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Article ; Online: What Is Your Diagnosis?

Kan, Tiffany / Casale, Sue A / Sinnott-Stutzman, Virginia B / Tsai, Steven L

Journal of the American Veterinary Medical Association

2020 Volume 256, Issue 12, Page(s) 1323–1326

MeSH term(s)	Animals
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.256.12.1323
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Article ; Online: Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein.

Wang, David Tzu-Wei / Tang, Tiffany Y C / Kuo, Chun-Ting / Yu, Yun-Ting / Chen, Eric H L / Lee, Ming-Tao / Tsai, Ruei-Fong / Chen, Hung-Ying / Chiang, Yun-Wei / Chen, Rita P Y

PNAS nexus

2023 Volume 2, Issue 5, Page(s) pgad162

Abstract: Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ ...

Abstract	Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ peptides are catabolic products of a type I membrane protein called amyloid precursor protein (APP). Aβ40 is the major product, whereas the 2-residue-longer version, Aβ42, induces amyloid plaque formation in the AD brain. Since cholesterol content is one risk factor for sporadic AD, we aimed to explore whether cholesterol in the membrane affects the structure of the APP transmembrane region, thereby modulating the γ-secretase cutting behavior. Here, we synthesized several peptides containing the APP transmembrane region (sequence 693-726, corresponding to the Aβ
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgad162
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Article ; Online: PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress.

Kim, Yong Kyung / Kim, Youngjung Rachel / Wells, Kristen L / Sarbaugh, Dylan / Guney, Michelle / Tsai, Chia-Feng / Zee, Tiffany / Karsenty, Gerard / Nakayasu, Ernesto S / Sussel, Lori

Diabetes

2023 Volume 73, Issue 3, Page(s) 434–447

MeSH term(s)	Mice ; Humans ; Animals ; Diabetes Mellitus, Type 1/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; Phosphoric Monoester Hydrolases ; Genome-Wide Association Study ; Proteomics ; Glucose ; Mice, Knockout
Chemical Substances	Protein Tyrosine Phosphatase, Non-Receptor Type 2 (EC 3.1.3.48) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Glucose (IY9XDZ35W2) ; PTPN2 protein, human (EC 3.1.3.48) ; Ptpn2 protein, mouse (EC 3.1.3.48)
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db23-0355
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Article ; Online: Social media users produce more affect that supports cultural values, but are more influenced by affect that violates cultural values.

Hsu, Tiffany W / Niiya, Yu / Thelwall, Mike / Ko, Michael / Knutson, Brian / Tsai, Jeanne L

Journal of personality and social psychology

2021 Volume 121, Issue 5, Page(s) 969–983

Abstract: Although social media plays an increasingly important role in communication around the world, social media research has primarily focused on Western users. Thus, little is known about how cultural values shape social media behavior. To examine how ... ...

Abstract	Although social media plays an increasingly important role in communication around the world, social media research has primarily focused on Western users. Thus, little is known about how cultural values shape social media behavior. To examine how cultural affective values might influence social media use, we developed a new sentiment analysis tool that allowed us to compare the affective content of Twitter posts in the United States (55,867 tweets, 1,888 users) and Japan (63,863 tweets, 1,825 users). Consistent with their respective cultural affective values, U.S. users primarily produced positive (vs. negative) posts, whereas Japanese users primarily produced low (vs. high) arousal posts. Contrary to cultural affective values, however, U.S. users were more influenced by changes in others' high arousal negative (e.g., angry) posts, whereas Japanese were more influenced by changes in others' high arousal positive (e.g., excited) posts. These patterns held after controlling for differences in baseline exposure to affective content, and across different topics. Together, these results suggest that across cultures, while social media users primarily produce content that supports their affective values, they are more influenced by content that violates those values. These findings have implications for theories about which affective content spreads on social media, and for applications related to the optimal design and use of social media platforms around the world. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
MeSH term(s)	Arousal ; Communication ; Humans ; Japan ; Sentiment Analysis ; Social Media ; United States
Language	English
Publishing date	2021-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3103-3
ISSN	1939-1315 ; 0022-3514
ISSN (online)	1939-1315
ISSN	0022-3514
DOI	10.1037/pspa0000282
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Article ; Online: A Peer-Teaching Model to Reinforce Pharmacy Students' Clinical Knowledge of Commonly Prescribed Medications.

Tsai, Tiffany / Vo, Kim / Ostrogorsky, Tanya L / McGregor, Jessina C / McCracken, Caitlin M / Singh, Harleen

American journal of pharmaceutical education

2021 Volume 85, Issue 5, Page(s) 8451

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Curriculum ; Education, Pharmacy ; Educational Measurement ; Humans ; Knowledge ; Pharmaceutical Services ; Students, Pharmacy
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.5688/ajpe8451
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Article ; Online: Health Insurance Coverage, Clinical Outcomes, and Health-Related Quality of Life Among Youth Born to Women Living With HIV.

Lemon, Tiffany L / Tassiopoulos, Katherine / Tsai, Alexander C / Cantos, Krystal / Escudero, Dan / Quinn, M K / Kacanek, Deborah / Berman, Claire / Salomon, Liz / Nichols, Sharon / Chadwick, Ellen G / Seage, George R / Williams, Paige L

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 92, Issue 1, Page(s) 6–16

Abstract: Background: Although sustained access to health care is essential, little is known about the relationship between insurance coverage and health among people born to women living with HIV (WLHIV).: Setting: Prospective cohort studies of youth and ... ...

Abstract	Background: Although sustained access to health care is essential, little is known about the relationship between insurance coverage and health among people born to women living with HIV (WLHIV). Setting: Prospective cohort studies of youth and young adults born to WLHIV from 2007 to 2019. Methods: We used adjusted generalized estimating equation models to estimate mean differences in, and relative risks (RRs) of, health-related quality of life (HR-QoL) and HIV disease measures over time by insurance status. HR-QoL scales with limited variability were dichotomized. Modified Poisson models were used to estimate RRs. Results: Six hundred sixty-nine Adolescent Master Protocol (AMP) youth [66% living with perinatally-acquired HIV (PHIV), 72% Black] and 939 AMP Up/AMP Up Lite young adults (89% PHIV, 68% Black) reported insurance. Most were publicly insured (87% youth, 67% young adults). Privately insured young adults living with PHIV had lower risk of antiretroviral therapy nonadherence [adjusted RR (aRR): 0.82, 95% CI: 0.70 to 0.97] than those with public insurance. There was a lower risk of suboptimal role functioning for young adults with private insurance (aRR: 0.58, 95% CI: 0.35 to 0.97) and those unaware of their coverage (aRR: 0.41, 95% CI: 0.21 to 0.78). Young adults with private insurance had higher health perception scores than those with public insurance (adjusted mean difference: 3.87, 95% CI: 0.37 to 7.38). For youth, we observed no differences in HR-QOL and HIV disease measures by insurance. Conclusion: These findings suggest meaningful differences in antiretroviral therapy adherence and some HR-QoL outcomes by health insurance coverage among young adults born to WLHIV.
MeSH term(s)	Adolescent ; Female ; Humans ; HIV Infections/drug therapy ; Insurance Coverage ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003100
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Article: An Update on Postoperative Cognitive Dysfunction.

Tsai, Tiffany L / Sands, Laura P / Leung, Jacqueline M

Advances in anesthesia

2010 Volume 28, Issue 1, Page(s) 269–284

Language	English
Publishing date	2010-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632613-4
ISSN	1878-0415 ; 0737-6146
ISSN (online)	1878-0415
ISSN	0737-6146
DOI	10.1016/j.aan.2010.09.003
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Article ; Online: Belun Ring (Belun Sleep System BLS-100): Deep learning-facilitated wearable enables obstructive sleep apnea detection, apnea severity categorization, and sleep stage classification in patients suspected of obstructive sleep apnea.

Strumpf, Zachary / Gu, Wenbo / Tsai, Chih-Wei / Chen, Pai-Lien / Yeh, Eric / Leung, Lydia / Cheung, Cynthia / Wu, I-Chen / Strohl, Kingman P / Tsai, Tiffany / Folz, Rodney J / Chiang, Ambrose A

Sleep health

2023 Volume 9, Issue 4, Page(s) 430–440

Abstract: Goal and aims: Our objective was to evaluate the performance of Belun Ring with second-generation deep learning algorithms in obstructive sleep apnea (OSA) detection, OSA severity categorization, and sleep stage classification.: Focus technology: ... ...

Abstract	Goal and aims: Our objective was to evaluate the performance of Belun Ring with second-generation deep learning algorithms in obstructive sleep apnea (OSA) detection, OSA severity categorization, and sleep stage classification. Focus technology: Belun Ring with second-generation deep learning algorithms REFERENCE TECHNOLOGY: In-lab polysomnography (PSG) SAMPLE: Eighty-four subjects (M: F = 1:1) referred for an overnight sleep study were eligible. Of these, 26% had PSG-AHI<5; 24% had PSG-AHI 5-15; 23% had PSG-AHI 15-30; 27% had PSG-AHI ≥ 30. Design: Rigorous performance evaluation by comparing Belun Ring to concurrent in-lab PSG using the 4% rule. Core analytics: Pearson's correlation coefficient, Student's paired t-test, diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, Cohen's kappa coefficient (kappa), Bland-Altman plots with bias and limits of agreement, receiver operating characteristics curves with area under the curve, and confusion matrix. Core outcomes: The accuracy, sensitivity, specificity, and kappa in categorizing AHI ≥ 5 were 0.85, 0.92, 0.64, and 0.58, respectively. The accuracy, sensitivity, specificity, and Kappa in categorizing AHI ≥ 15 were 0.89, 0.91, 0.88, and 0.79, respectively. The accuracy, sensitivity, specificity, and Kappa in categorizing AHI ≥ 30 were 0.91, 0.83, 0.93, and 0.76, respectively. BSP2 also achieved an accuracy of 0.88 in detecting wake, 0.82 in detecting NREM, and 0.90 in detecting REM sleep. Core conclusion: Belun Ring with second-generation algorithms detected OSA with good accuracy and demonstrated a moderate-to-substantial agreement in categorizing OSA severity and classifying sleep stages.
MeSH term(s)	Humans ; Deep Learning ; Sleep ; Sleep Apnea, Obstructive/diagnosis ; Sleep Stages ; Wearable Electronic Devices
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2813299-3
ISSN	2352-7226 ; 2352-7218
ISSN (online)	2352-7226
ISSN	2352-7218
DOI	10.1016/j.sleh.2023.05.001
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Article ; Online: The role of B cell immunity in VCA graft rejection and acceptance.

Kaufman, Christina L / Cascalho, Marilia / Ozyurekoglu, Tuna / Jones, Christopher M / Ramirez, Allan / Roberts, Tiffany / Tien, Huey Y / Moreno, Rodrigo / Galvis, Elkin / Tsai, Tsu-Min / Palazzo, Michelle / Farner, Scott / Platt, Jeffrey L

Human immunology

2019 Volume 80, Issue 6, Page(s) 385–392

Abstract: Vascularized composite allotransplantation (VCA) has emerged as the most recent field of transplantation to offer an alternative treatment for those patients that have failed or are not suitable candidates for conventional therapy. Most of the current ... ...

Abstract	Vascularized composite allotransplantation (VCA) has emerged as the most recent field of transplantation to offer an alternative treatment for those patients that have failed or are not suitable candidates for conventional therapy. Most of the current clinical experience in this field is with recipients of skin containing grafts such as the face, upper extremity and abdominal wall transplants. Like solid organ recipients, VCA recipients require lifelong systematic immunosuppression to maintain their grafts. To date, the most successful immunosuppressant regimens are calcineurin inhibitor based and have been targeted to the control of T cells. While these regimens have resulted in excellent short term graft survival in solid organ transplantation, achieving significant improvements in long term survival has been more challenging. The reasons are multi-factorial, but a role for B cells and humoral immunity has been proposed. Antibody mediated rejection leading to chronic rejection has been cited as the leading cause of renal graft loss. While the number of VCA transplants performed is still small, evidence to date suggests that antibody mediated rejection may occur less frequently than seen in solid organ transplants. Here we will discuss the role of B cell immunity in solid organ transplantation as it pertains and contrasts to the field of VCA and present some examples of possible sequela of B cell immunity in a series of hand transplant recipients.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; Graft Rejection/immunology ; Graft Survival ; Hand Transplantation ; Humans ; Immune Tolerance ; Immunity, Humoral ; Transplantation Immunology ; Vascularized Composite Allotransplantation
Language	English
Publishing date	2019-03-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	801524-7
ISSN	1879-1166 ; 0198-8859
ISSN (online)	1879-1166
ISSN	0198-8859
DOI	10.1016/j.humimm.2019.03.002
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Article ; Online: Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium.

Leung, Jacqueline M / Tsai, Tiffany L / Sands, Laura P

Anesthesia and analgesia

2011 Volume 112, Issue 5, Page(s) 1199–1201

Abstract: We investigated whether preoperative frailty among older noncardiac surgical patients provides information about the development of postoperative delirium that is in addition to traditional geriatric risk factors. One-third of patients had a frailty ... ...

Abstract	We investigated whether preoperative frailty among older noncardiac surgical patients provides information about the development of postoperative delirium that is in addition to traditional geriatric risk factors. One-third of patients had a frailty score ≥3, which is considered "frail" in others' research. Twenty-five percent of patients developed postoperative delirium, which was measured using the confusion assessment method. Multivariable logistic regression showed that age, activities of daily living dependence, instrumental activities of daily living dependence, and cognitive functioning did not contribute significantly to the prediction of postoperative delirium. Only preoperative symptoms of depression (odds ratio=1.42; 95% confidence interval=1.06-1.91; P=0.018) and the frailty score (odds ratio=1.84; 95% confidence interval=1.07-3.1; P=0.028) were independently associated with the development of postoperative delirium.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Chi-Square Distribution ; Delirium/diagnosis ; Delirium/etiology ; Delirium/psychology ; Depression/complications ; Depression/psychology ; Female ; Frail Elderly/psychology ; Geriatric Assessment ; Humans ; Logistic Models ; Male ; Multivariate Analysis ; Odds Ratio ; Pilot Projects ; Psychiatric Status Rating Scales ; Risk Assessment ; Risk Factors ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/psychology
Language	English
Publishing date	2011-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0b013e31820c7c06
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