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Article: Use of liquid biopsies in gastrointestinal cancers.

Khachfe, Hussein H

World journal of gastrointestinal oncology

2021 Volume 13, Issue 9, Page(s) 1210–1212

Abstract: The use of liquid biopsies is a relatively new tool in diagnosis and management of gastrointestinal cancers and is actively being investigated. Liquid biopsies have become extremely popular in cholangiocarcinoma and pancreatic cancer research. With more ... ...

Abstract	The use of liquid biopsies is a relatively new tool in diagnosis and management of gastrointestinal cancers and is actively being investigated. Liquid biopsies have become extremely popular in cholangiocarcinoma and pancreatic cancer research. With more prospective trials using this tool for early diagnosis, liquid biopsies may become an important part of cancer management.
Language	English
Publishing date	2021-09-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v13.i9.1210
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Article ; Online: Deliveries in Lebanon, the Country with the Highest Refugee Density in the World: A Descriptive Review.

Sammouri, Julie / Khachfe, Hussein H / Fares, Mohamad Y / Salhab, Hamza A / Nassar, Anwar H / Chamsy, Dina

Maternal and child health journal

2023 Volume 28, Issue 4, Page(s) 601–608

Abstract: Purpose: The aim of this study is to analyze obstetrical and reproductive health parameters in Lebanon from 2015 until 2018 in the setting of the Syrian refugee influx in order to evaluate potential risks and provide a management plan to improve ... ...

Abstract	Purpose: The aim of this study is to analyze obstetrical and reproductive health parameters in Lebanon from 2015 until 2018 in the setting of the Syrian refugee influx in order to evaluate potential risks and provide a management plan to improve outcomes. Description: Data from the Lebanese Ministry of Public Health (LMPH) on all obstetrical deliveries that occurred in Lebanon between 2015 and 2018 was screened and analyzed. Number and mode of delivery as well as maternal and neonatal outcomes were included. Joinpoint regression analysis was used for trends of selected parameters. Independent two-sample t-tests were used for comparisons. Assessment: Women of non-Lebanese nationality residing in Lebanon had a significantly greater number of total deliveries (p-value < 0.001), vaginal deliveries (p-value = 0.002), cesarean sections (p-value = 0.02). When looking at delivery trends from 2015 to 2018, Lebanese women had a significant decrease in total number of deliveries (p-value < 0.001) and vaginal deliveries (p-value < 0.001). Conclusion: Total number of deliveries and cesarean sections is on the rise in Lebanon. Cesarean section practice should be audited by the LMPH and the Lebanese Order of Physicians (LOP). Local and international agencies should prioritize the implementation and management of family planning facilities in refugee hosting countries.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; Cesarean Section ; Delivery, Obstetric ; Lebanon/epidemiology ; Public Health ; Refugees
Language	English
Publishing date	2023-11-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1339905-6
ISSN	1573-6628 ; 1092-7875
ISSN (online)	1573-6628
ISSN	1092-7875
DOI	10.1007/s10995-023-03826-x
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Article ; Online: Clinical and Diagnostic Characteristics of Calcaneal Apophysitis: A Systematic Review and Thematic Analysis.

Fares, Mohamad Y / Baydoun, Hasan / Khachfe, Hussein H / Salhab, Hamza A / Fares, Jawad / Musharrafieh, Umayya

Journal of the American Podiatric Medical Association

2023 Volume 113, Issue 4

Abstract: Background: Calcaneal apophysitis is an overuse injury in pediatric patients that causes heel pain and reduction in function. The aim of this study is to explore this condition and offer medical insight into its presentation and symptomatology, along ... ...

Abstract	Background: Calcaneal apophysitis is an overuse injury in pediatric patients that causes heel pain and reduction in function. The aim of this study is to explore this condition and offer medical insight into its presentation and symptomatology, along with current treatment options. Methods: We explored PubMed/Medline for studies involving calcaneal apophysitis in pediatric patients. The search included all articles published from database inception until June 1, 2021. We only included articles published in English. Clinical information and demographics extracted from the reported studies were analyzed and assessed. Results: Only 28 studies met our criteria, with a total of 1,362 cases. Of the cases reported, 973 affected boys (71.4%). Presentation was bilateral in 589 cases (43.2%) and unilateral in 433 cases (31.8%). Radiographic imaging was used for the diagnosis of 358 cases (26.3%). All reported treatment modalities were conservative, and these included physical therapy and rest, kinesiotherapy and taping, and orthotic devices. A total of 733 cases (53.7%) reported improved outcomes,32 cases (2.3%) reported no improvement, and the remainder of cases did not report prognostic outcomes (44%). Conclusions: Calcaneal apophysitis is an overuse disease commonly found in the pediatric population. Educating parents and coaches with regard to its symptomatology, etiology, and treatment is essential to diagnose the condition earlier and provide better outcomes.
MeSH term(s)	Male ; Humans ; Child ; Calcaneus/diagnostic imaging ; Foot Diseases/epidemiology ; Pain/etiology ; Orthotic Devices ; Radiography
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	632622-5
ISSN	1930-8264 ; 0003-0538 ; 8750-7315
ISSN (online)	1930-8264
ISSN	0003-0538 ; 8750-7315
DOI	10.7547/22-083
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Zs.A 364: Show issues

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Article ; Online: Epidemiological Study of Lung Cancer Incidence in Lebanon.

Salhab, Hamza A / Fares, Mohamad Y / Khachfe, Hussein H / Khachfe, Hassan M

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 6

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Epidemiologic Studies ; Female ; Humans ; Incidence ; Lebanon/epidemiology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Male ; Middle Aged ; Registries/statistics & numerical data
Language	English
Publishing date	2019-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55060217
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Zs.A 6270: Show issues

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Article ; Online: Breast Cancer Epidemiology among Lebanese Women: An 11-Year Analysis.

Fares, Mohamad Y / Salhab, Hamza A / Khachfe, Hussein H / Khachfe, Hassan M

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 8

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Female ; Humans ; Incidence ; Lebanon/epidemiology ; Middle Aged ; Registries/statistics & numerical data
Language	English
Publishing date	2019-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55080463
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Article ; Online: Physical Testing in Sports Rehabilitation: Implications on a Potential Return to Sport.

Fares, Mohamad Y / Khachfe, Hussein H / Salhab, Hamza A / Bdeir, Ahmad / Fares, Jawad / Baydoun, Hasan

Arthroscopy, sports medicine, and rehabilitation

2022 Volume 4, Issue 1, Page(s) e189–e198

Abstract: Strength and power constitute vital predictors for an individual's quality of life and athletic performance. Measurement of these two parameters is very important in the world of sports science and medicine and necessitates a high level of accuracy and ... ...

Abstract	Strength and power constitute vital predictors for an individual's quality of life and athletic performance. Measurement of these two parameters is very important in the world of sports science and medicine and necessitates a high level of accuracy and reliability. Several tests are used to measure strength and power, including the isometric maximal voluntary contraction test, the 1-repetition maximum test, and the Wingate test, as well as other tests that target upper and lower limbs. The unique characteristics present in each of these tests entail a subsequently unique mode of application during the process of rehabilitation. This helps athletic trainers and medical personnel evaluate recovery and decide on a potential return to sport. A comprehensive holistic approach that includes multiple testing, psychosocial assessment, and a gradual return to activity is best to achieve promising outcomes and preinjury athletic levels. Level of evidence: V, expert opinion.
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article
ISSN	2666-061X
ISSN (online)	2666-061X
DOI	10.1016/j.asmr.2021.09.034
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Article ; Online: Current State of Hypertrophic Cardiomyopathy Clinical Trials.

