LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 15

Search options

  1. Article: The Pinch Stitch: A Pearl for Suturing Wounds Under Tension.

    Farshchian, Mehdi / Sklar, Lindsay R.

    Journal of drugs in dermatology : JDD

    2020  Volume 19, Issue 12, Page(s) 1262

    Abstract: Closing defects under tension in areas such as the scalp and back may be challenging during dermatologic surgery. Different techniques have been advocated to ease the placement of the first deep suture under tension, including the slip-knot stitch, pully ...

    Abstract Closing defects under tension in areas such as the scalp and back may be challenging during dermatologic surgery. Different techniques have been advocated to ease the placement of the first deep suture under tension, including the slip-knot stitch, pully stitch, horizontal mattress suture, pulley set-back dermal suture, and tandem pulley stitch.
    MeSH term(s) Dermatologic Surgical Procedures/adverse effects ; Dermatologic Surgical Procedures/methods ; Humans ; Skin/injuries ; Suture Techniques/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.2020.5461
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: An Atypical Case of Warfarin-Induced Skin Necrosis.

    Sklar, Lindsay R / Messman, Anne

    Clinical practice and cases in emergency medicine

    2017  Volume 1, Issue 4, Page(s) 359–361

    Abstract: Skin necrosis is a relatively rare, potentially fatal side effect of warfarin. It is most commonly reported within 10 days of initiation of therapy in warfarin-naïve patients. We report an atypical case of warfarin-induced skin necrosis upon ... ...

    Abstract Skin necrosis is a relatively rare, potentially fatal side effect of warfarin. It is most commonly reported within 10 days of initiation of therapy in warfarin-naïve patients. We report an atypical case of warfarin-induced skin necrosis upon recommencement of warfarin in a non-naïve warfarin patient.
    Language English
    Publishing date 2017-10-11
    Publishing country United States
    Document type Case Reports
    ISSN 2474-252X
    ISSN (online) 2474-252X
    DOI 10.5811/cpcem.2017.3.33373
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Interrupted subcuticular suture spacing during linear wound closures and the effect on wound cosmesis: a randomized evaluator-blinded split-wound comparative effectiveness trial.

    Eshagh, Karin / Sklar, Lindsay R / Pourang, Aunna / Armstrong, April W / Dhaliwal, Harshaan / Eisen, Daniel B

    The British journal of dermatology

    2022  Volume 187, Issue 3, Page(s) 318–323

    Abstract: Background: Surgical reconstructions following Mohs micrographic surgery and standard surgical excisions are often closed with two layers of sutures: a deep subcuticular layer and a superficial cuticular layer. Some surgeons feel the need to place many ... ...

    Abstract Background: Surgical reconstructions following Mohs micrographic surgery and standard surgical excisions are often closed with two layers of sutures: a deep subcuticular layer and a superficial cuticular layer. Some surgeons feel the need to place many deep sutures in order to reduce tension on cuticular sutures, as they believe this may decrease incidence of track marks and dehiscence, and lead to better cosmetic outcomes. However, others feel that a higher number of subcuticular sutures increases the risk of a suture reaction, which leads to patient anxiety and poorer wound cosmesis. To our knowledge, there are no studies published on the effect of subcuticular suture spacing on wound cosmesis.
    Objectives: To determine whether suturing with 1-cm interval subcuticular sutures results in better cosmetic outcomes than suturing with 2-cm interval subcuticular sutures.
    Methods: Fifty patients were enrolled in a randomized clinical trial using a split-wound model, where half of the wound was repaired with sutures spaced 2 cm apart and the other half was repaired with sutures spaced 1 cm apart (ClinicalTrials.gov identifier NCT03327922). Both the evaluators and patients were blinded as to which side received which treatment. The scar was evaluated 3 months post-surgery by two blinded observers and the patients themselves using the Patient and Observer Scar Assessment Scale (POSAS), a validated scar assessment instrument.
    Results: The total mean POSAS score for observers for the sides that received 1-cm interval subcuticular sutures and the sides that received 2-cm interval subcuticular sutures did not differ significantly at 3 months (P = 0·34). There was also no significant difference in the patient assessment scale score between the two sides at 3 months (P = 0·084).
    Conclusions: We found that 1-cm suture spacing was not significantly associated with improved overall cosmetic outcome compared with 2-cm suture spacing when evaluated by blinded observers or the patients themselves. Our results support the use of either interval. What is already known about this topic? Surgeons have differing opinions on the ideal frequency of subcuticular sutures for optimizing cosmetic outcomes and minimizing suture reactions. The effect of subcuticular suture spacing on wound cosmesis has not been previously explored in the literature. What does this study add? There was no significant difference in cosmetic outcome between 1-cm suture spacing and 2-cm suture spacing when evaluated by blinded observers and patients. Dermatology surgeons can use 2-cm suture spacing for increased efficiency, without significantly different cosmetic outcomes, detected by blinded observers and patients.
    MeSH term(s) Cicatrix/etiology ; Cicatrix/pathology ; Cicatrix/prevention & control ; Cosmetics ; Humans ; Suture Techniques/adverse effects ; Sutures/adverse effects ; Treatment Outcome ; Wound Healing
    Chemical Substances Cosmetics
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21625
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Surgical and Noninvasive Modalities for Scar Revision.

