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  1. Article: Past and Future of Vaccinations: From Jenner to Nanovaccinology.

    Facciolà, Alessio / Visalli, Giuseppa

    Vaccines

    2023  Volume 11, Issue 2

    Abstract: Undoubtedly, vaccines are the most effective and safe weapons available to public health for the primary prevention of infectious diseases [ ... ]. ...

    Abstract Undoubtedly, vaccines are the most effective and safe weapons available to public health for the primary prevention of infectious diseases [...].
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11020384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Presence of

    Laganà, Pasqualina / Facciolà, Alessio / Palermo, Roberta / De Giglio, Osvalda / Delia, Santi Antonino / Gioffrè, Maria Eufemia

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Although today all of the aspects ... ...

    Abstract Although today all of the aspects of
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives.

    Facciolà, Alessio / Visalli, Giuseppa / Laganà, Antonio / Di Pietro, Angela

    Vaccines

    2022  Volume 10, Issue 5

    Abstract: Vaccinations are one of the most important preventive tools against infectious diseases. Over time, many different types of vaccines have been developed concerning the antigen component. Adjuvants are essential elements that increase the efficacy of ... ...

    Abstract Vaccinations are one of the most important preventive tools against infectious diseases. Over time, many different types of vaccines have been developed concerning the antigen component. Adjuvants are essential elements that increase the efficacy of vaccination practises through many different actions, especially acting as carriers, depots, and stimulators of immune responses. For many years, few adjuvants have been included in vaccines, with aluminium salts being the most commonly used adjuvant. However, recent research has focused its attention on many different new compounds with effective adjuvant properties and improved safety. Modern technologies such as nanotechnologies and molecular biology have forcefully entered the production processes of both antigen and adjuvant components, thereby improving vaccine efficacy. Microparticles, emulsions, and immune stimulators are currently in the spotlight for their huge potential in vaccine production. Although studies have reported some potential side effects of vaccine adjuvants such as the recently recognised ASIA syndrome, the huge worth of vaccines remains unquestionable. Indeed, the recent COVID-19 pandemic has highlighted the importance of vaccines, especially in regard to managing future potential pandemics. In this field, research into adjuvants could play a leading role in the production of increasingly effective vaccines.
    Language English
    Publishing date 2022-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10050819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Uptake of Breathable Nano- and Micro-Sized Polystyrene Particles: Comparison of Virgin and Oxidised nPS/mPS in Human Alveolar Cells.

    Laganà, Antonio / Visalli, Giuseppa / Facciolà, Alessio / Celesti, Consuelo / Iannazzo, Daniela / Di Pietro, Angela

    Toxics

    2023  Volume 11, Issue 8

    Abstract: Airborne micro- and nanoplastics are widely spread and pose a risk to human health. The third polymer plastic most commonly produced and present in atmospheric fallout is polystyrene (PS). For these reasons and for a more realistic assessment of ... ...

    Abstract Airborne micro- and nanoplastics are widely spread and pose a risk to human health. The third polymer plastic most commonly produced and present in atmospheric fallout is polystyrene (PS). For these reasons and for a more realistic assessment of biological effects, we examined in-home oxidised (ox-, simulating photoaging) nPS/mPS (0.1 and 1 μm), comparing the effects with virgin ones (v-). On human alveolar cells (A549), we quantified the cellular uptake, using FITC-functionalised nPS/mPS, while cytotoxicity, changes in the acidic compartment, ROS production, mitochondrial function, and DNA damage were assessed to study the effects of internalised v- and ox-nPS/mPS. The results showed that the uptake was dose-dependent and very fast (1 h), since, at the lowest dose (1.25 µg/well), it was 20.8% and 21.8% of nPS and mPS, respectively. Compared to v-, significant ROS increases, DNA damage, and mitochondrial impairment were observed after exposure to ox-nPS/mPS. The enhancement of effects due to environmental aging processes highlighted the true potential impact on human health of these airborne pollutants.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11080686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The COVID-19 pandemic and its implications on the environment.

    Facciolà, Alessio / Laganà, Pasqualina / Caruso, Gabriella

    Environmental research

    2021  Volume 201, Page(s) 111648

    Abstract: The emerging threat posed by COVID-19 pandemic has strongly modified our lifestyle, making urgent to re-consider the humans-environment relationships and stimulating towards more sustainable choices in our daily behavior. Scientific evidences showed that ...

