LIVIVO - Search results -

Search results

Result 1 - 10 of total 54

Search options

Article ; Online: Human Olfactory Receptor Sensor for Odor Reconstitution.

Kuroda, Shun'ichi / Nakaya-Kishi, Yukiko / Tatematsu, Kenji / Hinuma, Shuji

2023 Volume 23, Issue 13

Abstract: Among the five human senses, light, sound, and force perceived by the eye, ear, and skin, respectively are physical phenomena, and therefore can be easily measured and expressed as objective, univocal, and simple digital data with physical quantity. ... ...

Abstract	Among the five human senses, light, sound, and force perceived by the eye, ear, and skin, respectively are physical phenomena, and therefore can be easily measured and expressed as objective, univocal, and simple digital data with physical quantity. However, as taste and odor molecules perceived by the tongue and nose are chemical phenomena, it has been difficult to express them as objective and univocal digital data, since no reference chemicals can be defined. Therefore, while the recording, saving, transmitting to remote locations, and replaying of human visual, auditory, and tactile information as digital data in digital devices have been realized (this series of data flow is defined as DX (digital transformation) in this review), the DX of human taste and odor information is not yet in the realization stage. Particularly, since there are at least 400,000 types of odor molecules and an infinite number of complex odors that are mixtures of these molecules, it has been considered extremely difficult to realize "human olfactory DX" by converting all odors perceived by human olfaction into digital data. In this review, we discuss the current status and future prospects of the development of "human olfactory DX", which we believe can be realized by utilizing odor sensors that employ the olfactory receptors (ORs) that support human olfaction as sensing molecules (i.e., human OR sensor).
MeSH term(s)	Humans ; Odorants ; Receptors, Odorant ; Smell ; Nose ; Tongue
Chemical Substances	Receptors, Odorant
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23136164
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Cell Shape and Cell Lineage Conversion

Yukiko Nakaya / Guojun Sheng

The Journal of Poultry Science, Vol 52, Iss 1, Pp 1-

2015 Volume 6

Abstract: The organization of animal cells in vivo can be categorized as being either epithelial or mesenchymal. Inter-conversions between these two states, epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), often represent key ... ...

Abstract	The organization of animal cells in vivo can be categorized as being either epithelial or mesenchymal. Inter-conversions between these two states, epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), often represent key events in animal development and pathogenesis. The molecular and cellular mechanisms by which cell-cell and cell-substrate interactions are governed during EMT/MET have been examined extensively. Recent studies have also shown that EMT/MET is implicated in the acquisition of stemness in cancer cells and is accompanied by changes in epigenetic modifications. Ongoing progresses in regenerative medicine suggest that morphological and physical changes can facilitate somatic cell reprogramming and help achieve stemness. In this review, we will describe the principles of EMT/MET, their roles in cancer and normal animal development, and their relationship to stemness. We will conclude by emphasizing that studying cell shape changes in development is important for mechanistic understanding of how EMT/MET contributes to cell lineage conversion in cancer research and therapeutic medicine.
Keywords	cell shape ; cell biology ; chick ; epithelial mesenchymal transition ; pluripotency ; cancer stem cell ; Animal culture ; SF1-1100
Subject code	571
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Japan Poultry Science Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: An autopsy case of COVID-19 with a sudden death: Clinico-pathological comparison.

Shishido-Hara, Yukiko / Furukawa, Keizo / Nishio, Manabu / Honda, Kohei / Tando, So / Yaoi, Takeshi / Kawamoto, Masataka / Maehara, Yosuke / Nakaya, Takaaki / Itoh, Kyoko

Clinical case reports

2022 Volume 10, Issue 6, Page(s) e5961

Abstract: Autopsy was performed on a COVID-19 patient, who suddenly died despite the extensive anti-viral and anti-inflammatory therapies. Although moderate subpleural fibrosis was seen, pathology of DAD, a well-known cause for pulmonary failure, was minimum. ... ...

Abstract	Autopsy was performed on a COVID-19 patient, who suddenly died despite the extensive anti-viral and anti-inflammatory therapies. Although moderate subpleural fibrosis was seen, pathology of DAD, a well-known cause for pulmonary failure, was minimum. Instead, severe hemorrhage was observed. Therapeutic effects were indicated; however, why severe hemorrhage occurred was unclear.
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5961
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Biomechanical regulation of EMT and epithelial morphogenesis in amniote epiblast.

