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Book ; Online ; E-Book: Acromegaly

Blevins Jr., Lewis S. / Aghi, Manish K.

a guide to diagnosis and treatment

(Contemporary endocrinology)

2022

Author's details	Lewis S. Blevins Jr., Manish K. Aghi editors
Series title	Contemporary endocrinology
Keywords	Electronic books
Language	English
Size	1 Online-Ressource (x, 298 Seiten), Illustrationen, Diagramme
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021684818
ISBN	978-3-031-16258-9 ; 9783031162572 ; 3-031-16258-7 ; 3031162579
DOI	10.1007/978-3-031-16258-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Conference proceedings: Hyperenhancement of Pituitary Neuroendocrine Tumors on Preoperative MRI: Implications on Tumor Characteristics and Outcomes

Osorio, Robert C. / Shih, Philip E. / Leng, Lynn / Lugo, Blanca Morales / Gupta, Shiv / Theodosopoulos, Philip V. / Kunwar, Sandeep / II, Jose Gurrola / El-Sayed, Ivan H. / Jr, Lewis S. Blevins / Aghi, Manish K.

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1780049
Database	Thieme publisher's database

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Article ; Conference proceedings: Machine Learning and Statistical Analysis of Biochemical Remission Predictors in Somatotroph Adenoma Resections

Osorio, Robert C. / Kabir, Aymen / Haddad, Alexander F. / Badani, Aarav / Khela, Harmon / Saha, Atul / Peeran, Zain / Theodosopoulos, Philip V. / Kunwar, Sandeep / II, Jose Gurrola / El-Sayed, Ivan H. / Jr, Lewis S. Blevins / Aghi, Manish K.

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1780160
Database	Thieme publisher's database

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Article ; Conference proceedings: Predictors of New Need for Postoperative Hormone Supplementation After Nonfunctional Pituitary Neuroendocrine Tumor Resection: A Retrospective Review of 701 Cases

Osorio, Robert C. / Ramesh, Rithvik / Quintana, Daniel / Lee, Giuliana N. / Theodosopoulos, Philip V. / Kunwar, Sandeep / II, Jose Gurrola / El-Sayed, Ivan H. / Jr, Lewis S. Blevins / Aghi, Manish K. / Goldschmidt, Ezequiel

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1780005
Database	Thieme publisher's database

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Article: Important Management Considerations in Patients with Pituitary Disorders during the Time of the Covid-19 Pandemic

Kevin, C. J. Yuen / Blevins, Lewis S. / Jr., / Findling, James W.

Endocrine Practice

Abstract: Objective: In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19) that resulted in a global pandemic with substantial morbidity and mortality ... ...

Abstract	Objective: In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19) that resulted in a global pandemic with substantial morbidity and mortality Currently, there is no specific treatment or approved vaccine against COVID-19 The underlying associated comorbidity and diminished immune function of some pituitary patients (whether caused by the disease and its sequelae or treatment with excess glucocorticoids) increases their risk of contracting and developing complications from COVID-19 infection Methods: A review of studies in PubMed and Google Scholar published between January 2020 to the time of writing (May 1, 2020) was conducted using the search terms ‘pituitary,’ ‘coronavirus,’ ‘COVID-19’, ‘2019-nCoV’, ‘diabetes mellitus’, ‘obesity’, ‘adrenal,’ and ‘endocrine ’ Results: Older age and pre-existing obesity, hypertension, cardiovascular disease, and diabetes mellitus increase the risk of hospitalization and death in COVID-19 patients Men tend to be more severely affected than women;fortunately, most men, particularly of younger age, survive the infection In addition to general comorbidities that may apply to many pituitary patients, they are also susceptible due to the following pituitary disorder–specific features: hypercortisolemia and adrenal suppression with Cushing disease, adrenal insufficiency and diabetes insipidus with hypopituitarism, and sleep-apnea syndrome and chest wall deformity with acromegaly Conclusion: This review aims to focus on the impact of COVID-19 in patients with pituitary disorders As most countries are implementing mobility restrictions, we also discuss how this pandemic has affected patient attitudes and impacted our decision-making on management recommendations for these patients Abbreviations: ACE = angiotensin-converting enzyme;AI = adrenal insufficiency;ARB = angiotensin receptor blocker;ARDS = acute respiratory disease syndrome;COVID-19 = coronavirus disease 2019;CPAP = continuous positive airway pressure;DI = diabetes insipidus;DM = diabetes mellitus;SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #827024
Database	COVID19

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Article ; Conference proceedings: Does Having a Primary Care Physician Predict Neurosurgical Outcomes? An Analysis of 225 Nonfunctional Pituitary Adenoma Resections across Seven Years

Osorio, Robert C. / Pereira, Matheus P. / Joshi, Rushikesh S. / Donohue, Kevin C. / Theodosopoulos, Philip V. / Kunwar, Sandeep / El-Sayed, Ivan H. / II, José Gurrola / Jr, Lewis S. Blevins / Sneed, Patricia / Braunstein, Steve / Aghi, Manish K.

