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Article ; Online: Research Accelerator Program: A Strategic Initiative to Facilitate Interdisciplinary Collaboration That Advances Translational Research.

Briody, Melissa A / Rafferty, Miriam R / Fahey, Meghan / Sliwa, James A / Lieber, Richard L

American journal of physical medicine & rehabilitation

2023 Volume 103, Issue 1, Page(s) 66–73

Abstract: Abstract: Developing a culture of innovative thinking and one that emphasizes clinician-researcher interaction is critical for the future of rehabilitation. We designed and implemented a strategy to build a culture of interdisciplinary communication and ...

Abstract	Abstract: Developing a culture of innovative thinking and one that emphasizes clinician-researcher interaction is critical for the future of rehabilitation. We designed and implemented a strategy to build a culture of interdisciplinary communication and collaboration that facilitates translational research across several disciplines in our inpatient rehabilitation hospital. We colocated clinicians and researchers in workspaces within a new hospital and created the Research Accelerator Program-a collection of team-focused initiatives that promote communication and collaboration among researchers, clinicians, and other staff. The purpose of this article is to disseminate this strategy, which has increased staff participation in research activities and increased scientific productivity of interdisciplinary research teams over the past 8 yrs.
MeSH term(s)	Humans ; Translational Research, Biomedical ; Interdisciplinary Communication ; Medicine
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000002339
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Article ; Online: Mechanical Washing Prevents Transmission of Bacterial, Viral, and Protozoal Murine Pathogens from Cages.

Ritter, Amanda C / Ricart Arbona, Rodolfo J / Mourino, Anthony J / Palillo, Michael B / Aydin, Mert / Fahey, James R / Lipman, Neil S

Journal of the American Association for Laboratory Animal Science : JAALAS

2023 Volume 62, Issue 2, Page(s) 131–138

Abstract: Infectious agents have varying susceptibilities to thermal inactivation and/or mechanical removal from cages by the use of heated, pressurized water. In this study, we tested whether 5 specific infectious organisms ( ...

Abstract	Infectious agents have varying susceptibilities to thermal inactivation and/or mechanical removal from cages by the use of heated, pressurized water. In this study, we tested whether 5 specific infectious organisms (
MeSH term(s)	Animals ; Female ; Mice ; Housing, Animal ; Polymerase Chain Reaction/veterinary ; Bacteria ; Norovirus
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2769-6677
ISSN (online)	2769-6677
DOI	10.30802/AALAS-JAALAS-22-000105
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Article ; Online: Peripheral Blood Cell Ratios as Prognostic Indicators in a Neoadjuvant Chemotherapy-Treated Breast Cancer Cohort.

Jalali, Amirhossein / Miresse, David / Fahey, Matthew R / Ni Mhaonaigh, Niamh / McGuire, Andrew / Bourke, Emer / Kerin, Michael J / Brown, James A L

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 10, Page(s) 7512–7523

Abstract: Breast cancer represents a heterogeneous condition in which the interaction between host immune response and primary oncogenic events can impact disease progression. Ratios of systemic blood-based immunocytes have emerged as clinically-relevant ... ...

Abstract	Breast cancer represents a heterogeneous condition in which the interaction between host immune response and primary oncogenic events can impact disease progression. Ratios of systemic blood-based immunocytes have emerged as clinically-relevant prognostic biomarkers in cancer patients. The NLR (neutrophil-to-lymphocyte ratio) has been shown to be prognostic in a variety of cancers, including breast cancer. However, evaluation of the prognostic value for overall survival (OS) and disease-free survival (DFS) of other key immunocyte ratios-neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-white cell count ratio (NWR), lymphocyte-to-white cell count ratio (LWR), monocyte-to-white cell count ratio (MWR), platelet-to-lymphocyte (PLR)-by breast cancer subtypes in a neoadjuvant chemotherapy (NAC) cohort remains to be fully explored. An NAC-treated breast cancer cohort, comprised of Luminal A, Luminal B, HER2-positive, and triple negative/basal breast cancers, treated at a tertiary referral center (minimum 3-year follow-up), was used to calculate immunocyte ratios and immunocyte cut-off values, calculated with >80% specificity (using decision tree modeling). The association with subtype-specific OS, DFS, and tumor grade was analyzed using cut offs calculated using both receiver operating characteristic curves and decision tree modelling. Decision tree calculated ratios showed that LMR (5.29) and MWR (0.06) were significantly associated with Luminal A OS (
MeSH term(s)	Humans ; Prognosis ; Neoadjuvant Therapy ; Retrospective Studies ; Lymphocytes/pathology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29100591
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Article ; Online: An Overview of Typical Infections of Research Mice: Health Monitoring and Prevention of Infection.

Fahey, James R / Olekszak, Haiyan

Current protocols in mouse biology

2015 Volume 5, Issue 3, Page(s) 235–245

Abstract: There are many reasons to keep research mice healthy and free from infections. The two most important of these are to protect the health and welfare of research mice and to prevent infections from negatively impacting research. Just as the genetic ... ...

Abstract	There are many reasons to keep research mice healthy and free from infections. The two most important of these are to protect the health and welfare of research mice and to prevent infections from negatively impacting research. Just as the genetic integrity of a mouse strain will influence the reproducibility and validity of research data, so too will the microbiologic integrity of the animals. This has been repeatedly demonstrated in the literature of laboratory animal sciences wherein the direct impact of infections on physiologic parameters under study have been described. Therefore, it is of great importance that scientists pay close attention to the health status of their research animal colonies and maintain good communications with the animal facility personnel at their institution about mouse health issues. This overview provides information about animal health monitoring (HM) in research mouse colonies including commonly monitored agents, diagnostic methods, HM program, risk assessment, and animal facility biosecurity. Lastly, matters of communication with laboratory animal professionals at research institutions are also addressed.
MeSH term(s)	Animal Technicians/psychology ; Animals ; Animals, Laboratory/physiology ; Laboratory Animal Science/methods ; Mice ; Rodent Diseases/microbiology ; Rodent Diseases/parasitology ; Rodent Diseases/prevention & control ; Rodent Diseases/virology ; Workforce
Keywords	covid19
Language	English
Publishing date	2015-09-01
Publishing country	United States
Document type	Journal Article
ISSN	2161-2617
ISSN (online)	2161-2617
DOI	10.1002/9780470942390.mo150023
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Article ; Online: An investigation into the accuracy of follow-on GPRS/mobile data CDRs.

Duncan, Isabel / Hoy, Joseph / Fahey, Andrew / Morgan, Ruth / Nakhaeizadeh, Sherry / French, James

Science & justice : journal of the Forensic Science Society

2022 Volume 62, Issue 2, Page(s) 203–213

Abstract: This study investigated the accuracy of 3G and 4G follow-on GPRS (General Packet Radio Service)/mobile data CDRs (Call Detail Records) from three UK mobile network operators (EE, Vodafone and Three). Follow-on GPRS/mobile data CDRs are currently ... ...

Abstract	This study investigated the accuracy of 3G and 4G follow-on GPRS (General Packet Radio Service)/mobile data CDRs (Call Detail Records) from three UK mobile network operators (EE, Vodafone and Three). Follow-on GPRS/mobile data CDRs are currently considered to be more open to misinterpretation than voice/SMS CDRs as uncertainties exist regarding the correspondence between the timestamp and the Cell ID presented within the CDRs. Consequently, follow-on GPRS/mobile CDRs may be disregarded during criminal investigations, potentially losing valuable intelligence and evidence. To assess the accuracy of follow-on GPRS/mobile data CDRs, connected mode RF (Radio Frequency) surveys were conducted while simultaneously producing follow-on GPRS/mobile data CDRs in a travelling vehicle. This allowed a comparison of the start Cell ID presented in the CDR and the Cell ID that provided coverage to the device at the start time of the CDR to assess the correspondence between the timestamp and the Cell ID presented within the CDRs, and to consider the validity of the terminology used by experts. It was found that individual follow-on GPRS/mobile data CDRs cannot consistently place a device within the coverage area of the start Cell ID at the start time of the CDR. Instead, the results indicate that a terminology which places the device within the coverage area of the start Cell ID 'at or before' the start time of the CDR is appropriate. It is crucial that follow-on GPRS/mobile data CDRs are analysed with this consideration in mind so to interpret the evidence correctly.
MeSH term(s)	Humans ; Internet of Things
Language	English
Publishing date	2022-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1230910-2
ISSN	1876-4452 ; 1355-0306
ISSN (online)	1876-4452
ISSN	1355-0306
DOI	10.1016/j.scijus.2022.02.004
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Zs.A 854: Show issues

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Article ; Online: DinB (DNA polymerase IV), ImuBC and RpoS contribute to the generation of ciprofloxacin-resistance mutations in Pseudomonas aeruginosa.

Fahey, Declan / O'Brien, James / Pagnon, Joanne / Page, Simone / Wilson, Richard / Slamen, Nic / Roddam, Louise / Ambrose, Mark

Mutation research

2023 Volume 827, Page(s) 111836

Abstract: We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found that the ... ...

Abstract	We investigated the role(s) of the damage-inducible SOS response dinB and imuBC gene products in the generation of ciprofloxacin-resistance mutations in the important human opportunistic bacterial pathogen, Pseudomonas aeruginosa. We found that the overall numbers of ciprofloxacin resistant (Cip
MeSH term(s)	Humans ; DNA Polymerase beta/metabolism ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism ; Ciprofloxacin/pharmacology ; Ciprofloxacin/metabolism ; DNA Damage ; Mutation ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
Chemical Substances	DNA Polymerase beta (EC 2.7.7.7) ; Ciprofloxacin (5E8K9I0O4U) ; Bacterial Proteins
Language	English
Publishing date	2023-08-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206607-5
ISSN	1873-135X ; 1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
ISSN (online)	1873-135X
ISSN	1383-5718 ; 0027-5107 ; 0165-1110 ; 0165-1161 ; 0165-7992 ; 0921-8777 ; 0165-1218 ; 1383-5726 ; 0167-8817 ; 0921-8734 ; 1383-5742
DOI	10.1016/j.mrfmmm.2023.111836
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Zs.A 1316: Show issues

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Article ; Online: Payments reported by the pharmaceutical industry in Ireland from 2015 to 2019: An observational study.

Moriarty, Frank / Larkin, James / Fahey, Tom

Health policy (Amsterdam, Netherlands)

2021 Volume 125, Issue 10, Page(s) 1297–1304

Abstract: ... payments to HCOs, HCPs and for research and development (R&D). We quantified disclosure rates of names ... 2019, €84.6 million for R&D, with non-R&D payments of €45.1 million to HCOs and €33.6 million to HCPs ...

Abstract	Background: The pharmaceutical industry makes large numbers of payments to healthcare organisations (HCOs) and healthcare professionals (HCPs). Ireland has a large pharmaceutical industry presence and national debate on legislating for greater industry payment transparency. This study characterises payments in Ireland to HCPs and HCOs during 2015-2019, and the content, consistency and methodology of the data source. Methods: An observational study of TransfersOfValue.ie, the disclosure website for the Irish Pharmaceutical Health Association pharmaceutical companies. We conducted a quantitative analysis, summarising payments to HCOs, HCPs and for research and development (R&D). We quantified disclosure rates of names for HCP and HCO payment recipients. We also conducted a content analysis of the methodology notes and website content. Results: Payments totalling €163 million were reported by 47 companies during 2015-2019, €84.6 million for R&D, with non-R&D payments of €45.1 million to HCOs and €33.6 million to HCPs. HCOs were named for 91.2% of payments, and HCPs for 55.1-62.8% across study years. For 2019, ten companies disclosed >€1 million in payments, and three disclosed >€1 million in HCO and HCP payments. Content analysis of 132 data reports and 46 methodology notes indicated substantial variation in methodologies for reporting between companies. Conclusions: There are substantial payments in Ireland, often the recipient is undisclosed, and companies differ in their reporting. A mandatory disclosure system could enhance transparency.
MeSH term(s)	Conflict of Interest ; Disclosure ; Drug Industry ; Health Personnel ; Humans ; Ireland
Language	English
Publishing date	2021-08-03
Publishing country	Ireland
Document type	Journal Article ; Observational Study
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2021.07.016
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Article ; Online: Shared and distinctive features of the gut microbiome of C57BL/6 mice from different vendors and production sites, and in response to a new vivarium.

Long, Lauren L / Svenson, Karen L / Mourino, Anthony J / Michaud, Michael / Fahey, James R / Waterman, Linda / Vandegrift, Kathy L / Adams, Mark D

Lab animal

2021 Volume 50, Issue 7, Page(s) 185–195

Abstract: Animal models play a critical role in establishing causal relationships between gut microbiota and disease. The laboratory mouse is widely used to study the role of microbes in various disorders; however, differences between mouse vendors, genetic ... ...

