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Article: Drought stress in sorghum: Mitigation strategies, breeding methods and technologies—A review

Yahaya, Muhammad Ahmad / Shimelis, Hussein

Journal of agronomy and crop science. 2022 Apr., v. 208, no. 2

2022

Abstract: Agriculture accounts for 70% of the global use of available freshwater. Projections show that demand for water will increase significantly due to climate change, population growth and development of agricultural enterprises globally. There is a need to ... ...

Abstract	Agriculture accounts for 70% of the global use of available freshwater. Projections show that demand for water will increase significantly due to climate change, population growth and development of agricultural enterprises globally. There is a need to develop water‐use efficient crop cultivars for sustainable agricultural production. Sorghum [Sorghum bicolor (L.) Moench.] is a powerhouse crop in drier regions supporting more than 500 million people. It is a relatively drought‐tolerant crop adapted to grow and yield in marginal environments where other dominant crops such as maize and wheat fail to survive. However, the mean yield of sorghum in the semi‐arid regions has stagnated around 1.0 ton/ha compared with the global average of 2.5 ton/ha, mainly due to recurrent droughts and heat stress. Breeding for drought‐tolerant cultivars is an economic and sustainable mitigation strategy against the current and projected drought stress. Therefore, the objectives of this review were to document the impact of drought stress and the key mitigation strategies under drought‐prone semi‐arid sorghum production systems. The first section of the review highlighted the impact of drought and its mitigation strategies emphasizing on the use of drought‐tolerant cultivars as the best strategy. This is followed by perspectives on aspects of drought‐response mechanisms, breeding methods and complementary technologies for drought tolerance. Integration of the conventional and molecular breeding technologies with rapid generation advancement methods could reduce the breeding cycle and increase the efficiency of deploying new varieties. Information presented in this review will guide agronomists and breeders to develop and deploy drought‐tolerant sorghum cultivars that are adapted to the changing production environments in the semi‐arid regions.
Keywords	Sorghum bicolor ; agronomy ; climate change ; corn ; cultivars ; drought ; drought tolerance ; freshwater ; growth and development ; heat stress ; population growth ; sustainable agriculture ; water stress ; wheat
Language	English
Dates of publication	2022-04
Size	p. 127-142.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	635552-3
ISSN	0931-2250
ISSN	0931-2250
DOI	10.1111/jac.12573
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exploring soil radon (Rn) concentrations and their connection to geological and meteorological factors.

Muhammad, Ahmad / Danbatta, Salim Jibrin / Muhammad, Ibrahim Yahaya / Nasidi, Ibrahim Isah

Environmental science and pollution research international

2023 Volume 31, Issue 1, Page(s) 565–578

Abstract: The relationship between soil radon and meteorological parameters in a region can provide insight into natural processes occurring between the lithosphere and the atmosphere. Understanding this relationship can help models establish more realistic ... ...

Abstract	The relationship between soil radon and meteorological parameters in a region can provide insight into natural processes occurring between the lithosphere and the atmosphere. Understanding this relationship can help models establish more realistic results, rather than depending on theoretical consequences. Radon variation can be complicated to model due to the various physical variables which can affect it, posing a limitation in atmospheric studies. To predict Rn variation from meteorological parameters, a hybrid mod el called multiANN, which is a combination of multi-regression and artificial neural network (ANN) models, is established. The model was trained with 70% of the data and tested on the remaining 30%, and its robustness was tested using the Monte-Carlo method. The regions with low performance are identified and possibly related to seismic events. This model can be a good candidate for predicting Rn concentrations from meteorological parameters and establishing the lower boundary conditions in seismo-ionospheric coupling models.
MeSH term(s)	Radon/analysis ; Soil ; Radiation Monitoring ; Meteorological Concepts ; Air Pollutants, Radioactive/analysis
Chemical Substances	Radon (Q74S4N8N1G) ; Soil ; Air Pollutants, Radioactive
Language	English
Publishing date	2023-11-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31237-6
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Article: ABO Blood Group Genotypes and Demographic Traits in Susceptibility to Type 1 Diabetes Mellitus in Lagos, Southwest, Nigeria.

Yahaya, Tajudeen / Abdullahi, Haliru / Muhammad, Zaharaddin / Ibrahim, Yusuf / Abdullahi, Mustapha / Ribah, Samuel / Jimoh, Mariam

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria

2023 Volume 37, Issue 2, Page(s) 199–205

Abstract: Studies have shown that ABO blood groups and demographic traits influence susceptibility to type 1 diabetes mellitus (T1DM) and can be used in combination with insulin therapy to reduce the disease's burden. However, geographical variations exist in the ... ...

