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Article ; Online: DENV-1 genotype V circulation during the nonepidemic period in the Northeast of São Paulo State endemic area.

de La-Roque, Debora Glenda Lima / Santos, Elaine Vieira / Oliveira, Renata Aparecida Machado / Slavov, Svetoslav Nanev / Rodrigues, Evandra S / Fonseca, Vagner / Martins, Antonio Jorge / Giomo, Denise Bergamaschi / Torres, Paula Marilia Afonso / Gentil, Danielle Cristina Dacanal / Catoia, Erika Aparecida / Chiquito, Natalia do Carmo / Medeiros, Alessandra Paula Silva Soares / Yamamoto, Aparecida Y / Passos, Luzia Márcia Romanholi / Calado, Rodrigo Tocantins / Barros, Claudia Renata Dos Santos / Elias, Maria Carolina / Sampaio, Sandra Coccuzzo /

Giovanetti, Marta / Junior Alcantara, Luiz Carlos / Covas, Dimas T / Kashima, Simone

Journal of medical virology

2024 Volume 96, Issue 3, Page(s) e29526

MeSH term(s)	Humans ; Brazil/epidemiology ; Dengue Virus/genetics ; Dengue/epidemiology ; Genotype
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29526
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Article: Genomics-based timely detection of Dengue Virus type I genotypes I and V in Uruguay.

Morel, Noelia / Giovanetti, Marta / Fonseca, Vagner / Burgueño, Analía / Lima, Mauricio / Castro, Emerson / Guimarães, Natália R / Iani, Felipe C M / Bormida, Victoria / Cortinas, Maria Noel / Ramas, Viviana / Coppola, Leticia / Bento, Ana I / Rosewell, Alexander / Franco, Leticia / Rico, Jairo Mendez / Lourenço, José / Alcantara, Luiz Carlos Junior / Chiparelli, Hector

medRxiv : the preprint server for health sciences

2023

Abstract: We report the first whole-genome sequences of Dengue Virus type I genotypes I and V from Uruguay ...

Abstract	We report the first whole-genome sequences of Dengue Virus type I genotypes I and V from Uruguay, including the first cases ever reported in the country. Through timely genomic analysis, identification of these genotypes was possible, aiding in timely public health responses and intervention strategies to mitigate the impact of dengue outbreaks.
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.05.23295075
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Article: The dermal deposits in the finger of the Holy Roman Emperor Charles I of Spain and V of Germany.

Fernandez-Flores, Angel / Fonseca, Eduardo

Frontiers in medicine

2024 Volume 10, Page(s) 1287041

Abstract: Charles I of Spain and V of Germany was one of the most prominent figures in Christendom. The vast ...

Abstract	Charles I of Spain and V of Germany was one of the most prominent figures in Christendom. The vast empire ruled by the monarch extended across multiple continents. However, the final years of his life were overshadowed by depression and incapacitating joint degeneration, leading him to retire to the Monastery of Yuste in Cáceres, Spain. It was there that he contracted malaria, a disease that ultimately claimed his life. In this article, we evaluate the studies conducted on one of his mummified fingers to confirm the presence of malaria and investigate the cause of his joint degeneration, which was attributed to intense deposits of uric acid.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1287041
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Article ; Online: The dermal deposits in the finger of the Holy Roman Emperor Charles I of Spain and V of Germany

Angel Fernandez-Flores / Eduardo Fonseca

Frontiers in Medicine, Vol

2024 Volume 10

Abstract: Charles I of Spain and V of Germany was one of the most prominent figures in Christendom. The vast ...

Abstract	Charles I of Spain and V of Germany was one of the most prominent figures in Christendom. The vast empire ruled by the monarch extended across multiple continents. However, the final years of his life were overshadowed by depression and incapacitating joint degeneration, leading him to retire to the Monastery of Yuste in Cáceres, Spain. It was there that he contracted malaria, a disease that ultimately claimed his life. In this article, we evaluate the studies conducted on one of his mummified fingers to confirm the presence of malaria and investigate the cause of his joint degeneration, which was attributed to intense deposits of uric acid.
Keywords	Charles V ; Yuste ; malaria ; gout ; Zulueta ; Paludism Charles V ; Medicine (General) ; R5-920
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

Vincendeau, Estelle / Wei, Wenming / Zhang, Xuefei / Planchais, Cyril / Yu, Wei / Lenden-Hasse, Hélène / Cokelaer, Thomas / Pipoli da Fonseca, Juliana / Mouquet, Hugo / Adams, David J / Alt, Frederick W / Jackson, Stephen P / Balmus, Gabriel / Lescale, Chloé / Deriano, Ludovic

Nature communications

2022 Volume 13, Issue 1, Page(s) 3707

Abstract: ... While 53BP1 is essential for immunoglobulin heavy chain class switch recombination (CSR), long-range V(D)J ... remains elusive. Here we report that SHLD1 is dispensable for lymphocyte development and RAG-mediated V(D ... that 53BP1 promotes V(D)J recombination and CSR through two distinct mechanisms: SHLD-independent synapsis ...