    Abstract The emerging threat posed by COVID-19 pandemic has strongly modified our lifestyle, making urgent to re-consider the humans-environment relationships and stimulating towards more sustainable choices in our daily behavior. Scientific evidences showed that the onset of new viral pathogens with a high epidemic-pandemic potential is often the result of complex interactions between animals, humans and environment. In this context, the interest of the scientific community has also been attracted towards the potential interactions of SARS-CoV-2 with environmental compartments. Many issues, ranging from the epidemiology and persistence of SARS-CoV-2 in water bodies to the potential implications of lockdown measures on environmental quality status are here reviewed, with a special reference to marine ecosystems. Due to current sanitary emergence, the relevance of pilot studies regarding the interactions between SARS-CoV-2 spread and the direct and indirect environmental impacts of the COVID-19 pandemic, that are still a matter of scientific debate, is underlined.
    MeSH term(s) Animals ; COVID-19 ; Communicable Disease Control ; Ecosystem ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-07-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2021.111648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: The COVID-19 pandemic and its implications on the environment

    Facciolà, Alessio / Laganà, Pasqualina / Caruso, Gabriella

    Environmental research. 2021 Oct., v. 201

    2021  

    Abstract: The emerging threat posed by COVID-19 pandemic has strongly modified our lifestyle, making urgent to re-consider the humans-environment relationships and stimulating towards more sustainable choices in our daily behavior. Scientific evidences showed that ...

    Abstract The emerging threat posed by COVID-19 pandemic has strongly modified our lifestyle, making urgent to re-consider the humans-environment relationships and stimulating towards more sustainable choices in our daily behavior. Scientific evidences showed that the onset of new viral pathogens with a high epidemic-pandemic potential is often the result of complex interactions between animals, humans and environment. In this context, the interest of the scientific community has also been attracted towards the potential interactions of SARS-CoV-2 with environmental compartments. Many issues, ranging from the epidemiology and persistence of SARS-CoV-2 in water bodies to the potential implications of lockdown measures on environmental quality status are here reviewed, with a special reference to marine ecosystems. Due to current sanitary emergence, the relevance of pilot studies regarding the interactions between SARS-CoV-2 spread and the direct and indirect environmental impacts of the COVID-19 pandemic, that are still a matter of scientific debate, is underlined.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; environmental quality ; lifestyle ; research
    Language English
    Dates of publication 2021-10
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2021.111648
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Evaluation of Antibiotic Resistance in Bacterial Strains Isolated from Sewage of Slaughterhouses Located in Sicily (Italy).

    Facciolà, Alessio / Virga, Antonino / Gioffrè, Maria Eufemia / Laganà, Pasqualina

    International journal of environmental research and public health

    2021  Volume 18, Issue 18

    Abstract: Antimicrobial resistance is presently one of the most public health critical concerns. The frequent and often incorrect use of antibiotics in animal husbandry has led to the spread of antimicrobial resistance in this setting. Wastewater from ... ...

    Abstract Antimicrobial resistance is presently one of the most public health critical concerns. The frequent and often incorrect use of antibiotics in animal husbandry has led to the spread of antimicrobial resistance in this setting. Wastewater from slaughterhouses can be contaminated with multidrug-resistant bacteria, representing a possible cross-contamination route. We evaluated the presence of antibiotic-resistant bacteria in wastewater samples from slaughterhouses located in an Italian region. Specifically, 18 slaughterhouses were included in the study. Of the tested samples, 40 bacterial strains were chosen, identified, and tested for antibiotic susceptibility.
    MeSH term(s) Abattoirs ; Aeromonas ; Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests ; Sewage ; Sicily
    Chemical Substances Anti-Bacterial Agents ; Sewage
    Language English
    Publishing date 2021-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18189611
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  8. Article ; Online: An Overview of Vaccine Adjuvants

    Alessio Facciolà / Giuseppa Visalli / Antonio Laganà / Angela Di Pietro

    Vaccines, Vol 10, Iss 819, p

    Current Evidence and Future Perspectives

    2022  Volume 819

    Abstract: Vaccinations are one of the most important preventive tools against infectious diseases. Over time, many different types of vaccines have been developed concerning the antigen component. Adjuvants are essential elements that increase the efficacy of ... ...

    Abstract Vaccinations are one of the most important preventive tools against infectious diseases. Over time, many different types of vaccines have been developed concerning the antigen component. Adjuvants are essential elements that increase the efficacy of vaccination practises through many different actions, especially acting as carriers, depots, and stimulators of immune responses. For many years, few adjuvants have been included in vaccines, with aluminium salts being the most commonly used adjuvant. However, recent research has focused its attention on many different new compounds with effective adjuvant properties and improved safety. Modern technologies such as nanotechnologies and molecular biology have forcefully entered the production processes of both antigen and adjuvant components, thereby improving vaccine efficacy. Microparticles, emulsions, and immune stimulators are currently in the spotlight for their huge potential in vaccine production. Although studies have reported some potential side effects of vaccine adjuvants such as the recently recognised ASIA syndrome, the huge worth of vaccines remains unquestionable. Indeed, the recent COVID-19 pandemic has highlighted the importance of vaccines, especially in regard to managing future potential pandemics. In this field, research into adjuvants could play a leading role in the production of increasingly effective vaccines.
    Keywords vaccination ; adjuvants ; modern technologies ; future perspectives ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Newly Emerging Airborne Pollutants: Current Knowledge of Health Impact of Micro and Nanoplastics.

    Facciolà, Alessio / Visalli, Giuseppa / Pruiti Ciarello, Marianna / Di Pietro, Angela

    International journal of environmental research and public health

    2021  Volume 18, Issue 6

    Abstract: Plastics are ubiquitous persistent pollutants, forming the most representative material of the Anthropocene. In the environment, they undergo wear and tear (i.e., mechanical fragmentation, and slow photo and thermo-oxidative degradation) forming ... ...

    Abstract Plastics are ubiquitous persistent pollutants, forming the most representative material of the Anthropocene. In the environment, they undergo wear and tear (i.e., mechanical fragmentation, and slow photo and thermo-oxidative degradation) forming secondary microplastics (MPs). Further fragmentation of primary and secondary MPs results in nanoplastics (NPs). To assess potential health damage due to human exposure to airborne MPs and NPs, we summarize the evidence collected to date that, however, has almost completely focused on monitoring and the effects of airborne MPs. Only in vivo and in vitro studies have assessed the toxicity of NPs, and a standardized method for their analysis in environmental matrices is still missing. The main sources of indoor and outdoor exposure to these pollutants include synthetic textile fibers, rubber tires, upholstery and household furniture, and landfills. Although both MPs and NPs can reach the alveolar surface, the latter can pass into the bloodstream, overcoming the pulmonary epithelial barrier. Despite the low reactivity, the number of surface area atoms per unit mass is high in MPs and NPs, greatly enhancing the surface area for chemical reactions with bodily fluids and tissue in direct contact. This is proven in polyvinyl chloride (PVC) and flock workers, who are prone to persistent inflammatory stimulation, leading to pulmonary fibrosis or even carcinogenesis.
    MeSH term(s) Environmental Pollutants ; Humans ; Microplastics ; Plastics ; Polyvinyl Chloride ; Water Pollutants, Chemical/analysis
    Chemical Substances Environmental Pollutants ; Microplastics ; Plastics ; Water Pollutants, Chemical ; Polyvinyl Chloride (9002-86-2)
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18062997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Continuous Surveillance of InSTI Resistance Could be an Important Public Health Tool in the Fight Against HIV Infection.

    Visalli, Giuseppa / Facciolà, Alessio / Costanzo, Maria Giovanna / Di Pietro, Angela

    Current HIV research

    2021  Volume 19, Issue 4, Page(s) 358–367

    Abstract: Aims: To evaluate the frequency of the InSTIs mutations in a large cohort of HIV-infected people.: Background: The Highly Active Anti-Retroviral Therapy (HAART) allows turning HIV infection from a fatal disease to chronic infection, and Integrase ... ...

    Abstract Aims: To evaluate the frequency of the InSTIs mutations in a large cohort of HIV-infected people.
    Background: The Highly Active Anti-Retroviral Therapy (HAART) allows turning HIV infection from a fatal disease to chronic infection, and Integrase Strand Transfer Inhibitors (InSTIs) represent the cornerstone of this treatment. However, the spread of HIV-1 drug resistance mutations represents an emerging threat to the long-term success of HIV treatment programs.
    Objectives: To evaluate the trend of the HIV drug resistance to InSTIs in a large cohort of HIVpositive people in order to assess the risk represented by these subjects in the spread of the HIV infection to the community.
    Methods: A cross-sectional study was conducted analysing all the InSTIs resistance tests performed in HIV positive subjects during 2017-2019 by the HIV Laboratory of the University Hospital "Gaetano Martino" of Messina, Italy.
    Results: In 2017-2019, 252 InSTIs resistance tests were performed, with 59 (23.4%), 88 (34.9%), and 105 (41.7%) tests respectively in the three considered years. Overall, 28 (11.1%) samples showed resistance to at least one of the four InSTIs. We observed a significant percentage increase of 95% in the resistance to all four drugs.
    Conclusion: InSTI resistance is not rare. Therefore, continuous surveillance along with incessant health education and a wide offer of the HIV test, can be the most important tools in the fight against HIV infection.
    MeSH term(s) Cross-Sectional Studies ; Drug Resistance, Viral ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Integrase/genetics ; HIV Integrase Inhibitors/pharmacology ; Humans ; Mutation ; Persistent Infection ; Public Health
    Chemical Substances HIV Integrase Inhibitors ; HIV Integrase (EC 2.7.7.-)
    Language English
    Publishing date 2021-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2192348-6
    ISSN 1873-4251 ; 1570-162X
    ISSN (online) 1873-4251
    ISSN 1570-162X
    DOI 10.2174/1570162X19666210301104636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6102: Show issues Location:
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