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  1. Article: Historical Perspectives of the Korean Society for Thoracic and Cardiovascular Surgery: Sung Haing Lee (1919-2012), Who Performed the First Open Heart Surgery Using Hypothermia in Korea.

    Jung, Hanna / Park, Kook-Yang / Oh, Tae Yun / Kim, Wooshik

    Journal of chest surgery

    2023  Volume 57, Issue 1, Page(s) 103–107

    Language English
    Publishing date 2023-08-16
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2765-1606
    ISSN 2765-1606
    DOI 10.5090/jcs.23.089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Cerebral paragonimiasis and Bo Sung Sim's hemispherectomy in Korea in 1950s-1960s].

    Park, Jiyoung / Miyagawa, Takuya / Hong, Jeonghwa / Kim, Ockjoo

    Ui sahak

    2011  Volume 20, Issue 1, Page(s) 119–161

    Abstract: ... of cerebral paragonimiasis by Bo Sung Sim in Korea in 1950s-1960s. He demonstrated that cerebral ... that Bo Sung Sim's introduction of cerebral hemispherectomy to Korea was not a simple application ... spastic hemiplegia and mental deterioration. Bo Sung Sim, one of the neurosurgeons of the first generation in Korea ...

    Abstract This paper deals with cerebral paragonimiasis and cerebral hemispherectomy conducted as a treatment of cerebral paragonimiasis by Bo Sung Sim in Korea in 1950s-1960s. He demonstrated that cerebral hemispherectomy could be used for unilateral diffuse cerebral paragonimiasis. Sim learned cerebral hemispherectomy from Dr. L. A. French. at the University of Minnesota from 1955 to 1957 in America. The authors argues that Bo Sung Sim's introduction of cerebral hemispherectomy to Korea was not a simple application of an advanced medical technology, but a complicated and active process in that Sim used the technique to intervene intractable complications from cerebral paragonimiasis such as generalized convulsions, spastic hemiplegia and mental deterioration. Bo Sung Sim, one of the neurosurgeons of the first generation in Korea, was trained in neurology, neuropathology, neuroradiology and animal experiments as well as in neurosurgery at the University of Minnesota. After returning to Korea, Sim faced parasitic diseases, one of the most serious public health problems at that time, which were far different from what he learned in America. As a neurosurgeon, Sim tackled with parasitic diseases of the central nervous system with various diagnostics and therapeutics. In 1950s, more than one million populations suffered from pulmonary paragonimiasis acquired by eating raw crabs or by feeding juice of crushed crayfish for the treatment of measles in Korea. About 26.6 percent of people with paragonimiasis had cerebral paragonimiasis. Before bithionol therapy was introduced in 1962, neurosurgery was the only available treatment to control increased intracranial pressures, intractable epilepsy, paralysis and mental deterioration. Between 1958 to 1962, Bo Sung Sim operated on 24 patients of cerebral paragonimiasis. In two of them, he performed cerebral hemispherectomy to control intractable convulsions when he found diffuse cerebral paragonimiasis and cerebral atrophy at the operating table. The two patients were recovered dramatically after the operation. The first patient became a part of medical campus for 20 years after hemispherectomy, doing chores at the hospital and helping Bo Sung Sim for his teaching neuroanatomy. The presence of the hemispherectomized patient in the classroom impressed the students deeply. Furthermore, the hemispherectomized patient stimulated Sim and his school to perform research upon the neuroanatomy and neurophysiology of the brain with hemispherectomized animals.
    MeSH term(s) Animals ; Brain/parasitology ; Hemispherectomy/history ; History, 20th Century ; Humans ; Paragonimiasis/history ; Paragonimiasis/surgery ; Parasitic Diseases/history ; Parasitic Diseases/therapy ; Trematoda
    Language Korean
    Publishing date 2011-06-30
    Publishing country Korea (South)
    Document type Biography ; English Abstract ; Historical Article ; Journal Article
    ZDB-ID 2256536-X
    ISSN 2093-5609 ; 1225-505X
    ISSN (online) 2093-5609
    ISSN 1225-505X
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  3. Article ; Online: This symposium was specially dedicated to the recognition of Sung Wan Kim (USA) and his vast contributions over his career. Preface.

    Park, Kinam / Bae, You Han / Grainger, David W

    Journal of controlled release : official journal of the Controlled Release Society

    2011  Volume 155, Issue 2, Page(s) 113–114

    MeSH term(s) Drug Delivery Systems
    Language English
    Publishing date 2011-10-30
    Publishing country Netherlands
    Document type Introductory Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2011.08.042
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
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  4. Article: Bo Sung Sim (1924-2001): a pioneer of neurosurgery in Korea.

    Kim, Dong Gyu / Park, Chul-Kee / Paek, Sun Ha

    Journal of neurosurgery

    2006  Volume 105, Issue 3, Page(s) 494–497

    Abstract: Bo Sung Sim (1924-2001) stands as a prominent figure in the history of Korean neurosurgery ...

    Abstract Bo Sung Sim (1924-2001) stands as a prominent figure in the history of Korean neurosurgery. His devoted contributions have led to the fruitful development of modern neurosurgery in Korea. Sim practiced advanced neurosurgical techniques, undertook basic research, was passionate about education in the early years of neurosurgery in Korea, and played an essential role in founding the Korean Neurosurgical Society. Sim was a true neurosurgeon-a teacher, a scientist, and a superb pioneer in Korean neurosurgery.
    MeSH term(s) Education, Medical/history ; History, 20th Century ; Humans ; Korea ; Neurosurgery/education ; Neurosurgery/history ; Societies, Medical/history
    Language English
    Publishing date 2006-09
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.2006.105.3.494
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.135: Show issues Location:
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  5. Article ; Online: Deciphering the conformational preference and ionization dynamics of tetrahydrofuran: Insights from advanced spectroscopic techniques.

    Park, Sung Man / Kwon, Chan Ho

    The Journal of chemical physics

    2024  Volume 160, Issue 11

    Abstract: Tetrahydrofuran (THF) has garnered significant attention due to its pivotal role in biological and chemical processes. The diverse array of conformations exhibited by THF profoundly impacts its reactivity and interactions with other molecules. ... ...

    Abstract Tetrahydrofuran (THF) has garnered significant attention due to its pivotal role in biological and chemical processes. The diverse array of conformations exhibited by THF profoundly impacts its reactivity and interactions with other molecules. Understanding these conformational preferences is crucial for comprehending its molecular behavior. In this study, we utilize infrared (IR) resonant vacuum ultraviolet photoionization/mass-analyzed threshold ionization (VUV-PI/MATI) mass spectroscopies to capture distinctive vibrational spectra of individual conformers, namely, "twisted" and "bent," within THF. Our conformer-specific vibrational spectra provide valuable insights into the relative populations of these two conformers. The analysis reveals that the twisted (C2) conformer is more stable than the bent (CS) conformer by 17 ± 15 cm-1. By precisely tuning the VUV photon energy to coincide with vibrational excitation via IR absorption, we selectively ionize specific conformers, yielding two-photon IR + VUV-PI/MATI spectra corresponding to the twisted and bent conformers. This investigation conclusively affirms that both the twisted and bent conformers coexist in the neutral state, while only the twisted conformer exists in the cationic state. These findings not only bridge gaps in existing knowledge but also provide profound insights into the behavior of this pivotal molecule in the realms of biology and medicine.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0186570
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  6. Article ; Online: Conformational diversity and environmental implications of

    Park, Sung Man / Kwon, Chan Ho

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 42, Page(s) 28612–28620

    Abstract: This study investigates the conformational intricacies ... ...

    Abstract This study investigates the conformational intricacies of
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04204a
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  7. Article: Regulation of Macrophage Activation and Differentiation in Atherosclerosis.

    Park, Sung Ho

    Journal of lipid and atherosclerosis

    2021  Volume 10, Issue 3, Page(s) 251–267

    Abstract: Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed to ... ...

    Abstract Chronic inflammation is a hallmark of atherosclerosis and macrophages play a central role in controlling inflammation at all stages of atherosclerosis. In atherosclerosis, macrophages and monocyte-derived macrophages are continuously exposed to cholesterol, oxidized lipids, cell debris, cytokines, and chemokines. Not only do these stimuli induce a specific macrophage phenotype, but they also interact extensively, leading to macrophage heterogeneity in atherosclerotic plaques. Herein, we review the diverse phenotypes of macrophages, the mechanisms underlying macrophage activation, and the contributions of macrophages to atherosclerosis in this context. We also summarize recent studies on foamy macrophages and monocyte-derived macrophages in plaque during disease progression. We provide a comprehensive overview of transcriptional, epigenetic, and metabolic reprogramming of macrophages and discuss the emerging concepts of targeting cytokines and macrophages to modulate atherosclerosis.
    Language English
    Publishing date 2021-04-28
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3016001-7
    ISSN 2288-2561 ; 2287-2892
    ISSN (online) 2288-2561
    ISSN 2287-2892
    DOI 10.12997/jla.2021.10.3.251
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  8. Article ; Online: An Impaired Inflammatory and Innate Immune Response in COVID-19.

    Park, Sung Ho

    Molecules and cells

    2021  Volume 44, Issue 6, Page(s) 384–391

    Abstract: The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, ... ...

    Abstract The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity and death. We also discuss the immunological determinants behind COVID-19 severity and propose a rationale for the underlying mechanisms.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/virology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/mortality ; Cytokine Release Syndrome/virology ; Dexamethasone/therapeutic use ; Gene Expression Regulation ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate/drug effects ; Inflammation ; Interferon Type I/genetics ; Interferon Type I/immunology ; Interleukins/genetics ; Interleukins/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/mortality ; Severe Acute Respiratory Syndrome/virology ; Severity of Illness Index ; Signal Transduction ; Survival Analysis ; COVID-19 Drug Treatment
    Chemical Substances Anti-Inflammatory Agents ; Interferon Type I ; Interleukins ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2021.0068
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4713: Show issues Location:
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  9. Article ; Online: Unraveling the Conformational Preference of Morpholine: Insights from Infrared Resonant Vacuum Ultraviolet Photoionization Mass Spectroscopy.

    Park, Sung Man / Kwon, Chan Ho

    The journal of physical chemistry letters

    2023  Volume 14, Issue 42, Page(s) 9472–9478

    Abstract: The preference for different conformations in morpholine has a notable effect on its behavior and reactivity in organic synthesis. Herein, we explored the intricate conformational properties of morpholines through a combination of advanced mass ... ...

    Abstract The preference for different conformations in morpholine has a notable effect on its behavior and reactivity in organic synthesis. Herein, we explored the intricate conformational properties of morpholines through a combination of advanced mass spectrometric techniques and theoretical calculations. Notably, we employed infrared (IR) resonant vacuum ultraviolet (VUV) mass-analyzed threshold ionization spectroscopy to measure the unique vibrational spectra of the distinct conformers (Chair-Eq and Chair-Ax) in morpholine for the first time. Through precise VUV photon energy adjustments to coincide with the vibrational excitation via IR absorption, we effectively pinpointed the adiabatic ionization thresholds corresponding to the Chair-Eq (65 442 ± 4 cm
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02280
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  10. Article: Comparing the Benefits and Drawbacks of Stem Cell Therapy Based on the Cell Origin or Manipulation Process: Addressing Immunogenicity.

    Chang, Sung-Ho / Park, Chung Gyu

    Immune network

    2023  Volume 23, Issue 6, Page(s) e44

    Abstract: Mesenchymal stem cells (MSCs) are effective in treating autoimmune diseases and managing various conditions, such as engraftment of allogeneic islets. Additionally, autologous and HLA-matched allogeneic MSCs can aid in the engraftment of human allogeneic ...

    Abstract Mesenchymal stem cells (MSCs) are effective in treating autoimmune diseases and managing various conditions, such as engraftment of allogeneic islets. Additionally, autologous and HLA-matched allogeneic MSCs can aid in the engraftment of human allogeneic kidneys with or without low doses of tacrolimus, respectively. However, HLA alloantigens are problematic because cell therapy uses more HLA-mismatched allogeneic cells than autologous for convenience and standardization. In particular, HLA-mismatched MSCs showed increased Ag-specific T/B cells and reduced viability faster than HLA-matched MSCs. In CRISPR/Cas9-based cell therapy, Cas9 induce T cell activation in the recipient's immune system. Interestingly, despite their immunogenicity being limited to the cells with foreign Ags, the accumulation of HLA alloantigen-sensitized T/B cells may lead to allograft rejection, suggesting that alloantigens may have a greater scope of adverse effects than foreign Ags. To avoid alloantigen recognition, the β2-microglobulin knockout (B2MKO) system, eliminating class-I MHC, was able to avoid rejection by alloreactive CD8 T cells compared to controls. Moreover, universal donor cells in which both B2M and Class II MHC transactivator (
    Language English
    Publishing date 2023-11-23
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2023.23.e44
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