Abstract	SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 53BP1 is essential for immunoglobulin heavy chain class switch recombination (CSR), long-range V(D)J recombination and repair of RAG-induced DSBs in XLF-deficient cells, the function of SHLD during these processes remains elusive. Here we report that SHLD1 is dispensable for lymphocyte development and RAG-mediated V(D)J recombination, even in the absence of XLF. By contrast, SHLD1 is essential for restricting resection at AID-induced DSB ends in both NHEJ-proficient and NHEJ-deficient B cells, providing an end-protection mechanism that permits productive CSR by NHEJ and alternative end-joining. Finally, we show that this SHLD1 function is required for orientation-specific joining of AID-initiated DSBs. Our data thus suggest that 53BP1 promotes V(D)J recombination and CSR through two distinct mechanisms: SHLD-independent synapsis of V(D)J segments and switch regions within chromatin, and SHLD-dependent protection of AID-DSB ends against resection.
MeSH term(s)	DNA Breaks, Double-Stranded ; DNA End-Joining Repair ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Immunoglobulin Class Switching/genetics ; V(D)J Recombination/genetics
Chemical Substances	DNA-Binding Proteins
Language	English
Publishing date	2022-06-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-31287-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity".

Journal of medicinal chemistry

2022 Volume 65, Issue 7, Page(s) 5449–5461

Abstract: Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive ... ...

Abstract	Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive allosteric modulators (PAMs) of GLP-1R, including oral administration and reduced unwanted effects, could improve the utility of this class of drugs. Here, we describe the discovery of compound
MeSH term(s)	Administration, Oral ; Animals ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Obesity/drug therapy ; Peptides/therapeutic use
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Peptides
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.1c01842
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Article ; Online: A Germline-Encoded Structural Arginine Trap Underlies the Anti-DNA Reactivity of a Murine V Gene Segment.

Dos Santos Araújo, Ronny Petterson / França, Renato Kaylan Alves / Valadares, Napoleão Fonseca / Maranhão, Andrea Queiroz / Brigido, Marcelo Macedo

International journal of molecular sciences

2021 Volume 22, Issue 9

Abstract: ... we previously found a V segment from V ...

Abstract	Autoimmunity may have its origins of early repertoire selection in developmental B cells. Such a primary repertoire is probably shaped by selecting B cells that can efficiently perform productive signaling, stimulated by self-antigens in the bone marrow, such as DNA. In support of that idea, we previously found a V segment from V
MeSH term(s)	Amino Acid Sequence/genetics ; Animals ; Antibodies, Antinuclear/genetics ; Arginine/genetics ; Arginine/metabolism ; Autoantigens/genetics ; Autoimmunity/immunology ; Base Sequence/genetics ; DNA/immunology ; Germ Cells/immunology ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Heavy Chains/metabolism ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/metabolism ; Immunoglobulin Variable Region/ultrastructure ; Mice ; Single-Domain Antibodies/genetics ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/ultrastructure ; Structure-Activity Relationship
Chemical Substances	Antibodies, Antinuclear ; Autoantigens ; Immunoglobulin Heavy Chains ; Immunoglobulin Variable Region ; Single-Domain Antibodies ; DNA (9007-49-2) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22094541
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Article ; Online: Leishmania (V.) braziliensis infection promotes macrophage autophagy by a LC3B-dependent and BECLIN1-independent mechanism.

Duque, Thabata Lopes Alberto / Serrão, Thamires Christinne de Souza Lopes Cruz / Gonçalves, Antônio José da Silva / Pinto, Eduardo Fonseca / Oliveira-Neto, Manoel Paes / Pirmez, Claude / Pereira, Luiza de Oliveira Ramos / Menna-Barreto, Rubem Figueiredo Sadok

Acta tropica

2021 Volume 218, Page(s) 105890

Abstract: Leishmania (Viannia) braziliensis is one of the main etiological agents of tegumentary leishmaniasis in Latin America. The establishment of a successful infection in host cells requires several key events including phagocytosis, phagolysosomal maturation ...

