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Article ; Online: Authors' response.

Shang, Ren / Gao, Limin

Journal of the American Dental Association (1939)

2021 Volume 152, Issue 8, Page(s) 587

Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2021.06.006
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Article ; Online: Conformation-Activity Mechanism of Alcalase Hydrolysis for Reducing In Vitro Allergenicity of Instant Soy Milk Powder.

Ding, Jie / Qi, Libo / Zhong, Limin / Shang, Shan / Zhu, Chunyan / Lin, Songyi

Journal of agricultural and food chemistry

2024

Abstract: Effective reduction of the allergenicity of instant soy milk powder (ISMP) is practically valuable for expanding its applications. This study optimized the enzymolysis technology of ISMP using single-factor experiments and response surface methodology, ... ...

Abstract	Effective reduction of the allergenicity of instant soy milk powder (ISMP) is practically valuable for expanding its applications. This study optimized the enzymolysis technology of ISMP using single-factor experiments and response surface methodology, combined serological analysis, cellular immunological models, bioinformatics tools, and multiple spectroscopy techniques to investigate the effects of alcalase hydrolysis on allergenicity, spatial conformation, and linear epitopes of ISMP. Under the optimal process, special IgE and IgG1 binding abilities and allergenic activity to induce cell degranulation of alcalase-hydrolyzed ISMP were reduced by (64.72 ± 1.76)%, (56.79 ± 3.72)%, and (73.3 ± 1.19)%, respectively (
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c00767
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Article ; Online: Impact of hyperglycemia on the rate of implant failure and peri-implant parameters in patients with type 2 diabetes mellitus: Systematic review and meta-analysis.

Shang, Ren / Gao, Limin

Journal of the American Dental Association (1939)

2021 Volume 152, Issue 3, Page(s) 189–201.e1

Abstract: Background: The impact of hyperglycemia on dental implant therapy remains unclear. In this systematic review and meta-analysis, the authors compared the rates of implant failure and peri-implant bleeding on probing (BOP), probing depth (PD), and peri- ... ...

Abstract	Background: The impact of hyperglycemia on dental implant therapy remains unclear. In this systematic review and meta-analysis, the authors compared the rates of implant failure and peri-implant bleeding on probing (BOP), probing depth (PD), and peri-implant bone loss (PIBL) among patients with type 2 diabetes mellitus and nondiabetic patients. The authors performed subgroup analyses based on glycemic level to evaluate whether patients with higher glycemic levels were more prone to peri-implant inflammation. Type of studies reviewed: The authors searched 4 databases for original clinical studies. Studies in which the researchers provided information on the rate of implant failure or peri-implant parameters were included. Results: Nine clinical studies were identified on the basis of the inclusion criteria. No significant differences were found in rates of implant failure (P = .46) and PD (P = .1) between diabetic and nondiabetic patients. Significant differences in BOP (P < .00001) and PIBL (P = .02), favoring nondiabetic patients, were observed. Results of subgroup analyses indicated that the increase in glycemic level did not significantly influence BOP, PD, and PIBL values among diabetic patients. Conclusions and practical implications: Patients with type 2 diabetes mellitus seem to be able to achieve a rate of implant survival similar to that of healthy patients. Regarding peri-implant parameters, BOP and PIBL were higher in patients with type 2 diabetes mellitus, indicating that hyperglycemia is an important risk factor for peri-implant inflammation. No association was found between peri-implant parameters and glycemic level among patients with type 2 diabetes mellitus, providing oral hygiene was strictly maintained.
MeSH term(s)	Alveolar Bone Loss ; Dental Implants ; Dental Plaque Index ; Diabetes Mellitus, Type 2/complications ; Humans ; Hyperglycemia/etiology ; Peri-Implantitis ; Periodontal Index
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2020.11.015
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Article ; Online: Spontaneously ruptured multilocular cystic nephroma in an infant.

Xu, Ling / Wang, Limin / Tian, Xiangying / Gai, Yuanyuan / Shang, Ning

Journal of clinical ultrasound : JCU

2022

Abstract: We present the case of a 10-month-old girl with spontaneously ruptured cystic nephroma with a 1-week-old abdominal mass and a 1-day history of marked abdominal distension. The tumor presented as gourd-shaped, cystic solid mass in the right kidney with ... ...

Abstract	We present the case of a 10-month-old girl with spontaneously ruptured cystic nephroma with a 1-week-old abdominal mass and a 1-day history of marked abdominal distension. The tumor presented as gourd-shaped, cystic solid mass in the right kidney with fluid collection. The tumor was successfully removed by urgent surgery. The girl remained in good condition throughout six-month follow-up after.
Language	English
Publishing date	2022-07-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23267
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Zs.A 1186: Show issues

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Article ; Online: Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer's Disease.

Ma, Limin / Wang, Fengyu / Chen, Shuai / Wang, Shenghui / Wang, Zhenzhen / Xia, Mingrong / Li, Yongli / Ma, Huimin / Shang, Junkui / Zhang, Jiewen

Neuromolecular medicine

2024 Volume 26, Issue 1, Page(s) 6

Abstract: Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant inherited AD. ... ...

Abstract	Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant inherited AD. This study aimed to demonstrate a Chinese early-onset AD pedigree presenting as progressive memory impairment, apraxia, visual-spatial disorders, psychobehavioral disorders, and personality changes with a novel APP gene mutation. The family contains four patients, three carries and three normal family members. The proband underwent brain magnetic resonance imaging (MRI),
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Amyloid beta-Protein Precursor/genetics ; Fluorodeoxyglucose F18 ; Mutation ; China ; Presenilin-1/genetics ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Ethylene Glycols
Chemical Substances	florbetapir (6867Q6IKOD) ; Amyloid beta-Protein Precursor ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Presenilin-1 ; Amyloid beta-Peptides ; Aniline Compounds ; Ethylene Glycols
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2077809-0
ISSN	1559-1174 ; 1535-1084
ISSN (online)	1559-1174
ISSN	1535-1084
DOI	10.1007/s12017-023-08770-1
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Zs.A 5818: Show issues

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Article ; Online: Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain.

Wu, Shang / Zhang, Limin / Wang, Weizhi

Analytical chemistry

2022 Volume 94, Issue 33, Page(s) 11464–11469

Abstract: A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows ... ...

Abstract	A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.
MeSH term(s)	Humans ; Peptides/chemistry ; Prions ; Protein Binding ; Protein Conformation, alpha-Helical ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; COVID-19 Drug Treatment
Chemical Substances	Peptides ; Prions ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c02223
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Article ; Online: Selective CD47 targeting with a bispecific antibody.

Ferlin, Walter / Masternak, Krzysztof / Shang, Limin

Cancer immunology, immunotherapy : CII

2021 Volume 70, Issue 4, Page(s) 1161–1162

MeSH term(s)	Animals ; Antibodies, Bispecific/immunology ; Antibodies, Bispecific/pharmacology ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; CD47 Antigen/antagonists & inhibitors ; CD47 Antigen/immunology ; CD47 Antigen/metabolism ; Humans ; Immunotherapy/methods ; Molecular Targeted Therapy/methods ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy
Chemical Substances	Antibodies, Bispecific ; B7-H1 Antigen ; CD47 Antigen
Language	English
Publishing date	2021-01-02
Publishing country	Germany
Document type	Letter
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-020-02812-4
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Article ; Online: Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing.

Shang, Limin / Yu, Yixin / Jiang, Yujie / Liu, Xinyu / Sui, Ning / Yang, Dongqin / Zhu, Zhiling

ACS nano

2023 Volume 17, Issue 16, Page(s) 15962–15977

Abstract: Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by the diversity and synergy of drug ... ...

Abstract	Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by the diversity and synergy of drug functions as well as the DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine and ultrasmall gold nanoparticles and Cu
MeSH term(s)	Humans ; Hydrogels/pharmacology ; Blood Glucose ; Gold ; Metal Nanoparticles/therapeutic use ; Diabetes Mellitus ; Wound Healing ; Peroxidase ; Superoxide Dismutase ; Antioxidants ; Glucose Oxidase
Chemical Substances	Hydrogels ; Blood Glucose ; Gold (7440-57-5) ; Peroxidase (EC 1.11.1.7) ; Superoxide Dismutase (EC 1.15.1.1) ; Antioxidants ; Glucose Oxidase (EC 1.1.3.4)
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c04134
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Article: Screened α-Helix Peptide Inhibitor toward SARS-CoV-2 by Blocking a Prion-like Domain in the Receptor Binding Domain

Wu, Shang / Zhang, Limin / Wang, Weizhi

Analytical chemistry. 2022 July 11, v. 94, no. 33

2022

Abstract	A new peptide inhibitor was designed and optimized from an α-helix-rich peptide library specifically toward the critical prion-like domain (PLD) of SARS-CoV-2. It compactly blocked the S1 protein and potently neutralized the pseudovirus which shows promising potential for prophylactic and treatment of COVID-19.
Keywords	COVID-19 infection ; Pseudovirus ; Severe acute respiratory syndrome coronavirus 2 ; analytical chemistry ; peptide libraries
Language	English
Dates of publication	2022-0711
Size	p. 11464-11469.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c02223
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Article: American college of radiology ovarian-adnexal reporting and data system ultrasound (O-RADS): Diagnostic performance and inter-reviewer agreement for ovarian masses in children.

Wang, Huimin / Wang, Limin / An, Siwei / Ma, Qiuping / Tu, Yanping / Shang, Ning / Pan, Yunxiang

Frontiers in pediatrics

2023 Volume 11, Page(s) 1091735

Abstract: Objective: To evaluate the diagnostic performance and inter-observer agreement of the American College of Radiology Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS) in the diagnosis of ovarian masses in children.: Methods: From June 2012 ...

Abstract	Objective: To evaluate the diagnostic performance and inter-observer agreement of the American College of Radiology Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS) in the diagnosis of ovarian masses in children. Methods: From June 2012 to December 2021, 163 ovarian masses in 159 patients with pathologic results were retrospectively analyzed. Each mass was classified into an O-RADS category according to the criteria. The diagnostic performance of O-RADS for detecting malignant ovarian masses was assessed using histopathology as the reference standard. Kappa ( Results: Out of 163 ovarian masses, 18 (11.0%) were malignant and 145 (89.0%) were benign. The malignancy rates of O-RADS 5, O-RADS 4, and O-RADS 3 masses were 72.7%, 34.6%, and 4.8%, respectively. The area under the receiver operating characteristic curve was 0.944 (95% CI, 0.908-0.981). The optimal cutoff value for predicting malignant ovarian masses was > O-RADS 3 with a sensitivity, specificity, and accuracy of 94.4%, 86.2% and 86.2% respectively. The inter-observer agreement of the O-RADS category was good ( Conclusions: O-RADS has a high diagnostic performance for children with ovarian masses. It provides an effective malignant risk classification for ovarian masses in children, which shows high consistency between radiologists with different levels of experience.
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1091735
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