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Article: Non-pharmacological Treatment for Nontuberculous Mycobacterial Pulmonary Disease.

Kim, Hyung-Jun

2024

Abstract: Nontuberculous mycobacterial pulmonary disease (NTM-PD) arises from the exposure of susceptible hosts to a diverse group of environmental mycobacteria. The emphasis on non-pharmacological strategies is motivated by widespread presence of nontuberculous ... ...

Abstract	Nontuberculous mycobacterial pulmonary disease (NTM-PD) arises from the exposure of susceptible hosts to a diverse group of environmental mycobacteria. The emphasis on non-pharmacological strategies is motivated by widespread presence of nontuberculous mycobacteria (NTM) in various environments and the inconsistent success rates of pharmacological treatments. Modifiable factors contributing to NTM-PD development include impaired airway clearance, low body mass index, gastroesophageal reflux disease, and exposure to NTM habitats. This suggests that lifestyle and environmental modifications could affect disease development and progression. The review highlights several modalities that can modify the risk factors. Airway clearance techniques, informed by the "gel-on-brush" model of the bronchial epithelium, aims at enhancing mucociliary clearance and have potential in alleviating symptoms and potentially improving lung function. The impact of nutritional status is also examined, with a lower body mass index linked to an increased risk and progression of NTM-PD, indicating the importance of targeted nutritional support. Additionally, the theoretical and epidemiological links between gastroesophageal reflux disease and NTM-PD advocates for careful management of reflux episodes. Understanding the risk of NTM transmission through environmental exposure to contaminated water and soil is also crucial. Strategies to mitigate this risk, including effective water management and minimizing soil contact, are presented as vital preventive measures. In conclusion, the review supports the inclusion of non-pharmacological treatments within a comprehensive NTM-PD management strategy, alongside conventional pharmacological therapies. This integrated approach seeks to improve the overall understanding and handling of NTM-PD.
Language	English
Publishing date	2024-04-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2161256-0
ISSN	1738-3536 ; 0378-0066
ISSN	1738-3536 ; 0378-0066
DOI	10.4046/trd.2024.0033
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Book ; Online: Reformist Muslims in a Yogyakarta Village

Kim, Hyung-Jun

2007

Abstract: This study examines the religious life of reformist Muslims in a Yogyakarta village. The foci of this discussion are on Muslim villagers' construction, with the help of the reformist paradigm, of the image of the 'good Muslim' and 'Muslim-ness', on their ...

Abstract	This study examines the religious life of reformist Muslims in a Yogyakarta village. The foci of this discussion are on Muslim villagers' construction, with the help of the reformist paradigm, of the image of the 'good Muslim' and 'Muslim-ness', on their efforts to incorporate an (reformist) Islamic framework to question taken-for-granted practices and ideas, on the position of traditional practices and ideas and their relation to reformist Islam, and on the interplay of villagers who show a strong commitment to reformist Islam with those who do not. Another topic investigated in this study is the interactions between Muslim and Christian villagers and the impacts of Christian presence on the process by which Muslims define themselves, their neighbours, their religion and their religious community
Keywords	Sociology (General)
Size	1 electronic resource (295 p.)
Publisher	ANU Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020088184
ISBN	9781920942359 ; 1920942351
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Effect of 13 Weeks Long-Distance Bicycle Riding on Inflammatory Response Indicators Related to Joint Cartilage and Muscle Damage.

Kim, Hyung-Jun / Lee, Hyo-Cheol

International journal of environmental research and public health

2022 Volume 19, Issue 23

Abstract: This study was to investigate the effects of 13 weeks of long-distance cycling on biomarkers of joint cartilage, muscle damage and inflammation. All subjects in this study were seven participants of the “One Korea New-Eurasia Peace Cycle Expedition”, in ... ...