Abstract	Leishmania (Viannia) braziliensis is one of the main etiological agents of tegumentary leishmaniasis in Latin America. The establishment of a successful infection in host cells requires several key events including phagocytosis, phagolysosomal maturation impairment, and parasite replication. Autophagy is accountable for the physiological turnover of cellular organelles, degradation of macromolecular structures, and pathogen elimination. In many cases, autophagy control leads to a successful infection, both impairing pathogen elimination or providing nutrients. Here, we have investigated the relationship between autophagy and L. braziliensis infection. We observed that BECLIN1 expression was upregulated early on infection in both in vitro macrophage cultures and biopsies of cutaneous lesions from L. braziliensis infected patients. On the other hand, LC3B expression was downregulated in cutaneous lesions biopsies. A transient pattern of LC3+ cells was observed along L. braziliensis infection, but the number of LC3 puncta did not vary. Additionally, autophagy induction, with rapamycin treatment or through starvation, reduced infection. As expected, rapamycin increased the percentage of LC3+ cells and the number of puncta, but the presence of parasite restricted this effect, indicating LC3-associated autophagy impairment by L. braziliensis. Finally, silencing LC3B but not BECLIN1 promoted infection, confirming BECLIN1 independent and LC3B-related control by the parasite. Taken together, these data indicate macrophage autophagic machinery manipulation by L. braziliensis, resulting in successful establishment and survival into the host cell.
MeSH term(s)	Animals ; Autophagy ; Beclin-1/metabolism ; Female ; Humans ; Leishmania braziliensis/physiology ; Leishmaniasis, Cutaneous/immunology ; Leishmaniasis, Cutaneous/metabolism ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/parasitology ; Microtubule-Associated Proteins/metabolism ; Phagocytosis
Chemical Substances	Beclin-1 ; MAP1LC3B protein, human ; Microtubule-Associated Proteins
Language	English
Publishing date	2021-03-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.105890
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Article ; Online: V Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose.

Xavier, H T / Izar, M C / Faria Neto, J R / Assad, M H / Rocha, V Z / Sposito, A C / Fonseca, F A / dos Santos, J E / Santos, R D / Bertolami, M C / Faludi, A A / Martinez, T L R / Diament, J / Guimarães, A / Forti, N A / Moriguchi, E / Chagas, A C P / Coelho, O R / Ramires, J A F

Arquivos brasileiros de cardiologia

2013 Volume 101, Issue 4 Suppl 1, Page(s) 1–20

Title translation	V Brazilian Guidelines on Dyslipidemias and Prevention of Atherosclerosis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Atherosclerosis/prevention & control ; Atherosclerosis/therapy ; Biomarkers/blood ; Cardiovascular Diseases/etiology ; Child ; Cholesterol/blood ; Cholesterol Esters/blood ; Dyslipidemias/blood ; Dyslipidemias/prevention & control ; Dyslipidemias/therapy ; Fatty Acids/metabolism ; Female ; Fibric Acids/metabolism ; Humans ; Hypercholesterolemia/blood ; Hypertriglyceridemia/blood ; Life Expectancy ; Lipoproteins/metabolism ; Male ; Middle Aged ; Risk Factors ; Triglycerides/blood
Chemical Substances	Biomarkers ; Cholesterol Esters ; Fatty Acids ; Fibric Acids ; Lipoproteins ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	Portuguese
Publishing date	2013
Publishing country	Brazil
Document type	Journal Article ; Practice Guideline
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.2013S010
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Article ; Online: Dataset on the RETRO-BMC cruise onboard the R/V Hespérides, April 2017, Brazil-Malvinas Confluence.

Orúe-Echevarría, Dorleta / Pelegrí, Josep L / Castellanos, Paola / Guallar, Carles / Marotta, Humberto / Marrasé, Cèlia / Martín, Jacobo / Masdeu-Navarro, Marta / Paniagua, Guillermina F / Peña-Izquierdo, Jesús / Puigdefábregas, Joan / Rodríguez-Fonseca, Belén / Roget, Elena / Rosell-Fieschi, Miquel / Salat, Jordi / Salvador, Joaquín / Vallès-Casanova, Ignasi / Vidal, Montserrat / Viúdez, Álvaro

Data in brief

2020 Volume 30, Page(s) 105412

Abstract: ... onboard R/V Hespérides, departing from Ushuaia and arriving to Santos. Along its track, the vessel ...

Abstract	This dataset, gathered during the RETRO-BMC cruise, reports multiple-scale measurements at the Confluence of the Brazil and Malvinas Currents. The cruise was carried out between 8 and 28 April 2017 onboard R/V Hespérides, departing from Ushuaia and arriving to Santos. Along its track, the vessel recorded near-surface temperature and salinity, as well as the horizontal flow from 20 m down to about 800 m. A total of 33 hydrographic stations were completed in a region off the Patagonian Shelf, within 41.2°S-35.9°S and out to 53.0°W. At each station, a multiparametric probe and velocity sensors were deployed inside the frame of a rosette used to collect water samples at selected depths; these samples were later used for several water analyses, including inorganic nutrient concentrations. Microstructure measurements were carried out in 11 of these hydrographic stations. In addition, two high-resolution three-dimensional surveys were conducted with an instrumented undulating vehicle between 40.6°S-39.0°S and 55.6°W-53.8°W. Lastly, eight high-frequency vertical profilers were deployed in the region and five position-transmitting drifters were launched. These data allow the description of the Confluence from the regional scale to the microscale, and provide a view of the variability of the frontal region on time scales from days to weeks.
Language	English
Publishing date	2020-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.105412
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