Article ; Online: Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor.
2009 Volume 37, Issue 6, Page(s) 1994–1999
Abstract: Objective: To evaluate the use of a Na/H exchanger (NHE-1) inhibitor as a cardioprotective adjunct ...
| Abstract | Objective: To evaluate the use of a Na/H exchanger (NHE-1) inhibitor as a cardioprotective adjunct therapy to low-volume resuscitation in two different rat models of traumatic hemorrhagic shock. Design: Experimental, prospective study. Setting: Medical center research laboratory. Subjects: Sprague Dawley male rats. Interventions: Series 1: femur fracture was induced in anesthetized rats, followed by pressure-controlled hemorrhage (40 mm Hg for 20 minutes) and resuscitation. Groups: 1) no therapy; 2) 15 mL/kg hetastarch; and 3) 3 mg/kg benzamide, N-(aminoiminomethyl)-4-[4-(2-furanylcarbonyl)-1-piperazinyl]-3-(methylsulfonyl), methanesulfonate (BIIB513) (NHE-1 inhibitor) + 15 mL/kg hetastarch infusion over 40 minutes. The experiment was terminated at 6 hours after resuscitation. Series 2: the rats received laparotomy and closure under anesthesia and subsequently remained conscious for the rest of the study. The rats were subjected to volume-controlled hemorrhage (2.5 mL/100 g) followed by resuscitation as described in series 1. The experiment was terminated at 24 hours after resuscitation. Measurements and main results: Series 1: all animals in the no-therapy group died within 2 hours. Compared with hetastarch infusion alone, the addition of NHE-1 inhibitor improved the hemodynamic response to fluid resuscitation, increased blood oxygen content, prevented metabolic acidosis, and improved 6-hour survival (42% in hetastarch group vs. 80% in BIIB513 + hetastarch group). NHE-1 inhibition also resulted in reduced plasma levels of tumor necrosis factor-alpha, intercellular adhesion molecule-1, and C-reactive protein, and attenuated neutrophil infiltration in the liver. Series 2: all animals in the no-therapy group died within 4 hours after hemorrhage. Compared with hetastarch infusion alone, the addition of BIIB513 improved 24-hour survival (44% in hetastarch group vs. 78% in BIIB513 + hetastarch group). NHE-1 inhibition also reduced plasma levels alanine aminotransferase at 24 hours after resuscitation. Conclusions: NHE-1 inhibition facilitated the hemodynamic response to fluid resuscitation, attenuated tissue inflammatory injury, and organ dysfunction, but most importantly improved survival. |
|---|---|
| MeSH term(s) | Animals ; Male ; Mesylates/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Resuscitation/methods ; Shock, Hemorrhagic/etiology ; Shock, Hemorrhagic/therapy ; Sodium-Hydrogen Exchangers/antagonists & inhibitors ; Wounds and Injuries/complications |
| Chemical Substances | Mesylates ; Sodium-Hydrogen Exchangers ; BIIB 513 (Q6418LHE3S) |
| Language | English |
| Publishing date | 2009-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 197890-1 |
| ISSN | 1530-0293 ; 0090-3493 |
| ISSN (online) | 1530-0293 |
| ISSN | 0090-3493 |
| DOI | 10.1097/CCM.0b013e3181a0052e |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1261: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.