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Article ; Online: Author Correction: An ADAMTS Sol narae is required for cell survival in Drosophila.

Tsogtbaatar, Orkhon / Won, Jong-Hoon / Kim, Go-Woon / Han, Jeong-Hoon / Bae, Young-Kyung / Cho, Kyung-Ok

2019 Volume 9, Issue 1, Page(s) 17116

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2019-11-14
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-53741-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An ADAMTS Sol narae is required for cell survival in Drosophila.

Tsogtbaatar, Orkhon / Won, Jong-Hoon / Kim, Go-Woon / Han, Jeong-Hoon / Bae, Young-Kyung / Cho, Kyung-Ok

Scientific reports

2019 Volume 9, Issue 1, Page(s) 1270

Abstract: ... proliferation, preventing tissue loss after environmental stresses. Here, we show that Sol narae (Sona ...

Abstract	Cell survival is essential for all living organisms to cope against multiple environmental insults. Intercellular signaling between dying and surviving cells plays an important role to ensure compensatory proliferation, preventing tissue loss after environmental stresses. Here, we show that Sol narae (Sona), a Disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in Drosophila is required for cell survival. sona exhibited a positive genetic interaction with Death-associated inhibitor of apoptosis 1 (Diap1), and a negative genetic interaction with reaper (rpr). Transcription patterns of sona, Diap1, and rpr genes in the pouch region of wing discs were coordinately changed after irradiation. Interestingly, there was a negative correlation in the expression levels of Sona and DIAP1, and both cell types, one with high Sona level and the other with high Diap1 level, were resistant to irradiation-induced cell death. The sona-expressing cells rarely entered into cell cycle themselves but promoted the nearby cells to proliferate in irradiation conditions. We found that these sona-expressing cells are able to upregulate Cyclin D (Cyc D) and increase tissue size. Furthermore, transient Sona overexpression increased survival rate and promoted development of flies in irradiation conditions. We propose that the two types of radiation-resistant cells, one with high Sona level and the other with high Diap1 level, communicate with dying cells and between each other for cell survival and proliferation in response to irradiation.
MeSH term(s)	Animals ; Cell Cycle ; Cell Survival ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Imaginal Discs/cytology ; Imaginal Discs/embryology ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Wings, Animal/cytology ; Wings, Animal/embryology
Chemical Substances	DIAP1 protein, Drosophila ; Drosophila Proteins ; Inhibitor of Apoptosis Proteins ; rpr protein, Drosophila
Language	English
Publishing date	2019-02-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-37557-9
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Article ; Online: ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila.

Won, Jong-Hoon / Kim, Go-Woon / Kim, Ja-Young / Cho, Dong-Gyu / Kwon, Buki / Bae, Young-Kyung / Cho, Kyung-Ok

Cell death & disease

2019 Volume 10, Issue 8, Page(s) 564

Abstract: ... but the mechanisms by which secreted Wnt/Wg is processed remain largely unknown. A Drosophila Sol narae (Sona) is ...

