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  1. Book ; Online: Synthetic Biology Brings New Opportunity for Antibiotics Discovery

    Tong, Yaojun / Deng, Zixin / Bai, Linquan

    2023  

    Keywords Research & information: general ; Biology, life sciences ; global regulator ; milbemycins ; Streptomyces bingchenggensis ; SspH ; actinorhodin ; avermectin ; ceftriaxone ; hepatotoxicity ; metal complexes ; oxidative stress ; Streptomyces ; comparative transcriptome ; polyether antibiotics ; salinomycin ; exporter genes ; spectroscopic studies ; antioxidant capacities ; hepatic functions ; cancer cells ; cefotaxime ; Inonotus hispidus ; natural product ; biological activity ; medicinal fungi ; phytochemicals ; antimicrobial agents ; biosynthetic pathway ; secondary metabolites ; 1-benzazepine ; l-kynurenine ; genome mining ; biosynthesis ; iterative methyltransferase ; genetic dereplication ; cyclodipeptide ; OSMAC ; cytotoxicity ; Zymomonas mobilis ; antibiotic resistance ; ampicillin ; genome editing ; CRISPR−Cas12a ; resistance selection markers ; traditional Chinese medicine ; antifungal drug ; immune regulation ; combination of drugs ; fungal infection ; n/a
    Language English
    Size 1 electronic resource (198 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377927
    ISBN 9783036572604 ; 3036572600
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Discovering the next decade's synthetic biology research trends with ChatGPT.

    Tong, Yaojun / Zhang, Lixin

    Synthetic and systems biotechnology

    2023  Volume 8, Issue 2, Page(s) 220–223

    Language English
    Publishing date 2023-02-22
    Publishing country China
    Document type Editorial
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Natural products research in the modern age.

    Tong, Yaojun

    Synthetic and systems biotechnology

    2020  Volume 5, Issue 4, Page(s) 314–315

    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country China
    Document type Editorial
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2020.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discovering the next decade's synthetic biology research trends with ChatGPT

    Yaojun Tong / Lixin Zhang

    Synthetic and Systems Biotechnology, Vol 8, Iss 2, Pp 220-

    2023  Volume 223

    Keywords Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Natural products research in the modern age

    Yaojun Tong

    Synthetic and Systems Biotechnology, Vol 5, Iss 4, Pp 314-

    2020  Volume 315

    Keywords Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Synthetic Biology Facilitates Antimicrobials Discovery.

    Bai, Linquan / Deng, Zixin / Tong, Yaojun

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: We are currently facing two big global challenges: antibiotics shortage and multidrug resistance [ ... ]. ...

    Abstract We are currently facing two big global challenges: antibiotics shortage and multidrug resistance [...].
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Optogenetic tools for microbial synthetic biology.

    Chia, Natalie / Lee, Sang Yup / Tong, Yaojun

    Biotechnology advances

    2022  Volume 59, Page(s) 107953

    Abstract: Chemical induction is one of the most common modalities used to manipulate gene expression in living systems. However, chemical induction can be toxic or expensive that compromise the economic feasibility when it comes to industrial-scale synthetic ... ...

    Abstract Chemical induction is one of the most common modalities used to manipulate gene expression in living systems. However, chemical induction can be toxic or expensive that compromise the economic feasibility when it comes to industrial-scale synthetic biology applications. These complications have driven the pursuit of better induction systems. Optogenetics technique can be a solution as it not only enables dynamic control with unprecedented spatiotemporal precision but also is inexpensive and eco-friendlier. The optogenetic technique harnesses natural light-sensing modules that are genetically encodable and re-programmable in various hosts. By further engineering these modules to connect with the microbial regulatory machinery, gene expression and protein activity can be finely tuned simply through light irradiation. Recent works on applying optogenetics to microbial synthetic biology have yielded remarkable achievements. To further expand the usability of optogenetics, more optogenetic tools with greater portability that are compatible with different microbial hosts need to be developed. This review focuses on non-opsin optogenetic systems and the current state of optogenetic advancements in microbes, by showcasing the different designs and functions of optogenetic tools, followed by an insight into the optogenetic approaches used to circumvent challenges in synthetic biology.
    MeSH term(s) Light ; Optogenetics/methods ; Synthetic Biology
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 47165-3
    ISSN 1873-1899 ; 0734-9750
    ISSN (online) 1873-1899
    ISSN 0734-9750
    DOI 10.1016/j.biotechadv.2022.107953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3730: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Systems Analysis of Highly Multiplexed CRISPR-Base Editing in Streptomycetes.

    Whitford, Christopher M / Gren, Tetiana / Palazzotto, Emilia / Lee, Sang Yup / Tong, Yaojun / Weber, Tilmann

    ACS synthetic biology

    2023  Volume 12, Issue 8, Page(s) 2353–2366

    Abstract: CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically simplified genetic manipulation of streptomycetes. One major advantage of CRISPR base editing technology is the possibility to multiplex ... ...

    Abstract CRISPR tools, especially Cas9n-sgRNA guided cytidine deaminase base editors such as CRISPR-BEST, have dramatically simplified genetic manipulation of streptomycetes. One major advantage of CRISPR base editing technology is the possibility to multiplex experiments in genomically instable species. Here, we demonstrate scaled up Csy4 based multiplexed genome editing using CRISPR-mcBEST in
    MeSH term(s) Gene Editing ; CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; RNA, Guide, CRISPR-Cas Systems ; Actinomycetales/genetics ; Systems Analysis
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An aurora of natural products-based drug discovery is coming.

    Tong, Yaojun / Deng, Zixin

    Synthetic and systems biotechnology

    2020  Volume 5, Issue 2, Page(s) 92–96

    Abstract: Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthesis, are now proving themselves as most wonderful gifts from mother nature for human beings. Many of ... ...

    Abstract Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthesis, are now proving themselves as most wonderful gifts from mother nature for human beings. Many of them have been used successfully as medicines, as well as the most important sources of drug leads, food additives, and many industry relevant products for millennia. Most notably, more than half of the antibiotics and anti-cancer drugs currently in use are, or derived from, natural products. However, the speed and outputs of NP-based drug discovery has been slowing down dramatically after the fruitful harvest of the "low-hanging fruit" during the golden age of 1950s-1960s. With recent scientific advances combining metabolic sciences and technology, multi-omics, big data, combinatorial biosynthesis, synthetic biology, genome editing technology (such as CRISPR), artificial intelligence (AI), and 3D printing, the "high-hanging fruit" is becoming more and more accessible with reduced costs. We are now more and more confident that a new age of natural products discovery is dawning.
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country China
    Document type Journal Article
    ISSN 2405-805X
    ISSN (online) 2405-805X
    DOI 10.1016/j.synbio.2020.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An aurora of natural products-based drug discovery is coming

    Yaojun Tong / Zixin Deng

    Synthetic and Systems Biotechnology, Vol 5, Iss 2, Pp 92-

    2020  Volume 96

    Abstract: Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthesis, are now proving themselves as most wonderful gifts from mother nature for human beings. Many of ... ...

    Abstract Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthesis, are now proving themselves as most wonderful gifts from mother nature for human beings. Many of them have been used successfully as medicines, as well as the most important sources of drug leads, food additives, and many industry relevant products for millennia. Most notably, more than half of the antibiotics and anti-cancer drugs currently in use are, or derived from, natural products. However, the speed and outputs of NP-based drug discovery has been slowing down dramatically after the fruitful harvest of the “low-hanging fruit” during the golden age of 1950s-1960s. With recent scientific advances combining metabolic sciences and technology, multi-omics, big data, combinatorial biosynthesis, synthetic biology, genome editing technology (such as CRISPR), artificial intelligence (AI), and 3D printing, the “high-hanging fruit” is becoming more and more accessible with reduced costs. We are now more and more confident that a new age of natural products discovery is dawning.
    Keywords Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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