Journal of Neurological Surgery Part B: Skull Base

2021 Volume 82, Issue S 02

Event/congress	Special Virtual Symposium of the North American Skull Base Society, Online, 2021-02-13
Language	English
Publishing date	2021-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0041-1725248
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

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Article ; Conference proceedings: Can Private versus Government Insurance Predict Neurosurgical Outcomes? An Analysis of 218 Nonfunctional Pituitary Adenoma Resections across Seven Years

Journal of Neurological Surgery Part B: Skull Base

2021 Volume 82, Issue S 02

Event/congress	Special Virtual Symposium of the North American Skull Base Society, Online, 2021-02-13
Language	English
Publishing date	2021-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0041-1725358
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

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Article: Long term outcome following repeat transsphenoidal surgery for recurrent endocrine-inactive pituitary adenomas

Chang, Edward F / Sughrue, Michael E / Zada, Gabriel / Wilson, Charles B / Blevins, Lewis S. Jr / Kunwar, Sandeep

Pituitary. 2010 Sept., v. 13, no. 3

2010

Abstract: It is widely accepted that the standard first-line treatment for most endocrine inactive pituitary macroadenomas (EIA) is surgery, usually via a transsphenoidal approach. What is less clear is what approach to take when these tumors recur, especially ... ...

Abstract	It is widely accepted that the standard first-line treatment for most endocrine inactive pituitary macroadenomas (EIA) is surgery, usually via a transsphenoidal approach. What is less clear is what approach to take when these tumors recur, especially when this recurrence involves areas which are difficult to surgically remove tumor from, such as the suprasellar region or cavernous sinuses. We present long term follow-up for a series of 81 patients who underwent repeat surgery for recurrent non-secreting pituitary adenomas. We analyzed data collected from all adult patients undergoing their second microsurgical transsphenoidal resection of a histologically proven endocrine-inactive pituitary adenoma at the University of California at San Francisco between January 1970 and March 2001. Data for these patients were collected by review of medical records, mail, and/or telephone interviews. Visual function, anterior pituitary function, and tumor control rates were analyzed for the series. Records were available for a total of 81 recurrent EIA patients. The median time between their initial and repeat operations was 4.1 years. The mean tumor size was 2.2 ± 0.2 cm. A total of 35/81 patients had greater than 5 years of follow-up. A total of 24/81 patients had greater than 10 years of follow-up. Over one half of these patients presented with visual disturbance, and we found that 39% of these patients experienced improved vision with a second surgery. More importantly, no one with normal vision suffered any appreciable decline in vision. Approximately, 35% of patients with pre-operative anterior pituitary dysfunction recovered function after surgery in our series; and no patient's function worsened. A total of 4/52 (8%) patients with greater than 2 years of post-op follow-up experienced a clinically meaningful tumor recurrence requiring additional treatment. Our data suggest that when performed by experienced transsphenoidal surgeons, durable tumor control can be obtained in these frequently locally aggressive tumors with acceptable rates of post-operative morbidity.
Language	English
Dates of publication	2010-09
Size	p. 223-229.
Publisher	Springer US
Publishing place	Boston
Document type	Article
ZDB-ID	1385151-2
ISSN	1573-7403 ; 1386-341X
ISSN (online)	1573-7403
ISSN	1386-341X
DOI	10.1007/s11102-010-0221-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Pre-operative dopamine agonist therapy improves post-operative tumor control following prolactinoma resection

Sughrue, Michael E / Chang, Edward F / Tyrell, J. Blake / Kunwar, Sandeep / Wilson, Charles B / Blevins, Lewis S. Jr

Pituitary. 2009 Sept., v. 12, no. 3

2009

Abstract: Objective Normalization of serum prolactin concentrations in patients with prolactinomas is an accepted endpoint of therapy. Clinical signs and symptoms of hyperprolactinemia are usually resolved when prolactin levels are lowered to within the normal ... ...