Hamidi, Sofiane / Nakaya, Yukiko / Nagai, Hiroki / Alev, Cantas / Shibata, Tatsuo / Sheng, Guojun

Physical biology

2019 Volume 16, Issue 4, Page(s) 41002

Abstract: Epiblast is composed of pluripotent cells which will give rise to all cell lineages in a human body. It forms a single-cell layered epithelium conserved among all amniotic vertebrates (birds, reptiles and mammals) and undergoes complex morphogenesis both ...

Abstract	Epiblast is composed of pluripotent cells which will give rise to all cell lineages in a human body. It forms a single-cell layered epithelium conserved among all amniotic vertebrates (birds, reptiles and mammals) and undergoes complex morphogenesis both before and during gastrulation. Our knowledge of the amniote epiblast is based on data acquired through cellular and molecular analyses of early chick and mouse embryos in vivo and mammalian pluripotent stem cells (PSCs) in vitro. Very few studies have been published on biomechanical characteristics of the amniote epiblast, largely due to lack of experimental tools for measuring and perturbing biomechanical properties. Also missing is a conceptual framework that can integrate both biomechanical and molecular parameters of the epiblast. This review is aimed at providing a background based on which epiblast morphogenesis, including its transition between the epithelial and mesenchymal states, can be understood from a biomechanical perspective. This simple developmental biology system is suitable for testing a multitude of theoretical models in biomechanics, leading to a better understanding of biomechanical logics and constraints governing multicellular organization.
MeSH term(s)	Animals ; Biomechanical Phenomena/physiology ; Cell Communication/physiology ; Cell Line ; Epithelial Cells/metabolism ; Epithelial-Mesenchymal Transition/physiology ; Gastrulation/physiology ; Germ Layers/cytology ; Germ Layers/growth & development ; Humans ; Models, Theoretical ; Morphogenesis/physiology
Language	English
Publishing date	2019-04-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2133216-2
ISSN	1478-3975 ; 1478-3967
ISSN (online)	1478-3975
ISSN	1478-3967
DOI	10.1088/1478-3975/ab1048
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: EMT in developmental morphogenesis.

Nakaya, Yukiko / Sheng, Guojun

Cancer letters

2013 Volume 341, Issue 1, Page(s) 9–15

Abstract: Carcinomas, cancers of epithelial origin, constitute the majority of all cancers. Loss of epithelial characteristics is an early step in carcinoma progression. Malignant transformation and metastasis involve additional loss of cell-cycle control and gain ...

Abstract	Carcinomas, cancers of epithelial origin, constitute the majority of all cancers. Loss of epithelial characteristics is an early step in carcinoma progression. Malignant transformation and metastasis involve additional loss of cell-cycle control and gain of migratory behaviors. Understanding the relationships among epithelial homeostasis, cell proliferation, and cell migration is therefore fundamental in understanding cancer. Interestingly, these cellular events also occur frequently during animal development, but without leading to tumor formation. Can we learn anything about carcinomas from developmental biology? In this review, we focus on one aspect of carcinoma progression, the Epithelial-Mesenchymal Transition (EMT), and provide an overview of how the EMT is involved in normal amniote development. We discuss 12 developmental and morphogenetic processes that clearly involve the EMT. We conclude by emphasizing the diversity of EMT processes both in terms of their developmental context and of their cellular morphogenesis. We propose that there is comparable diversity in cancer microenvironment and molecular regulation of cancer EMTs.
MeSH term(s)	Animals ; Blastocyst/physiology ; Cell Transformation, Neoplastic/pathology ; Embryonic Development/physiology ; Endocardium/embryology ; Epithelial Cells/cytology ; Epithelial Cells/pathology ; Epithelial-Mesenchymal Transition ; Epithelium/physiology ; Female ; Gastrulation/physiology ; Humans ; Kidney/cytology ; Kidney/embryology ; Liver/cytology ; Liver/embryology ; Male ; Mammary Glands, Human/cytology ; Mammary Glands, Human/growth & development ; Morphogenesis/physiology ; Neoplasms/pathology ; Neural Crest/embryology ; Neural Crest/growth & development ; Pancreas/cytology ; Pancreas/embryology ; Prostate/cytology ; Prostate/embryology ; Somites/embryology ; Trophoblasts/pathology
Language	English
Publishing date	2013-11-28
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2013.02.037
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1177: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: EMT in developmental morphogenesis

Nakaya, Yukiko / Sheng, Guojun

Cancer letters. 2013 Nov. 28, v. 341, no. 1

2013

Abstract	Carcinomas, cancers of epithelial origin, constitute the majority of all cancers. Loss of epithelial characteristics is an early step in carcinoma progression. Malignant transformation and metastasis involve additional loss of cell-cycle control and gain of migratory behaviors. Understanding the relationships among epithelial homeostasis, cell proliferation, and cell migration is therefore fundamental in understanding cancer. Interestingly, these cellular events also occur frequently during animal development, but without leading to tumor formation. Can we learn anything about carcinomas from developmental biology? In this review, we focus on one aspect of carcinoma progression, the Epithelial–Mesenchymal Transition (EMT), and provide an overview of how the EMT is involved in normal amniote development. We discuss 12 developmental and morphogenetic processes that clearly involve the EMT. We conclude by emphasizing the diversity of EMT processes both in terms of their developmental context and of their cellular morphogenesis. We propose that there is comparable diversity in cancer microenvironment and molecular regulation of cancer EMTs.
Keywords	animal development ; carcinoma ; cell cycle ; cell movement ; cell proliferation ; homeostasis ; metastasis ; migratory behavior ; morphogenesis
Language	English
Dates of publication	2013-1128
Size	p. 9-15.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2013.02.037
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1177: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Induced pluripotent stem cells of endangered avian species

Masafumi Katayama / Tomokazu Fukuda / Takehito Kaneko / Yuki Nakagawa / Atsushi Tajima / Mitsuru Naito / Hitomi Ohmaki / Daiji Endo / Makoto Asano / Takashi Nagamine / Yumiko Nakaya / Keisuke Saito / Yukiko Watanabe / Tetsuya Tani / Miho Inoue-Murayama / Nobuyoshi Nakajima / Manabu Onuma

Communications Biology, Vol 5, Iss 1, Pp 1-

2022 Volume 20

Abstract: iPSCs from three endangered avian species (including Okinawa rail, Japanese ptarmigan, and Blakiston’s fish owl) are developed and characterized as a potential resource for their conservation. ...

Abstract	iPSCs from three endangered avian species (including Okinawa rail, Japanese ptarmigan, and Blakiston’s fish owl) are developed and characterized as a potential resource for their conservation.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Induced pluripotent stem cells of endangered avian species.

Katayama, Masafumi / Fukuda, Tomokazu / Kaneko, Takehito / Nakagawa, Yuki / Tajima, Atsushi / Naito, Mitsuru / Ohmaki, Hitomi / Endo, Daiji / Asano, Makoto / Nagamine, Takashi / Nakaya, Yumiko / Saito, Keisuke / Watanabe, Yukiko / Tani, Tetsuya / Inoue-Murayama, Miho / Nakajima, Nobuyoshi / Onuma, Manabu

Communications biology

2022 Volume 5, Issue 1, Page(s) 1049

Abstract: The number of endangered avian-related species increase in Japan recently. The application of new technologies, such as induced pluripotent stem cells (iPSCs), may contribute to the recovery of the decreasing numbers of endangered animals and ... ...

Abstract	The number of endangered avian-related species increase in Japan recently. The application of new technologies, such as induced pluripotent stem cells (iPSCs), may contribute to the recovery of the decreasing numbers of endangered animals and conservation of genetic resources. We established novel iPSCs from three endangered avian species (Okinawa rail, Japanese ptarmigan, and Blakiston's fish owl) with seven reprogramming factors (M3O, Sox2, Klf4, c-Myc, Nanog, Lin28, and Klf2). The iPSCs are pluripotency markers and express pluripotency-related genes and differentiated into three germ layers in vivo and in vitro. These three endangered avian iPSCs displayed different cellular characteristics even though the same reprogramming factors use. Japanese ptarmigan-derived iPSCs have different biological characteristics from those observed in other avian-derived iPSCs. Japanese ptarmigan iPSCs contributed to chimeras part in chicken embryos. To the best of our knowledge, our findings provide the first evidence of the potential value of iPSCs as a resource for endangered avian species conservation.
MeSH term(s)	Chick Embryo ; Animals ; Induced Pluripotent Stem Cells ; Cellular Reprogramming ; Endangered Species ; Cell Differentiation/genetics ; Transcription Factors/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2022-10-24
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03964-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation.