Abstract	This study was to investigate the effects of 13 weeks of long-distance cycling on biomarkers of joint cartilage, muscle damage and inflammation. All subjects in this study were seven participants of the “One Korea New-Eurasia Peace Cycle Expedition”, in which they rode cycles from Berlin, Germany to Seoul, Korea for thirteen weeks. The total course of the expedition was divided into three sub-courses: course 1 (from Berlin to Moscow), course 2 (from Moscow to Ulaanbaatar) and course 3 (from Ulaanbaatar to Seoul). All the selected participants rode 87.4 km/day (course 1), 70.4 km/day (course 2) and 57.6 km/day (course 3) on average, respectively. We collected their blood samples before the expedition in Seoul (S1), after course 1 in Moscow (M), after course 2 in Ulaanbaatar (U) and after the expedition in Seoul (S2), to analyze biomarkers of joint cartilage damage (Cartilage Oligomeric Matrix Protein; COMP), muscle damage (Creatine Phosphokinase; CPK, Lactate Dehydrogenase; LDH, Myoglobin), inflammation (Interleukin-6; IL-6, Interleukin-1β; IL-1β, Tumor Necrosis Factor-α; TNF-α, C-Reactive Protein; CRP) and stress hormone (Cortisol). According to this result, COMP (S1; 188.37 ± 46.68 ng/mL) showed a significant increase after the expedition course 1 (M; 246.69 ± 51.69 ng/mL, p = 0.012) and course 2 (U; 237.09 ± 62.57 ng/mL, p = 0.047), and recovered to the stable state after expedition course 3 (S2; 218.46 ± 34.78. p = 0.047). Biomarkers of muscle damage (CPK, LDH and Myoglobin) and inflammation (IL-6, IL-1β, TNF-α and CRP) were not significantly changed in all courses, but CRP (S1; 1.07 ± 0.76 ng/mL) showed a tendency to decrease after the expedition course 1 (M; 0.3 ± 0.1 mg/mL, p = 0.044). Lastly, the Cortisol level significantly increased in all courses (per p < 0.05), but the Cortisol level after expedition course 3 (S2; 21.00 ± 3.65 mg/mL) was lower than that of after the expedition course 1 (M; 24.23 ± 2.47 mg/mL, p = 0.028). In summary, it seems that repetitive and continuous 50−90 km/day of cycling can increase joint cartilage damage risk and stress hormone temporarily. However, this result suggests that the appropriate intensity of cycling for thirteen weeks does not increase physical damage, and rather enhances the human body to adapt to exercise training.
MeSH term(s)	Humans ; Biomarkers ; Cartilage, Articular/injuries ; Cartilage, Articular/metabolism ; Hormones ; Inflammation ; Interleukin-6 ; Muscles/injuries ; Muscles/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Bicycling/physiology
Chemical Substances	Biomarkers ; Hormones ; Interleukin-6 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192316314
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Article ; Online: Bronchiectasis and Nontuberculous Mycobacteria: It Is Not Over till It Is Over.

Kim, Hyung-Jun / Yim, Jae-Joon

Respiration; international review of thoracic diseases

2021 Volume 100, Issue 12, Page(s) 1149–1150

MeSH term(s)	Bronchiectasis/microbiology ; Humans ; Mycobacterium Infections, Nontuberculous/epidemiology ; Nontuberculous Mycobacteria ; Prevalence
Language	English
Publishing date	2021-08-24
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	206674-9
ISSN	1423-0356 ; 0025-7931
ISSN (online)	1423-0356
ISSN	0025-7931
DOI	10.1159/000518329
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Article: Successful Early Lamotrigine and Aripiprazole Augmentation of Clomipramine in Severe Obsessive-compulsive Disorder.

Seo, Eun Hyun / Kim, Seung-Gon / Lee, Jae-Hon / Yoon, Hyung-Jun

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

2023 Volume 21, Issue 3, Page(s) 604–608

Abstract: Lamotrigine and aripiprazole have shown efficacy as augmentation agents of serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder (OCD). To date, the efficacy of lamotrigine/aripiprazole augmentation has not been reported in ... ...

