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  1. Article: Megatrends in Infectious Diseases: The Next 10 to 15 Years.

    Wong, Sin Yew / Tan, Ban Hock

    Annals of the Academy of Medicine, Singapore

    2019  Volume 48, Issue 6, Page(s) 188–194

    Abstract: It has been about 100 years since the Spanish influenza pandemic of 1918-19 that killed an estimated 50 million individuals globally. While we have made remarkable progress in reducing infection-related mortality, infections still account for 13 to 15 ... ...

    Abstract It has been about 100 years since the Spanish influenza pandemic of 1918-19 that killed an estimated 50 million individuals globally. While we have made remarkable progress in reducing infection-related mortality, infections still account for 13 to 15 million deaths annually. This estimate is projected to remain unchanged until 2050. We have identified 4 megatrends in infectious diseases and these are "emerging and re-emerging infections", "antimicrobial resistance", "demographic changes" and "technological advances". Understanding these trends and challenges should lead to opportunites for the medical community to reshape the future. Further inroads will also require broad approaches involving surveillance, public health and translating scientific discoveries into disease control efforts.
    MeSH term(s) Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/prevention & control ; Communicable Diseases, Emerging/therapy ; Drug Resistance, Microbial ; Humans ; Infection Control/trends ; Infections/epidemiology ; Infections/therapy ; Inventions/trends ; Population Dynamics/trends
    Keywords covid19
    Language English
    Publishing date 2019-08-01
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of a rapid access chest pain clinic in Singapore to improve evaluation of new-onset chest pain.

    Toh, Lay Cheng / Khoo, Christina / Goh, Cheng Huang / Choa, Gary / Quek, Lit Sin / Phang, Jonathan / Wong, Franco / Tsou, Keith / Kwan, Yew Seng / Kojodjojo, Pipin

    Postgraduate medical journal

    2023  Volume 99, Issue 1171, Page(s) 500–505

    Abstract: Background: Chest pain (CP) accounts for 5% of emergency department (ED) visits, unplanned hospitalisations and costly admissions. Conversely, outpatient evaluation requires multiple hospital visits and longer time to complete testing. Rapid access ... ...

    Abstract Background: Chest pain (CP) accounts for 5% of emergency department (ED) visits, unplanned hospitalisations and costly admissions. Conversely, outpatient evaluation requires multiple hospital visits and longer time to complete testing. Rapid access chest pain clinics (RACPCS) are established in the UK for timely, cost-effective CP assessment. This study aims to evaluate the feasibility, safety, clinical and economic benefits of a nurse-led RACPC in a multiethnic Asian country.
    Methods: Consecutive CP patients referred from a polyclinic to the local general hospital were recruited. Referring physicians were left to their discretion to refer patients to the ED, RACPC (launched in April 2019) or outpatients. Patient demographics, diagnostic journey, clinical outcomes, costs, HEART (History, ECG, Age, Risk Factors, Troponin) scores and 1-year overall mortality were recorded.
    Results: 577 CP patients (median HEAR score of 2.0) were referred; 237 before the launch of RACPC. Post RACPC, fewer patients were referred to the ED (46.5% vs 73.9%, p < 0.01), decreased adjusted bed days for CP, more non-invasive tests (46.8 vs 39.2 per 100 referrals, p = 0.07) and fewer invasive coronary angiograms (5.6 vs 12.2 per 100 referrals, p < 0.01) were performed. Time from referral to diagnosis was shortened by 90%, while requiring 66% less visits (p < 0.01). System cost to evaluate CP was reduced by 20.7% and all RACPC patients were alive at 12 months.
    Conclusions: An Asian nurse-led RACPC expedited specialist evaluation of CP with less visits, reduced ED attendances and invasive testing whilst saving costs. Wider implementation across Asia would significantly improve CP evaluation.
    MeSH term(s) Humans ; Pain Clinics ; Singapore ; Chest Pain/diagnosis ; Chest Pain/etiology ; Coronary Angiography ; Hospitalization ; Emergency Service, Hospital
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2021-141427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An elderly couple with COVID-19 pneumonia treated in Singapore: contrasting clinical course and management.

    Wong, Sin Yew / Leong, Keng Hong / Ng, Kheng Siang / Tan, Seng Hoe / Lo, Pau Lin Constance / Chan, Kenneth

    Singapore medical journal

    2020  Volume 61, Issue 7, Page(s) 392–394

    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; DNA, Viral/analysis ; Disease Management ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Singapore
    Chemical Substances DNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Antimicrobial stewardship: the next big thing?

    Wong, Sin Yew / Allen, David Michael

    Annals of the Academy of Medicine, Singapore

    2012  Volume 41, Issue 1, Page(s) 1–3

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Microbial/drug effects ; Education, Medical, Continuing/standards ; Humans ; Practice Guidelines as Topic
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2012-03-19
    Publishing country Singapore
    Document type Editorial ; Comment
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications

    Fang Hoong Yeoh / Choy Sin Lee / Yew Beng Kang / Shew Fung Wong / Sit Foon Cheng / Wei Seng Ng

    Polymers, Vol 12, Iss 1842, p

    2020  Volume 1842

    Abstract: Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, ... ...

    Abstract Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, petrochemical-based polyols were often incorporated to improve the thermal and mechanical properties of polyurethane. In this work, palm oil-based polyester polyol (PPP) derived from epoxidized palm olein and glutaric acid was reacted with isophorone diisocyanate to produce an aliphatic polyurethane, without the incorporation of any commercial petrochemical-based polyol. The effects of water content and isocyanate index were investigated. The polyurethanes produced consisted of > 90% porosity with interconnected micropores and macropores (37–1700 µm) and PU 1.0 possessed tensile strength and compression stress of 111 kPa and 64 kPa. The polyurethanes with comparable thermal stability, yet susceptible to enzymatic degradation with 7–59% of mass loss after 4 weeks of treatment. The polyurethanes demonstrated superior water uptake (up to 450%) and did not induce significant changes in pH of the medium. The chemical changes of the polyurethanes after enzymatic degradation were evaluated by FTIR and TGA analyses. The polyurethanes showed cell viability of 53.43% and 80.37% after 1 and 10 day(s) of cytotoxicity test; and cell adhesion and proliferation in cell adhesion test. The polyurethanes produced demonstrated its potential as biomaterial for soft tissue engineering applications.
    Keywords palm oil-based polyester polyol ; polyurethane ; biodegradable ; biocompatible ; biomaterial ; tissue engineering ; Organic chemistry ; QD241-441
    Subject code 571
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: An elderly couple with COVID-19 pneumonia treated in Singapore: contrasting clinical course and management

    Wong, Sin Yew / Leong, Keng Hong / Ng, Kheng Siang / Tan, Seng Hoe / Lo, Pau Lin Constance / Chan, Kenneth

    Singapore Med J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #95002
    Database COVID19

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  7. Article ; Online: Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications.

    Yeoh, Fang Hoong / Lee, Choy Sin / Kang, Yew Beng / Wong, Shew Fung / Cheng, Sit Foon / Ng, Wei Seng

    Polymers

    2020  Volume 12, Issue 8

    Abstract: Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, ... ...

    Abstract Being biodegradable and biocompatible are crucial characteristics for biomaterial used for medical and biomedical applications. Vegetable oil-based polyols are known to contribute both the biodegradability and biocompatibility of polyurethanes; however, petrochemical-based polyols were often incorporated to improve the thermal and mechanical properties of polyurethane. In this work, palm oil-based polyester polyol (PPP) derived from epoxidized palm olein and glutaric acid was reacted with isophorone diisocyanate to produce an aliphatic polyurethane, without the incorporation of any commercial petrochemical-based polyol. The effects of water content and isocyanate index were investigated. The polyurethanes produced consisted of > 90% porosity with interconnected micropores and macropores (37-1700 µm) and PU 1.0 possessed tensile strength and compression stress of 111 kPa and 64 kPa. The polyurethanes with comparable thermal stability, yet susceptible to enzymatic degradation with 7-59% of mass loss after 4 weeks of treatment. The polyurethanes demonstrated superior water uptake (up to 450%) and did not induce significant changes in pH of the medium. The chemical changes of the polyurethanes after enzymatic degradation were evaluated by FTIR and TGA analyses. The polyurethanes showed cell viability of 53.43% and 80.37% after 1 and 10 day(s) of cytotoxicity test; and cell adhesion and proliferation in cell adhesion test. The polyurethanes produced demonstrated its potential as biomaterial for soft tissue engineering applications.
    Language English
    Publishing date 2020-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym12081842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Antimicrobial resistance: a new beginning and the need for action.