Abstract	Wnt/ Wingless (Wg) is essential for embryonic development and adult homeostasis in all metazoans, but the mechanisms by which secreted Wnt/Wg is processed remain largely unknown. A Drosophila Sol narae (Sona) is a member of A Disintegrin And Metalloprotease with ThromboSpondin motif (ADAMTS) family, and positively regulates Wg signaling by promoting Wg secretion. Here we report that Sona and Wg are secreted by both conventional Golgi and exosomal transports, and Sona cleaves extracellular Wg at the two specific sites, leading to the generation of N-terminal domain (NTD) and C-terminal domain (CTD) fragments. The cleaved forms of extracellular Wg were detected in the extracellular region of fly wing discs, and its level was substantially reduced in sona mutants. Transient overexpression of Wg-CTD increased wing size while prolonged overexpression caused lethality and developmental defects. In contrast, Wg-NTD did not induce any phenotype. Moreover, the wing defects and lethality induced by sona RNAi were considerably rescued by Wg-CTD, indicating that a main function of extracellular Sona is the generation of Wg-CTD. Wg-CTD stabilized cytoplasmic Armadillo (Arm) and had genetic interactions with components of canonical Wg signaling. Wg-CTD also induced Wg downstream targets such as Distal-less (Dll) and Vestigial (Vg). Most importantly, Cyclin D (Cyc D) was induced by Wg-CTD but not by full-length Wg. Because Sona also induces Cyc D in a cell non-autonomous manner, Wg-CTD generated by Sona in the extracellular region activates a subset of Wg signaling whose major function is the regulation of cell proliferation.
MeSH term(s)	ADAMTS Proteins/genetics ; ADAMTS Proteins/metabolism ; Animals ; Animals, Genetically Modified ; Cell Line ; Cell Proliferation/genetics ; Cyclin D/metabolism ; Drosophila/metabolism ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Exosomes/metabolism ; Golgi Apparatus/metabolism ; Phenotype ; Protein Domains/genetics ; Protein Stability ; RNA Interference ; Wings, Animal/growth & development ; Wings, Animal/metabolism ; Wnt1 Protein/chemistry ; Wnt1 Protein/genetics ; Wnt1 Protein/metabolism
Chemical Substances	Cyclin D ; Drosophila Proteins ; Wnt1 Protein ; wg protein, Drosophila ; ADAMTS Proteins (EC 3.4.24.-)
Language	English
Publishing date	2019-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-019-1794-8
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Article ; Online: An ADAMTS Sol narae is required for cell survival in Drosophila

Orkhon Tsogtbaatar / Jong-Hoon Won / Go-Woon Kim / Jeong-Hoon Han / Young-Kyung Bae / Kyung-Ok Cho

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 15

Abstract: ... compensatory proliferation, preventing tissue loss after environmental stresses. Here, we show that Sol narae ...

Abstract	Abstract Cell survival is essential for all living organisms to cope against multiple environmental insults. Intercellular signaling between dying and surviving cells plays an important role to ensure compensatory proliferation, preventing tissue loss after environmental stresses. Here, we show that Sol narae (Sona), a Disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in Drosophila is required for cell survival. sona exhibited a positive genetic interaction with Death-associated inhibitor of apoptosis 1 (Diap1), and a negative genetic interaction with reaper (rpr). Transcription patterns of sona, Diap1, and rpr genes in the pouch region of wing discs were coordinately changed after irradiation. Interestingly, there was a negative correlation in the expression levels of Sona and DIAP1, and both cell types, one with high Sona level and the other with high Diap1 level, were resistant to irradiation-induced cell death. The sona-expressing cells rarely entered into cell cycle themselves but promoted the nearby cells to proliferate in irradiation conditions. We found that these sona-expressing cells are able to upregulate Cyclin D (Cyc D) and increase tissue size. Furthermore, transient Sona overexpression increased survival rate and promoted development of flies in irradiation conditions. We propose that the two types of radiation-resistant cells, one with high Sona level and the other with high Diap1 level, communicate with dying cells and between each other for cell survival and proliferation in response to irradiation.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2019-02-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: Exosomal arrow (Arr)/lipoprotein receptor protein 6 (LRP6) in Drosophila melanogaster increases the extracellular level of Sol narae (Sona) in a Wnt-independent manner.

Han, Jeong-Hoon / Kim, Yeon / Cho, Kyung-Ok

Cell death & disease

2020 Volume 11, Issue 11, Page(s) 944

Abstract: Wg/Wnt as a signaling protein binds to Frizzled (Fz) and Arrow (Arr), two Wg co-receptors essential for Wg signaling for cell proliferation, differentiation, and cell survival. Arr has a long extracellular region, a single transmembrane domain and an ... ...

Abstract	Wg/Wnt as a signaling protein binds to Frizzled (Fz) and Arrow (Arr), two Wg co-receptors essential for Wg signaling for cell proliferation, differentiation, and cell survival. Arr has a long extracellular region, a single transmembrane domain and an intracellular region. Here, we report that a new arr
MeSH term(s)	Animals ; Cell Proliferation ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Exosomes/metabolism ; Low Density Lipoprotein Receptor-Related Protein-6/genetics ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Metalloendopeptidases/genetics ; Metalloendopeptidases/metabolism ; Phenotype ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Wings, Animal/growth & development ; Wings, Animal/metabolism ; Wnt Proteins/genetics ; Wnt Proteins/metabolism
Chemical Substances	Drosophila Proteins ; Low Density Lipoprotein Receptor-Related Protein-6 ; Receptors, Cell Surface ; Wnt Proteins ; arr protein, Drosophila ; Metalloendopeptidases (EC 3.4.24.-) ; sona protein, Drosophila (EC 3.4.24.-)
Language	English
Publishing date	2020-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-020-02850-x
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Article ; Online: Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling.

Kim, Go-Woon / Won, Jong-Hoon / Lee, Ok-Kyung / Lee, Sang-Soo / Han, Jeong-Hoon / Tsogtbaatar, Orkhon / Nam, Sujin / Kim, Yeon / Cho, Kyung-Ok

Scientific reports

2016 Volume 6, Page(s) 31863

Abstract: ... disorders in connective tissues. We report here that a Drosophila ADAMTS named Sol narae (Sona) promotes Wnt ...

Abstract	ADAMTS (a disintegrin and metalloproteases with thrombospondin motif) family consists of secreted proteases, and is shown to cleave extracellular matrix proteins. Their malfunctions result in cancers and disorders in connective tissues. We report here that a Drosophila ADAMTS named Sol narae (Sona) promotes Wnt/Wingless (Wg) signaling. sona loss-of-function mutants are lethal and rare escapers had malformed appendages, indicating that sona is essential for fly development and survival. sona exhibited positive genetic interaction with wntless (wls) that encodes a cargo protein for Wg. Loss of sona decreased the level of extracellular Wg, and also reduced the expression level of Wg effector proteins such as Senseless (Sens), Distalless (Dll) and Vestigial (Vg). Sona and Wg colocalized in Golgi and endosomal vesicles, and were in the same protein complex. Furthermore, co-expression of Wg and Sona generated ectopic wing margin bristles. This study suggests that Sona is involved in Wg signaling by regulating the level of extracellular Wg.
Language	English
Publishing date	2016-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep31863
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to "Novel RNA Viral Vectors for Chemically Regulated Gene Expression in Embryonic Stem Cells".

Kim, Narae / Yokobayashi, Yohei

ACS synthetic biology

2022 Volume 11, Issue 8, Page(s) 2908

Language	English
Publishing date	2022-07-30
Publishing country	United States
Document type	Published Erratum
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.2c00383
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: pH variation impacts molecular pathways associated with somatic cell reprogramming and differentiation of pluripotent stem cells.

Kim, Narae

Reproductive medicine and biology

2020 Volume 20, Issue 1, Page(s) 20–26

Abstract: Rationale: The study of somatic cell reprogramming and cell differentiation is essential for the application of recent techniques in regenerative medicine. It is, specifically, necessary to determine the appropriate conditions required for the induction ...

Abstract	Rationale: The study of somatic cell reprogramming and cell differentiation is essential for the application of recent techniques in regenerative medicine. It is, specifically, necessary to determine the appropriate conditions required for the induction of reprogramming and cell differentiation. Methods: Based on a comprehensive literature review, the effects of pH fluctuation on alternative splicing, mitochondria, plasma membrane, and phase separation, in several cell types are discussed. Additionally, the associated molecular pathways important for the induction of differentiation and reprogramming are reviewed. Results: While cells change their state, several factors such as cytokines and physical parameters affect cellular reprogramming and differentiation. As the extracellular and intracellular pH affects biophysical phenomena in a cell, the effects of pH fluctuation can ultimately decide the cell fate through molecular pathways. Though few studies have reported on the direct effects of culture pH on cell state, there is substantial information on the pathways related to stem cell differentiation and somatic cell reprogramming that can be stimulated by environmental pH. Conclusion: Environmental pH fluctuations may decide cell fate through the molecular pathways associated with somatic cell reprogramming and cell differentiation.
Language	English
Publishing date	2020-09-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2185775-1
ISSN	1447-0578 ; 1445-5781
ISSN (online)	1447-0578
ISSN	1445-5781
DOI	10.1002/rmb2.12346
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article ; Online: Post-Hair Transplantation Complication: Kinky or Severely Curly Hair.

Park, Jae Hyun / Kim, Narae / Manonukul, Kotchamol

The Journal of craniofacial surgery

2024

Abstract: Objective: To investigate the etiology and preventive measures of posttransplant kinky or curly hair growth after female hairline correction surgery.: Background: Hair transplant surgery can be accompanied by various adverse effects, one of which is ... ...

Abstract	Objective: To investigate the etiology and preventive measures of posttransplant kinky or curly hair growth after female hairline correction surgery. Background: Hair transplant surgery can be accompanied by various adverse effects, one of which is severely kinky or curly hair after surgery. Posttransplant kinky or curly hair is not well-understood for its cause or prevention. Methods: The study was targeted at a total of 980 patients who were confirmed whether they developed kinky or curly hair after female hairline correction surgery. Incidence, surgical method, degree of curliness, predisposed location, characteristics, hair caliber (thin, medium, and thick), and left-right differences were examined. Results: Among the total 980 patients, posttransplant curly hair (PTCH) was manifested in 38(3.9%) patients. None of the patients who underwent surgery at the present clinic developed posttransplant kinky hair; all 38 patients showed PTCH growth. In 36 cases, transplanted hair started to grow in curly patterns around 4 months after surgery. However, the remaining 2 cases showed no curly growth pattern when the transplanted hair was short at postoperative 4 months, but started to grow curly starting at 6 to 8 months after surgery as the hair growth direction was obstructed or compressed by the existing hair. Conclusion: Familiarity with the cause, prevention, and management of posttransplant kinky hair and PTCH will be of great help to hair surgeons.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009926
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Mushroom consumption and cardiometabolic health outcomes in the general population: a systematic review.

Hong, Jee Yeon / Kim, Mi Kyung / Yang, Narae

Nutrition research and practice

2024 Volume 18, Issue 2, Page(s) 165–179

Abstract: Background/objectives: Mushroom consumption, rich in diverse nutrients and bioactive compounds, is suggested as a potential significant contributor to preventing cardiometabolic diseases (CMDs). This systematic review aimed to explore the association ... ...

Abstract	Background/objectives: Mushroom consumption, rich in diverse nutrients and bioactive compounds, is suggested as a potential significant contributor to preventing cardiometabolic diseases (CMDs). This systematic review aimed to explore the association between mushrooms and cardiometabolic health outcomes, utilizing data from prospective cohort studies and clinical trials focusing on the general population, with mushrooms themselves as a major exposure. Subjects/methods: All original articles, published in English until July 2023, were identified through searches on PubMed, Ovid-Embase, and google scholar. Of 1,328 studies, we finally selected 5 prospective cohort studies and 4 clinical trials. Results: Existing research is limited, typically consisting of 1 to 2 studies for each CMD and cardiometabolic condition. Examination of articles revealed suggestive associations in some cardiometabolic conditions including blood glucose (both fasting and postprandial), high-density lipoprotein cholesterol related indices, high-sensitivity C-reactive protein, and obesity indices (body weight, body mass index, and waist circumference). However, mushroom consumption showed no association with the mortality and morbidity of cardiovascular diseases, stroke, and type 2 diabetes, although there was a potentially beneficial connection with all cause-mortality, hyperuricemia, and metabolic syndrome. Conclusion: Due to the scarcity of available studies, drawing definitive conclusions is premature. Further comprehensive investigations are needed to clarify the precise nature and extent of this relationship before making conclusive recommendations for the general population.
Language	English
Publishing date	2024-03-22
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2387946-4
ISSN	2005-6168 ; 1976-1457
ISSN (online)	2005-6168
ISSN	1976-1457
DOI	10.4162/nrp.2024.18.2.165
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