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  1. Article ; Online: Ventriculosubgaleal shunt: an institutional experience.

    Anurag, Jain / Sandeep, Chopra / Arunav, Sharma

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 39, Issue 8, Page(s) 2131–2137

    Abstract: Background and objective: Ventriculosubgaleal shunt (VSGS) was first described in 1896 by Von Mickulicz. It allows CSF to flow from the dilated ventricle to the subgaleal pouch developed in the scalp through a small silicon tube. The possibility that ... ...

    Abstract Background and objective: Ventriculosubgaleal shunt (VSGS) was first described in 1896 by Von Mickulicz. It allows CSF to flow from the dilated ventricle to the subgaleal pouch developed in the scalp through a small silicon tube. The possibility that the hydrocephalic state in infants caused by hemorrhage/ + infection will only last a short while prompts the search for temporary management options, which must be a closed system in order to be more physiological given that these infants are frequently preterm (LBW) and immunologically immature. VSGS is one such option. To the best of our knowledge, most of the studies done on VSGS are retrospective, and there are very few prospective studies (none on Indian subjects till now). We aim to study the efficacy of VSGS in preventing the placement of VP Shunt in infants with post-hemorrhagic/post-infectious hydrocephalus.
    Method: Our study (prospective observational) comprises 30 infants in whom VSGS was inserted at Sir Gangaram Hospital between August 2017 and October 2020 and who were followed up for 6 months after VSGS insertion.
    Result: Most of the infants had a birth weight between 1501 and 2000 g with a mean gestational age of 31.2 weeks. Thirteen out of 30 patients did not require the placement of VP shunt. The rates were higher in the post-infectious group (50%) in contrary to the post hemorrhagic group where it was 38.8%. Complications encountered with VSGS include CSF leak (13.3%) and wound dehiscence (6.6%). None had VSGS blockage, migration, and infection.
    Conclusion: We conclude that VSGS is a reliable, safe, easy to perform, and temporary treatment option in infants with post-hemorrhagic and post-infectious hydrocephalus and helps in avoiding VP shunt dependency in nearly half of them.
    MeSH term(s) Infant, Newborn ; Infant ; Humans ; Retrospective Studies ; Prospective Studies ; Cerebral Hemorrhage/complications ; Hydrocephalus/surgery ; Hydrocephalus/complications ; Cerebrospinal Fluid Shunts/adverse effects ; Ventriculoperitoneal Shunt/adverse effects
    Language English
    Publishing date 2023-04-01
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-05937-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.

    Negi, Sandeep / Bala, Lakshmi / Shukla, Saumya / Chopra, Deepti

    Toxicology and industrial health

    2022  Volume 38, Issue 7, Page(s) 417–434

    Abstract: Today, tattooing has become very popular among people all over the world. Tattooists, with the help of tiny needles, place tattoo ink inside the skin surface and unintentionally introduce a large number of unknown ingredients. These ingredients include ... ...

    Abstract Today, tattooing has become very popular among people all over the world. Tattooists, with the help of tiny needles, place tattoo ink inside the skin surface and unintentionally introduce a large number of unknown ingredients. These ingredients include polycyclic aromatic hydrocarbons (PAHs), heavy metals, and primary aromatic amines (PAAs), which are either unintentionally introduced along with the ink or produced inside the skin by different types of processes for example cleavage, metabolism and photodecomposition. These could pose toxicological risks to human health, if present beyond permissible limits. PAH such as Benzo(a)pyrene is present in carbon black ink. PAAs could be formed inside the skin as a result of reductive cleavage of organic azo dyes. They are reported to be highly carcinogenic by environmental protection agencies. Heavy metals, namely, cadmium, lead, mercury, antimony, beryllium, and arsenic are responsible for cancer, neurodegenerative diseases, cardiovascular, gastrointestinal, lungs, kidneys, liver, endocrine, and bone diseases. Mercury, cobalt sulphate, other soluble cobalt salts, and carbon black are in Group 2B, which means they may cause cancer in humans. Cadmium and compounds of cadmium, on the other hand, are in Group 1 (carcinogenic to humans). The present article addresses the various ingredients of tattoo inks, their metabolic fate inside human skin and unintentionally added impurities that could pose toxicological risk to human health. Public awareness and regulations that are warranted to be implemented globally for improving the safety of tattooing.
    MeSH term(s) Amines/toxicity ; Cadmium ; Carcinogens/toxicity ; Humans ; Ink ; Mercury ; Metals ; Polycyclic Aromatic Hydrocarbons/analysis ; Polycyclic Aromatic Hydrocarbons/toxicity ; Soot ; Tattooing/adverse effects
    Chemical Substances Amines ; Carcinogens ; Metals ; Polycyclic Aromatic Hydrocarbons ; Soot ; Cadmium (00BH33GNGH) ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2022-05-19
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/07482337221100870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wound dressings: Recent updates.

    Chopra, Hitesh / Kumar, Sandeep / Safi, Sher Zaman / Singh, Inderbir / Emran, Talha Bin

    International journal of surgery (London, England)

    2022  Volume 104, Page(s) 106793

    MeSH term(s) Bandages ; Humans ; Wound Healing
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical outcome of percutaneous common extensor tenotomy for recalcitrant lateral humeral epicondylitis

    Sandeep Dathik / Rajesh Kumar Chopra / Ashish Jaiman

    Ķazaķstannyṇ Klinikalyķ Medicinasy, Vol 19, Iss 2, Pp 57-

    2022  Volume 61

    Abstract: Introduction: Tennis elbow is a commonly encountered problem in orthopaedic clinical practice. The patients are usually in their financially productive years and many a times, this is a work related disorder that becomes severe enough leading for lost ... ...

    Abstract Introduction: Tennis elbow is a commonly encountered problem in orthopaedic clinical practice. The patients are usually in their financially productive years and many a times, this is a work related disorder that becomes severe enough leading for lost work days. Conservative treatment is almost always the first choice; but once it fails, there is no clear consensus for the management of recalcitrant cases. We undertook this study to evaluate the clinical outcomes of percutaneous tenotomy in cases of resistant lateral epicondylitis. Materials and methods: This was a prospective study done over a period of 5 years. A total of 108 patients with recalcitrant tennis elbow were recruited and underwent percutaneous tenotomy. They were followed up for an average period of 14 months. The outcomes measured were: tenderness, DASH score, Roles & Maudsley scale, Visual analogue scale (VAS), and Grip strength. Statistical analysis was done using Paired t-test. Results: 95% patients were pain free after an average of 12 weeks. The 6 months postoperative improvement in VAS score was 6.84 and change in mean DASH score was 23.04. The average increase in mean grip strength was 13.30 kg. These results were statistically significant. Conclusion: Percutaneous tenotomy can be considered as a useful treatment option for resistant cases of tennis elbow.
    Keywords lateral epicondylitis ; office procedure ; percutaneous tenotomy ; tennis elbow ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
    Subject code 796 ; 616
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher National Scientific Medical Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Strategies and Therapies for Wound Healing: A Review.

    Chopra, Hitesh / Kumar, Sandeep / Singh, Inderbir

    Current drug targets

    2021  Volume 23, Issue 1, Page(s) 87–98

    Abstract: Wound healing is a complex and never-ending process that involves numerous mediators, enzymatic cascades that are directly or indirectly involved in the mechanism. So, it becomes necessary to closely examine critical factors such as gaseous exchange, a ... ...

    Abstract Wound healing is a complex and never-ending process that involves numerous mediators, enzymatic cascades that are directly or indirectly involved in the mechanism. So, it becomes necessary to closely examine critical factors such as gaseous exchange, a moist environment, anti- microbial activity, and exudation liquids' absorption while designing wound dressings. There is a heap of wound dressings available for human use, but they all are way apart from the ideal dressing. The use of biopolymers may be a solution to tackle the difficulties such as combining with growth factors and cells that can trigger wound healing. This article reviews such therapies for wound healing application.
    MeSH term(s) Bandages ; Humans ; Wound Healing
    Language English
    Publishing date 2021-05-05
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450122666210415101218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Correction to: Postpartum Collapse Subsequent to Catatonia in a Female with COVID-19 Infection: A Rare Entity Visited.

    Joshi, Bharti / Sahoo, Swapnajeet / Prasad, G R V / Suri, Vanita / Mahajan, Varun / Grover, Sandeep / Brar, Rinnie / Chopra, Seema

    Journal of obstetrics and gynaecology of India

    2023  , Page(s) 1

    Abstract: This corrects the article DOI: 10.1007/s13224-022-01737-5.]. ...

    Abstract [This corrects the article DOI: 10.1007/s13224-022-01737-5.].
    Language English
    Publishing date 2023-04-29
    Publishing country India
    Document type Published Erratum
    ZDB-ID 410688-x
    ISSN 0971-9202 ; 0022-3190
    ISSN 0971-9202 ; 0022-3190
    DOI 10.1007/s13224-023-01756-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Postpartum Collapse Subsequent to Catatonia in a Female with COVID-19 Infection: a Rare Entity Visited.

    Joshi, Bharti / Sahoo, Swapnajeet / Prasad, G R V / Suri, Vanita / Mahajan, Varun / Grover, Sandeep / Brar, Rinne / Chopra, Seema

    Journal of obstetrics and gynaecology of India

    2023  Volume 73, Issue 3, Page(s) 279–281

    Abstract: Postpartum collapse is a life-threatening condition caused by obstetrical and non-obstetrical events. In this case report, we discuss a case of postpartum collapse in COVID-19-positive woman who required intensive care and mechanical ventilation for two ... ...

