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  1. Article ; Online: A narrative review of the intermediate category of the antimicrobial susceptibility test: relation with dosing and possible impact on antimicrobial stewardship.

    Yusuf, Erlangga / Zeitlinger, Markus / Meylan, Sylvain

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 2, Page(s) 338–345

    Abstract: The interpretation of 'susceptible (S)' or 'resistant (R)' results of antimicrobial susceptibility testing is easily understood, but the interpretation of the 'intermediate (I)' category can be confusing. This review critically discusses how this ... ...

    Abstract The interpretation of 'susceptible (S)' or 'resistant (R)' results of antimicrobial susceptibility testing is easily understood, but the interpretation of the 'intermediate (I)' category can be confusing. This review critically discusses how this categorization (clinical breakpoints) comes into being with the emphasis on the use of pharmacokinetics and pharmacodynamic data. It discusses the differences between the 'I' according to the CLSI and the EUCAST. This review also discusses the recent EUCAST change of the 'I' definition, and the impact of this change from laboratory and clinical points of view.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacokinetics ; Antimicrobial Stewardship ; Microbial Sensitivity Tests ; Laboratories
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac413
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    Zs.A 1197: Show issues Location:
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  2. Article ; Online: 'In the name of common sense' - Author's reply.

    Meylan, Sylvain / Guery, Benoit

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2020  Volume 26, Issue 12, Page(s) 1696

    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.08.024
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  3. Article ; Online: An Unusual Cause of Severe Granulomatous Hepatitis and Jaundice.

    Coukos, Alexander / Uldry, Emilie / Meylan, Sylvain / Schmidt, Sabine / Fasquelle, François / Sempoux, Christine / Fraga, Montserrat

    The American journal of gastroenterology

    2023  Volume 118, Issue 11, Page(s) 1920

    MeSH term(s) Humans ; Jaundice/etiology ; Hepatitis/complications ; Hepatitis/diagnosis ; Granuloma/diagnosis ; Granuloma/etiology ; Jaundice, Obstructive
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002358
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  4. Article ; Online: In the name of common sense: EUCAST breakpoints and potential pitfalls.

    Meylan, Sylvain / Guery, Benoit

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2020  Volume 26, Issue 12, Page(s) 1593–1594

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/standards ; Anti-Bacterial Agents/therapeutic use ; Bacteria/classification ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Humans ; Microbial Sensitivity Tests/standards ; Practice Guidelines as Topic
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.07.025
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    Zs.MO 284: Show issues

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  5. Article: [No title information]

    Wuerzner, Grégoire / Ponte, Belén / Meylan, Sylvain / Pechère-Bertschi, Antoinette

    Revue medicale suisse

    2021  Volume 17, Issue 750, Page(s) 1547

    Title translation Hypertension : faut-il aborder les effets indésirables possibles des médicaments avec nos patients ?
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions ; Humans ; Hypertension ; Iatrogenic Disease ; Medical History Taking
    Language French
    Publishing date 2021-09-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
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    Zs.A 5998: Show issues Location:
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  6. Article: Nouveaux antibiotiques pour la clinique : un tour d’horizon.

    Meylan, Sylvain / Portillo Tunon, Vera / Guery, Benoît

    Revue medicale suisse

    2020  Volume 16, Issue 690, Page(s) 713–718

    Abstract: Antibiotic resistance has become a major medical problem of our time. In 2015, the World Health Organisation (WHO) endorsed a global action plan in response. One of the main axes of this plan has been the sustained development of new antimicrobials. ... ...

    Title translation New antibiotics for the clinical setting, an overview.
    Abstract Antibiotic resistance has become a major medical problem of our time. In 2015, the World Health Organisation (WHO) endorsed a global action plan in response. One of the main axes of this plan has been the sustained development of new antimicrobials. Despite its challenges, over half a dozen new substances have become clinically available in the last decade. Here, we review a selection of these novel antimicrobial and their applications and discuss their possible use in the clinical setting.
    MeSH term(s) Anti-Bacterial Agents/supply & distribution ; Anti-Bacterial Agents/therapeutic use ; Drug Development ; Drug Discovery ; Drug Resistance, Microbial ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language French
    Publishing date 2020-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
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    Zs.A 5998: Show issues Location:
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  7. Article ; Online: Sepsis awareness and knowledge amongst nurses, physicians and paramedics of a tertiary care center in Switzerland: A survey-based cross-sectional study.

    Regina, Jean / Le Pogam, Marie-Annick / Niemi, Tapio / Akrour, Rachid / Pepe, Santino / Lehn, Isabelle / Wasserfallen, Jean-Blaise / Calandra, Thierry / Meylan, Sylvain

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0285151

    Abstract: Background: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improve outcomes.: Methods: We conducted a survey among nurses and physicians of all adult departments of the Lausanne University ... ...

