2-B to precisely identify the atherosclerotic plaques
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic ; Fluorescent Dyes/chemistry ; Peroxynitrous Acid ; Lipid Droplets ; Optical Imaging
Chemical Substances	Fluorescent Dyes ; Peroxynitrous Acid (14691-52-2)
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.2c02590
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Article: Effect of in situ Mg2Sip contents on microstructure and mechanical properties of Mg2Sip/AZ91D composites

Li, Pubo / Yang, Hua / Tan, Wanting / Gao, Mangmang

Journal of materials science. 2021 Apr., v. 56, no. 11

2021

Abstract: The in situ Mg₂Si nanoparticles (Mg₂Siₚ)-reinforced AZ91D composites were fabricated by powder thixoforming that involved introduction of Si nanoparticles (Siₚ) by ball milling followed by partial remelting and thixoforming. The results indicated that ... ...

Abstract	The in situ Mg₂Si nanoparticles (Mg₂Siₚ)-reinforced AZ91D composites were fabricated by powder thixoforming that involved introduction of Si nanoparticles (Siₚ) by ball milling followed by partial remelting and thixoforming. The results indicated that Siₚ can be homogeneously dispersed on the surface of AZ91D powders, while they will be clustered when their amount exceeded 0.91 vol%. The thixoformed microstructure of the composites consisted of spheroidal primary α-Mg particles, intergranular secondary solidified structures (SSS) and in situ Mg₂Siₚ that dispersed in the SSS. The tensile strength and elongation of Mg₂Siₚ/AZ91D composites increased with the increased content of Mg₂Siₚ, but the improved degree in the mechanical properties was reduced when its content exceeded 3vol%. The 4.5 vol.%Mg₂Siₚ/AZ91D composite has the excellent mechanical properties, achieving an ultimate tensile strength (UTS) of 288 MPa, yield strength (YS) of 205 MPa and elongation (ɛf) of 6.9%, which were increased by 50% and 48.6% and decreased by 9.2%, respectively, compared to those of the AZ91D alloy. The strong Mg₂Siₚ/Mg interfacial bonding and homogeneously distributed Mg₂Siₚ were beneficial to activating the combined strengthening effects of thermal mismatch and Orowan mechanisms, improving the mechanical properties of the Mg₂Siₚ/AZ91D composites. However, the Mg₂Siₚ clustering degraded the strength of the composites with higher Mg₂Siₚ content.
Keywords	alloys ; microstructure ; tensile strength
Language	English
Dates of publication	2021-04
Size	p. 6799-6813.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-020-05693-1
Database	NAL-Catalogue (AGRICOLA)

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