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Article ; Online: Localised erythema nodosum leprosum-A rare entity managed with thalidomide.

Patel, Chandni / De Barros, Barbara / Walker, Stephen L

Skin health and disease

2024 Volume 4, Issue 2, Page(s) e339

Abstract: Leprosy is caused ... ...

Abstract	Leprosy is caused by
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Case Reports
ISSN	2690-442X
ISSN (online)	2690-442X
DOI	10.1002/ski2.339
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Article: A comparative genomics study of the microbiome and freshwater resistome in Southern Pantanal.

de Oliveira, André R / de Toledo Rós, Bárbara / Jardim, Rodrigo / Kotowski, Nelson / de Barros, Adriana / Pereira, Ricardo H G / Almeida, Nalvo Franco / Dávila, Alberto M R

Frontiers in genetics

2024 Volume 15, Page(s) 1352801

Abstract: This study explores the resistome and bacterial diversity of two small lakes in the Southern Pantanal, one in Aquidauana sub-region, close to a farm, and one in Abobral sub-region, an environmentally preserved area. ...

Abstract	This study explores the resistome and bacterial diversity of two small lakes in the Southern Pantanal, one in Aquidauana sub-region, close to a farm, and one in Abobral sub-region, an environmentally preserved area.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2024.1352801
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Article ; Online: Cervical Pain in a Seventeen-year-old Girl.

Baptista de Lima, Joana / Barros, Bárbara / Mota Pinheiro, Isabel / Souto, José Paulo / Cerqueira Silva, Marta / Pires Borges, Joana / Machado, Leonilde / Pereira, Joana / Cunha, Joaquim

The Pediatric infectious disease journal

2024 Volume 43, Issue 6, Page(s) 606–608

MeSH term(s)	Humans ; Female ; Adolescent ; Neck Pain/etiology
Language	English
Publishing date	2024-05-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004303
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Zs.A 1852: Show issues

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Article ; Online: Single-dose rifampicin and BCG to prevent leprosy.

Lockwood, Diana N / De Barros, Barbara / Walker, Stephen L

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 92, Page(s) 269–270

MeSH term(s)	BCG Vaccine ; Chemoprevention ; Humans ; Immunization ; Leprosy ; Rifampin
Chemical Substances	BCG Vaccine ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2020-01-31
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.01.054
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Zs.A 4516: Show issues

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Article ; Online: Preoperative α1-Blockers Impact on Outcomes of Patients Undergoing Ureteroscopy with Ureteral Access Sheaths: A Systematic Review and Meta-Analysis.

Victor, David Romeiro / Oliveira, Rafael de Albuquerque Pereira de / Melão, Bárbara Vieira Lima Aguiar / Coelho, Henrique Guimarães Barbosa / Barros Júnior, Thomé Décio Pinheiro

Journal of endourology

2024

Abstract: Introduction: Ureteral access sheath (UAS) use during ureteroscopy has been associated with the risk for ureteral injuries. Preoperative administration of α1-blockers presents as a potential mitigator of such lesions by inducing ureteral relaxation, ... ...

Abstract	Introduction: Ureteral access sheath (UAS) use during ureteroscopy has been associated with the risk for ureteral injuries. Preoperative administration of α1-blockers presents as a potential mitigator of such lesions by inducing ureteral relaxation, which may also contribute to improving other surgical outcomes. Methods: A comprehensive literature search was conducted across MEDLINE, Embase, and Cochrane databases for studies that compared preoperative α1-blockers administration versus its non-use in adult patients without pre-stenting undergoing ureteroscopy. Binary outcomes were evaluated using risk ratios (RR) and odds ratios (OR) with 95% confidence intervals. Heterogeneity was measured with the Cochran Q test, I2 statistics, and prediction intervals (PI). A DerSimonian and Laird random-effects model was utilized for all outcomes. Results: Eleven studies encompassing 1074 patients undergoing ureteroscopy were included, of whom 522 (48.60%) received α1-blockers before the procedure. Preoperative α1-blockers were associated with a reduction in significant ureteral injuries (RR 0.30; 95% CI 0.17-0.53; I²=6%; PI 0.10-0.88) and an increase in mean successful ureteral access sheath insertion (OR 2.14; 95% CI 1.08-4.23; I²=23%; PI 0.51-8.93). In patients undergoing ureteroscopy lithotripsy, the medications also reduced total complications (RR 0.62; 95% CI 0.46-0.84; I²=0%), and complications graded Clavien-Dindo III or higher (RR 0.16; 95% CI 0.04-0.69; I²=0%). No significant difference between groups was found in the stone-free rate (RR 1.10; 95% CI 0.86-1.40; I²=91%; PI 0.47-2.59). Conclusion: Preoperative α1-blockers were linked to a decrease in significant ureteral injuries with UAS use and fewer complications during ureteroscopy lithotripsy procedures. However, their impact on the successful insertion of a UAS remains uncertain. Consideration of administering preoperative α1-blockers in patients undergoing ureteroscopy with UAS is advisable.
Language	English
Publishing date	2024-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2024.0060
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 208: Show issues

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Article ; Online: COVID-19 vaccination and leprosy-A UK hospital-based retrospective cohort study.

de Barros, Barbara / Pierce, Rachel / Sprenger, Cathryn / Ong, Eugene Liat Hui / Walker, Stephen L

PLoS neglected tropical diseases

2023 Volume 17, Issue 8, Page(s) e0011493

Abstract: Background: Individuals with leprosy are at risk of leprosy reactions, T-cell mediated immunological complications, which lead to nerve function impairment. Leprosy reactions require systemic immunosuppression which is a risk factor for severe COVID-19. ...

Abstract	Background: Individuals with leprosy are at risk of leprosy reactions, T-cell mediated immunological complications, which lead to nerve function impairment. Leprosy reactions require systemic immunosuppression which is a risk factor for severe COVID-19. Vaccination for SARS-CoV-2 infection is recommended in the UK and became widely available in 2021 with individuals at increased risk of severe disease, including the immunosuppressed, prioritised. Vaccines for SARS-CoV-2 may provoke a T cell response. The latter poses a theoretical risk of provoking an immunological response to latent Mycobacterium leprae infection leading to clinical disease or in those with clinical disease triggering a leprosy reaction. BCG vaccination is associated with the development of leprosy in a small proportion of healthy contacts of people with leprosy within twelve weeks of administration. BCG causes a Th1 immune response. Methodology/principal findings: We performed a retrospective cohort study to determine the SARS-CoV-2 vaccination status of individuals diagnosed with leprosy attending the Leprosy Clinic in 2021 and whether any had developed leprosy or experienced a new leprosy reaction within twelve weeks of receiving a dose of a SARS-CoV-2 vaccine. The electronic patient records were used to retrieve data. Fifty-two individuals with leprosy attended the clinic in 2021 of which five people were newly diagnosed with leprosy. Thirty-seven (71%) were male and the median age was 48.5 years old (Range 27-85 years). Eight (15.4%) individuals were taking multi-drug therapy (MDT) and eight (15.4%) had completed MDT within three years of the study. Twenty-two (41.5%) individuals were prescribed a systemic immunosuppressant drug during 2021. Ten (18.9%) individuals have one or more risk factors for severe COVID-19. The SARS-CoV-2 vaccination status of fifty (96%) were recorded of which forty-nine were vaccinated (98%). One individual had declined vaccination. One individual was diagnosed with borderline tuberculoid (BT) leprosy having developed red skin lesions with reduced sensation (which increased in size and number) and thickened peripheral nerves one week after a second dose of BNT162b2 vaccine. Another individual who had completed MDT more than three years earlier developed red plaques and tender thickened nerves consistent with a leprosy Type 1 reaction eight weeks after a single dose of BNT162b2 vaccine (having received two doses of CoronaVac vaccine three months earlier). Conclusions/significance: The development of BT leprosy and a Type 1 reaction in another individual shortly after a dose of BNT162b2 vaccine may be associated with vaccine mediated T cell responses. The benefits of vaccination to reduce the risk of severe COVID-19 outweigh these unwanted events but data from leprosy endemic countries may provide further information about potential adverse effects of augmented T cell responses in individuals with leprosy or latent M. leprae infection.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; BCG Vaccine/adverse effects ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Hypersensitivity/drug therapy ; Leprosy ; Mycobacterium leprae ; Retrospective Studies ; SARS-CoV-2 ; United Kingdom/epidemiology ; Vaccination
Chemical Substances	BCG Vaccine ; BNT162 Vaccine ; COVID-19 Vaccines ; sinovac COVID-19 vaccine
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011493
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Article ; Online: Sleep deprivation induces genetic damage in mammalian cells: a systematic review.

de Souza, Daniel Vitor / Rosario, Barbara Dos Anjos / Viana, Milena de Barros / Pisani, Luciana Pellegrini / da Silva, Glenda Nicioli / Ribeiro, Daniel Araki

Revista da Associacao Medica Brasileira (1992)

2024 Volume 70, Issue 1, Page(s) e20231097

MeSH term(s)	Animals ; Humans ; Sleep Deprivation/complications ; Mammals
Language	English
Publishing date	2024-03-15
Publishing country	Brazil
Document type	Systematic Review ; Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20231097
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Zs.B 654: Show issues

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Article ; Online: Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions.

Pinto, Thiago Guedes / Dos Anjos Rosario, Barbara / de Moraes Malinverni, Andrea Cristina / Xavier, Rosana / Ferreira, Yasmin Alaby Martins / Pisani, Luciana Pellegrini / de Aquino, Pedro Everson Alexandre / de Barros Viana, Glauce Socorro / de Souza, Daniel Vitor / de Barros Viana, Milena / Ribeiro, Daniel Araki

Archives of toxicology

2024 Volume 98, Issue 6, Page(s) 1877–1890

Abstract: Cannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was ...

Abstract	Cannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1, Experimental group (G2): treated with cannabis nano emulsion (THC and CBD) at a dose of 2.5 mg/kg, Experimental group (G3): treated with cannabis nano emulsion (THC and CBD) at a dose of 5 mg/kg, Experimental group (G4): treated with cannabis nano emulsion (CBD) at a dose of 2.5 mg/kg; Experimental group (G5): treated with cannabis nano emulsion (CBD) at a dose of 5 mg/kg. Exposure to the nano emulsion was carried out for 21 days, once a day, orally (gavage). Our results showed that cannabis nano emulsions at higher doses (5 mg/kg), regardless of the composition, induced histopathologic changes in the liver (G3 and G5) in comparison with the control group. In line with that, placental glutathione S-transferase (GST-P) positive foci increased in both G3 and G5 (p < 0.05), as well as the immune expression of Ki-67, vascular endothelial growth factor (VEGF) and p53 (p < 0.05). Also, the nano emulsion intake induced an increase in the number of micronucleated hepatocytes in G5 (p < 0.05) whereas G3 showed an increase in binucleated cells (p < 0.05). As for metanuclear alterations, karyolysis and pyknosis had an increased frequency in G3 (p < 0.05). Taken together, the results show that intake of cannabis nano emulsion may induce degenerative changes and genotoxicity in the liver in higher doses, demonstrating a clear dose-response relationship.
MeSH term(s)	Animals ; Rats, Wistar ; Emulsions ; Male ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; Cannabidiol/toxicity ; Cannabidiol/administration & dosage ; Cannabis/chemistry ; Dose-Response Relationship, Drug ; Dronabinol/toxicity ; Dronabinol/administration & dosage ; Rats ; Nanoparticles/toxicity ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/etiology
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-024-03712-7
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Uf I Zs.90: Show issues

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Article ; Online: Hepatozoon spp. in stray cats from the metropolitan area of Rio de Janeiro, Brazil.

Traversa, Donato / Di Cesare, Angela / Morelli, Simone / Paoletti, Barbara / Grillini, Marika / di Regalbono, Antonio Frangipane / da Silva de Mattos Queiroz, Aline / Beugnet, Frederic / Brustenga, Leonardo / Milillo, Piermarino / Antunes Barros, Luciano

Parasite (Paris, France)

2024 Volume 31, Page(s) 24

Abstract: ... of Hepatozoon spp. in cats from Niterói, a municipality within the metropolitan area of Rio de Janeiro, Brazil ... This is the first report of H. felis in cats living in the State of Rio de Janeiro, and the present data ...

Title translation	Hepatozoon spp. chez les chats errants de la zone métropolitaine de Rio de Janeiro, Brésil.
Abstract	In the last few years, the number of studies on feline hepatozoonosis has increased, but our knowledge on the actual species of Hepatozoon and/or different genotypes affecting felines is still incipient. At least three species, namely Hepatozoon felis, H. canis, and H. silvestris, have been isolated from domestic cats in various countries. Additionally, there are indications that other species and genotypes may affect felines in given geographic areas. This study was carried out to investigate the occurrence of Hepatozoon spp. in cats from Niterói, a municipality within the metropolitan area of Rio de Janeiro, Brazil. Individual blood samples were collected from 28 cats enrolled in a spaying/castration program. DNA was extracted from all samples and subjected to sequencing specific for Hepatozoon spp. DNA of H. felis was found in 21/28 cats (75%), and four genetic polymorphisms never described thus far were detected. This is the first report of H. felis in cats living in the State of Rio de Janeiro, and the present data confirm that H. felis is a species complex encompassing different genotypes circulating within cat populations. Further studies are warranted to investigate whether different genotypes have different biology or pathogenicity for felids.
MeSH term(s)	Animals ; Cats ; Brazil/epidemiology ; Cat Diseases/parasitology ; Cat Diseases/epidemiology ; Coccidiosis/veterinary ; Coccidiosis/epidemiology ; Coccidiosis/parasitology ; Eucoccidiida/genetics ; Eucoccidiida/isolation & purification ; Eucoccidiida/classification ; Male ; DNA, Protozoan ; Female ; Genotype ; Polymorphism, Genetic ; Phylogeny
Language	English
Publishing date	2024-05-17
Publishing country	France
Document type	Journal Article
ZDB-ID	1187629-3
ISSN	1776-1042 ; 1252-607X
ISSN (online)	1776-1042
ISSN	1252-607X
DOI	10.1051/parasite/2024026
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Zs.A 3965: Show issues

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Article ; Online: Anfíbios Anuros de um remanescente de Mata Atlântica em área urbana de Pouso Alegre, Sul de Minas Gerais, Brasil

Raissane Furtado de Mendonça / Thais Helena Condez / Allyson Luciano Vieira / Gustavo Cruz Lima / Leandro Gustavo do Prado / Ana Bárbara Barros

Revista de Biologia Neotropical, Vol 19, Iss esp (2023)

2023

Abstract: Embora o estado de Minas Gerais seja considerado privilegiado na composição de seus recursos naturais, o conhecimento sobre os anfíbios do estado é ainda insuficiente. Isso se deve à sua grande extensão territorial e existência de regiões subamostradas, ... ...

Abstract	Embora o estado de Minas Gerais seja considerado privilegiado na composição de seus recursos naturais, o conhecimento sobre os anfíbios do estado é ainda insuficiente. Isso se deve à sua grande extensão territorial e existência de regiões subamostradas, principalmente no que se diz respeito à porção sul do estado. Neste trabalho, analisamos a comunidade de anfíbios anuros do Parque Natural Municipal Professor Doutor Fernando Afonso Bonillo Fernandes, um importante remanescente da Mata Atlântica protegido localizado em área urbana, no município de Pouso Alegre. Entre os meses de janeiro de 2020 e outubro de 2021 foram registradas realizando-se a procura ativa, armadilhas de interceptação e queda e encontros ocasionais, 20 espécies de anuros pertencentes a sete famílias. As espécies mais abundantes foram Dendropsophus minutus, Physalaemus cuvieri e Boana polytaenia. Os resultados adicionam ao conhecimento sobre distribuição, abundância, diversidade e conservação das espécies encontradas, evidenciam a necessidade de estudos primários de levantamento de fauna em lacunas amostrais, bem como ressaltam a importância dos remanescentes naturais para a conservação das comunidades de anfíbios em áreas urbanas.
Keywords	Anura ; Riqueza de espécies ; Abundância ; Diversidade ; Conservação ; Biology (General) ; QH301-705.5 ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Universidade Federal de Goiás
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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