Abstract	Animal models play a critical role in establishing causal relationships between gut microbiota and disease. The laboratory mouse is widely used to study the role of microbes in various disorders; however, differences between mouse vendors, genetic lineages and husbandry protocols have been shown to contribute to variation in phenotypes and to non-reproducibility of experimental results. We sought to understand how gut microbiome profiles of mice vary by vendor, vendor production facility and health status upon receipt into an academic facility and how they change over 12 weeks in the new environment. C57BL/6 mice were sourced from two different production sites for each of three different vendors. Mice were shipped to an academic research vivarium, and fresh-catch stool samples were collected from mice immediately from the shipping box upon receipt, and again after 2, 6 and 12 weeks in the new facility. Substantial variation in bacterial proportional abundance was observed among mice from each vendor at the time of receipt, but shared microbes accounted for most sequence reads. Vendor-specific microbes were generally of low abundance. Microbial profiles of mice from all vendors exhibited shifts over time, highlighting the importance of environmental conditions on microbial dynamics. Our results emphasize the need for continued efforts to account for sources of variation in animal models and understand how they contribute to experimental reproducibility.
MeSH term(s)	Animals ; Bacteria ; Feces ; Gastrointestinal Microbiome ; Mice ; Mice, Inbred C57BL ; Reproducibility of Results
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1548-4475
ISSN (online)	1548-4475
DOI	10.1038/s41684-021-00777-0
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Article ; Online: The Intercellular Tight Junction and Spontaneous Coronary Artery Dissection.

Fahey, James K / Williams, Sarah M / Tyagi, Sonika / Powell, David R / Hallab, Jeannette C / Chahal, Gulrez / Ramialison, Mirana S M / White, Anthony J

Journal of the American College of Cardiology

2018 Volume 72, Issue 14, Page(s) 1752–1753

MeSH term(s)	Acute Coronary Syndrome/etiology ; Adult ; Adult Children ; Amino Acid Substitution/genetics ; Aneurysm, Dissecting/genetics ; Cell Adhesion Molecules/genetics ; Coronary Aneurysm/genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Middle Aged ; Mothers ; Receptors, Cell Surface/genetics ; Tight Junctions/genetics
Chemical Substances	Cell Adhesion Molecules ; F11R protein, human ; Receptors, Cell Surface
Language	English
Publishing date	2018-09-27
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2018.07.040
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Suicide in frontotemporal dementia and Huntington disease: analysis of family-reported pedigree data and implications for genetic healthcare for asymptomatic relatives.

Sexton, Adrienne / West, Kirsty / Gill, Gulvir / Wiseman, Allan / Taylor, Jessica / Purvis, Rebecca / Fahey, Michael / Storey, Elsdon / Walsh, Maie / James, Paul

Psychology & health

2020 Volume 36, Issue 11, Page(s) 1397–1402

Abstract: Objective: Genomic testing for early-onset dementia is becoming more accessible, along with predictive testing for at-risk relatives; however, complex counselling issues are important to address. The topic of suicide often has stigma associated, and ... ...

Abstract	Objective: Genomic testing for early-onset dementia is becoming more accessible, along with predictive testing for at-risk relatives; however, complex counselling issues are important to address. The topic of suicide often has stigma associated, and thoughts or experiences may not be volunteered without prompting. Little has been published with consideration to suicide rates in the context of family experiences and their significance in genetic counselling for relatives of people with Huntington disease and frontotemporal dementia. Design: This study included pedigree information for 267 symptomatic individuals with frontotemporal dementia or Huntington disease, provided via genetic counselling clinics. Main outcome measures: Descriptive statistics and suicide rate calculations based on family reported pedigree data. Results: The suicide rate was 2996 per 100,000 compared with the population rate of 10 per 100,000. Approximately one in 15 families reported suicide of an affected family member, and file notes indicated that one in five families had experienced suicide, suicidal thoughts or suicide attempts in one or more affected, unaffected or pre-symptomatic relative. Conclusion: Health professional awareness of family experiences, including suicide of a relative, is vital in facilitating client decisions about genetic testing, and in providing adequate psychosocial support during the process of genetic testing and adaption to results.
MeSH term(s)	Delivery of Health Care ; Frontotemporal Dementia/genetics ; Genetic Counseling/methods ; Genetic Counseling/psychology ; Humans ; Huntington Disease/genetics ; Huntington Disease/psychology ; Pedigree
Language	English
Publishing date	2020-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	625255-2
ISSN	1476-8321 ; 0887-0446
ISSN (online)	1476-8321
ISSN	0887-0446
DOI	10.1080/08870446.2020.1849700
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