Abstract	Studies have shown that ABO blood groups and demographic traits influence susceptibility to type 1 diabetes mellitus (T1DM) and can be used in combination with insulin therapy to reduce the disease's burden. However, geographical variations exist in the influence of demographic traits and ABO blood groups on susceptibility to diseases and thus require establishing it in every locality. This study determined the influence of demographic traits and ABO blood groups on the prevalence of T1DM in Lagos, Nigeria. A structured checklist was used to collect data from the health records of non-obese 150 type 1 diabetic patients at Ayobo Primary Health Center, Lagos. The results revealed that males, with 88 participants (52.7%), constituted the majority, while females had 62 (41.3%). The age group 40 years and older had the highest proportion of participants with 37 (24.7%), followed by 31-40 years with 32 (21.30%), 21-30 years with 30 (20%), 11-20 years with 27 (18%), and 1-10 years with 24 (16%). Christianity had the highest with 74 participants (49.3%), followed by Islam with 71 participants (47.3%), and traditional religion with 5 participants (3.3%). Eight (5.3%) of the participants were primary school graduates; 34 (22.7%) were secondary school graduates; and 108 (72%) were tertiary school graduates. The Yoruba ethnic group, with 77 participants (51.3%), was the most prevalent, followed by Igbo with 50 (33.3%), and Hausa with 3 (2.0%). ABO blood group A and B (positive and negative) individuals were the most diabetic and expressed the most severe cases, while group O positive and AB negative individuals were the least diabetic. T1DM prevention should be a priority for blood group A and B residents.
MeSH term(s)	Male ; Female ; Humans ; Adult ; ABO Blood-Group System/genetics ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/genetics ; Nigeria/epidemiology ; Ethnicity ; Genotype
Chemical Substances	ABO Blood-Group System
Language	English
Publishing date	2023-02-05
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	2197951-0
ISSN	0794-859X
ISSN	0794-859X
DOI	10.54548/njps.v37i2.6
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Article ; Online: Genetic Diversity and Population Structure of African Sorghum (Sorghum bicolor L. Moench) Accessions Assessed through Single Nucleotide Polymorphisms Markers

Yahaya, Muhammad Ahmad / Shimelis, Hussein / Nebie, Baloua / Ojiewo, Chris Ochieng / Rathore, Abhishek / Das, Roma

Genes (Basel). 2023 July 20, v. 14, no. 7

2023

Abstract: Assessing the genetic diversity and population structure of cultivated sorghum is important for heterotic grouping, breeding population development, marker-assisted cultivar development, and release. The objectives of the present study were to assess the ...

Abstract	Assessing the genetic diversity and population structure of cultivated sorghum is important for heterotic grouping, breeding population development, marker-assisted cultivar development, and release. The objectives of the present study were to assess the genetic diversity and deduce the population structure of 200 sorghum accessions using diversity arrays technology (DArT)-derived single nucleotide polymorphism (SNP) markers. The expected heterozygosity values ranged from 0.10 to 0.50 with an average of 0.32, while the average observed heterozygosity (0.15) was relatively low, which is a typical value for autogamous crops species like sorghum. Moderate polymorphic information content (PIC) values were identified with a mean of 0.26, which indicates the informativeness of the chosen SNP markers. The population structure and cluster analyses revealed four main clusters with a high level of genetic diversity among the accessions studied. The variation within populations (41.5%) was significantly higher than that among populations (30.8%) and between samples within the structure (27.7%). The study identified distantly related sorghum accessions such as SAMSORG 48, KAURA RED GLUME; Gadam, AS 152; CSRO1, ICNSL2014-062; and YALAI, KAFI MORI. The accessions exhibited wide genetic diversity that will be useful in developing new gene pools and novel genotypes for West Africa sorghum breeding programs.
Keywords	Sorghum bicolor ; autogamy ; cultivars ; genes ; genetic variation ; heterosis ; heterozygosity ; population structure ; single nucleotide polymorphism ; Western Africa
Language	English
Dates of publication	2023-0720
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14071480
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genetic Diversity and Population Structure of African Sorghum (

Yahaya, Muhammad Ahmad / Shimelis, Hussein / Nebie, Baloua / Ojiewo, Chris Ochieng / Rathore, Abhishek / Das, Roma

Genes

2023 Volume 14, Issue 7

Abstract	Assessing the genetic diversity and population structure of cultivated sorghum is important for heterotic grouping, breeding population development, marker-assisted cultivar development, and release. The objectives of the present study were to assess the genetic diversity and deduce the population structure of 200 sorghum accessions using diversity arrays technology (DArT)-derived single nucleotide polymorphism (SNP) markers. The expected heterozygosity values ranged from 0.10 to 0.50 with an average of 0.32, while the average observed heterozygosity (0.15) was relatively low, which is a typical value for autogamous crops species like sorghum. Moderate polymorphic information content (PIC) values were identified with a mean of 0.26, which indicates the informativeness of the chosen SNP markers. The population structure and cluster analyses revealed four main clusters with a high level of genetic diversity among the accessions studied. The variation within populations (41.5%) was significantly higher than that among populations (30.8%) and between samples within the structure (27.7%). The study identified distantly related sorghum accessions such as SAMSORG 48, KAURA RED GLUME; Gadam, AS 152; CSRO1, ICNSL2014-062; and YALAI, KAFI MORI. The accessions exhibited wide genetic diversity that will be useful in developing new gene pools and novel genotypes for West Africa sorghum breeding programs.
MeSH term(s)	Polymorphism, Single Nucleotide/genetics ; Genetic Variation/genetics ; Sorghum/genetics ; Plant Breeding ; Genotype ; Edible Grain
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14071480
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Article ; Online: The Clinical Characteristics and Outcomes of Infantile Seizures in the First Year of Life: A Single-Center Study.

Anuar, Muhamad Azamin / Zainal Abidin, Muhammad 'Adil / Tan, Soo Hong / Yeap, Cai Fong / Yahaya, Nor Azni

Pediatric neurology

2023 Volume 150, Page(s) 10–14

Abstract: Background: Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. Although considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, ... ...

Abstract	Background: Epilepsy has a high incidence among infants during their first year of life, yet the prognosis can vary significantly. Although considerable research has been conducted on infantile spasms, studies examining infantile-onset epilepsy, excluding infantile spasms, remain limited, particularly concerning the factors influencing outcomes. Therefore, our study aims to elucidate seizure control, developmental outcomes, and prognostic factors in infants with epilepsy during their first year of life, within a single-center study in Malaysia. Methods: We retrieved data from patients who experienced seizures before age 12 months and were followed for over two years, using electronic patient records at Hospital Raja Perempuan Zainab II in Kelantan, a state in Malaysia's east coast. We retrospectively reviewed these records and assessed clinical outcomes based on the last follow-up. Results: Of 75 patients, 61 (81.3%) achieved good seizure control or remission. At the last follow-up, 24 (32%) exhibited developmental delay, whereas 19 (25.3%) displayed abnormal neuroimaging. Patients with abnormal background electroencephalographic (EEG) activity, as well as abnormal radiological findings, were more likely to experience poor seizure control and unfavorable developmental outcomes (P < 0.05). Conclusions: Our study underscores that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and characteristics, as well as neuroimaging abnormalities. The management of infantile-onset epilepsies may necessitate substantial resources and precise interventions to enhance overall outcomes.
MeSH term(s)	Infant ; Humans ; Spasms, Infantile/complications ; Retrospective Studies ; Seizures/etiology ; Seizures/complications ; Epilepsy/epidemiology ; Prognosis ; Electroencephalography
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2023.10.004
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Article ; Online: Response of African Sorghum Genotypes for Drought Tolerance under Variable Environments

Yahaya, Muhammad Ahmad / Shimelis, Hussein / Nebié, Baloua / Mashilo, Jacob / Pop, Georgeta

Agronomy. 2023 Feb. 15, v. 13, no. 2

2023

Abstract: Sorghum (Sorghum bicolor (L.) Moench) is the main food staple for millions of people in Sub-Saharan Africa (SSA) and Asia. Sorghum is relatively drought tolerant and cultivated in arid and semi-arid regions under rain-fed production. However, severe ... ...

Abstract	Sorghum (Sorghum bicolor (L.) Moench) is the main food staple for millions of people in Sub-Saharan Africa (SSA) and Asia. Sorghum is relatively drought tolerant and cultivated in arid and semi-arid regions under rain-fed production. However, severe drought stress often leads to crop loss and declined productivity. The development and deployment of high-yielding and drought-adapted genotypes is a cost-effective strategy for sustainable sorghum production globally. The objective of this study was to determine drought tolerance and genotype-by-environment interaction (GEI) effects on grain yields of a population of African sorghum genotypes to identify high-yielding and drought-adapted genotypes for direct production and also for use in breeding programs. Two hundred and twenty-five sorghum genotypes were evaluated under non-stressed (NS), pre-anthesis drought stress (PreADS), and post-anthesis drought stress (PoADS) conditions under field and greenhouse environments using a 15 × 15 alpha lattice design in two replicates. The three water regimes and two environments resulted in six testing environments. Data were collected on grain yield and drought tolerance parameters, and additive main effect and multiplicative interaction (AMMI) analysis were computed. The mean grain yield under NS, PreADS, and PoADS were 3.70, 1.76, and 2.58 t/ha, in that order. The best genotypes adapted to non-stressed environments were G09, and G109, whereas G114 and G56 were suitable for non-stressed and stressed conditions. G72 and G75 displayed the best performance in PreADS conditions only, whereas genotypes G210 and G12 were identified as high performers under PoADS only. The AMMI analysis revealed that genotype (G), environment (E), and GEI were significant (p < 0.05), which accounted for 38.7, 44.6, and 16.6% of the total explained variation in grain yield. AMMI 4 was the best-fitting model for grain yield. Based on AMMI 4 and the Best Linear Unbiased Estimates (BLUPs) calculations, genotypes G119 and G127 with a grain yield of 5.6 t/ha and 6.3 t/ha were selected as being suitable for non-stressed conditions. Genotypes G8 and G71 with BLUPs of 2.5 t/ha and 2.6 t/ha were best-suited for pre-anthesis drought stress conditions, whereas genotypes G115 and G120 with BLUPs of 4.2 t/ha and 4.3 t/ha are recommended for post-anthesis drought-prone environments, respectively. The identified sorghum genotypes are recommended for production in dry agro-ecologies of sub-Saharan Africa characterized by pre-and-post anthesis drought stress. In addition, the identified genotypes are valuable genetic resources to develop novel drought-tolerance material.
Keywords	Sorghum bicolor ; agronomy ; cost effectiveness ; crop losses ; drought tolerance ; flowering ; genotype ; genotype-environment interaction ; grain yield ; greenhouses ; models ; people ; rainfed farming ; water stress ; Asia ; Sub-Saharan Africa
Language	English
Dates of publication	2023-0215
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2607043-1
ISSN	2073-4395
ISSN	2073-4395
DOI	10.3390/agronomy13020557
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A systematic review of urethral complications following male circumcision

Musa Yahaya Muhammad / Christian Agbo Agbo

Nigerian Journal of Medicine, Vol 31, Iss 2, Pp 125-

The importance of provider training

2022 Volume 132

Abstract: Background: Male circumcision is one of the most common elective surgical procedures worldwide. Adverse events affecting the urethra may occur following the procedure. Aim: The aim of this paper is to provide a review of the existing literature on ... ...

Abstract	Background: Male circumcision is one of the most common elective surgical procedures worldwide. Adverse events affecting the urethra may occur following the procedure. Aim: The aim of this paper is to provide a review of the existing literature on urethral complications of male circumcision. Materials and Methods: A search of PubMed and Google Scholar was conducted between November 20, 2020, and November 30, 2020 and updated on January 12, 2021. Several keywords related to male circumcision were searched on the two databases. A further manual search of the reference lists of relevant papers was carried out. Studies that reported frequencies of urethral complications following circumcision were included in the analysis. A total of 83 candidate papers were identified and studied before arriving at 38 studies that contained sufficient information suitable for the analysis. Results: Overall, we found that the reported frequencies of urethral complications of male circumcision varied (range 0.01% to 39%; median 1.7%). Meatal stenosis (MS) and urethrocutaneous fistula (UCF) were by far the most frequently reported urethral complications of male circumcision with cases reported in 30 and 18 studies, respectively. Meatitis and urethral stricture were the other urethral complications found in our search. Conclusion: The urethral complications of male circumcision we found were UCF, MS, meatitis/meatal ulcer, and urethral stricture. Neonatal circumcision and circumcision by untrained providers are associated with higher incidences of urethral tragedies following male circumcision. The type of male circumcision provider is also a determinant of the frequency of complications.
Keywords	circumcision complications ; male circumcision ; prevention ; urethra ; Medicine ; R
Subject code	590
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain.

Muhammad Abdul Kadar, Nellysha Namela / Ahmad, Fairus / Teoh, Seong Lin / Yahaya, Mohamad Fairuz

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: There is mounting evidence that metabolic syndrome (MetS) contributes to the development of neurodegenerative disorders such as Alzheimer’s disease. Honey, which has been used for generations, is high in antioxidants and has been demonstrated to benefit ... ...

Abstract	There is mounting evidence that metabolic syndrome (MetS) contributes to the development of neurodegenerative disorders such as Alzheimer’s disease. Honey, which has been used for generations, is high in antioxidants and has been demonstrated to benefit the brain and mental health by reducing oxidative stress and boosting cognitive outcomes. Honey from the stingless bees of Heterotrigona itama has been found to have higher phenolic content compared to other types of honeys. The aim of this study is to investigate the effects of stingless bee honey (SBH) supplementation and to compare it with a pure form of antioxidant, caffeic acid (CA), on MetS parameters and inflammatory markers in the brains of MetS-induced rats. A total of 32 male Wistar rats were divided equally into groups of control, high-carbohydrate high-fructose (HCHF) diet (MetS), HCHF + SBH supplemented (1 g/kg) (SBH), and HCHF + CA supplemented (10 mg/kg) (CA) groups. The total duration for SBH and CA supplementation was eight weeks. The HCHF diet was found to promote hypertension, hyperglycemia, and hypertriglyceridemia, and to increase brain TNF-α levels. Supplementation with SBH and CA significantly reversed (p < 0.05) the hyperglycemic and hypertensive effects of the HCHF diet. Although both supplemented groups showed no significant changes to serum HDL or TG, SBH significantly reduced (p < 0.05) brain TNF-α levels and increased (p < 0.05) brain BDNF levels. Immunohistochemistry investigations of neurogenesis (EdU) and apoptosis (TUNEL) on the cornu Ammonis 1 (CA1) and dentate gyrus (DG) areas of the hippocampus showed no changes with SBH and CA supplementation compared to the control. These findings suggest that SBH and CA have the potential to mitigate HCHF-induced MetS effects and possess neuroprotective abilities.
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11112154
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Article ; Online: Targeted Sequencing of Cytokine-Induced PI3K-Related Genes in Ulcerative Colitis, Colorectal Cancer and Colitis-Associated Cancer.

Razali, Nurul Nadirah / Raja Ali, Raja Affendi / Muhammad Nawawi, Khairul Najmi / Yahaya, Azyani / Mokhtar, Norfilza M

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Chronic relapsing inflammatory bowel disease is strongly linked to an increased risk of colitis-associated cancer (CAC). One of the well-known inflammatory carcinogenesis pathways, phosphatidylinositol 3-kinase (PI3K), was identified to be a crucial ... ...

Abstract	Chronic relapsing inflammatory bowel disease is strongly linked to an increased risk of colitis-associated cancer (CAC). One of the well-known inflammatory carcinogenesis pathways, phosphatidylinositol 3-kinase (PI3K), was identified to be a crucial mechanism in long-standing ulcerative colitis (UC). The goal of this study was to identify somatic variants in the cytokine-induced PI3K-related genes in UC, colorectal cancer (CRC) and CAC. Thirty biopsies (n = 8 long-standing UC, n = 11 CRC, n = 8 paired normal colorectal mucosa and n = 3 CAC) were subjected to targeted sequencing on 13 PI3K-related genes using Illumina sequencing and the SureSelectXT Target Enrichment System. The Genome Analysis Toolkit was used to analyze variants, while ANNOVAR was employed to detect annotations. There were 5116 intronic, 355 exonic, 172 untranslated region (UTR) and 59 noncoding intronic variations detected across all samples. Apart from a very small number of frameshifts, the distribution of missense and synonymous variants was almost equal. We discovered changed levels of
MeSH term(s)	Colitis, Ulcerative/genetics ; Colitis-Associated Neoplasms/genetics ; Colorectal Neoplasms/genetics ; Cytokines/genetics ; Humans ; Neoplasm Recurrence, Local/genetics ; Phosphatidylinositol 3-Kinase/genetics ; Untranslated Regions
Chemical Substances	Cytokines ; Untranslated Regions ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911472
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