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  1. Article ; Online: High-Quality Parasitic Disease Laboratory Services Are a Priority at the CDC.

    Purfield, Anne E / Butler, Jay C / Cain, Kevin P / Kuhnert, Wendi / Muehlenbachs, Atis / Parise, Monica / Pirkle, Jim

    The American journal of tropical medicine and hygiene

    2022  

    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.22-0235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
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  2. Article ; Online: Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children.

    Khambati, Nisreen / Song, Rinn / Smith, Jonathan P / Bijker, Else Margreet / McCarthy, Kimberly / Click, Eleanor S / Mchembere, Walter / Okumu, Albert / Musau, Susan / Okeyo, Elisha / Perez-Velez, Carlos M / Cain, Kevin

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 3, Page(s) 116302

    Abstract: For microbiological confirmation of pediatric pulmonary tuberculosis (PTB), gastric aspirates (GA) are often operationally unfeasible without hospitalization, and the encapsulated orogastric string test is not easily swallowed in young children. The ... ...

    Abstract For microbiological confirmation of pediatric pulmonary tuberculosis (PTB), gastric aspirates (GA) are often operationally unfeasible without hospitalization, and the encapsulated orogastric string test is not easily swallowed in young children. The Combined-NasoGastric-Tube-and-String-Test (CNGTST) enables dual collection of GA and string specimens. In a prospective cohort study in Kenya, we examined its feasibility in children under five with presumptive PTB and compared the bacteriological yield of string to GA. Paired GA and string samples were successfully collected in 95.6 % (281/294) of children. Mycobacterium tuberculosis was isolated from 7.0 % (38/541) of GA and 4.3 % (23/541) of string samples, diagnosing 8.2 % (23/281) of children using GA and 5.3 % (15/281) using string. The CNGTST was feasible in nearly all children. Yield from string was two-thirds that of GA despite a half-hour median dwelling time. In settings where the feasibility of hospitalisation for GA is uncertain, the string component can be used to confirm PTB.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
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  3. Article: Clinical and Radiologic Factors Associated With Detection of

    Smith, Jonathan P / Song, Rinn / McCarthy, Kimberly D / Mchembere, Walter / Click, Eleanor S / Cain, Kevin P

    Open forum infectious diseases

    2022  Volume 9, Issue 11, Page(s) ofac560

    Abstract: Background: Pediatric tuberculosis (TB) remains a critical public health concern, yet bacteriologic confirmation of TB in children is challenging. Clinical, demographic, and radiological factors associated with a positive : Methods: We conducted a ... ...

    Abstract Background: Pediatric tuberculosis (TB) remains a critical public health concern, yet bacteriologic confirmation of TB in children is challenging. Clinical, demographic, and radiological factors associated with a positive
    Methods: We conducted a prospective cohort study of young children with presumptive TB and examined clinical, demographic, and radiologic factors associated with invasive and noninvasive specimen collection techniques (gastric aspirate, induced sputum, nasopharyngeal aspirate, stool, and string test); up to 2 samples were taken per child, per technique. We estimated associations between these factors and a positive specimen for each technique using generalized estimating equations (GEEs) and logistic regression.
    Results: A median (range) of 544 (507-566) samples were obtained for each specimen collection technique from 300 enrolled children; bacteriologic yield was low across all collection techniques (range, 1%-7% from Xpert MTB/RIF or culture), except for lymph node fine needle aspiration (29%) taken for children with cervical lymphadenopathy. Factors associated with positive
    Conclusions: Identifying factors that lead to a positive
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac560
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  4. Article ; Online: (Not) measuring in the dark.

    Cain, Kevin P / Shah, N Sarita

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2015  Volume 19, Issue 11, Page(s) 1270

    MeSH term(s) Female ; Humans ; Lung/pathology ; Male ; Mycobacterium tuberculosis/isolation & purification ; Tuberculosis/diagnosis ; Tuberculosis/mortality
    Language English
    Publishing date 2015-11
    Publishing country France
    Document type Comment ; Editorial
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.15.0782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  5. Article ; Online: Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children.

    Smith, Jonathan P / Milligan, Kyle / McCarthy, Kimberly D / Mchembere, Walter / Okeyo, Elisha / Musau, Susan K / Okumu, Albert / Song, Rinn / Click, Eleanor S / Cain, Kevin P

    PLOS digital health

    2023  Volume 2, Issue 5, Page(s) e0000249

    Abstract: Diagnosis of tuberculosis (TB) among young children (<5 years) is challenging due to the paucibacillary nature of clinical disease and clinical similarities to other childhood diseases. We used machine learning to develop accurate prediction models of ... ...

    Abstract Diagnosis of tuberculosis (TB) among young children (<5 years) is challenging due to the paucibacillary nature of clinical disease and clinical similarities to other childhood diseases. We used machine learning to develop accurate prediction models of microbial confirmation with simply defined and easily obtainable clinical, demographic, and radiologic factors. We evaluated eleven supervised machine learning models (using stepwise regression, regularized regression, decision tree, and support vector machine approaches) to predict microbial confirmation in young children (<5 years) using samples from invasive (reference-standard) or noninvasive procedure. Models were trained and tested using data from a large prospective cohort of young children with symptoms suggestive of TB in Kenya. Model performance was evaluated using areas under the receiver operating curve (AUROC) and precision-recall curve (AUPRC), accuracy metrics. (i.e., sensitivity, specificity), F-beta scores, Cohen's Kappa, and Matthew's Correlation Coefficient. Among 262 included children, 29 (11%) were microbially confirmed using any sampling technique. Models were accurate at predicting microbial confirmation in samples obtained from invasive procedures (AUROC range: 0.84-0.90) and from noninvasive procedures (AUROC range: 0.83-0.89). History of household contact with a confirmed case of TB, immunological evidence of TB infection, and a chest x-ray consistent with TB disease were consistently influential across models. Our results suggest machine learning can accurately predict microbial confirmation of M. tuberculosis in young children using simply defined features and increase the bacteriologic yield in diagnostic cohorts. These findings may facilitate clinical decision making and guide clinical research into novel biomarkers of TB disease in young children.
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3170
    ISSN (online) 2767-3170
    DOI 10.1371/journal.pdig.0000249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Reassessing the link between risk aversion and entrepreneurial intention

    Zhang, Pingying / Cain, Kevin W

    International journal of entrepreneurial behaviour & research Vol. 23, No. 5 , p. 793-811

    the mediating role of the determinants of planned behavior

    2017  Volume 23, Issue 5, Page(s) 793–811

    Author's details Pingying Zhang and Kevin W. Cain
    Keywords Risk aversion ; Entrepreneurial intention ; Planned behaviour
    Language English
    Publisher Emerald
    Publishing place Bingley
    Document type Article
    ZDB-ID 2509434-8 ; 1447640-x
    ISSN 1355-2554
    ISSN 1355-2554
    Database ECONomics Information System

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  7. Article ; Online: Caveat emptor? Control of latent tuberculosis infection in the United States.

    Schwartzman, Kevin / Cain, Kevin P

    American journal of respiratory and critical care medicine

    2011  Volume 184, Issue 5, Page(s) 501–502

    MeSH term(s) Female ; Humans ; Latent Tuberculosis/epidemiology ; Male ; Mass Screening ; Models, Economic ; Tuberculin Test/economics
    Language English
    Publishing date 2011-09-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201107-1241ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: The molecular epidemiology of tuberculosis in settings with a high HIV prevalence: implications for control.

    Borgdorff, Martien W / Cain, Kevin P / DeCock, Kevin M

    The Journal of infectious diseases

    2015  Volume 211, Issue 1, Page(s) 8–9

    MeSH term(s) Female ; HIV Infections/microbiology ; HIV Infections/virology ; Humans ; Male ; Tuberculosis/transmission ; Tuberculosis/virology
    Language English
    Publishing date 2015-01-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiu404
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    Zs.MO 445: Show issues

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  9. Article ; Online: Joseph Adera Odhiambo, 1954-2012 [Obituary].

    Cain, Kevin P / De Cock, Kevin M

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2013  Volume 17, Issue 6, Page(s) 852

    Language English
    Publishing date 2013-06-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.13.0263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4776: Show issues Location:
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    Zs.MO 261: Show issues

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  10. Article: Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody.

    Allen, Kevin J H / Kwon, Ohyun / Hutcheson, Matthew R / Grudzinski, Joseph J / Cain, Stuart M / Cruz, Frederic A / Vinayakamoorthy, Remitha M / Sun, Ying S / Fairley, Lindsay / Prabaharan, Chandra B / Dickinson, Ryan / MacDonald-Dickinson, Valerie / Uppalapati, Maruti / Bednarz, Bryan P / Dadachova, Ekaterina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 7

    Abstract: Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we ... ...

    Abstract Background: Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need for effective treatments to extend the survival of patients with OS. Here, we examine the dosimetry in beagle dogs and cross-reactivity with human tissues of a novel human antibody, IF3, that targets the insulin growth factor receptor type 2 (IGF2R), which is overexpressed on OS cells, making it a candidate for radioimmunotherapy of OS.
    Methods: [
    Results: PET/CT revealed that only the liver, bone marrow, and adrenal glands had high uptake. Clearance was initially through renal and hepatobiliary excretion in the first 72 h followed by primarily physical decay. RAPID analysis showed bone marrow to be the dose-limiting organ with a therapeutic range for
    Conclusions: Image-based dosimetry has defined a safe therapeutic range for canine clinical trials, while immunohistochemistry has suggested that the antibody will not cross-react with healthy human tissues.
    Language English
    Publishing date 2023-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16070979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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