    Ward, Rachel E / Sklar, Lindsay R / Eisen, Daniel B

    Dermatologic clinics

    2019  Volume 37, Issue 3, Page(s) 375–386

    Abstract: Scar revision is of premier importance to the dermatologic surgeon. Some of the least invasive modalities include use of silicone gel sheets, resurfacing with electrosurgical instruments, dermabrasion, chemical peels, and subcision. Laser technology also ...

    Abstract Scar revision is of premier importance to the dermatologic surgeon. Some of the least invasive modalities include use of silicone gel sheets, resurfacing with electrosurgical instruments, dermabrasion, chemical peels, and subcision. Laser technology also has been implemented to selectively target and ablate fibrous scar tissue via selective thermolysis. Other lasers have been used to target dyschromia associated with scar formation. Lastly, invasive modalities of scar revision include excisional modalities and/or rearrangement of skin to enhance cosmesis of unsightly or morbid scars. Herein is a discussion of the multiple modalities of scar revision as well as advantages and disadvantages of each.
    MeSH term(s) Ablation Techniques ; Adrenal Cortex Hormones/administration & dosage ; Chemexfoliation ; Cicatrix/surgery ; Cicatrix/therapy ; Dermabrasion ; Gels ; Humans ; Injections, Intralesional ; Laser Therapy ; Massage ; Silicones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Gels ; Silicones
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2019.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Reverse beveling to improve wound edge apposition.

    Beroukhim, Kourosh / Sklar, Lindsay R / Eisen, Daniel B

    Journal of the American Academy of Dermatology

    2018  Volume 81, Issue 3, Page(s) e63–e64

    MeSH term(s) Cicatrix/etiology ; Cicatrix/prevention & control ; Dermatologic Surgical Procedures/adverse effects ; Dermatologic Surgical Procedures/methods ; Humans ; Surgical Wound/complications ; Suture Techniques
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2018.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Blueberry muffin rash secondary to hereditary spherocytosis.

    Daum, Lisa M / Sklar, Lindsay R / Mehregan, Darius R

    Cutis

    2018  Volume 101, Issue 2, Page(s) 111–114

    Abstract: The term blueberry muffin rash is used to describe the clinical presentation of dermal extramedullary hematopoiesis. The common culprits of this rash include a TORCH (toxoplasmosis, other agents, rubella, cytomegalovirus, herpes) infection or hematologic ...

    Abstract The term blueberry muffin rash is used to describe the clinical presentation of dermal extramedullary hematopoiesis. The common culprits of this rash include a TORCH (toxoplasmosis, other agents, rubella, cytomegalovirus, herpes) infection or hematologic dyscrasia. Association of this rash with hereditary spherocytosis is extremely rare. We present a unique case of a neonate born with a blueberry muffin rash secondary to hereditary spherocytosis.
    MeSH term(s) Exanthema/etiology ; Hematopoiesis, Extramedullary ; Humans ; Infant, Newborn ; Male ; Spherocytosis, Hereditary/complications ; Spherocytosis, Hereditary/diagnosis
    Language English
    Publishing date 2018-03-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Squamous Cell Carcinoma Arising Within an Accessory Tragus.

    Sklar, Lindsay R / Tolkachjov, Stanislav N / Harmon, Christopher B

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2017  Volume 43, Issue 11, Page(s) 1401–1402

    MeSH term(s) Aged ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Ear Auricle ; Ear Neoplasms/pathology ; Ear Neoplasms/surgery ; Humans ; Male ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000001098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Comparison of Running Cutaneous Suture Spacing During Linear Wound Closures and the Effect on Wound Cosmesis of the Face and Neck: A Randomized Clinical Trial.

    Sklar, Lindsay R / Pourang, Aunna / Armstrong, April W / Dhaliwal, Simran K / Sivamani, Raja K / Eisen, Daniel B

    JAMA dermatology

    2019  Volume 155, Issue 3, Page(s) 321–326

    Abstract: Importance: Surgeons have varying opinions on the ideal cutaneous suture spacing for optimal cosmetic outcomes. To date, no studies concerning the effect of suture spacing on cosmetic outcomes exist in the literature.: Objective: To compare outcomes ... ...

