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  1. Article ; Online: Correction to: MASCC guideline: cannabis for cancer‑related pain and risk of harms and adverse events.

    To, Josephine / Davis, Mellar / Sbrana, Andrea / Alderman, Bryony / Hui, David / Mukhopadhyay, Sandip / Bouleuc, Carole / Case, Amy A / Amano, Koji / Crawford, Gregory B / de Feo, Giulia / Tanco, Kimberson / Garsed, Jessica

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 6, Page(s) 323

    Language English
    Publishing date 2023-05-06
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07789-1
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    Zs.A 3697: Show issues Location:
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  2. Article ; Online: An audit of end-of-life symptom control in patients with corona virus disease 2019 (COVID-19) dying in a hospital in the United Kingdom.

    Alderman, Bryony / Webber, Katherine / Davies, Andrew

    Palliative medicine

    2020  Volume 34, Issue 9, Page(s) 1249–1255

    Abstract: Background: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these.: Aim: The aim of this audit was to assess the utility of our end-of-life care plan, ... ...

    Abstract Background: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these.
    Aim: The aim of this audit was to assess the utility of our end-of-life care plan, and specifically the effectiveness of our standardised end-of-life care treatment algorithms, in dying patients with COVID-19.
    Design: The audit primarily involved data extraction from the end-of-life care plan, which includes four hourly nursing (ward nurses) assessments of specific problems: patients with problems were managed according to standardised treatment algorithms, and the intervention was deemed to be effective if the problem was not present at subsequent assessments.
    Setting/participants: This audit was undertaken at a general hospital in England, covered the 8 weeks from 16 March to 11 May 2020 and included all inpatients with COVID-19 who had an end-of-life care plan (and died).
    Results: Sixty-one patients met the audit criteria: the commonest problem was shortness of breath (57.5%), which was generally controlled with conservative doses of morphine (10-20 mg/24 h via a syringe pump). Cough and audible respiratory secretions were relatively uncommon. The second most common problem was agitation/delirium (55.5%), which was generally controlled with standard pharmacological interventions. The cumulative number of patients with shortness of breath, agitation and audible respiratory secretions increased over the last 72 h of life, but most patients were symptom controlled at the point of death.
    Conclusion: Patients dying of COVID-19 experience similar end-of-life problems to other groups of patients. Moreover, they generally respond to standard interventions for these end-of-life problems.
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesics, Opioid/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/nursing ; Delirium/drug therapy ; Drug Therapy/standards ; Drug Therapy/statistics & numerical data ; Dyspnea/drug therapy ; Female ; Hospice Care/standards ; Hospice Care/statistics & numerical data ; Humans ; Hypnotics and Sedatives/therapeutic use ; Male ; Middle Aged ; Morphine/therapeutic use ; Palliative Care/standards ; Palliative Care/statistics & numerical data ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/nursing ; Practice Guidelines as Topic ; SARS-CoV-2 ; Terminal Care/standards ; Terminal Care/statistics & numerical data ; United Kingdom/epidemiology
    Chemical Substances Analgesics, Opioid ; Hypnotics and Sedatives ; Morphine (76I7G6D29C)
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/0269216320947312
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  3. Article ; Online: Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression.

    De Feo, Giulia / Case, Amy A / Crawford, Gregory B / Hui, David / To, Josephine / Sbrana, Andrea / Alderman, Bryony / Mukhopadhyay, Sandip / Bouleuc, Carole / Amano, Koji / Tanco, Kimberson / Garsed, Jessica / Davis, Mellar

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 3, Page(s) 176

    Abstract: Purpose: During the treatment of cancer, 18% of patients use cannabis for symptom management. Anxiety, depression, and sleep disturbances are common symptoms in cancer. A systematic review of the evidence for cannabis use for psychological symptoms in ... ...

    Abstract Purpose: During the treatment of cancer, 18% of patients use cannabis for symptom management. Anxiety, depression, and sleep disturbances are common symptoms in cancer. A systematic review of the evidence for cannabis use for psychological symptoms in cancer patients was undertaken to develop a guideline.
    Methods: A literature search of randomized trials and systematic reviews was undertaken up to November 12, 2021. Studies were independently assessed for evidence by two authors and then evaluated by all authors for approval. The literature search involved MEDLINE, CCTR, EMBASE, and PsychINFO databases. Inclusion criteria included randomized control trials and systematic reviews on cannabis versus placebo or active comparator in patients with cancer and psychological symptom management (anxiety, depression, and insomnia).
    Results: The search yielded 829 articles; 145 from Medline, 419 from Embase, 62 from PsychINFO, and 203 from CCTR. Two systematic reviews and 15 randomized trials (4 on sleep, 5 on mood, 6 on both) met eligibility criteria. However, no studies specifically assessed the efficacy of cannabis on psychological symptoms as primary outcomes in cancer patients. The studies varied widely in terms of interventions, control, duration, and outcome measures. Six of 15 RCTs suggested benefits (five for sleep, one for mood).
    Conclusion: There is no high-quality evidence to recommend the use of cannabis as an intervention for psychological symptoms in patients with cancer until more high-quality research demonstrates benefit.
    MeSH term(s) Humans ; Cannabis ; Depression/therapy ; Sleep Initiation and Maintenance Disorders ; Anxiety/therapy ; Anxiety Disorders ; Neoplasms/therapy
    Language English
    Publishing date 2023-02-21
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07628-3
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  4. Article ; Online: Maximizing medical student engagement in specialty placements: Ideas from child health.

    Jacob, Hannah / Alderman, Bryony / Fertleman, Caroline

    Medical teacher

    2016  Volume 38, Issue 7, Page(s) 751

    MeSH term(s) Career Choice ; Child Health ; Focus Groups ; Group Processes ; Humans ; Patient Care Team ; Pediatrics/education ; Students, Medical/psychology ; United Kingdom
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.3109/0142159X.2016.1170789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2176: Show issues Location:
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  5. Article ; Online: MASCC guideline: cannabis for cancer-related pain and risk of harms and adverse events.

    To, Josephine / Davis, Mellar / Sbrana, Andrea / Alderman, Bryony / Hui, David / Mukhopadhyay, Sandip / Bouleuc, Carole / Case, Amy A / Amano, Koji / Crawford, Gregory B / de Feo, Giulia / Tanco, Kimberson / Garsed, Jessica

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 4, Page(s) 202

    Abstract: Background: Approximately 18% of patients with cancer use cannabis at one time as palliation or treatment for their cancer. We performed a systematic review of randomized cannabis cancer trials to establish a guideline for its use in pain and to ... ...

    Abstract Background: Approximately 18% of patients with cancer use cannabis at one time as palliation or treatment for their cancer. We performed a systematic review of randomized cannabis cancer trials to establish a guideline for its use in pain and to summarize the risk of harm and adverse events when used for any indication in cancer patients.
    Methods: A systematic review of randomized trials with or without meta-analysis was carried out from MEDLINE, CCTR, Embase, and PsychINFO. The search involved randomized trials of cannabis in cancer patients. The search ended on November 12, 2021. The Jadad grading system was used for grading quality. Inclusion criteria for articles were randomized trials or systematic reviews of randomized trials of cannabinoids versus either placebo or active comparator explicitly in adult patients with cancer.
    Results: Thirty-four systematic reviews and randomized trials met the eligibility criteria for cancer pain. Seven were randomized trials involving patients with cancer pain. Two trials had positive primary endpoints, which could not be reproduced in similarly designed trials. High-quality systematic reviews with meta-analyses found little evidence that cannabinoids are an effective adjuvant or analgesic to cancer pain. Seven systematic reviews and randomized trials related to harms and adverse events were included. There was inconsistent evidence about the types and levels of harm patients may experience when using cannabinoids.
    Conclusion: The MASCC panel recommends against the use of cannabinoids as an adjuvant analgesic for cancer pain and suggests that the potential risk of harm and adverse events be carefully considered for all cancer patients, particularly with treatment with a checkpoint inhibitor.
    MeSH term(s) Adult ; Humans ; Cannabis ; Cancer Pain ; Pain ; Adjuvants, Immunologic ; Cannabinoids ; Neoplasms
    Chemical Substances Adjuvants, Immunologic ; Cannabinoids
    Language English
    Publishing date 2023-03-06
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07662-1
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  6. Article: Infection in the older patient.

    Alderman, Bryony / Frank, Lucy-Anne / Khan, Shahid A

    British journal of hospital medicine (London, England : 2005)

    2017  Volume 78, Issue 8, Page(s) C120–C123

    MeSH term(s) Aged ; Aging/physiology ; Cholecystitis/diagnosis ; Cholecystitis/physiopathology ; Cholecystitis/therapy ; Humans ; Immunosenescence ; Malnutrition ; Multiple Chronic Conditions ; Patient Care Management/methods ; Pneumonia/diagnosis ; Pneumonia/physiopathology ; Pneumonia/therapy ; Risk Adjustment ; Risk Factors ; Sepsis/diagnosis ; Sepsis/etiology ; Sepsis/mortality ; Sepsis/therapy ; Skin Diseases, Infectious/diagnosis ; Skin Diseases, Infectious/physiopathology ; Skin Diseases, Infectious/therapy ; Soft Tissue Infections/diagnosis ; Soft Tissue Infections/physiopathology ; Soft Tissue Infections/therapy ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/physiopathology ; Urinary Tract Infections/therapy
    Language English
    Publishing date 2017-08-03
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2017.78.8.C120
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  7. Article: An audit of end-of-life symptom control in patients with corona virus disease 2019 (COVID-19) dying in a hospital in the United Kingdom

    Alderman, Bryony / Webber, Katherine / Davies, Andrew

    Palliat Med

    Abstract: BACKGROUND: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these. AIM: The aim of this audit was to assess the utility of our end-of-life care plan, and ... ...

    Abstract BACKGROUND: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these. AIM: The aim of this audit was to assess the utility of our end-of-life care plan, and specifically the effectiveness of our standardised end-of-life care treatment algorithms, in dying patients with COVID-19. DESIGN: The audit primarily involved data extraction from the end-of-life care plan, which includes four hourly nursing (ward nurses) assessments of specific problems: patients with problems were managed according to standardised treatment algorithms, and the intervention was deemed to be effective if the problem was not present at subsequent assessments. SETTING/PARTICIPANTS: This audit was undertaken at a general hospital in England, covered the 8 weeks from 16 March to 11 May 2020 and included all inpatients with COVID-19 who had an end-of-life care plan (and died). RESULTS: Sixty-one patients met the audit criteria: the commonest problem was shortness of breath (57.5%), which was generally controlled with conservative doses of morphine (10-20 mg/24 h via a syringe pump). Cough and audible respiratory secretions were relatively uncommon. The second most common problem was agitation/delirium (55.5%), which was generally controlled with standard pharmacological interventions. The cumulative number of patients with shortness of breath, agitation and audible respiratory secretions increased over the last 72 h of life, but most patients were symptom controlled at the point of death. CONCLUSION: Patients dying of COVID-19 experience similar end-of-life problems to other groups of patients. Moreover, they generally respond to standard interventions for these end-of-life problems.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #690192
    Database COVID19

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  8. Article ; Online: An audit of end-of-life symptom control in patients with corona virus disease 2019 (COVID-19) dying in a hospital in the United Kingdom

    Alderman, Bryony / Webber, Katherine / Davies, Andrew

    Palliative Medicine

    2020  Volume 34, Issue 9, Page(s) 1249–1255

    Abstract: Background: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these. Aim: The aim of this audit was to assess the utility of our end-of-life care plan, and ... ...