Abstract	Lamotrigine and aripiprazole have shown efficacy as augmentation agents of serotonin reuptake inhibitors for treatment-resistant obsessive-compulsive disorder (OCD). To date, the efficacy of lamotrigine/aripiprazole augmentation has not been reported in OCD treatment. Herein, we report the case of a 37-year-old male with severe OCD and comorbid depression whose symptoms markedly improved after low-dose lamotrigine/aripiprazole augmentation to clomipramine. Our report suggests that early glutamatergic/antipsychotic augmentation contributes to rapid remission of OCD symptoms.
Language	English
Publishing date	2023-07-09
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2211550-X
ISSN	1738-1088
ISSN	1738-1088
DOI	10.9758/cpn.22.1044
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Article: Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis.

Jeon, Yu-Mi / Kwon, Younghwi / Lee, Shinrye / Kim, Hyung-Jun

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1047897

Abstract: The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and cellular homeostasis. ER stress results from structural and functional dysfunction of the organelle, along with the accumulation of misfolded proteins and changes ...

Abstract	The endoplasmic reticulum (ER) is a major organelle involved in protein quality control and cellular homeostasis. ER stress results from structural and functional dysfunction of the organelle, along with the accumulation of misfolded proteins and changes in calcium homeostasis, it leads to ER stress response pathway such as unfolded protein response (UPR). Neurons are particularly sensitive to the accumulation of misfolded proteins. Thus, the ER stress is involved in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, prion disease and motor neuron disease (MND). Recently, the complex involvement of ER stress pathways has been demonstrated in experimental models of amyotrophic lateral sclerosis (ALS)/MND using pharmacological and genetic manipulation of the unfolded protein response (UPR), an adaptive response to ER stress. Here, we aim to provide recent evidence demonstrating that the ER stress pathway is an essential pathological mechanism of ALS. In addition, we also provide therapeutic strategies that can help treat diseases by targeting the ER stress pathway.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1047897
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Article ; Online: Investigation on Contact Properties of 2D van der Waals Semimetallic 1T-TiS

Yoon, Hwi / Lee, Sangyoon / Seo, Jeongwoo / Sohn, Inkyu / Jun, Sukhwan / Hong, Sungjae / Im, Seongil / Nam, Yunyong / Kim, Hyung-Jun / Lee, Yujin / Chung, Seung-Min / Kim, Hyungjun

ACS applied materials & interfaces

2024 Volume 16, Issue 9, Page(s) 12095–12105

Abstract: Two-dimensional transition metal dichalcogenides (2D TMDCs) are considered promising alternatives to Si as channel materials because of the possibility of retaining their superior electronic transport properties even at atomic body thicknesses. However, ... ...

Abstract	Two-dimensional transition metal dichalcogenides (2D TMDCs) are considered promising alternatives to Si as channel materials because of the possibility of retaining their superior electronic transport properties even at atomic body thicknesses. However, the realization of high-performance 2D TMDC field-effect transistors remains a challenge owing to Fermi-level pinning (FLP) caused by gap states and the inherent high Schottky barrier height (SBH) within the metal contact and channel layer. This study demonstrates that high-quality van der Waals (vdW) heterojunction-based contacts can be formed by depositing semimetallic TiS
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c18982
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Article ; Online: pKr-2 induces neurodegeneration

Kim, Sehwan / Sharma, Chanchal / Shin, Minsang / Kim, Hyung-Jun / Kim, Jaekwang / Kim, Sang Ryong

Brain, behavior, & immunity - health

2023 Volume 28, Page(s) 100593

Abstract: We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial ... ...

Abstract	We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial Alzheimer's disease mutation (5XFAD) mice. In the present study, we aimed to determine whether pKr-2 induces microglial activation by stimulating toll-like receptor 4 (TLR4) upregulation and examine whether this response contributes to pKr-2-induced neuroinflammatory damage in the hippocampi of mice models. We observed that inflammatory responses induced by pKr-2 administration in the hippocampi of wild-type mice were significantly abrogated in TLR4-deficient mice (TLR4
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2023.100593
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Article ; Online: The association between Adenosine A2A receptor gene polymorphisms and attention deficit hyperactivity disorder in Korean children

Kim, Ga Eun / Kim, Hyung-Jun / Jin, Han Jun

Gene. 2023 Aug., v. 876 p.147503-

2023

Abstract: Attention deficit hyperactivity disorder (ADHD) is a common and heritable neurodevelopmental disorder. Particularly, ADHD is known to be related to the dopaminergic system. ADHD symptoms can appear when the dopamine binding affinity diminishes due to ... ...

Abstract	Attention deficit hyperactivity disorder (ADHD) is a common and heritable neurodevelopmental disorder. Particularly, ADHD is known to be related to the dopaminergic system. ADHD symptoms can appear when the dopamine binding affinity diminishes due to dopamine receptor abnormalities, such as the dopamine D₂ receptor (D₂R). This receptor interacts with the adenosine A₂A receptor (A₂AR). The A₂AR acts as an antagonist of D₂R, that is, the increased binding of adenosine with A₂AR inhibits the D₂R activity. Furthermore, it is found that the single nucleotide polymorphisms of the adenosine A₂A receptor gene (ADORA2A) revealed a significant relationship with ADHD in various populations. Therefore, we examined the genetic relationship between ADORA2A polymorphisms (rs2297838, rs5751876, and rs4822492) and Korean ADHD children. A case-control study was performed for 150 cases and 322 controls. Genotyping of ADORA2A polymorphisms was conducted by PCR-RFLP. The results demonstrated that the rs5751876 TC genotype was associated with children with ADHD (p = 0.018). The rs2298383 CC genotype was significantly associated with children with ADHD/HI (p = 0.026). However, when Bonferroni correction was used, the significance vanished (pₐdⱼᵤₛₜₑd = 0.054 and pₐdⱼᵤₛₜₑd = 0.078, respectively). Haplotype analysis showed that TTC, TCC, and CTG demonstrated a significant difference between ADHD/C children and control groups (pₐdⱼᵤₛₜₑd = 0.006, pₐdⱼᵤₛₜₑd = 0.011, and pₐdⱼᵤₛₜₑd = 0.028, respectively). In conclusion, we propose a possible association between ADORA2A polymorphisms with Korean children having ADHD.
Keywords	adenosine ; antagonists ; case-control studies ; dopamine ; dopamine receptors ; genes ; genetic relationships ; genotyping ; haplotypes ; purinergic receptors ; ADHD ; ADORA2A ; rs2298383 ; rs5751876 ; rs4822492 ; D2R ; A2AR ; CHEER ; K-ARS ; DSM-IV ; SNP ; PCR ; PCR-RFLP ; OR ; CI ; LD
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147503
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A CRISPR/Cas12 trans-cleavage reporter enabling label-free colorimetric detection of SARS-CoV-2 and its variants.

Kim, Hansol / Jang, Hyowon / Song, Jayeon / Lee, Sang Mo / Lee, Seoyoung / Kwon, Hyung-Jun / Kim, Sunjoo / Kang, Taejoon / Park, Hyun Gyu

Biosensors & bioelectronics

2024 Volume 251, Page(s) 116102

Abstract: We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide ( ... ...

Abstract	We present a label-free colorimetric CRISPR/Cas-based method enabling affordable molecular diagnostics for SARS-CoV-2. This technique utilizes 3,3'-diethylthiadicarbocyanine iodide (DISC
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; CRISPR-Cas Systems/genetics ; Colorimetry ; RNA, Viral ; Biosensing Techniques ; Adenine ; Nucleic Acid Amplification Techniques
Chemical Substances	RNA, Viral ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116102
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