    Abstract Importance: Surgeons have varying opinions on the ideal cutaneous suture spacing for optimal cosmetic outcomes. To date, no studies concerning the effect of suture spacing on cosmetic outcomes exist in the literature.
    Objective: To compare outcomes and wound cosmesis achieved with running cutaneous sutures spaced 2 vs 5 mm apart.
    Design, setting, and participants: This randomized clinical trial was conducted at the University of California, Davis dermatology clinic from November 28, 2017, to June 15, 2018. Fifty-six patients 18 years or older with surgical fusiform wounds (from Mohs procedure or surgical excision) on the head or neck with assumed closure lengths of at least 3 cm were screened. Six patients were excluded, 50 patients were enrolled, and 48 patients were followed up.
    Interventions: Fifty surgical fusiform wounds were randomized to running cuticular closure with 2-mm spacing on half and 5-mm spacing on half.
    Main outcomes and measures: At 3 months, patients and 2 masked observers evaluated each scar using the Patient and Observer Scar Assessment Scale (POSAS).
    Results: A total of 50 patients (mean [SD] age, 71.1 [11.4] years; 43 [86%] male; 50 [100%] white) were enrolled in the study. The mean (SD) sum of the POSAS observer component scores was 10.7 (4.3) for the 2-mm interval side and 10.8 (3.5) for the 5-mm side at 3 months (P = .77). No statistically significant difference was found in the mean (SD) sum of the patient component for the POSAS score between the 2-mm interval side (10.2 [4.7]) and the 5-mm interval side (11.5 [6.4]) at 3 months (P = .24). No statistically significant difference was observed in mean (SD) scar width between the 2-mm side (0.9 [0.6] mm) and the 5-mm side (0.8 [0.4] mm; P = .15).
    Conclusions and relevance: No statistically significant difference in wound cosmesis or total complications were noted between running cuticular sutures spaced 2 vs 5 mm apart. Both suturing techniques resulted in similar cosmetic outcomes and complication rates. Surgeons may want to consider whether the extra time involved in placing very closely spaced cuticular sutures is worthwhile.
    Trial registration: ClinicalTrials.gov identifier: NCT03330041.
    MeSH term(s) Aged ; Cicatrix/prevention & control ; Esthetics ; Facial Injuries/surgery ; Humans ; Middle Aged ; Mohs Surgery/methods ; Risk Assessment ; Skin/injuries ; Suture Techniques ; Sutures ; Treatment Outcome ; Wound Closure Techniques
    Language English
    Publishing date 2019-01-16
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2018.5057
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Laser-assisted patient positioning: a straightforward method to ensure consistent head and neck aesthetic photographs.

    Sklar, Lindsay R / So, Jeffrey J / Burnett, Christopher T / Ozog, David M

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2013  Volume 39, Issue 2, Page(s) 306–308

    MeSH term(s) Dermatologic Surgical Procedures ; Esthetics ; Female ; Head ; Humans ; Lasers ; Male ; Neck ; Patient Positioning/methods ; Photography ; Reproducibility of Results
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1111/dsu.12034
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Germline Genetic and Treatment-Related Risk Factors for Diabetes Mellitus in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study and St Jude Lifetime Cohorts.

    Richard, Melissa A / Mostoufi-Moab, Sogol / Rathore, Nisha / Baedke, Jessica / Brown, Austin L / Chanock, Stephen J / Friedman, Danielle N / Gramatges, M Monica / Howell, Rebecca M / Kamdar, Kala Y / Leisenring, Wendy M / Meacham, Lillian R / Morton, Lindsay M / Oeffinger, Kevin / Robison, Leslie L / Sapkota, Yadav / Sklar, Charles A / Armstrong, Gregory T / Bhatia, Smita /
    Lupo, Philip J

    JCO precision oncology

    2022  Volume 6, Page(s) e2200239

    Abstract: Purpose: To characterize germline genetic risk factors of diabetes mellitus among long-term survivors of childhood cancer.: Methods: Adult survivors of childhood cancer from the Childhood Cancer Survivor Study (CCSS) Original Cohort (n = 5,083; 383 ... ...

    Abstract Purpose: To characterize germline genetic risk factors of diabetes mellitus among long-term survivors of childhood cancer.
    Methods: Adult survivors of childhood cancer from the Childhood Cancer Survivor Study (CCSS) Original Cohort (n = 5,083; 383 with diabetes) were used to conduct a discovery genome-wide association study. Replication was performed using the CCSS Expansion (n = 2,588; 40 with diabetes) and the St Jude Lifetime (SJLIFE; n = 3,351; 208 with diabetes) cohorts. Risk prediction models, stratified on exposure to abdominal radiation, were calculated using logistic regression including attained age, sex and body mass index, diagnosis, alkylating chemotherapy, age at cancer diagnosis, and a polygenic risk score (PRS) on the basis of 395 diabetes variants from the general population. Area under the receiver operating characteristic curve (AUC) was calculated for models on the basis of traditional risk factors, clinical risk factors, and PRS.
    Results: There was a genome-wide significant association of rs55849673-A with diabetes among survivors (odds ratio, 2.9; 95% CI, 2.0 to 4.2;
    Conclusion: There is evidence for a novel locus of diabetes among survivors not exposed to abdominal radiation. Further refinement and validation of clinic-based risk prediction models for diabetes among long-term survivors of childhood cancer is warranted.
    MeSH term(s) Child ; Humans ; Cancer Survivors ; Neoplasms/epidemiology ; Genome-Wide Association Study ; Diabetes Mellitus ; Risk Factors ; DNA Helicases
    Chemical Substances ERCC6L2 protein, human (EC 3.6.4.12) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.22.00239
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top