    Abstract Background: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improve outcomes.
    Methods: We conducted a survey among nurses and physicians of all adult departments of the Lausanne University Hospital (LUH) and paramedics transporting patients to our hospital. Measured outcomes included professionals' demographics (age, profession, seniority, unit of activity), quantification of prior sepsis education, self-evaluation, and knowledge of sepsis epidemiology, definition, recognition, and management. Correlation between surveyed personnel and sepsis perceptions and knowledge were assessed with univariable and multivariable logistic regression models.
    Results: Between January and October 2020, we contacted 1'216 of the 4'417 professionals (27.5%) of the LUH, of whom 1'116 (91.8%) completed the survey, including 619 of 2'463 (25.1%) nurses, 348 of 1'664 (20.9%) physicians and 149 of 290 (51.4%) paramedics. While 98.5% of the participants were familiar with the word "sepsis" (97.4% of nurses, 100% of physicians and 99.3% of paramedics), only 13% of them (physicians: 28.4%, nurses: 5.9%, paramedics: 6.8%) correctly identified the Sepsis-3 consensus definition. Similarly, only 48% and 49.3% of the physicians and 10.1% an 11.9% of the nurses knew that SOFA was a sepsis defining score and that the qSOFA score was a predictor of increased mortality, respectively. Furthermore, 15.8% of the physicians and 1.0% of the nurses knew the three components of the qSOFA score. For patients with suspected sepsis, 96.1%, 91.6% and 75.8% of physicians respectively chose blood cultures, broad-spectrum antibiotics and fluid resuscitation as therapeutic interventions to be initiated within 1 (76.4%) to 3 (18.2%) hours. For nurses and physicians, recent training correlated with knowledge of SOFA score (ORs [95%CI]: 3.956 [2.018-7.752] and 2.617 [1.527-4.485]) and qSOFA (ORs [95%CI]: 5.804 [2.653-9.742] and 2.291 [1.342-3.910]) scores purposes. Furthermore, recent training also correlated with adequate sepsis definition (ORs [95%CI]: 1.839 [1.026-3.295]) and the components of qSOFA (ORs [95%CI]: 2.388 [1.110-5.136]) in physicians.
    Conclusions: This sepsis survey conducted among physicians, nurses and paramedics of a tertiary Swiss medical center identified a deficit of sepsis awareness and knowledge reflecting a lack of sepsis-specific continuing education requiring immediate corrective measures.
    MeSH term(s) Adult ; Humans ; Switzerland/epidemiology ; Cross-Sectional Studies ; Paramedics ; Tertiary Care Centers ; Hospital Mortality ; Sepsis/diagnosis ; Sepsis/epidemiology ; Sepsis/therapy ; Physicians ; Nurses ; Organ Dysfunction Scores ; Retrospective Studies ; Prognosis ; Intensive Care Units
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285151
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  8. Article ; Online: Stage III Hypertension in Patients After mRNA-Based SARS-CoV-2 Vaccination.

    Meylan, Sylvain / Livio, Françoise / Foerster, Maryline / Genoud, Patrick James / Marguet, François / Wuerzner, Gregoire

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 77, Issue 6, Page(s) e56–e57

    MeSH term(s) Aged ; BNT162 Vaccine ; Blood Pressure Determination/methods ; Blood Pressure Determination/psychology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Causality ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/etiology ; Male ; Needs Assessment ; Psychology ; Risk Factors ; SARS-CoV-2 ; Switzerland/epidemiology ; Symptom Assessment/methods ; Vaccination/methods ; Vaccination/psychology
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Letter
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.17316
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    Zs.A 1488: Show issues Location:
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  9. Article ; Online: When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureus.

    Kuehl, Richard / Morata, Laura / Meylan, Sylvain / Mensa, Josep / Soriano, Alex

    The Journal of antimicrobial chemotherapy

    2020  Volume 75, Issue 5, Page(s) 1071–1086

    Abstract: Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent ... ...

    Abstract Staphylococcus aureus is a major human pathogen causing a vast array of infections with significant mortality. Its versatile physiology enables it to adapt to various environments. Specific physiological changes are thought to underlie the frequent failure of antimicrobial therapy despite susceptibility in standard microbiological assays. Bacteria capable of surviving high antibiotic concentrations despite having a genetically susceptible background are described as 'antibiotic tolerant'. In this review, we put current knowledge on environmental triggers and molecular mechanisms of increased antibiotic survival of S. aureus into its clinical context. We discuss animal and clinical evidence of its significance and outline strategies to overcome infections with antibiotic-tolerant S. aureus.
    MeSH term(s) Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; Drug Resistance, Bacterial
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-01-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkz559
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  10. Article ; Online: Four cases of audio-vestibular disorders related to immunisation with SARS-CoV-2 mRNA vaccines.

    Ekobena, Pierre / Rothuizen, Laura E / Bedussi, Francesca / Guilcher, Pierre / Meylan, Sylvain / Ceschi, Alessandro / Girardin, François / Dao, Kim

    International journal of audiology

    2022  Volume 62, Issue 6, Page(s) 587–591

    Abstract: Objective: To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.: Design: Case description.: Study sample: We ... ...

    Abstract Objective: To gain medical insight into the clinical course and safety of otolaryngologic disorders following immunisation with severe acute respiratory coronavirus (SARS-CoV-2) mRNA-based vaccines.
    Design: Case description.
    Study sample: We report four cases of transient audio-vestibular symptoms, which occurred shortly after inoculation of two BNT162b2 (Pfizer-BioNTech
    Results: Hearing loss was unilateral in all cases and recovered at least partially: it was associated with persistent gait instability in two cases, after 1 and 7 months. Trigger mechanisms underpinning audio-vestibular impairment remain uncertain. Immune tolerance mechanisms with off-target innate activation of T-lymphocytes may be involved in vestibulocochlear nerve disorders, as for other cranial nerves involvement.
    Conclusions: The occurrence of audio-vestibular manifestations following mRNA-based vaccines needs ENT monitoring to support their causality in such rare vaccine-related adverse events. Audio-vestibular disorders appeared of transitory nature, including hearing loss, and should not deter further efforts in large-scale vaccination campaigns against SARS-CoV-2.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 Vaccines/adverse effects ; BNT162 Vaccine ; COVID-19/prevention & control ; Immunization ; Vestibular Diseases/etiology ; Vestibular Diseases/genetics ; Deafness ; RNA, Messenger
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; RNA, Messenger
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2073098-6
    ISSN 1708-8186 ; 1499-2027
    ISSN (online) 1708-8186
    ISSN 1499-2027
    DOI 10.1080/14992027.2022.2056721
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