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  1. Article ; Online: The need to better understand the physiology of lung collapse during one-lung ventilation.

    Pfitzner, John

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2021  Volume 68, Issue 9, Page(s) 1452–1453

    MeSH term(s) Humans ; One-Lung Ventilation ; Pulmonary Atelectasis ; Respiration, Artificial
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-021-02040-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Non-ventilated lung airway occlusion during one-lung ventilation: a need for further research?

    Pfitzner, John

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2021  Volume 68, Issue 9, Page(s) 1456–1457

    MeSH term(s) Airway Obstruction ; Humans ; Lung/diagnostic imaging ; One-Lung Ventilation ; Thoracic Surgery, Video-Assisted
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-021-02053-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Reasons for using nitrous oxide in one-lung ventilation, especially for thoracoscopic surgery.

    Pfitzner, John

    Anaesthesia and intensive care

    2019  Volume 47, Issue 5, Page(s) 478–479

    MeSH term(s) Humans ; Nitrous Oxide ; One-Lung Ventilation ; Thoracoscopy
    Chemical Substances Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Letter
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
    DOI 10.1177/0310057X19877657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1017: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Selecting the Level of Positive End-expiratory Pressure for One-lung Ventilation: "By Formula" or "By Feel"?

    Pfitzner, John

    Anesthesiology

    2016  Volume 125, Issue 6, Page(s) 1254–1255

    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000001350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  5. Article ; Online: Characterization of membrane protein interactions by peptidisc-mediated mass photometry.

    Young, John William / Pfitzner, Emanuel / van Wee, Raman / Kirschbaum, Carla / Kukura, Philipp / Robinson, Carol V

    iScience

    2024  Volume 27, Issue 2, Page(s) 108785

    Abstract: Membrane proteins perform numerous critical functions in the cell, making many of them primary drug targets. However, their preference for a lipid environment makes them challenging to study using established solution-based methods. Here, we show that ... ...

    Abstract Membrane proteins perform numerous critical functions in the cell, making many of them primary drug targets. However, their preference for a lipid environment makes them challenging to study using established solution-based methods. Here, we show that peptidiscs, a recently developed membrane mimetic, provide an ideal platform to study membrane proteins and their interactions with mass photometry (MP) in detergent-free conditions. The mass resolution for membrane protein complexes is similar to that achievable with soluble proteins owing to the low carrier heterogeneity. Using the ABC transporter BtuCD, we show that MP can quantify interactions between peptidisc-reconstituted membrane protein receptors and their soluble protein binding partners. Using the BAM complex, we further show that MP reveals interactions between a membrane protein receptor and a bactericidal antibody. Our results highlight the utility of peptidiscs for membrane protein characterization in detergent-free solution and provide a rapid and powerful platform for quantifying membrane protein interactions.
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Facilitating lung collapse during one lung ventilation can be rational.

    Pfitzner, John

    Anesthesia and analgesia

    2014  Volume 119, Issue 4, Page(s) 1002–1003

    MeSH term(s) Anesthesia, General/methods ; Bronchi/drug effects ; Female ; Humans ; Male ; Nitrous Oxide/administration & dosage ; One-Lung Ventilation/methods ; Pulmonary Atelectasis
    Chemical Substances Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2014-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000000336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.78: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 149: Show issues

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  7. Article ; Online: An alternative continuous positive airway pressure system for COVID-19 patients.

    Pfitzner, John / Maddern, Guy J / Reid, Jessica

    British journal of anaesthesia

    2020  Volume 125, Issue 3, Page(s) e310–e313

    MeSH term(s) Betacoronavirus ; COVID-19 ; Continuous Positive Airway Pressure/methods ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.05.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Characterization of membrane protein interactions by peptidisc-mediated mass photometry

    John William Young / Emanuel Pfitzner / Raman van Wee / Carla Kirschbaum / Philipp Kukura / Carol V. Robinson

    iScience, Vol 27, Iss 2, Pp 108785- (2024)

    2024  

    Abstract: Summary: Membrane proteins perform numerous critical functions in the cell, making many of them primary drug targets. However, their preference for a lipid environment makes them challenging to study using established solution-based methods. Here, we ... ...

    Abstract Summary: Membrane proteins perform numerous critical functions in the cell, making many of them primary drug targets. However, their preference for a lipid environment makes them challenging to study using established solution-based methods. Here, we show that peptidiscs, a recently developed membrane mimetic, provide an ideal platform to study membrane proteins and their interactions with mass photometry (MP) in detergent-free conditions. The mass resolution for membrane protein complexes is similar to that achievable with soluble proteins owing to the low carrier heterogeneity. Using the ABC transporter BtuCD, we show that MP can quantify interactions between peptidisc-reconstituted membrane protein receptors and their soluble protein binding partners. Using the BAM complex, we further show that MP reveals interactions between a membrane protein receptor and a bactericidal antibody. Our results highlight the utility of peptidiscs for membrane protein characterization in detergent-free solution and provide a rapid and powerful platform for quantifying membrane protein interactions.
    Keywords Biochemistry methods ; Biotechnology ; Membranes ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: An alternative Continuous Positive Airway Pressure device for COVID-19 patients

    Pfitzner, John / Maddern, Guy J. / Reid, Jessica

    Br J Anaesth

    Keywords covid19
    Publisher Elsevier; PMC; WHO
    Document type Article ; Online
    Note WHO #Covidence: #457189
    DOI 10.1016/j.bja.2020.05.035
    Database COVID19

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    Inter-library loan at ZB MED

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