LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 469

Search options

  1. Article: Pediatric Brain Maturation and Migration Disorders.

    Barkovich, Matthew J

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: Neurodevelopmental disorders, including neuronal migration disorders, are best understood in the context of altered normal development. Neurons normally migrate from their site of origin to their (usually cortical) destination using a wide range of ... ...

    Abstract Neurodevelopmental disorders, including neuronal migration disorders, are best understood in the context of altered normal development. Neurons normally migrate from their site of origin to their (usually cortical) destination using a wide range of molecular and cellular signaling as a guide. In the case of abnormal migration neurons: (1) do not migrate and remain at their site of origin; (2) incompletely migrate and remain within the white matter; (3) migrate to the cortex but fail to organize correctly; or (4) over-migrate, beyond the cortex. In this review, we discuss normal brain development, along with the malformations that result from these different migration abnormalities.
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12051123
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Pediatric neuroimaging

    Barkovich, Anthony James / Raybaud, Charles

    2012  

    Author's details eds. A. James Barkovich ; Charles Raybaud
    Keywords Central Nervous System Diseases / diagnosis ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging ; Infant ; Child ; Nervous system/Magnetic resonance imaging ; Nervous system/Ultrasonic imaging ; Pediatric diagnostic imaging ; Neuroradiologie ; Kind
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size XVII, 1125 S. : zahlr. Ill.
    Edition 5. ed.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT016950636
    ISBN 978-1-60547-714-5 ; 1-60547-714-1
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3419 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Technical and practical tips for performing brain magnetic resonance imaging in premature neonates.

    Barkovich, Matthew J / Williams, Cassandra / Barkovich, A James

    Seminars in perinatology

    2021  Volume 45, Issue 7, Page(s) 151468

    Abstract: MR imaging of premature neonates is challenging due to their small size, need for temperature support and monitoring, and immature central nervous system. Use of MR compatible incubators and MR compatible monitoring apparatus, careful selection of ... ...

    Abstract MR imaging of premature neonates is challenging due to their small size, need for temperature support and monitoring, and immature central nervous system. Use of MR compatible incubators and MR compatible monitoring apparatus, careful selection of imaging protocols, and real time review of images by a radiologist can streamline the imaging process and improve image quality. Imaging should be focused upon (1) the child's biorhythms (imaging during sleep cycles), (2) minimizing delays during transport and (3) delaying noisy MR sequences until the end of an examination. Successful imaging of premature neonates requires teamwork: advanced planning, careful communication among neonatologists, nurses, and radiologists, established imaging protocols, and coordination among team members during all aspects of the process.
    MeSH term(s) Brain/diagnostic imaging ; Child ; Equipment Design ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Magnetic Resonance Imaging
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1016/j.semperi.2021.151468
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1339: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: MR Imaging of Normal Brain Development.

    Barkovich, Matthew J / Barkovich, Anthony James

    Neuroimaging clinics of North America

    2019  Volume 29, Issue 3, Page(s) 325–337

    Abstract: Normal brain development is best evaluated by MR imaging in the fetal and pediatric patient. As the developing brain grows, myelinates, and sulcates rapidly, understanding the normal appearance of the brain throughout development is critical. The fetal ... ...

    Abstract Normal brain development is best evaluated by MR imaging in the fetal and pediatric patient. As the developing brain grows, myelinates, and sulcates rapidly, understanding the normal appearance of the brain throughout development is critical. The fetal brain can be evaluated by MR imaging after 16 weeks gestational age, both morphologically and biometrically. Sulcation of the fetal brain lags behind premature neonates of equivalent gestational age. Sensory axons generally myelinate before motor axons with central to peripheral and dorsal to ventral myelination gradients. By 2 years of age, the brain has a near adult appearance by conventional anatomic MR imaging.
    MeSH term(s) Brain/diagnostic imaging ; Brain/growth & development ; Humans ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging/methods ; Reference Values
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1314594-0
    ISSN 1557-9867 ; 1052-5149
    ISSN (online) 1557-9867
    ISSN 1052-5149
    DOI 10.1016/j.nic.2019.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 1309: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Pediatric neuroimaging

    Barkovich, Anthony James

    2005  

    Author's details A. James Barkovich
    Keywords Central Nervous System Diseases / diagnosis ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging ; Infant ; Child ; Nervous system/Magnetic resonance imaging ; Nervous system/Ultrasonic imaging ; Pediatric diagnostic imaging ; Neuroradiologie ; Kind
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Subject code 618.928047548
    Language English
    Size XXIV, 932 S. : zahlr. Ill.
    Edition 4. ed
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014330312
    ISBN 0-7817-5766-5 ; 978-0-7817-5766-9
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 2505 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Pediatric Brain Maturation and Migration Disorders

    Matthew J. Barkovich

    Diagnostics, Vol 12, Iss 1123, p

    2022  Volume 1123

    Abstract: Neurodevelopmental disorders, including neuronal migration disorders, are best understood in the context of altered normal development. Neurons normally migrate from their site of origin to their (usually cortical) destination using a wide range of ... ...

    Abstract Neurodevelopmental disorders, including neuronal migration disorders, are best understood in the context of altered normal development. Neurons normally migrate from their site of origin to their (usually cortical) destination using a wide range of molecular and cellular signaling as a guide. In the case of abnormal migration neurons: (1) do not migrate and remain at their site of origin; (2) incompletely migrate and remain within the white matter; (3) migrate to the cortex but fail to organize correctly; or (4) over-migrate, beyond the cortex. In this review, we discuss normal brain development, along with the malformations that result from these different migration abnormalities.
    Keywords neurodevelopmental disorders ; migration disorders ; brain development ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: iRGD-targeted Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Delivery.

    Barkovich, Krister J / Zhao, Zhongchao / Steinmetz, Nicole F

    Small science

    2023  Volume 3, Issue 8

    Abstract: Nanomedicine provides a promising platform for the molecular treatment of disease. An ongoing challenge in nanomedicine is the targeted delivery of intravenously administered nanoparticles to particular tissues, which is of special interest in cancer. In ...

    Abstract Nanomedicine provides a promising platform for the molecular treatment of disease. An ongoing challenge in nanomedicine is the targeted delivery of intravenously administered nanoparticles to particular tissues, which is of special interest in cancer. In this study, we show that the conjugation of iRGD peptides, which specifically target tumor neovasculature, to the surface of Physalis mottle virus (PhMV)-like nanoparticles leads to rapid cellular uptake
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3042766-6
    ISSN 2688-4046 ; 2688-4046
    ISSN (online) 2688-4046
    ISSN 2688-4046
    DOI 10.1002/smsc.202300067
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Physalis Mottle Virus-Like Nanocarriers with Expanded Internal Loading Capacity.

    Barkovich, Krister J / Wu, Zhuohong / Zhao, Zhongchao / Simms, Andrea / Chang, Eric Y / Steinmetz, Nicole F

    Bioconjugate chemistry

    2023  Volume 34, Issue 9, Page(s) 1585–1595

    Abstract: An ongoing challenge in precision medicine is the efficient delivery of therapeutics to tissues/organs of interest. Nanoparticle delivery systems have the potential to overcome traditional limitations of drug and gene delivery through improved ... ...

    Abstract An ongoing challenge in precision medicine is the efficient delivery of therapeutics to tissues/organs of interest. Nanoparticle delivery systems have the potential to overcome traditional limitations of drug and gene delivery through improved pharmacokinetics, tissue targeting, and stability of encapsulated cargo. Physalis mottle virus (PhMV)-like nanoparticles are a promising nanocarrier platform which can be chemically targeted on the exterior and interior surfaces through reactive amino acids. Cargo-loading to the internal cavity is achieved with thiol-reactive small molecules. However, the internal loading capacity of these nanoparticles is limited by the presence of a single reactive cysteine (C75) per coat protein with low inherent reactivity. Here, we use structure-based design to engineer cysteine-added mutants of PhMV VLPs that display increased reactivity toward thiol-reactive small molecules. Specifically, the A31C and S137C mutants show a greater than 10-fold increased rate of reactivity towards thiol-reactive small molecules, and PhMV Cys1 (A31C), PhMV Cys2 (S137C), and PhMV Cys1+2 (double mutant) VLPs display up to three-fold increased internal loading of the small molecule chemotherapeutics aldoxorubicin and vcMMAE and up to four-fold increased internal loading of the MRI imaging reagent DOTA(Gd). These results further improve upon a promising plant virus-based nanocarrier system for use in targeted delivery of small-molecule drugs and imaging reagents in vivo.
    MeSH term(s) Cysteine ; Amino Acids ; Engineering ; Nanoparticles
    Chemical Substances Cysteine (K848JZ4886) ; Amino Acids
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.3c00269
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Pediatric MR neuroimaging

    Barkovich, Anthony James

    (Magnetic resonance imaging clinics of North America ; 9,1)

    2001  

    Author's details A. James Barkovich ..., guest ed
    Series title Magnetic resonance imaging clinics of North America ; 9,1
    Collection
    Language English
    Size X, 250 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013151972
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1375 -9,1- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: Pediatric neuroimaging

    Barkovich, Anthony James

    2000  

    Author's details A. James Barkovich
    Keywords Nervous System Diseases / child ; Nervous System Diseases / infant ; Magnetic Resonance Imaging / child ; Magnetic Resonance Imaging / infant ; Nervous System Diseases / diagnosis ; Tomography, X-Ray Computed / child ; Tomography, X-Ray Computed / infant ; Neuroradiologie ; Kind
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language English
    Size XXIII, 850 S. : zahlr. Ill.
    Edition 3. ed.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT011218517
    ISBN 0-7817-1740-X ; 978-0-7817-1740-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 712 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top