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  1. Article ; Online: Gil de Andrés, Carlos

    Sergio Cañas Díez

    Historia Actual Online, Vol 0, Iss 32, Pp 222-

    50 cosas que hay que saber sobre la historia de España. Barcelona, Ariel, 2013, 223 pp.

    2013  Volume 223

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Language English
    Publishing date 2013-10-01T00:00:00Z
    Publisher Asociación de Historia Actual
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Casanova, Julián y Gil Andrés, Carlos, Breve historia de España en el siglo XX. Barcelona, Ariel, 2012, 267 pp.

    Sergio Cañas Díez

    Historia Actual Online, Vol 0, Iss 33, Pp 203-

    2014  Volume 205

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Publisher Asociación de Historia Actual
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Biological and Medical Aspects Related to South American Rattlesnake

    Cañas, Carlos A

    Toxins

    2022  Volume 14, Issue 12

    Abstract: In Colombia, South America, there is a subspecies of the South American ... ...

    Abstract In Colombia, South America, there is a subspecies of the South American rattlesnake
    MeSH term(s) Animals ; Humans ; Crotalus/metabolism ; Colombia ; Crotalid Venoms/toxicity ; Crotalid Venoms/metabolism ; Brazil ; South American People
    Chemical Substances Crotalid Venoms
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14120875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The triggering of post-COVID-19 autoimmunity phenomena could be associated with both transient immunosuppression and an inappropriate form of immune reconstitution in susceptible individuals.

    Cañas, Carlos A

    Medical hypotheses

    2020  Volume 145, Page(s) 110345

    Abstract: With the progression of the COVID-19 pandemic, there have been different reports about the development of autoimmune diseases once the infection is controlled. After entering the respiratory epithelial cells, SARS-CoV-2-the virus that causes the disease- ... ...

    Abstract With the progression of the COVID-19 pandemic, there have been different reports about the development of autoimmune diseases once the infection is controlled. After entering the respiratory epithelial cells, SARS-CoV-2-the virus that causes the disease-triggers a severe inflammatory state in some patients known as "cytokine storm" and the development of thrombotic phenomena-both conditions being associated with high mortality. Patients additionally present severe lymphopenia and, in some cases, complement consumption and autoantibody development. There is a normalization of lymphocytes once the infection is controlled. After this, autoimmune conditions of unknown etiology may occur. A hypothesis for the development of post-COVID-19 autoimmunity is proposed based on the consequences of both a transient immunosuppression (both of innate and acquired immunity) in which self-tolerance is lost and an inappropriate form of immune reconstitution that amplifies the process.
    MeSH term(s) Adaptive Immunity ; Autoantibodies/chemistry ; Autoantigens ; Autoimmunity/immunology ; COVID-19/blood ; COVID-19/immunology ; Cytokines/immunology ; Disease Progression ; Disease Susceptibility ; Humans ; Immune Reconstitution ; Immune Tolerance ; Immunity, Innate ; Immunosuppression Therapy ; Inflammation ; Lymphocytes/immunology ; Models, Theoretical ; Pandemics
    Chemical Substances Autoantibodies ; Autoantigens ; Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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  5. Article: Major depression associated with a levonorgestrel-releasing intrauterine system mimicking frontotemporal dementia: a case report.

    Valencia-Cifuentes, Valeria / Cañas, Carlos A / Rivas, Juan Carlos

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1266419

    Abstract: This case illustrates the adverse cognitive and affective effects associated with the use of an intrauterine hormonal contraceptive, which could be confused with symptoms of early onset dementia. We present a case of a 42-year-old woman diagnosed with ... ...

    Abstract This case illustrates the adverse cognitive and affective effects associated with the use of an intrauterine hormonal contraceptive, which could be confused with symptoms of early onset dementia. We present a case of a 42-year-old woman diagnosed with seronegative spondyloarthropathy who subsequently developed anxiety and depressive symptoms after the implantation of a Levonorgestrel-Releasing Intrauterine System (LNG-IUS). Three years later, she began to experience memory and attentional failures, refractory pain, and severe depression. The progression of psychiatric symptoms led to a diagnosis of bipolar affective disorder and treatment with antidepressants and anxiolytics. Due to cognitive and psychiatric symptoms, autoimmune encephalitis was considered, but no improvement was shown with treatment. Early onset dementia was suspected, and a brain PET scan revealed frontal lobe hypometabolism. An adverse effect of LNG-IUS was considered; after its removal, mood and cognitive function improvements were observed. This case report emphasizes the importance of considering organic causes of unexplained psychiatric manifestations and highlights the potential impact of hormonal interventions on mental health.
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1266419
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  6. Article ; Online: The triggering of post-COVID-19 autoimmunity phenomena could be associated with both transient immunosuppression and an inappropriate form of immune reconstitution in susceptible individuals

    Cañas, Carlos A.

    Medical Hypotheses

    2020  Volume 145, Page(s) 110345

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110345
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: The triggering of post-COVID-19 autoimmunity phenomena could be associated with both transient immunosuppression and an inappropriate form of immune reconstitution in susceptible individuals

    Cañas, Carlos A

    Med Hypotheses

    Abstract: With the progression of the COVID-19 pandemic, there have been different reports about the development of autoimmune diseases once the infection is controlled. After entering the respiratory epithelial cells, SARS-CoV-2-the virus that causes the disease- ... ...

    Abstract With the progression of the COVID-19 pandemic, there have been different reports about the development of autoimmune diseases once the infection is controlled. After entering the respiratory epithelial cells, SARS-CoV-2-the virus that causes the disease-triggers a severe inflammatory state in some patients known as "cytokine storm" and the development of thrombotic phenomena-both conditions being associated with high mortality. Patients additionally present severe lymphopenia and, in some cases, complement consumption and autoantibody development. There is a normalization of lymphocytes once the infection is controlled. After this, autoimmune conditions of unknown etiology may occur. A hypothesis for the development of post-COVID-19 autoimmunity is proposed based on the consequences of both a transient immunosuppression (both of innate and acquired immunity) in which self-tolerance is lost and an inappropriate form of immune reconstitution that amplifies the process.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #856996
    Database COVID19

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  8. Article: Severe cerebral edema related to oral methadone: A case report and literature review.

    Cañas, Carlos A / Posso-Osorio, Ivan / Rivera-Londoño, Robert / Bolaños, Juan D / Granados, Ana M

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26111

    Abstract: Introduction: Opioids are widely used for pain management, and increased intracranial pressure (ICP) has been evidenced in some cases. We reported a patient with severe cerebral edema after initiating methadone and its complete resolution upon ... ...

    Abstract Introduction: Opioids are widely used for pain management, and increased intracranial pressure (ICP) has been evidenced in some cases. We reported a patient with severe cerebral edema after initiating methadone and its complete resolution upon discontinuing the medication. Additionally, a review of the literature is made.
    Case report: A 53-year-old woman patient with a history of systemic lupus erythematosus developed mechanic chronic lower back pain, refractory to conventional treatments. She presented improvement with oxycodone. She withdrew this medication due to a lack of supplies in her country (Colombia) and showed withdrawal symptoms. She consulted the emergency department, where oral methadone was started and symptom control was achieved. Three days after admission, she presented intense headaches and emesis. A brain CT scan was performed in which severe cerebral edema was appreciated. Methadone was discontinued, and neurological symptoms quickly disappeared. A follow-up brain CT scan was performed later, finding full resolution of the edema.
    Conclusion: A case of severe cerebral edema associated with the initiation of oral methadone and its rapid resolution without neurological sequelae after its withdrawal is presented, clinicians must be attentive to this adverse event.
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26111
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  9. Article ; Online: Systemic lupus erythematosus flare during SARS-CoV-2 infection: Report of 3 cases presented during the fourth wave of the pandemic in Colombia.

    Naranjo-Millán, Julián Alberto / Bedoya-Joaqui, Vanessa / Cañas, Carlos A

    International journal of rheumatic diseases

    2023  Volume 26, Issue 9, Page(s) 1807–1810

    Abstract: Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a worldwide pandemic since first discovered in 2019. Systemic lupus erythematosus (SLE) flare has been reported in the post-infectious period. In Colombia, the ...

    Abstract Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has become a worldwide pandemic since first discovered in 2019. Systemic lupus erythematosus (SLE) flare has been reported in the post-infectious period. In Colombia, the fourth pandemic wave started at the beginning of 2022 when we observed flare of 3 SLE patients during active infection.
    Case presentation: We describe 3 patients with inactive SLE, who presented coronavirus disease 2019 and severe flare in early 2022, 2 patients with nephritis and 1 with severe thrombocytopenia. All patients had increase of antinuclear and anti-DNA antibody titers and complement consumption.
    Conclusions: Three cases with SLE flare concomitant with active SARS-CoV-2 infection were different from others reported earlier in the pandemic with post-infectious flare.
    MeSH term(s) Humans ; Pandemics ; Colombia/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6098: Show issues Location:
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  10. Article ; Online: The Colombian bushmasters Lachesis acrochorda (García, 1896) and Lachesis muta (Linnaeus, 1766): Snake species, venoms, envenomation, and its management.

    Cañas, Carlos A / Castaño-Valencia, Santiago / Castro-Herrera, Fernando

    Toxicon : official journal of the International Society on Toxinology

    2023  Volume 230, Page(s) 107152

    Abstract: In Colombia, there are two species of bushmaster snakes, Lachesis acrochorda, which is distributed mainly in the west of the country (in the Choco region), and Lachesis muta in the southeast (in the Amazon and Orinoquia region), whose presence has been ... ...

    Abstract In Colombia, there are two species of bushmaster snakes, Lachesis acrochorda, which is distributed mainly in the west of the country (in the Choco region), and Lachesis muta in the southeast (in the Amazon and Orinoquia region), whose presence has been reduced due to the destruction of their habitats. Captive maintenance is challenging, making it difficult to obtain their venom for study and antivenom manufacturing. They are the largest vipers in the world. The occurrence of human envenomation is quite rare, but when it occurs, it is associated with high mortality. Bushmaster venom is necrotizing, hemorrhagic, myotoxic, hemolytic, and cardiovascular depressant. Due to the presence of bradycardia, hypotension, emesis, and diarrhea in some patients (Lachesis syndrome), the possibility of a vagal or cholinergic effect is raised. The treatment of envenomation is hindered by the scarcity of antivenom and the need to use high doses. A review of the most relevant biological and medical aspects of bushmaster snakes is presented, mainly for those occurring in Colombia, to facilitate their recognition and raise awareness about the need for special attention to improve their conservation and advance scientific knowledge, in particular, about their venom.
    MeSH term(s) Animals ; Humans ; Viperidae ; Antivenins/therapeutic use ; Colombia ; Crotalid Venoms
    Chemical Substances Antivenins ; Crotalid Venoms
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2023.107152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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