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  1. Article ; Online: The nature of blood(y) extracellular vesicles.

    Hendrix, An

    Nature reviews. Molecular cell biology

    2021  Volume 22, Issue 4, Page(s) 243

    Language English
    Publishing date 2021-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-021-00348-8
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    Zs.A 5446: Show issues Location:
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  2. Article ; Online: Systemically circulating bacterial extracellular vesicles: origin, fate, and function.

    Hendrix, An / De Wever, Olivier

    Trends in microbiology

    2022  Volume 30, Issue 3, Page(s) 213–216

    Abstract: Bacteria contribute to human host (patho)physiology through the production of a myriad of biomolecules enclosed in membrane vesicles [bacterial extracellular vesicles (BEVs)]. Recent research revealed that BEVs, as a functional output of bacteria, enter ... ...

    Abstract Bacteria contribute to human host (patho)physiology through the production of a myriad of biomolecules enclosed in membrane vesicles [bacterial extracellular vesicles (BEVs)]. Recent research revealed that BEVs, as a functional output of bacteria, enter the systemic circulation. Here, we highlight the current state of knowledge on the origin, translocation, distribution, function, and excretion or elimination of systemically circulating BEVs and delineate knowledge gaps. Further investigations on the so far occult stages of BEV entry beyond the walls of epithelial and immune barriers will unmask the role of BEVs in health and disease.
    MeSH term(s) Bacteria ; Extracellular Vesicles ; Humans
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.12.012
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    Zs.A 3738: Show issues Location:
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  3. Article ; Online: Towards the Clinical Implementation of Extracellular Vesicle-Based Biomarker Assays for Cancer.

    Van Dorpe, Sofie / Tummers, Philippe / Denys, Hannelore / Hendrix, An

    Clinical chemistry

    2024  Volume 70, Issue 1, Page(s) 165–178

    Abstract: Background: Substantial research has been devoted to elucidating the role of extracellular vesicles (EVs) in the different hallmarks of cancer. Consequently, EVs are increasingly explored as a source of cancer biomarkers in body fluids. However, the ... ...

    Abstract Background: Substantial research has been devoted to elucidating the role of extracellular vesicles (EVs) in the different hallmarks of cancer. Consequently, EVs are increasingly explored as a source of cancer biomarkers in body fluids. However, the heterogeneity in EVs, the complexity of body fluids, and the diversity in methods available for EV analysis, challenge the development and translation of EV-based biomarker assays.
    Content: Essential steps in EV-associated biomarker development are emphasized covering biobanking, biomarker discovery, verification and validation, and clinical implementation. A meticulous study design is essential and ideally results from close interactions between clinicians and EV researchers. A plethora of different EV preparation protocols exists which warrants quality control and transparency to ensure reproducibility and thus enable verification of EV-associated biomarker candidates identified in the discovery phase in subsequent independent cohorts. The development of an EV-associated biomarker assay requires thorough analytical and clinical validation. Finally, regulatory affairs must be considered for clinical implementation of EV-based biomarker assays.
    Summary: In this review, the current challenges that prevent us from exploiting the full potential of EV-based biomarker assays are identified. Guidelines and tools to overcome these hurdles are highlighted and are crucial to advance EV-based biomarker assays into clinical use.
    MeSH term(s) Humans ; Biological Specimen Banks ; Reproducibility of Results ; Biomarkers, Tumor ; Neoplasms/diagnosis ; Extracellular Vesicles
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad189
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  4. Article: Systemically circulating bacterial extracellular vesicles: origin, fate, and function

    Hendrix, An / De Wever, Olivier

    Trends in microbiology. 2022 Mar., v. 30, no. 3

    2022  

    Abstract: Bacteria contribute to human host (patho)physiology through the production of a myriad of biomolecules enclosed in membrane vesicles [bacterial extracellular vesicles (BEVs)]. Recent research revealed that BEVs, as a functional output of bacteria, enter ... ...

    Abstract Bacteria contribute to human host (patho)physiology through the production of a myriad of biomolecules enclosed in membrane vesicles [bacterial extracellular vesicles (BEVs)]. Recent research revealed that BEVs, as a functional output of bacteria, enter the systemic circulation. Here, we highlight the current state of knowledge on the origin, translocation, distribution, function, and excretion or elimination of systemically circulating BEVs and delineate knowledge gaps. Further investigations on the so far occult stages of BEV entry beyond the walls of epithelial and immune barriers will unmask the role of BEVs in health and disease.
    Keywords biochemical compounds ; epithelium ; excretion ; humans
    Language English
    Dates of publication 2022-03
    Size p. 213-216.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.12.012
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  5. Article ; Online: Density-Based Fractionation of Cell-Conditioned Medium to Prepare Proteomics Grade Extracellular Vesicles.

    Roux, Quentin / Deville, Sarah / Hendrix, An

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2718, Page(s) 253–269

    Abstract: The identification of the molecular composition of extracellular vesicles (EV) by omics approaches, including proteomics, requires the separation of EV from non-EV confounding factors present in the source biofluid. In this protocol, we present the ... ...

    Abstract The identification of the molecular composition of extracellular vesicles (EV) by omics approaches, including proteomics, requires the separation of EV from non-EV confounding factors present in the source biofluid. In this protocol, we present the sequential implementation of density gradient ultracentrifugation and size-exclusion chromatography to prepare EV from cell-conditioned medium with high specificity and repeatability. This approach enables the recovery of intact purified EV suited for downstream functional assays and biomarker discovery by omics approaches.
    MeSH term(s) Extracellular Vesicles/chemistry ; Cell Fractionation ; Culture Media, Conditioned ; Humans ; Cytological Techniques/methods ; Proteomics ; Centrifugation, Density Gradient ; Chromatography, Gel
    Chemical Substances Culture Media, Conditioned
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3457-8_14
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  6. Article ; Online: Relations Between Abiotic and Biotic Environmental Variables and Occupancy of Delta Smelt (Hypomesus transpacificus) in Autumn

    Hendrix, A. Noble / Fleishman, Erica / Zillig, Martha Wohlfeil / Jennings, Eva Dusek

    Estuaries and Coasts. 2023 Jan., v. 46, no. 1 p.149-165

    2023  

    Abstract: There is much debate about the extent to which water management in the upper San Francisco Estuary, California, affects the habitat and status of delta smelt (Hypomesus transpacificus), an endemic fish protected under the US and California Endangered ... ...

    Abstract There is much debate about the extent to which water management in the upper San Francisco Estuary, California, affects the habitat and status of delta smelt (Hypomesus transpacificus), an endemic fish protected under the US and California Endangered Species Acts. For example, current management reflects the hypothesis that salinity, and in some cases the location of the tidally averaged salinity of 2 parts per thousand (X2), is a reliable indication of habitat quality. We evaluated hypotheses about environmental drivers of the quality of delta smelt habitat (probability of occupancy) during autumn that were developed by experts on the species and estuary. We fit Bayesian occupancy models, which account for imperfect detection, and identified those that best predicted the presence of delta smelt in catch data from 1980 to 2015. The most strongly supported model indicated that occupancy was associated with salinity (measured as specific conductance) and temperature, and detection was associated with body size, sample volume, water clarity, and tidal stage. The second most strongly supported model indicated that occupancy was associated with the abundance of a hypothesized competitor, threadfin shad (Dorosoma petenense), an expert-elicited index of predation intensity, and water clarity, and detection was associated with body size, sample volume, water clarity, and time of day. Our results suggested that clarity did not affect occupancy, but affected finer-resolution processes of local presence and detection at sampling stations. Spatial patterns in occupancy were consistent in wet and dry years, suggesting that management on the basis of salinity oversimplifies estimation of habitat quantity and quality.
    Keywords Bayesian theory ; Dorosoma petenense ; Hypomesus transpacificus ; autumn ; body size ; estuaries ; habitats ; indigenous species ; models ; predation ; probability ; salinity ; temperature ; water management ; water quality ; California
    Language English
    Dates of publication 2023-01
    Size p. 149-165.
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 2229170-2
    ISSN 1559-2731 ; 1559-2723
    ISSN (online) 1559-2731
    ISSN 1559-2723
    DOI 10.1007/s12237-022-01100-x
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  7. Article ; Online: Exploring the Role of Low-Density Neutrophils During

