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  1. Article: HLA typing in lung transplantation: does high resolution fit all?

    Deaglio, Silvia / Amoroso, Antonio / Rinaldi, Mauro / Boffini, Massimo

    Annals of translational medicine

    2020  Volume 8, Issue 3, Page(s) 45

    Language English
    Publishing date 2020-03-10
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytokines Removal During

    Boffini, Massimo / Marro, Matteo / Simonato, Erika / Scalini, Fabrizio / Costamagna, Andrea / Fanelli, Vito / Barbero, Cristina / Solidoro, Paolo / Brazzi, Luca / Rinaldi, Mauro

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 10777

    Abstract: ... Ex ... ...

    Abstract Ex Vivo
    MeSH term(s) Humans ; Cytokines ; Extracorporeal Circulation ; Interleukin-10 ; Perfusion ; Lung Transplantation ; Tissue and Organ Harvesting/methods
    Chemical Substances Cytokines ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.10777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Herpes Virus Infection in Lung Transplantation: Diagnosis, Treatment and Prevention Strategies.

    Patrucco, Filippo / Curtoni, Antonio / Sidoti, Francesca / Zanotto, Elisa / Bondi, Alessandro / Albera, Carlo / Boffini, Massimo / Cavallo, Rossana / Costa, Cristina / Solidoro, Paolo

    Viruses

    2023  Volume 15, Issue 12

    Abstract: Lung transplantation is an ultimate treatment option for some end-stage lung diseases; due to the intense immunosuppression needed to reduce the risk of developing acute and chronic allograft failure, infectious complications are highly incident. Viral ... ...

    Abstract Lung transplantation is an ultimate treatment option for some end-stage lung diseases; due to the intense immunosuppression needed to reduce the risk of developing acute and chronic allograft failure, infectious complications are highly incident. Viral infections represent nearly 30% of all infectious complications, with herpes viruses playing an important role in the development of acute and chronic diseases. Among them, cytomegalovirus (CMV) is a major cause of morbidity and mortality, being associated with an increased risk of chronic lung allograft failure. Epstein-Barr virus (EBV) is associated with transformation of infected B cells with the development of post-transplantation lymphoproliferative disorders (PTLDs). Similarly, herpes simplex virus (HSV), varicella zoster virus and human herpesviruses 6 and 7 can also be responsible for acute manifestations in lung transplant patients. During these last years, new, highly sensitive and specific diagnostic tests have been developed, and preventive and prophylactic strategies have been studied aiming to reduce and prevent the incidence of these viral infections. In this narrative review, we explore epidemiology, diagnosis and treatment options for more frequent herpes virus infections in lung transplant patients.
    MeSH term(s) Humans ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Herpesviridae Infections/diagnosis ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/prevention & control ; Lung Transplantation/adverse effects ; Herpesvirus 3, Human ; Simplexvirus ; Herpes Zoster/complications
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15122326
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  4. Article: Epidemiology and Risk Factors for Nosocomial Infections in Left Ventricular Assist Device Recipients.

    Mornese Pinna, Simone / Corcione, Silvia / Cavallone, Elena / Shbaklo, Nour / Vita, Davide / De Benedetto, Ilaria / Montrucchio, Giorgia / Pasero, Daniela / Trompeo, Anna Chiara / Costamagna, Andrea / Brazzi, Luca / Rinaldi, Mauro / Boffini, Massimo / De Rosa, Francesco Giuseppe

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Left ventricular assist devices (LVADs) have been increasingly used as a valid option to improve the prognosis and reduce the symptoms of end-stage heart failure. However, long-term complications, mostly infections and coagulation disorders, are frequent. ...

    Abstract Left ventricular assist devices (LVADs) have been increasingly used as a valid option to improve the prognosis and reduce the symptoms of end-stage heart failure. However, long-term complications, mostly infections and coagulation disorders, are frequent. We described the epidemiology and risk factors for nosocomial infections (NIs) in a cohort of adult patients who underwent continuous-flow LVAD implant between January 2010 and December 2017 in Turin, Italy. Secondary outcomes were the prevalence of multidrug-resistant (MDR) bacteria and mortality. Results: Overall, 64 LVADs were implanted. A total of 32 (50%) patients experienced at least one episode of NI, with a total of 46 infectious events. VAD-related infections occurred in 22 patients (68.8%). Non VAD-related NIs occurred in 12 patients (37.5%), mainly low respiratory tract infections. Length of intensive care unit admission was a risk factor for NI (OR 1.224, 95%CI; 1.049, 1.429). Gram-negative bacilli were responsible for 58.8% of VAD-related infections and 79.5% of non-VAD related infections. In sixteen patients (50%), at least one episode of infection was related to an MDR strain. INTERMACS class and length of MV were independent risk factors for NIs by MDR strains (respectively, OR 2.12, 95%CI: 1.08, 6.80;
    Language English
    Publishing date 2024-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14020270
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  5. Article: Traumatic heart and great vessels injuries.

    Barbero, Cristina / Ricci, Davide / Boffini, Massimo / Rinaldi, Mauro

    Journal of thoracic disease

    2018  Volume 11, Issue Suppl 2, Page(s) S192–S195

    Language English
    Publishing date 2018-07-13
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.10.73
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  6. Article ; Online: Corrigendum: Five-Year Outcome After Continuous Flow LVAD With Full-Magnetic (HeartMate 3) Versus Hybrid Levitation System (HeartWare): A Propensity-Score Matched Study From an All-Comers Multicentre Registry.

    Francica, Alessandra / Loforte, Antonio / Attisani, Matteo / Maiani, Massimo / Iacovoni, Attilio / Nisi, Teodora / Comisso, Marina / Terzi, Amedeo / De Bonis, Michele / Vendramin, Igor / Boffini, Massimo / Musumeci, Francesco / Luciani, Giovanni Battista / Rinaldi, Mauro / Pacini, Davide / Onorati, Francesco

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 12088

    Abstract: This corrects the article DOI: 10.3389/ti.2023.11675.]. ...

    Abstract [This corrects the article DOI: 10.3389/ti.2023.11675.].
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.12088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Twelve-month effects of everolimus on renal and lung function in lung transplantation: differences in chronic lung allograft dysfunction phenotypes.

    Patrucco, Filippo / Allara, Elias / Boffini, Massimo / Rinaldi, Mauro / Costa, Cristina / Albera, Carlo / Solidoro, Paolo

    Therapeutic advances in chronic disease

    2021  Volume 12, Page(s) 2040622321993441

    Abstract: Background: Chronic lung allograft dysfunction (CLAD), a complication affecting the survival of lung transplanted patients, includes two clinical phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Everolimus is ...

    Abstract Background: Chronic lung allograft dysfunction (CLAD), a complication affecting the survival of lung transplanted patients, includes two clinical phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Everolimus is used in CLAD because of its antiproliferative mechanism. In lung transplant patients treated with everolimus, the clinical course of renal and lung function has not yet been assessed systematically in CLAD, BOS and RAS patients for more than 6 months.
    Methods: We retrospectively evaluated the 12-month follow-up of renal and lung function of lung-transplanted patients switched to everolimus and evaluated the reduction in immunosuppressant dosage (ISD) and mortality. Subgroups were based on indication for everolimus treatment: CLAD and non-CLAD patients, BOS and RAS among CLAD patients.
    Results: We included 26 patients, 17 with CLAD (10 BOS, seven RAS). After 1 year from the everolimus switch, we observed renal function improvement (serum creatinine -17%, estimated glomerular filtration rate +24%) and stable pulmonary function [forced expiratory volume in the first second (FEV
    Conclusion: Lung transplant patients treated with everolimus had improvements in renal function and reduced ISD. We observed sustained improvements in lung function for CLAD related to BOS subgroup results, whereas RAS confirmed the 1-year worsening functional trend. Data seem to suggest one more piece of the puzzle in CLAD phenotyping.
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622321993441
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  8. Article ; Online: Interventricular Septal Rupture in a 62-Year-Old Man With Familial Amyloid Polyneuropathy.

    Pidello, Stefano / Simonato, Erika / Orzan, Fulvio / Frea, Simone / Barreca, Antonella / Rinaldi, Mauro / Boffini, Massimo

    Texas Heart Institute journal

    2021  Volume 47, Issue 4, Page(s) 302–305

    Abstract: Cardiac involvement in familial amyloid polyneuropathy consists of arrhythmias, conduction disturbances, and heart failure. To our knowledge, heart rupture has never been described in association with this condition. We report the case of a 62-year-old ... ...

    Abstract Cardiac involvement in familial amyloid polyneuropathy consists of arrhythmias, conduction disturbances, and heart failure. To our knowledge, heart rupture has never been described in association with this condition. We report the case of a 62-year-old man with a 6-year history of refractory familial amyloid polyneuropathy who underwent liver transplantation. The operation was complicated by severe hypotension because the neuropathy involved the autonomic system. Perioperatively, the patient had a myocardial infarction, and during the next 10 days, a complete interventricular septal rupture developed, resulting in a systemic-to-pulmonary shunt. Coronary angiographic findings were normal. However, the shunt caused unstable hemodynamics, resulting in cardiogenic shock. An attempt to close the rupture percutaneously failed. The patient underwent successful heart transplantation 50 days later. Macroscopic examination of the explanted heart showed thickening of both ventricles, septal rupture, and a gray scar in the interventricular septum around the cavity. Histopathologic examination revealed intramural amyloid angiopathy. Our case shows that heart rupture can occur in patients with familial amyloid polyneuropathy who have no history of obstructive coronary artery disease, perhaps as a result of tissue fragility caused by amyloid angiopathy. Therefore, autonomic disturbances should be regarded with concern and promptly treated in the perioperative period.
    MeSH term(s) Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis ; Cardiac Surgical Procedures/methods ; Echocardiography ; Electrocardiography ; Humans ; Male ; Middle Aged ; Ventricular Septal Rupture/diagnosis ; Ventricular Septal Rupture/etiology ; Ventricular Septal Rupture/surgery
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604761-0
    ISSN 1526-6702 ; 0730-2347
    ISSN (online) 1526-6702
    ISSN 0730-2347
    DOI 10.14503/THIJ-18-6799
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  9. Article: Off-pump left ventricular assist device implantation via bilateral mini-thoracotomy in cardiac reoperations: the extrapericardial subxiphoid route.

    Attisani, Matteo / Pocar, Marco / Lodo, Vittoria / Barbero, Cristina / Marchetto, Giovanni / Centofanti, Paolo / Rinaldi, Mauro / Boffini, Massimo

    Annals of cardiothoracic surgery

    2021  Volume 10, Issue 2, Page(s) 298–300

    Language English
    Publishing date 2021-03-15
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2020-cfmcs-25
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  10. Article ; Online: Five-Year Outcome After Continuous Flow LVAD With Full-Magnetic (HeartMate 3) Versus Hybrid Levitation System (HeartWare): A Propensity-Score Matched Study From an All-Comers Multicentre Registry.

    Francica, Alessandra / Loforte, Antonio / Attisani, Matteo / Maiani, Massimo / Iacovoni, Attilio / Nisi, Teodora / Comisso, Marina / Terzi, Amedeo / De Bonis, Michele / Vendramin, Igor / Boffini, Massimo / Musumeci, Francesco / Luciani, Giovanni Battista / Rinaldi, Mauro / Pacini, Davide / Onorati, Francesco

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11675

    Abstract: Despite the withdrawal of the HeartWare Ventricular Assist Device (HVAD), hundreds of patients are still supported with this continuous-flow pump, and the long-term management of these patients is still under debate. This study aims to analyse 5 years ... ...

    Abstract Despite the withdrawal of the HeartWare Ventricular Assist Device (HVAD), hundreds of patients are still supported with this continuous-flow pump, and the long-term management of these patients is still under debate. This study aims to analyse 5 years survival and freedom from major adverse events in patients supported by HVAD and HeartMate3 (HM3). From 2010 to 2022, the MIRAMACS Italian Registry enrolled all-comer patients receiving a LVAD support at seven Cardiac Surgery Centres. Out of 447 LVAD implantation, 214 (47.9%) received HM3 and 233 (52.1%) received HVAD. Cox-regression analysis adjusted for major confounders showed an increased risk for mortality (HR 1.5 [1.2-1.9];
    MeSH term(s) Humans ; Hemorrhagic Stroke ; Registries ; Heart-Assist Devices ; Propensity Score ; Magnetic Phenomena
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11675
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