Khachfe, Hussein H / Salhab, Hamza A / Fares, Mohamad Y / Khachfe, Hassan M

Global heart

2019 Volume 14, Issue 3, Page(s) 317–325

Abstract: Background: Hypertrophic cardiomyopathy (HCM) is a genetic disorder with a very large global burden for which more therapeutic management regimens are required.: Objectives: In this study, the authors explore HCM-related clinical trials, determine ... ...

Abstract	Background: Hypertrophic cardiomyopathy (HCM) is a genetic disorder with a very large global burden for which more therapeutic management regimens are required. Objectives: In this study, the authors explore HCM-related clinical trials, determine the shortcomings leading to the lack of development of new HCM therapies, and attempt to shed light on potential areas for improvement. Methods: In January 2019, the authors completed a search on ClinicalTrials.gov for all therapeutic and interventional clinical trials involving HCM, without any limits for location or date. Information on trial characteristics such as phase, start and end dates, sample size, experimental intervention, publications, study design, selection criteria, and results were collected and analyzed. Results: Sixty-three trials met the selection criteria. The average trial duration across phases was around 3 years. Around one-half of the trials were conducted in North America (United States and Canada) and 44% of the trials were in their early phases (I and II). Approximately one-third of the trials were completed. Only 14 publications were produced from all the clinical trials studied. Conclusions: The study revealed a low number of trials, lack of geographic diversity, and scarcity of published results concerning HCM clinical trials. Proper management of HCM trials is of vast importance to achieve effective therapies.
MeSH term(s)	Cardiomyopathy, Hypertrophic/therapy ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/statistics & numerical data ; Global Health/statistics & numerical data ; Humans ; Publications/statistics & numerical data ; Sample Size
Language	English
Publishing date	2019-08-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2629633-0
ISSN	2211-8179 ; 2211-8160
ISSN (online)	2211-8179
ISSN	2211-8160
DOI	10.1016/j.gheart.2019.07.005
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Article ; Online: Probing the Colorectal Cancer Incidence in Lebanon: an 11-Year Epidemiological Study.

Khachfe, Hussein H / Salhab, Hamza A / Fares, Mohamad Y / Khachfe, Hassan M

Journal of gastrointestinal cancer

2019 Volume 51, Issue 3, Page(s) 805–812

Abstract: Background and objectives: Lebanon has witnessed an increase in the rates of several cancer sub-types over the past couple of years. The aim of our study is to investigate the incidence rates of colorectal cancer over 11 years in Lebanon and compare ... ...

Abstract	Background and objectives: Lebanon has witnessed an increase in the rates of several cancer sub-types over the past couple of years. The aim of our study is to investigate the incidence rates of colorectal cancer over 11 years in Lebanon and compare them with other countries. Materials and methods: Data was collected from the National Cancer Registry (NCR) of Lebanon from the years of 2005 till 2015 inclusive. Data of other countries was retrieved from the online database "Cancer Incidence in Five Continents". The age-specific and age-standardized incidence rates (ASR(w)) were calculated and analyzed using Joinpoint regression. Results: Colorectal cancer ranked as the 5th most common cancer in Lebanon. The average ASR(w) was 12.6 per 100,00 for males and 10.7 per 100,00 for females. Colorectal cancer ASR (w) showed a significantly increasing trend in both males and females. Lebanon had the second highest incidence of colorectal cancer in the MENA region. Conclusion: Incidence of colorectal cancer has been increasing significantly over the course of our study. It is important to study the risk factors associated with colorectal cancer and develop proper preventive and screening policies in order to decrease exposure and therefore decrease incidence rates in the future.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Child ; Child, Preschool ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Epidemiologic Studies ; Female ; Health Policy ; Humans ; Incidence ; Lebanon/epidemiology ; Male ; Mass Screening/standards ; Middle Aged ; Registries/statistics & numerical data ; Risk Factors ; Sex Factors ; Young Adult
Language	English
Publishing date	2019-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-019-00284-z
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Zs.A 2184: Show issues

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Article ; Online: Preoperative MELD score predicts adverse outcomes following gastrectomy: An ACS NSQIP analysis.

Khachfe, Hussein H / Araji, Tarek Z / Nassereldine, Hasan / El-Asmar, Rudy / Baydoun, Hussein A / Hallal, Ali H / Jamali, Faek R

American journal of surgery

2022 Volume 224, Issue 1 Pt B, Page(s) 501–505

Abstract: Background: The Model End-Stage Liver Disease (MELD) has been widely used to predict the mortality and morbidity of various surgical procedures. We aimed to assess the impact of preoperative MELD score on adverse 30-day postoperative outcomes following ... ...

Abstract	Background: The Model End-Stage Liver Disease (MELD) has been widely used to predict the mortality and morbidity of various surgical procedures. We aimed to assess the impact of preoperative MELD score on adverse 30-day postoperative outcomes following gastrectomy. Methods: Patients who underwent elective, non-emergent gastrectomy were identified from the ACS NSQIP 2014-2019 database. Patients were categorized according to a calculated MELD score. The primary outcomes of this study were the 30-day overall complications and major complication rates following gastrectomy. Results: Compared to MELD <11, patients with MELD ≥11 had significantly higher rates of mortality, any complication, and major complication. MELD score ≥11 was significantly associated with any complication (OR 1.73, p = 0.011) and major complications (1.85, p = 0.014) on multivariate analysis. Conclusions: MELD score ≥11 was associated with poorer outcomes in patients undergoing gastrectomy compared to lower MELD scores.
MeSH term(s)	Elective Surgical Procedures/adverse effects ; End Stage Liver Disease/complications ; Gastrectomy/adverse effects ; Humans ; Morbidity ; Postoperative Complications/etiology ; Retrospective Studies
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2022.01.027
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Uk I Zs.42: Show issues

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Article ; Online: Clinical Trials in Hepatopancreatobiliary Surgery: Assessing Trial Characteristics, Early Discontinuation, Result Reporting, and Publication.

Khachfe, Hussein H / Habib, Joseph R / Nassour, Ibrahim / Baydoun, Hussein A / Ghabi, Elie M / Chahrour, Mohamad A / Hallal, Ali H / Jamali, Faek R

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2022 Volume 26, Issue 8, Page(s) 1628–1636

Abstract: Background: Hepatopancreaticobiliary (HPB) diseases carry high morbidity despite efforts aimed at their reduction. An assessment of their trial characteristics is paramount to determine trial design adequacy and highlight areas for improvement. As such, ...

Abstract	Background: Hepatopancreaticobiliary (HPB) diseases carry high morbidity despite efforts aimed at their reduction. An assessment of their trial characteristics is paramount to determine trial design adequacy and highlight areas for improvement. As such, the aim of this study is to assess HPB surgery trial characteristics, summarize logistic, financial, and practical reasons behind early discontinuation, and propose potential interventions to prevent this in the future. Methods: All clinical trials investigating HPB surgery registered on ClinicalTrials.gov from October 1st, 2007 (inclusive), to April 20th, 2021 (inclusive), were examined. Trial characteristics were collected including, but not limited to, study phase, duration, patient enrollment size, location, and study design. Peer-reviewed publications associated with the selected trials were also assessed to determine outcome reporting. Results: A total of 1776 clinical trials conducted in 43 countries were identified, the majority of which were conducted in the USA. Of these trials, 32% were reported as "completed" whereas 12% were "discontinued." The most common cause of trial discontinuation was low accrual, which was reported in 37% of terminated studies. These resulted in 413 published studies. Most trials had multiple assignment, randomized, or open-label designs. Treatment was the most common study objective (73%) with pharmacological therapy being the most commonly studied intervention. Conclusions: The main reasons for early discontinuation of clinical trials in HPB surgery are poor patient recruitment and inadequate funding. Improved trial design, recruitment strategies and increased funding are needed to prevent trial discontinuation and increase publication rates of HPB surgery clinical trials.
MeSH term(s)	Humans ; Patient Selection
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-022-05387-w
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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