    Rankin, Ananda N / Hendrix, Skyler V / Naik, Sumanta K / Stallings, Christina L

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 901590

    Abstract: Tuberculosis (TB) is caused by infection with the ... ...

    Abstract Tuberculosis (TB) is caused by infection with the bacterium
    MeSH term(s) COVID-19 ; Humans ; Lung ; Mycobacterium tuberculosis ; Neutrophils ; Tuberculosis
    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.901590
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  8. Article ; Online: A supporting ecosystem to mature extracellular vesicles into clinical application.

    De Wever, Olivier / Hendrix, An

    The EMBO journal

    2019  Volume 38, Issue 9

    MeSH term(s) Biomarkers/analysis ; Biotechnology ; Ecosystem ; Extracellular Vesicles/physiology ; Humans ; Translational Medical Research
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2018101412
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    Zs.A 1808: Show issues Location:
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  9. Article ; Online: Targets, pitfalls and reference materials for liquid biopsy tests in cancer diagnostics.

    Geeurickx, Edward / Hendrix, An

    Molecular aspects of medicine

    2019  Volume 72, Page(s) 100828

    Abstract: Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and ... ...

    Abstract Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection, tumor dynamics assessment, minimal residual disease detection and therapy monitoring. However, few liquid biopsy tests progress towards clinical application because results are often discordant and challenging to reproduce. Reproducibility can be enhanced by the development and implementation of standard operating procedures and reference materials to identify and correct for pre-analytical variables. In this review we elaborate on the technological considerations, pre-analytical variables and the use and availability of reference materials for the assessment of liquid biopsy targets in blood and highlight initiatives towards the standardization of liquid biopsy testing.
    MeSH term(s) Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/analysis ; Cell-Free Nucleic Acids/blood ; Cell-Free Nucleic Acids/genetics ; Circulating Tumor DNA/analysis ; Extracellular Vesicles ; Humans ; Liquid Biopsy/methods ; Liquid Biopsy/standards ; Neoplasms/diagnosis ; Neoplasms/pathology ; Reference Standards ; Reproducibility of Results
    Chemical Substances Biomarkers, Tumor ; Cell-Free Nucleic Acids ; Circulating Tumor DNA
    Language English
    Publishing date 2019-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2019.10.005
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  10. Article ; Online: Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts.

    Fischer, Suzanne / Creytens, David / Gijsels, Stefanie / Descamps, Benedicte / Lapeire, Lore / Hendrix, An / Sys, Gwen / De Wever, Olivier

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102863

    Abstract: Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to ... ...

    Abstract Despite optimal multimodal treatment including surgical resection, 50%-80% of high-grade soft tissue sarcoma (STS) patients metastasize. Here, we present a protocol for the generation and use of post-surgical minimal residual disease models to investigate metastatic relapse in STS patient-derived xenografts. We describe steps for orthotopic engraftment of high-grade STS patient-derived tumor tissue. We then detail procedures for primary tumor resection with broad, negative resection margins and follow-up until metastases using MRI. For complete details on the use and execution of this protocol, please refer to Fischer et al. (2023).
    MeSH term(s) Humans ; Neoplasm, Residual ; Heterografts ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/surgery ; Soft Tissue Neoplasms/pathology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102863
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