Hamidi, Sofiane / Nakaya, Yukiko / Nagai, Hiroki / Alev, Cantas / Kasukawa, Takeya / Chhabra, Sapna / Lee, Ruda / Niwa, Hitoshi / Warmflash, Aryeh / Shibata, Tatsuo / Sheng, Guojun

Development (Cambridge, England)

2020 Volume 147, Issue 3

Abstract: The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when the epiblast generates mesoderm and endoderm germ layers through epithelial-mesenchymal transition (EMT). Although ... ...

Abstract	The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when the epiblast generates mesoderm and endoderm germ layers through epithelial-mesenchymal transition (EMT). Although gastrulation EMT coincides with loss of epiblast pluripotency, pluripotent cells in development and
MeSH term(s)	Animals ; Cell Differentiation ; Cell Line ; Chick Embryo ; Endoderm/cytology ; Epithelial-Mesenchymal Transition/physiology ; Gastrulation/physiology ; Gene Expression Regulation, Developmental ; Humans ; Mesoderm/cytology ; Morphogenesis/genetics ; Pluripotent Stem Cells/cytology
Language	English
Publishing date	2020-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.184960
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 91: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis.

Akiyama, Kanoko / Nishioka, Keisuke / Khan, Khaleque N / Tanaka, Yukiko / Mori, Taisuke / Nakaya, Takaaki / Kitawaki, Jo

American journal of reproductive immunology (New York, N.Y. : 1989)

2019 Volume 82, Issue 2, Page(s) e13147

Abstract: Problem: Intrauterine microbial colonization and its association with the pathogenesis of endometriosis via an innate immune cascade have been reported. As a potential source of microbial transmission, information on microbial colonization in cervical ... ...

Abstract	Problem: Intrauterine microbial colonization and its association with the pathogenesis of endometriosis via an innate immune cascade have been reported. As a potential source of microbial transmission, information on microbial colonization in cervical mucus is unknown. We investigated pattern of microbiota in the cervical mucus collected from women with and without endometriosis using next-generation sequencing (NGS) technology. Method of study: Cervical mucus samples were collected from women with (n = 30) and without (n = 39) endometriosis. The communities of microbiota in cervical mucus in the endometriosis group and the control group were examined by Gram staining and NGS targeting the V5-V6 region of 16S ribosomal RNA gene. Copy number of some target bacteria was detected by real-time PCR. Results: We confirmed visual presence of bacteria in cervical mucus by Gram staining. NGS analysis showed that distribution of microbiota was similar in cervical mucus of women with and without endometriosis regardless of the phases of the menstrual cycle. In addition to predominant Lactobacilli spp., the populations of Corynebacterium, Enterobacteriaceae, Flavobacterium, Pseudomonas, and Streptococcus were increased in the endometriosis group. Of them, Enterobacteriaceae and Streptococcus were identified as the more significant candidates in the endometriosis group than in controls by real-time PCR (P < 0.05 for each). Conclusion: Our NGS analysis of cervical mucus indicated that among a variable microbiota, two candidates (Enterobacteriaceae and Streptococcus) were more frequently detected in women with endometriosis. Further investigation is needed to elucidate a mechanistic link of these bacteria in the pathophysiology of endometriosis.
MeSH term(s)	Adult ; Bacteria/classification ; Bacteria/genetics ; Cervix Mucus/microbiology ; Corynebacterium/genetics ; Corynebacterium/isolation & purification ; Endometriosis/microbiology ; Enterobacteriaceae/genetics ; Enterobacteriaceae/isolation & purification ; Female ; Flavobacterium/genetics ; Flavobacterium/isolation & purification ; Gentian Violet ; High-Throughput Nucleotide Sequencing ; Humans ; Lactobacillus/genetics ; Lactobacillus/isolation & purification ; Microbiota/genetics ; Phenazines ; Pseudomonas/genetics ; Pseudomonas/isolation & purification ; RNA, Ribosomal, 16S/genetics ; Real-Time Polymerase Chain Reaction ; Streptococcus/genetics ; Streptococcus/isolation & purification ; Young Adult
Chemical Substances	Gram's stain ; Phenazines ; RNA, Ribosomal, 16S ; Gentian Violet (J4Z741D6O5)
Language	English
Publishing date	2019-05-24
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.13147
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1653: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito