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  1. Article ; Online: "Normal" Is Not Normal: The Role of the Immune Microenvironment of Adjacent Non-Neoplastic Tissue in Dictating the Biology of Early-Stage NSCLC.

    Denize, Thomas / Mino-Kenudson, Mari

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2023  Volume 18, Issue 9, Page(s) 1121–1123

    MeSH term(s) Humans ; Lung Neoplasms ; Biology ; Tumor Microenvironment
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2023.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6664: Show issues Location:
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    Zs.MO 652: Show issues

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  2. Article ; Online: An alternative COVID-19 checklist.

    Thomas, Mari

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2020  Volume 70, Issue 694, Page(s) 230

    MeSH term(s) Anesthesia, General ; Betacoronavirus ; COVID-19 ; Checklist ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; General Practitioners ; Humans ; Interprofessional Relations ; Pandemics ; Patient Care Team ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Professional-Patient Relations ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Letter
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp20X709541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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  4. Article ; Online: H2A.Z is involved in premature aging and DSB repair initiation in muscle fibers.

    Belotti, Edwige / Lacoste, Nicolas / Iftikhar, Arslan / Simonet, Thomas / Papin, Christophe / Osseni, Alexis / Streichenberger, Nathalie / Mari, Pierre-Olivier / Girard, Emmanuelle / Graies, Mohamed / Giglia-Mari, Giuseppina / Dimitrov, Stefan / Hamiche, Ali / Schaeffer, Laurent

    Nucleic acids research

    2024  Volume 52, Issue 6, Page(s) 3031–3049

    Abstract: Histone variants are key epigenetic players, but their functional and physiological roles remain poorly understood. Here, we show that depletion of the histone variant H2A.Z in mouse skeletal muscle causes oxidative stress, oxidation of proteins, ... ...

    Abstract Histone variants are key epigenetic players, but their functional and physiological roles remain poorly understood. Here, we show that depletion of the histone variant H2A.Z in mouse skeletal muscle causes oxidative stress, oxidation of proteins, accumulation of DNA damages, and both neuromuscular junction and mitochondria lesions that consequently lead to premature muscle aging and reduced life span. Investigation of the molecular mechanisms involved shows that H2A.Z is required to initiate DNA double strand break repair by recruiting Ku80 at DNA lesions. This is achieved via specific interactions of Ku80 vWA domain with H2A.Z. Taken as a whole, our data reveal that H2A.Z containing nucleosomes act as a molecular platform to bring together the proteins required to initiate and process DNA double strand break repair.
    MeSH term(s) Animals ; Mice ; Histones/genetics ; Histones/metabolism ; DNA Breaks, Double-Stranded ; Aging, Premature/genetics ; Nucleosomes ; DNA ; Muscle Fibers, Skeletal/metabolism
    Chemical Substances Histones ; Nucleosomes ; DNA (9007-49-2)
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Clinical features of thrombosis and bleeding in COVID-19.

    Thomas, Mari R / Scully, Marie

    Blood

    2022  Volume 140, Issue 3, Page(s) 184–195

    Abstract: Infection with the SARS-CoV-2 virus, resulting in COVID-19 disease, has presented a unique scenario associated with high rates of thrombosis. The risk of venous thrombosis is some three- to sixfold higher than for patients admitted to a hospital for ... ...

    Abstract Infection with the SARS-CoV-2 virus, resulting in COVID-19 disease, has presented a unique scenario associated with high rates of thrombosis. The risk of venous thrombosis is some three- to sixfold higher than for patients admitted to a hospital for other indications, and for patients who have thrombosis, mortality appears to increase. Thrombosis may be a presenting feature of COVID-19. Pulmonary thrombi are the most frequent events, some related to deep vein thrombosis, but also to in situ microvascular and macrovascular thrombosis. Other venous thromboses include catheter- and circuit-associated in patients requiring hemofiltration and extracorporeal membrane oxygenation. Arterial thrombosis is less commonly documented, with 3% of patients in intensive care units having major arterial strokes and up to 9% having myocardial infarction, both of which are most likely multifactorial. Risk factors for thrombosis above those already documented in hospital settings include duration of COVID-19 symptoms before admission to the hospital. Laboratory parameters associated with higher risk of thrombosis include higher D-dimer, low fibrinogen, and low lymphocyte count, with higher factor VIII and von Willebrand factor levels indicative of more severe COVID-19 infection. All patients should receive thromboprophylaxis when admitted with COVID-19 infection, but the dose and length of treatment are still debated. Thrombosis continues to be treated according to standard VTE guidelines, but adjustments may be needed depending on other factors relevant to the patient's admission.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/complications ; Hemorrhage/chemically induced ; Humans ; SARS-CoV-2 ; Thrombosis/complications ; Venous Thromboembolism/etiology ; Venous Thrombosis/complications
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021012247
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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  6. Article: Organizational democracy and meaningful work: The mediating role of employees corporate social responsibility perceptions.

    Svendsen, Mari / Jønsson, Thomas Faurholt

    Frontiers in psychology

    2022  Volume 13, Page(s) 946656

    Abstract: Meaningful work is an important field of research, relating to both organizational outcomes and employee welfare. Organizational democracy has been theoretically proposed as an important antecedent to meaningful work. Nevertheless, this relationship is ... ...

    Abstract Meaningful work is an important field of research, relating to both organizational outcomes and employee welfare. Organizational democracy has been theoretically proposed as an important antecedent to meaningful work. Nevertheless, this relationship is yet to be empirically explored. Thus, the objective of the current research is to explore the relationship between organizational democracy and meaningful work. We used structural equation modeling with self-reported, cross-sectional data from different nations and industries to test a mediation model in which corporate social responsibility (CSR) perceptions mediate the positive relationship between organizational democracy and meaningful work. Our findings confirmed that CSR perceptions partially mediate in the relationship between organizational democracy and meaningful work. Thus, based on our findings we can conclude that organizational democracy can play a direct role in increasing the experience of meaningful work, but also an indirect role trough the employees experience of CSR. Our findings have theoretical implications by adding to the classical theoretical literature that connect organizational democracy and meaningful work, and by disentangling the role of CSR perceptions in this relationship. Moreover, our findings have practical implications as our results give important knowledge to managers and organizational stakeholders that wish to increase the experience of meaningful work in organizations.
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.946656
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  7. Article: A Perspective on the Strategy for Advancing ETVAX

    Hossain, M Jahangir / Svennerholm, Ann-Mari / Carlin, Nils / D'Alessandro, Umberto / Wierzba, Thomas F

    Microorganisms

    2023  Volume 12, Issue 1

    Abstract: For the first time in over 20 years, an ... ...

    Abstract For the first time in over 20 years, an Enterotoxigenic
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010090
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  8. Article ; Online: Disparities among patients with respiratory failure.

    Blank, Jessica A / Armstrong-Hough, Mari / Valley, Thomas S

    Current opinion in critical care

    2023  Volume 29, Issue 5, Page(s) 493–504

    Abstract: Purpose of review: Disparities are common within healthcare, and critical illness is no exception. This review summarizes recent literature on health disparities within respiratory failure, focusing on race, ethnicity, socioeconomic status, and sex.: ... ...

    Abstract Purpose of review: Disparities are common within healthcare, and critical illness is no exception. This review summarizes recent literature on health disparities within respiratory failure, focusing on race, ethnicity, socioeconomic status, and sex.
    Recent findings: Current evidence indicates that Black patients have higher incidence of respiratory failure, while the relationships among race, ethnicity, and mortality remains unclear. There has been renewed interest in medical device bias, specifically pulse oximetry, for which data demonstrate patients with darker skin tones may be at risk for undetected hypoxemia and worse outcomes. Lower socioeconomic status is associated with higher mortality, and respiratory failure can potentiate socioeconomic inequities via illness-related financial toxicity. Literature on sex-based disparities is limited; however, evidence suggests males receive more invasive care, including mechanical ventilation.
    Summary: Most studies focused on disparities in incidence and mortality associated with respiratory failure, but few relied on granular clinical data of patients from diverse backgrounds. Future studies should evaluate processes of care for respiratory failure that may mechanistically contribute to disparities in order to develop interventions that improve outcomes.
    MeSH term(s) Male ; Humans ; Respiration, Artificial ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001079
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4999: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Electronic Health Record Maturity Matters! Texas Nurses Speak Out in Their Second Statewide Study.

    McBride, Susan / Tietze, Mari / Thomas, Laura / Hanley, Mary Anne

    Computers, informatics, nursing : CIN

    2023  Volume 41, Issue 2, Page(s) 110–122

    Abstract: With the passage of the Health Information Technology for Economic and Clinical Health Act in 2009, Texas nurses were faced with the rapid uptake of technology driven by this legislation. Texas Nurses Association and Texas Organization for Nursing ... ...

    Abstract With the passage of the Health Information Technology for Economic and Clinical Health Act in 2009, Texas nurses were faced with the rapid uptake of technology driven by this legislation. Texas Nurses Association and Texas Organization for Nursing Leadership formed a partnership to collectively track the impact on practicing nurses. The Health IT Committee was commissioned to evaluate the changing health information technology environment and associated solutions. As such, a study in 2015, entitled "Statewide Study Assessing the Experiences of Nurses with their Electronic Health Records," was conducted. The follow-up study in 2020 was conducted to compare 2015 and 2020 findings to identify improvements made on nurses' satisfaction with EHRs and identify improvement opportunities. The study design was an exploratory descriptive comparative analysis with a cross-sectional survey from a random sample of Texas nurses for the two study periods of 2015 (n = 1177) and 2020 (n = 1117). The Clinical Information Systems Implementation Evaluation Scale and a demographic survey including the Meaningful Use Maturity-Sensitive Index were the measurement instruments. Results and key covariates are discussed along with recommendations for achieving more mature EHRs and more mature organizational culture and leadership.
    MeSH term(s) Humans ; Electronic Health Records ; Texas ; Cross-Sectional Studies ; Follow-Up Studies ; Nurses ; Surveys and Questionnaires
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000000915
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  10. Book ; Online ; Thesis: Proteomics approaches to study the novel SARS coronavirus

    Mari, Tommaso [Verfasser] / Selbach, Matthias [Gutachter] / Sommer, Thomas [Gutachter] / Ralser, Markus [Gutachter]

    2022  

    Author's details Tommaso Mari ; Gutachter: Matthias Selbach, Thomas Sommer, Markus Ralser
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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