    Abstract Postpartum collapse is a life-threatening condition caused by obstetrical and non-obstetrical events. In this case report, we discuss a case of postpartum collapse in COVID-19-positive woman who required intensive care and mechanical ventilation for two days. After confusing collision of many provisional diagnoses soldiering for three days, she was ultimately diagnosed with malignant catatonia. Targeted therapy with lorazepam challenge resulted in drastic improvement, and she was discharged with her baby in healthy condition.
    Language English
    Publishing date 2023-01-10
    Publishing country India
    Document type Case Reports
    ZDB-ID 410688-x
    ISSN 0971-9202 ; 0022-3190
    ISSN 0971-9202 ; 0022-3190
    DOI 10.1007/s13224-022-01737-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application.

    Chopra, Hitesh / Bibi, Shabana / Kumar, Sandeep / Khan, Muhammad Saad / Kumar, Pradeep / Singh, Inderbir

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 2

    Abstract: In the present study, chitosan/polyvinyl alcohol (PVA)-based honey hydrogel films were developed for potential wound healing application. The hydrogel films were developed by a solvent-casting method and were evaluated in terms of thickness, weight ... ...

    Abstract In the present study, chitosan/polyvinyl alcohol (PVA)-based honey hydrogel films were developed for potential wound healing application. The hydrogel films were developed by a solvent-casting method and were evaluated in terms of thickness, weight variation, folding endurance, moisture content and moisture uptake. The water vapor transmission rate was found to range between 1650.50 ± 35.86 and 2698.65 ± 76.29 g/m
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8020111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Involvement of type-1 pathway in phototoxicity of benzo[ghi]perylenean ingredient of tattoo ink at ambient exposure of UVR and sunlight.

    Negi, Sandeep / Chopra, Deepti / Shukla, Saumya / Vikram, Apeksha / Patel, Sunil Kumar / Bala, Lakshmi / Dwivedi, Ashish / Ray, Ratan Singh

    Journal of photochemistry and photobiology. B, Biology

    2023  Volume 244, Page(s) 112700

    Abstract: Tattooing on different parts of the body is a very common fashion trend in all sections of society globally. Skin allergies and other related skin diseases are very common among tattoo users. Benzo[ghi]perylene (BP) is a PAH and an important component of ...

    Abstract Tattooing on different parts of the body is a very common fashion trend in all sections of society globally. Skin allergies and other related skin diseases are very common among tattoo users. Benzo[ghi]perylene (BP) is a PAH and an important component of tattoo ink that showed prominent absorption under ultraviolet radiation (UVR) region. Therefore, to provide safety to the skin, a thorough safety study of BP exposed under UVR and Sunlight is very essential to understand their hazardous impact on the skin. BP showed a strong absorption of UVA and UVB radiation of sunlight. It is photolabile and degraded under UVA, UVB, and Sunlight in progressing order of time (1-4 h) without generating any novel photoproducts. Further, BP showed a specific generation of O
    MeSH term(s) Humans ; Ultraviolet Rays ; Sunlight ; Reactive Oxygen Species/metabolism ; Tattooing ; Ink ; Cell Line ; Keratinocytes/metabolism ; Dermatitis, Phototoxic/metabolism ; DNA Damage
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2023.112700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeting multidrug resistant Staphylococcus aureus with cationic chlorpromazine-peptide conjugates.

    Panjla, Apurva / Kaul, Grace / Akhir, Abdul / Saxena, Deepanshi / Joshi, Saurabh / Modak, Chandrima / Kumari, Dipti / Jain, Alok / Chopra, Sidharth / Verma, Sandeep

    Chemistry, an Asian journal

    2023  Volume 18, Issue 10, Page(s) e202300169

    Abstract: Antimicrobial resistance is a serious public health risk. Its severity is fueled on an unprecedented scale, necessitating the demand for novel antimicrobial scaffolds aimed at novel targets. Herein, we present cationic chlorpromazine peptide conjugates ... ...

    Abstract Antimicrobial resistance is a serious public health risk. Its severity is fueled on an unprecedented scale, necessitating the demand for novel antimicrobial scaffolds aimed at novel targets. Herein, we present cationic chlorpromazine peptide conjugates that are rationally intended to targetmultidrug-resistant (MDR) bacteria. The most potent compound, CPWL, of all the conjugates evaluated, showed promising antibacterial activity against clinical, MDR S. aureus, with no cytotoxicity. The molecular docking experiments confirmed that CPWL possessed a very high affinity for S. aureus enoyl reductase (saFabI). Furthermore, CPWL antibacterial action against saFabI was further corroborated by MD simulation studies. Thus, our findings highlight cationic chlorpromazine as a promising scaffold for the development of saFabI inhibitors to target severe staphylococcal infections.
    MeSH term(s) Humans ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Chlorpromazine/pharmacology ; Molecular Docking Simulation ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Peptides ; Staphylococcal Infections/drug therapy ; Microbial Sensitivity Tests
    Chemical Substances Chlorpromazine (U42B7VYA4P) ; Anti-Bacterial Agents ; Peptides
    Language English
    Publishing date 2023-04-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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