Abstract	Objective Normalization of serum prolactin concentrations in patients with prolactinomas is an accepted endpoint of therapy. Clinical signs and symptoms of hyperprolactinemia are usually resolved when prolactin levels are lowered to within the normal range. While most patients are treated with dopamine agonist drugs, some patients require surgical resection of their tumors. We sought to determine whether preoperative treatment with dopamine agonists alters the outcome of surgical intervention. Methods and results We present an analysis of 253 patients with prolactinomas treated surgically during the period of time when dopamine agonist therapy was first introduced and prior to its widespread use as first-line therapy. We compared both short- and long-term outcomes of patients treated with dopamine agonists prior to surgery with those undergoing surgery as their initial treatment modality. Our data showed that that patients treated with dopamine agonists prior to surgery experienced greater reductions in prolactin levels, had lower prolactin levels, were more likely to have normal prolactin levels at long term follow-up, and were less likely to require additional therapy to control their prolactin levels. Conclusion Our study provides strong evidence suggesting that, regardless of initial prolactin level, preoperative dopamine agonist therapy is not detrimental. In fact, pretreatment with dopamine agonist drugs, possibly by inducing tumor regression, seemed to improve the surgeon's ability to resect a greater percentage of the tumor and led to better control of the prolactin level.
Language	English
Dates of publication	2009-09
Size	p. 158-164.
Publisher	Springer US
Publishing place	Boston
Document type	Article
ZDB-ID	1385151-2
ISSN	1573-7403 ; 1386-341X
ISSN (online)	1573-7403
ISSN	1386-341X
DOI	10.1007/s11102-008-0135-1
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A comprehensive long-term retrospective analysis of silent corticotrophic adenomas vs hormone-negative adenomas.

Jahangiri, Arman / Wagner, Jeffrey R / Pekmezci, Melike / Hiniker, Anne / Chang, Edward F / Kunwar, Sandeep / Blevins, Lewis / Aghi, Manish K

Neurosurgery

2013 Volume 73, Issue 1, Page(s) 8–17; discussion 17–8

Abstract: Background: Silent corticotrophic adenomas (SCAs) stain adrenocorticotropic hormone (ACTH)+ without causing Cushing disease. SCAs are reportedly more aggressive, but information comes from small series.: Objective: To determine whether SCAs behave ... ...

Abstract	Background: Silent corticotrophic adenomas (SCAs) stain adrenocorticotropic hormone (ACTH)+ without causing Cushing disease. SCAs are reportedly more aggressive, but information comes from small series. Objective: To determine whether SCAs behave more aggressively than hormone-negative adenomas (HNAs), and characterize SCA ACTH production alterations. Methods: SCAs (n = 75) and HNAs (n = 1726) diagnosed at our institution from 1990 to 2011 were retrospectively reviewed. RT-PCR was used to compare expression of ACTH-producing factors. Results: SCA patients exhibited comparable sex and age as HNA patients (P = .7-.9). SCAs exhibited comparable size as HNAs (2.2 vs 2.0 cm, P = .2), with cavernous sinus invasion in 30% of SCAs vs 18% of HNAs (P = .03). SCA patients had higher mean preoperative serum ACTH (46 vs 19 ng/L; P = .005; normal = 5-27 ng/L), but comparable serum cortisol (13 vs 12 μg/dL; normal = 4-22 μg/dL; P < .05) as HNA patients. SCAs were gross totally resected 59% of the time, vs 53% for HNAs (P = .8). Kaplan-Meier 3-year progression/recurrence rates were 34% for strongly ACTH-positive Type I SCAs, 10% for weakly ACTH-positive Type II SCAs, and 6% for HNAs (P < .001 SCA vs HNA; P < .001 Type I vs HNA; and P = .08 Type II vs HNA). Expression of ACTH precursor pro-opiomelanocortin was 900-fold elevated in SCAs and 1300-fold elevated in Cushing disease-causing adenomas (CDCAs) vs HNAs (P < .001). Transcription of PC1/3, which cleaves pro-opiomelanocortin into ACTH, was 30-fold higher in CDCAs than SCAs (P = .02). Conclusion: In the largest series to date, SCAs exhibited comparable size, but increased cavernous sinus invasion and progression/recurrence vs HNAs. SCAs exhibit deficient pro-opiomelanocortin to ACTH conversion. Close follow-up is warranted for SCAs.
MeSH term(s)	ACTH-Secreting Pituitary Adenoma/blood ; ACTH-Secreting Pituitary Adenoma/epidemiology ; ACTH-Secreting Pituitary Adenoma/therapy ; Adenoma/blood ; Adenoma/epidemiology ; Adenoma/therapy ; Adolescent ; Adrenocorticotropic Hormone/blood ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Child ; Female ; Humans ; Hydrocortisone/blood ; Longitudinal Studies ; Male ; Middle Aged ; Neoplasm Recurrence, Local/blood ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Prevalence ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; San Francisco/epidemiology ; Sensitivity and Specificity ; Sex Distribution ; Treatment Outcome ; Young Adult
Chemical Substances	Biomarkers ; Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2013-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/01.neu.0000429858.96652.1e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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