LIVIVO - Search results -

Search results

Result 1 - 10 of total 22

Search options

Article ; Online: The Wiener Index of Circulant Graphs

Houqing Zhou

Journal of Chemistry, Vol

2014 Volume 2014

Keywords	Chemistry ; QD1-999 ; Science ; Q
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Wiener Index of Circulant Graphs

Houqing Zhou

Journal of Chemistry, Vol

2014 Volume 2014

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The Wiener Index of Circulant Graphs

Houqing Zhou

Journal of Chemistry, Vol

2014 Volume 2014

Abstract: Circulant graphs are an important class of interconnection networks in parallel and distributed computing. In this paper, we discuss the relation of the Wiener index and the Harary index of circulant graphs and the largest eigenvalues of distance matrix ... ...

Abstract	Circulant graphs are an important class of interconnection networks in parallel and distributed computing. In this paper, we discuss the relation of the Wiener index and the Harary index of circulant graphs and the largest eigenvalues of distance matrix and reciprocal distance matrix of circulants. We obtain the following consequence: W/λ=H/μ; 2W/n=λ; 2H/n=μ, where W, H denote the Wiener index and the Harary index and λ, μ denote the largest eigenvalues of distance matrix and reciprocal distance matrix of circulant graphs, respectively. Moreover we also discuss the Wiener index of nonregular graphs with cut edges.
Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: LncRNA H19 Regulates Proliferation, Apoptosis and ECM Degradation of Aortic Smooth Muscle Cells Via miR-1-3p/ADAM10 Axis in Thoracic Aortic Aneurysm

Fan, Zhineng / Liu, Shuan / Zhou, Houqing

Biochemical genetics. 2022 Apr., v. 60, no. 2

2022

Abstract: Thoracic aortic aneurysm (TAA) is a prevalent health problem worldwide. Long non-coding RNA H19was highly expressed in TAA patients, but the function and mechanism of H19 in TAA remain unknown. The expression levels of H19, microRNA-1-3p (miR-1-3p), and ... ...

Abstract	Thoracic aortic aneurysm (TAA) is a prevalent health problem worldwide. Long non-coding RNA H19was highly expressed in TAA patients, but the function and mechanism of H19 in TAA remain unknown. The expression levels of H19, microRNA-1-3p (miR-1-3p), and a disintegrin and metalloproteinase 10 (ADAM10) were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Receiver operating characteristic (ROS) cure was performed to evaluate the diagnostic value of H19 on TAA patients. Proliferation and apoptosis were detected by Cell Counting Kit-8 (CCK-8), colony formation, and flow cytometry. Protein levels of proliferating cell nuclear antigen (PCNA), Cleaved-caspase 3 (Cleaved-cas3), Cleaved-caspase 9 (Cleaved-cas9), Collagen I, Collagen III, and ADAM10 were tested by western blot assay. The binding relationship between miR-1-3p and H19 or ADAM10 was predicted by LncBase Predicted v.2 or Starbase, and verified by the dual-luciferase reporter, RNA pull-down assay, and RNA Immunoprecipitation (RIP) assays. H19 was increased in TAA aorta tissues and serum and vascular smooth muscle cell (VSMC), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ECM) degradation of VSMC. Moreover, miR-1-3p was decreased, and ADAM10 was upregulated in TAA aorta tissues and VSMC. The mechanical analysis confirmed that H19 affected ADAM10 expression by targeting miR-1-3p. Our results indicated that H19 inhibited proliferation, and accelerated apoptosis and ECM degradation of VSMC, providing an underlying lncRNA-targeted therapy for TAA treatment.
Keywords	Western blotting ; aneurysm ; aorta ; apoptosis ; blood serum ; collagen ; disease diagnosis ; extracellular matrix ; flow cytometry ; metalloproteinases ; non-coding RNA ; precipitin tests ; quantitative polymerase chain reaction ; smooth muscle ; therapeutics
Language	English
Dates of publication	2022-04
Size	p. 790-806.
Publishing place	Springer US
Document type	Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-021-10118-y
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/712: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome.

Chen, Jingjing / Wang, Dan / Wang, Zequn / Han, Mengyuan / Yin, Houqing / Zhou, Wenting / Yan, Ribai / Pan, Yan

Oncology research

2024 Volume 32, Issue 5, Page(s) 911–923

Abstract: Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]-10,15,20-triphenyl-porphyrin (DTP) mediated ... ...