    Abstract Background: The literature contains limited information on the problems faced by dying patients with COVID-19 and the effectiveness of interventions to manage these. Aim: The aim of this audit was to assess the utility of our end-of-life care plan, and specifically the effectiveness of our standardised end-of-life care treatment algorithms, in dying patients with COVID-19. Design: The audit primarily involved data extraction from the end-of-life care plan, which includes four hourly nursing (ward nurses) assessments of specific problems: patients with problems were managed according to standardised treatment algorithms, and the intervention was deemed to be effective if the problem was not present at subsequent assessments. Setting/participants: This audit was undertaken at a general hospital in England, covered the 8 weeks from 16 March to 11 May 2020 and included all inpatients with COVID-19 who had an end-of-life care plan (and died). Results: Sixty-one patients met the audit criteria: the commonest problem was shortness of breath (57.5%), which was generally controlled with conservative doses of morphine (10–20 mg/24 h via a syringe pump). Cough and audible respiratory secretions were relatively uncommon. The second most common problem was agitation/delirium (55.5%), which was generally controlled with standard pharmacological interventions. The cumulative number of patients with shortness of breath, agitation and audible respiratory secretions increased over the last 72 h of life, but most patients were symptom controlled at the point of death. Conclusion: Patients dying of COVID-19 experience similar end-of-life problems to other groups of patients. Moreover, they generally respond to standard interventions for these end-of-life problems.
    Keywords Anesthesiology and Pain Medicine ; General Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639247-7
    ISSN 1477-030X ; 0269-2163
    ISSN (online) 1477-030X
    ISSN 0269-2163
    DOI 10.1177/0269216320947312
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 2285: Show issues Location:
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  9. Article ; Online: Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer.

    Alderman, Bryony / Allan, Lindsey / Amano, Koji / Bouleuc, Carole / Davis, Mellar / Lister-Flynn, Stephanie / Mukhopadhyay, Sandip / Davies, Andrew

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2021  Volume 30, Issue 4, Page(s) 2983–2992

    Abstract: Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the Palliative Care Study Group of the ... ...

    Abstract Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the Palliative Care Study Group of the Multinational Association of Supportive Care in Cancer (MASCC) formed a Subgroup to develop evidence-based guidance on the use CAN in patients with advanced cancer.
    Methods: This guidance was developed in accordance with the MASCC Guidelines Policy. A search strategy for Medline was developed, and the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were explored for relevant reviews/trials respectively. The outcomes of the review were categorised by the level of evidence, and a "category of guideline" based on the level of evidence (i.e. "recommendation", "suggestion", or "no guideline possible").
    Results: The Subgroup produced 11 suggestions, and 1 recommendation (due to the paucity of evidence). These outcomes relate to assessment of patients, indications for CAN, contraindications for CAN, procedures for initiating CAN, and re-assessment of patients.
    Conclusions: This guidance provides a framework for the use of CAN in advanced cancer, although every patient needs individualised management.
    MeSH term(s) Expert Testimony ; Humans ; Neoplasms/therapy ; Nutritional Status ; Palliative Care
    Language English
    Publishing date 2021-10-19
    Publishing country Germany
    Document type Journal Article ; Practice Guideline
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-021-06613-y
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  10. Article ; Online: Hypoplasia of the inferior vena cava in a young man presenting with extensive deep venous thrombosis.

    Alderman, Bryony Eloise Pfyffer / de Boisanger, James / Bottomley, Thomas

    BMJ case reports

    2015  Volume 2015

    Abstract: We present a case of a 34-year-old man with extensive deep venous thrombosis (DVT) who was found to have multiple abnormalities of venous anatomy, notably hypoplasia of the inferior vena cava with azygous continuation. DVT has an annual incidence of ... ...

    Abstract We present a case of a 34-year-old man with extensive deep venous thrombosis (DVT) who was found to have multiple abnormalities of venous anatomy, notably hypoplasia of the inferior vena cava with azygous continuation. DVT has an annual incidence of around 1 in 1000 people in the UK. Many cases will have readily identifiable risk factors, such as underlying malignancy, immobility or thrombophilia, but at times, these might not be so straightforward and unexpected contributing factors may be found. Although relatively uncommon in the general population, congenital venous abnormalities have been found at higher incidence in young adults presenting with spontaneous DVT and should therefore remain a consideration when classical risk factors are absent.
    MeSH term(s) Adult ; Humans ; Male ; Risk Factors ; Thrombophilia/complications ; Vascular Malformations/complications ; Vena Cava, Inferior/abnormalities ; Venous Thrombosis/etiology
    Language English
    Publishing date 2015-10-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-211849
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