    Wong, Sin Yew / Hsu, Li Yang

    Annals of the Academy of Medicine, Singapore

    2008  Volume 37, Issue 10, Page(s) 817–818

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Microbial ; Humans ; Singapore
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2008-10-29
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
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    In stock of ZB MED Cologne/Königswinter

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  9. Article: Treatment of Primary Aldosteronism and Reversal of Renin Suppression Improves Left Ventricular Systolic Function.

    Puar, Troy H / Cheong, Chin Kai / Foo, Roger S Y / Saffari, Seyed Ehsan / Tu, Tian Ming / Chee, Min Ru / Zhang, Meifen / Ng, Keng Sin / Wong, Kang Min / Wong, Andrew / Ng, Foo Cheong / Aw, Tar Choon / Khoo, Joan / Gani, Linsey / King, Thomas / Loh, Wann Jia / Soh, Shui Boon / Au, Vanessa / Tay, Tunn Lin /
    Tan, Eberta / Mae, Lily / Yew, Jielin / Tan, Yen Kheng / Tong, Khim Leng / Lee, Sheldon / Chai, Siang Chew

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 916744

    Abstract: Introduction: Primary aldosteronism (PA) is associated with increased risk of cardiovascular events. However, treatment of PA has not been shown to improve left ventricular (LV) systolic function using the conventional assessment with LV ejection ... ...

    Abstract Introduction: Primary aldosteronism (PA) is associated with increased risk of cardiovascular events. However, treatment of PA has not been shown to improve left ventricular (LV) systolic function using the conventional assessment with LV ejection fraction (LVEF). We aim to use speckle-tracking echocardiography to assess for improvement in subclinical systolic function after treatment of PA.
    Methods: We prospectively recruited 57 patients with PA, who underwent 24-h ambulatory blood pressure (BP) measurements and echocardiography, including global longitudinal strain (GLS) assessment of left ventricle, at baseline and 12 months post-treatment.
    Results: At baseline, GLS was low in 14 of 50 (28.0%) patients. On multivariable analysis, GLS was associated with diastolic BP (
    Conclusion: Treatment of hyperaldosteronism is effective in improving subclinical LV systolic dysfunction. Elevation of renin levels after treatment, which reflects adequate reversal of sodium overload state, is associated with better systolic function after treatment.
    Clinical trial registration: www.ClinicalTrials.gov, identifier: NCT03174847.
    MeSH term(s) Blood Pressure Monitoring, Ambulatory ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/drug therapy ; Renin ; Systole ; Ventricular Function, Left
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.916744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Role of pneumococcal vaccination in prevention of pneumococcal disease among adults in Singapore.

    Eng, Philip / Lim, Lean Huat / Loo, Chian Min / Low, James Alvin / Tan, Carol / Tan, Eng Kiat / Wong, Sin Yew / Setia, Sajita

    International journal of general medicine

    2014  Volume 7, Page(s) 179–191

    Abstract: The burden of disease associated with Streptococcus pneumoniae infection in adults can be considerable but is largely preventable through routine vaccination. Although substantial progress has been made with the recent licensure of the new vaccines for ... ...

    Abstract The burden of disease associated with Streptococcus pneumoniae infection in adults can be considerable but is largely preventable through routine vaccination. Although substantial progress has been made with the recent licensure of the new vaccines for prevention of pneumonia in adults, vaccine uptake rates need to be improved significantly to tackle adult pneumococcal disease effectively. Increased education regarding pneumococcal disease and improved vaccine availability may contribute to a reduction in pneumococcal disease through increased vaccination rates. The increase in the elderly population in Singapore as well as globally makes intervention in reducing pneumococcal disease an important priority. Globally, all adult vaccines remain underused and family physicians give little priority to pneumococcal vaccination for adults in daily practice. Family physicians are specialists in preventive care and can be leaders in ensuring that adult patients get the full benefit of protection against vaccine-preventable diseases. They can play a key role in the immunization delivery of new and routine vaccines by educating the public on the risks and benefits associated with vaccines. Local recommendations by advisory groups on vaccination in adults will also help to tackle vaccine preventable diseases in adults.
    Language English
    Publishing date 2014-03-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S54963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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