Abstract	Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]-10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 cells. The ROS scavenger N-acetyl-L-cysteine (NAC) and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced cytotoxicity. DTP-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2, which could also be inhibited by NAC or SB203580. The level of LC3B-II, a marker of autophagy, was increased by DTP-PDT. A total of 3496 DERs were obtained after DTP-PDT. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes, the nuclear lumen, protein binding, cell cycle, protein targeting to the endoplasmic reticulum, and ribosomal DNA replication. Disease Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle checkpoints. Protein-protein interaction results demonstrated that
MeSH term(s)	Humans ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Reactive Oxygen Species/metabolism ; Transcriptome ; Apoptosis/drug effects ; Cell Line, Tumor ; Porphyrins/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Autophagy/drug effects ; MCF-7 Cells ; Gene Expression Regulation, Neoplastic/drug effects ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/metabolism ; Neoplasms/genetics ; Gene Expression Profiling
Chemical Substances	Photosensitizing Agents ; Reactive Oxygen Species ; Porphyrins
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1114699-0
ISSN	1555-3906 ; 0965-0407
ISSN (online)	1555-3906
ISSN	0965-0407
DOI	10.32604/or.2023.042384
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3087: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: LncRNA H19 Regulates Proliferation, Apoptosis and ECM Degradation of Aortic Smooth Muscle Cells Via miR-1-3p/ADAM10 Axis in Thoracic Aortic Aneurysm.

Fan, Zhineng / Liu, Shuan / Zhou, Houqing

Biochemical genetics

2021 Volume 60, Issue 2, Page(s) 790–806

Abstract	Thoracic aortic aneurysm (TAA) is a prevalent health problem worldwide. Long non-coding RNA H19was highly expressed in TAA patients, but the function and mechanism of H19 in TAA remain unknown. The expression levels of H19, microRNA-1-3p (miR-1-3p), and a disintegrin and metalloproteinase 10 (ADAM10) were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Receiver operating characteristic (ROS) cure was performed to evaluate the diagnostic value of H19 on TAA patients. Proliferation and apoptosis were detected by Cell Counting Kit-8 (CCK-8), colony formation, and flow cytometry. Protein levels of proliferating cell nuclear antigen (PCNA), Cleaved-caspase 3 (Cleaved-cas3), Cleaved-caspase 9 (Cleaved-cas9), Collagen I, Collagen III, and ADAM10 were tested by western blot assay. The binding relationship between miR-1-3p and H19 or ADAM10 was predicted by LncBase Predicted v.2 or Starbase, and verified by the dual-luciferase reporter, RNA pull-down assay, and RNA Immunoprecipitation (RIP) assays. H19 was increased in TAA aorta tissues and serum and vascular smooth muscle cell (VSMC), and hindered proliferation as well as promoted apoptosis and extracellular matrix (ECM) degradation of VSMC. Moreover, miR-1-3p was decreased, and ADAM10 was upregulated in TAA aorta tissues and VSMC. The mechanical analysis confirmed that H19 affected ADAM10 expression by targeting miR-1-3p. Our results indicated that H19 inhibited proliferation, and accelerated apoptosis and ECM degradation of VSMC, providing an underlying lncRNA-targeted therapy for TAA treatment.
MeSH term(s)	ADAM10 Protein/genetics ; ADAM10 Protein/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Aorta/metabolism ; Aortic Aneurysm, Thoracic/genetics ; Aortic Aneurysm, Thoracic/metabolism ; Apoptosis/genetics ; Cell Proliferation/genetics ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocytes, Smooth Muscle/metabolism ; RNA, Long Noncoding/genetics
Chemical Substances	H19 long non-coding RNA ; MIRN1 microRNA, human ; Membrane Proteins ; MicroRNAs ; RNA, Long Noncoding ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81)
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-021-10118-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 578: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline

Cheng, Xi / Yu, Haiming / Li, Jinying / Han, Xiaona / Meng, Erhong / Zhou, Houqing / Wang, Dongliang / Niu, Beifang / Zhang, Xiaotao

Cancer biology & therapy

2022 Volume 23, Issue 1, Page(s) 393–400

Abstract: Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, ...

Abstract	Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, including
MeSH term(s)	Adult ; BRCA2 Protein/genetics ; Biomarkers ; Endodermal Sinus Tumor/genetics ; Endodermal Sinus Tumor/pathology ; Endodermal Sinus Tumor/radiotherapy ; Frameshift Mutation ; Germ-Line Mutation ; Humans ; Male ; Mediastinal Neoplasms/genetics ; Mediastinal Neoplasms/pathology ; Mediastinal Neoplasms/radiotherapy
Chemical Substances	BRCA2 Protein ; BRCA2 protein, human ; Biomarkers
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2022.2072635
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: An alternative way of SARS-COV-2 to induce cell stress and elevated DNA damage risk in cardiomyocytes without direct infection.

Zhou, Houqing / Ren, Xiaohu / Yang, Yang / Xu, Benhong / Li, Yichong / Feng, Yin / Shisong, Fang / Liu, Jianjun

Immunity, inflammation and disease

2022 Volume 10, Issue 7, Page(s) e638

Abstract: Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in 2020 has led to millions of deaths worldwide. Case reports suggested that infection of SARS-CoV-2 is potentially associated with occurrences of cardiovascular ... ...

Abstract	Background: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in 2020 has led to millions of deaths worldwide. Case reports suggested that infection of SARS-CoV-2 is potentially associated with occurrences of cardiovascular pathology. However, the mode of action and mechanisms of SARS-CoV-2 influencing cardiomyocytes still remain largely unclear. Aims: To explore the mechanisms underlying cardiomyocytes damage induced by SARS-CoV-2 infection. Materials & methods: the serum markers of cardiovascular injury were analyzed by ELISA. The isolated SARS-CoV-2 virus were co-cultured with human cardiomyocytes (AC16) and immunofluorescence assay was used evaluate the invasion of virus. Moreover, serum obtained from acute stage of SARS-CoV-2 infected patients and healthy controls were used to incubate with AC16 cells, then indicators associated with cell stress and DNA damage were analyzed by Western-blot. Results: we found that high-sensitivity troponin T (hsTnT), an indicator of cardiovascular disease, was higher in the acute stage of COVID-19. Additionally, in vitro coculture of SARS-CoV-2 and AC16 cells showed almost no infectious ability of SARS-CoV-2 to directly infect AC16 cells. Results of serum treatment suggested that serum from infected subjects induced cell stress (upregulation of p53 and HSP70) and elevation of DNA damage risk (increased γH2Ax and H3K79me2) in AC16. Discussion: our observations indicated a hard way for SARS-CoV-2 to infect cardiomyocytes directly. However, infection-induced immune storm in serum could bring stress and elevated DNA damage risks to cardiovascular system. Conclusion: These findings indicated the possibilities of SARS-CoV-2 inducing stress and elevating DNA damage risk to cardiomyocytes without direct infection.
MeSH term(s)	COVID-19 ; DNA Damage ; Humans ; Myocytes, Cardiac/pathology ; SARS-CoV-2
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.638
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Genomic characterization of two metagenome-assembled genomes of

Lv, Zhongdong / Chen, Yong / Zhou, Houqing / Chen, Zhonglin / Yao, Qianru / Ren, Jiali / Liu, Xianglu / Liu, Shuang / Deng, Xiaomei / Pang, Yingchen / Chen, Weijun / Yang, Huiling / Xu, Ping

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 947486

Abstract: Whipple's disease is a rare chronic systemic disease that affects almost any organ system of the body caused by the intracellular ... ...

Abstract	Whipple's disease is a rare chronic systemic disease that affects almost any organ system of the body caused by the intracellular bacterium
MeSH term(s)	Fluoroquinolones ; Genomics ; Metagenome ; Phylogeny ; Tropheryma/genetics ; Virulence Factors
Chemical Substances	Fluoroquinolones ; Virulence Factors
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.947486
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Integrative Expression and Prognosis Analysis of DHX37 in Human Cancers by Data Mining

Kang Huang / Tudi Pang / Changjun Tong / Houqing Chen / Yupeng Nie / Jiayi Wu / Yandong Zhang / Ganghong Chen / Wei Zhou / Dazhi Yang

BioMed Research International, Vol

2021 Volume 2021

Abstract: DHEA-Box Helicase 37 (DHX37) is a putative RNA helicase. It is involved in various RNA secondary structure alteration processes, including translation, nuclear splicing, and ribosome assembly. It is reported to be associated with the neurodevelopmental ... ...

Abstract	DHEA-Box Helicase 37 (DHX37) is a putative RNA helicase. It is involved in various RNA secondary structure alteration processes, including translation, nuclear splicing, and ribosome assembly. It is reported to be associated with the neurodevelopmental disorder with brain anomalies, and a recent study suggests that DHX37 is a functional regulator of CD8 T cells. Dysregulation of the CD8 T cell function is closely related to defective antitumor immune responses. In the present study, we investigated the expression, mutation, and prognostic role of DHX37 in human cancers, mainly by mining publicly available datasets. Our results suggested that DHX37 was significantly upregulated in 17 kinds of tumors. Mutations including deletions, insertions, and substitutions of DHX37 were widely detected. Besides, the expression of DHX37 was negatively correlated with immune-related genes PD-L1, RGS16, and TOX, and it was positively associated with TIM3, LAG3, and NCOR2. Through biofunctional analysis, we observed that DHX37 was significantly enriched in cancer-related pathways such as cell cycle, DNA replication, mismatch repair, RNA degradation, and RNA polymerase. In conclusion, the study explored the significance of DHX37 in human cancers. DHX37 may serve as a potential target for cancer immunotherapy.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED