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  1. Article ; Online: Geriatric mental health practice with dementia patients in Bangladesh: Challenges and future directions.

    Alam, Rifat B / Ostler, Teresa

    Asian journal of psychiatry

    2024  Volume 94, Page(s) 103945

    MeSH term(s) Humans ; Aged ; Mental Health ; Bangladesh ; Mental Disorders ; Dementia/therapy ; Dementia/psychology
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.103945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Assessment of parenting competency in mothers with mental illness

    Ostler, Teresa

    2008  

    Author's details by Teresa Ostler
    Language English
    Size XIV, 188 S.
    Publisher Brookes
    Publishing place Baltimore, Md. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015482552
    ISBN 978-1-55766-665-9 ; 1-55766-665-2
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Retinal Oxygenation With Conventional 100-ms Versus Short-Pulse Pan-Retinal Laser Photocoagulation.

    Gallagher, Kevin / Ostler, Timothy / Woolley, Thomas E

    Ophthalmic surgery, lasers & imaging retina

    2024  Volume 55, Issue 1, Page(s) 40–45

    Abstract: Background and objective: Conventional (100 ms) pan-retinal photocoagulation (PRP) laser burns are larger than short-pulse (10 ms to 20 ms) PRP burns. This study investigates the effect of PRP burns of different sizes on retinal oxygenation.: Method: ...

    Abstract Background and objective: Conventional (100 ms) pan-retinal photocoagulation (PRP) laser burns are larger than short-pulse (10 ms to 20 ms) PRP burns. This study investigates the effect of PRP burns of different sizes on retinal oxygenation.
    Method: A mathematical model using COMSOL Multiphysics 6 was used to create a three-dimensional abstraction of the coupled biology of the choroid, photoreceptor, and retinal tissues. Laser burn sizes were varied in the model, specifically considering burn diameters of 500 μm, 250 μm, and 125 μm, while keeping the total burn area constant.
    Results: Total increase in retinal oxygenation was the same for different burn sizes, but the oxygen distribution differed. Smaller burns resulted in a more even lateral oxygen distribution but with reduced penetration into the inner retina.
    Conclusions: Conventional and short-pulse PRP may affect retinal oxygenation differently, even when total burn area is the same. Further investigation into optimum burn size and pattern is required.
    MeSH term(s) Humans ; Retina/surgery ; Choroid ; Laser Coagulation ; Oxygen ; Radiation Injuries ; Lasers
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20231114-01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.

    Forster, Florian / Paster, Wolfgang / Supper, Verena / Schatzlmaier, Philipp / Sunzenauer, Stefan / Ostler, Nicole / Saliba, Anna / Eckerstorfer, Paul / Britzen-Laurent, Nathalie / Schütz, Gerhard / Schmid, Johannes A / Zlabinger, Gerhard J / Naschberger, Elisabeth / Stürzl, Michael / Stockinger, Hannes

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 192, Issue 2, Page(s) 771–781

    Abstract: ... a regulator of T cell activation. Silencing of GBP-1 leads to enhanced activation of early T cell Ag receptor ... of TCR/CD3 and CD45 in GBP-1 silenced T cells that explain their enhanced TCR/CD3 signaling. We conclude ... that GBP-1 is a downstream processor of IFN-γ via which T cells regulate cytoskeleton-dependent cell ...

    Abstract GTPases act as important switches in many signaling events in cells. Although small and heterotrimeric G proteins are subjects of intensive studies, little is known about the large IFN-inducible GTPases. In this article, we show that the IFN-γ-inducible guanylate binding protein 1 (GBP-1) is a regulator of T cell activation. Silencing of GBP-1 leads to enhanced activation of early T cell Ag receptor/CD3 signaling molecules, including Lck, that is translated to higher IL-2 production. Mass spectrometry analyses showed that regulatory cytoskeletal proteins, like plastin-2 that bundles actin fibers and spectrin β-chain, brain 1 that links the plasma membrane to the actin cytoskeleton, are binding partners of GBP-1. The spectrin cytoskeleton influences cell spreading and surface expression of TCR/CD3 and the leukocyte phosphatase CD45. We found higher cell spreading and enhanced surface expression of TCR/CD3 and CD45 in GBP-1 silenced T cells that explain their enhanced TCR/CD3 signaling. We conclude that GBP-1 is a downstream processor of IFN-γ via which T cells regulate cytoskeleton-dependent cell functions.
    MeSH term(s) CD3 Complex/genetics ; CD3 Complex/metabolism ; Cell Line ; Cell Line, Tumor ; Cytoskeleton/genetics ; Cytoskeleton/metabolism ; Cytosol/metabolism ; GTP-Binding Proteins/genetics ; GTP-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interleukin-2/genetics ; Interleukin-2/metabolism ; Jurkat Cells ; Leukocyte Common Antigens ; Leukocytes/metabolism ; Lymphocyte Activation/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Receptor-CD3 Complex, Antigen, T-Cell/genetics ; Receptor-CD3 Complex, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/genetics ; T-Lymphocytes/metabolism ; Up-Regulation/genetics
    Chemical Substances CD3 Complex ; GBP1 protein, human ; Interleukin-2 ; Membrane Glycoproteins ; Microfilament Proteins ; Receptor-CD3 Complex, Antigen, T-Cell ; Receptors, Antigen, T-Cell ; plastin ; Interferon-gamma (82115-62-6) ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; Leukocyte Common Antigens (EC 3.1.3.48) ; PTPRC protein, human (EC 3.1.3.48) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2014-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1300377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Simulations of magnetization reversal in FM/AFM bilayers with THz frequency pulses.

    Hirst, Joel / Ruta, Sergiu / Jackson, Jerome / Ostler, Thomas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12270

    Abstract: It is widely known that antiferromagnets (AFMs) display a high frequency response in the terahertz (THz) range, which opens up the possibility for ultrafast control of their magnetization for next generation data storage and processing applications. ... ...

    Abstract It is widely known that antiferromagnets (AFMs) display a high frequency response in the terahertz (THz) range, which opens up the possibility for ultrafast control of their magnetization for next generation data storage and processing applications. However, because the magnetization of the different sublattices cancel, their state is notoriously difficult to read. One way to overcome this is to couple AFMs to ferromagnets-whose state is trivially read via magneto-resistance sensors. Here we present conditions, using theoretical modelling, that it is possible to switch the magnetization of an AFM/FM bilayer using THz frequency pulses with moderate field amplitude and short durations, achievable in experiments. Consistent switching is observed in the phase diagrams for an order of magnitude increase in the interface coupling and a tripling in the thickness of the FM layer. We demonstrate a range of reversal paths that arise due to the combination of precession in the materials and the THz-induced fields. Our analysis demonstrates that the AFM drives the switching and results in a much higher frequency dynamics in the FM due to the exchange coupling at the interface. The switching is shown to be robust over a broad range of temperatures relevant for device applications.
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39175-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: "Bystander" recruitment of systemic memory T cells delays the immune response to respiratory virus infection.

    Ostler, Tobias / Pircher, Hanspeter / Ehl, Stephan

    European journal of immunology

    2003  Volume 33, Issue 7, Page(s) 1839–1848

    Abstract: The concept of heterologous T cell immunity postulates that nonspecific memory T cells recruited ... to lymphocytic choriomeningitis virus (LCMV) leads to substantial recruitment of systemic LCMV-specific memory CD8 T cells to the lung ... lung could induce a single round of cell division among LCMV-specific T cells. However, it did not ...

    Abstract The concept of heterologous T cell immunity postulates that nonspecific memory T cells recruited and reactivated in the context of an unrelated virus infection may contribute to protective antiviral immunity. Pulmonary infection with respiratory syncytial virus (RSV) of mice immune to lymphocytic choriomeningitis virus (LCMV) leads to substantial recruitment of systemic LCMV-specific memory CD8 T cells to the lung. Using a sensitive TCR-transgenic model, we show that such "bystander" recruitment to the RSV-infected lung could induce a single round of cell division among LCMV-specific T cells. However, it did not change their activation status as assessed by expression of surface markers, the extent or kinetics of IFN-gamma production and cytolytic effector function. Moreover,recruitment of LCMV-specific bystander T cells not only failed to enhance immunity to RSV, but significantly delayed virus elimination and slightly enhanced RSV-induced weight loss in non-transgenic BALB/c mice. This correlated with a delay in the recruitment of RSV-specific T cells to the lung. These data show that bystander recruitment of heterologous T cells is not necessarily accompanied by bystander activation. More importantly, bystander recruitment of systemic memory T cells can impair antiviral immunity, presumably by interference with the recruitment of specific T cells.
    MeSH term(s) Animals ; Cell Movement/physiology ; Immunologic Memory/immunology ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Mice, Inbred BALB C ; Respiratory Syncytial Viruses/immunology ; Respiratory Tract Infections/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology
    Language English
    Publishing date 2003-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.200323460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Virus clearance and immunopathology by CD8(+) T cells during infection with respiratory syncytial virus are mediated by IFN-gamma.

    Ostler, Tobias / Davidson, Wendy / Ehl, Stephan

    European journal of immunology

    2002  Volume 32, Issue 8, Page(s) 2117–2123

    Abstract: CD8(+) T cells (CTL) are important effector cells for virus control and immunopathology after ... control and significantly reduced CD8(+) T cell-mediated pathology. In IFN-gamma-deficient mice, high-dose ... immunopathology and in CD8(+) T cell-mediated control of RSV infection. ...

    Abstract CD8(+) T cells (CTL) are important effector cells for virus control and immunopathology after primary infection with respiratory syncytial virus (RSV). To investigate the effector mechanisms involved, we set up an adoptive transfer model, in which effector CTL specific for p82-90 of RSV M2 were generated in vivo, followed by short-term restimulation in vitro and transfusion into infected recipients. A total of 4 x 10(4) donor-derived p82-specific CTL homing to the lung within 4 days after transfusion were sufficient to completely eliminate a virusinoculum of 1.5 x 10(6) pfu. This was accompanied by significant lung pathology. Surprisingly, virus control and immunopathology proceeded unimpaired when donor cells lacking perforin, CD95 ligand or TNF were transfused. By contrast, treatment of recipient mice with a neutralizing antibody against IFN-gamma or transfusion of IFN-gamma-deficient effector CTL largely abolished virus control and significantly reduced CD8(+) T cell-mediated pathology. In IFN-gamma-deficient mice, high-dose primary infection experiments revealed attenuated immunopathology, but only slightly delayedvirus clearance, suggesting that other cells and molecules can partly substitute for the effects of CTL-derived IFN-gamma on virus clearance. These experiments identify IFN-gamma as a key molecule in RSV-induced immunopathology and in CD8(+) T cell-mediated control of RSV infection.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Division ; Fas Ligand Protein ; Interferon-gamma/physiology ; Lung/immunology ; Lung/pathology ; Membrane Glycoproteins/physiology ; Mice ; Mice, Inbred BALB C ; Perforin ; Pore Forming Cytotoxic Proteins ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/pathology ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Necrosis Factor-alpha/physiology
    Chemical Substances Fas Ligand Protein ; Fasl protein, mouse ; Membrane Glycoproteins ; Pore Forming Cytotoxic Proteins ; Tumor Necrosis Factor-alpha ; Perforin (126465-35-8) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2002-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/1521-4141(200208)32:8<2117::AID-IMMU2117>3.0.CO;2-C
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Pulmonary T cells induced by respiratory syncytial virus are functional and can make an important contribution to long-lived protective immunity.

    Ostler, Tobias / Ehl, Stephan

    European journal of immunology

    2002  Volume 32, Issue 9, Page(s) 2562–2569

    Abstract: The contribution of T cell responses to immunity against respiratory syncytial virus (RSV) is not ... induced pulmonary T cell suppression suggest that RSV may have evolved strategies to escape T ... T cell responses in vivo. Surprisingly, we found strong ex vivo cytolytic activity and interferon ...

    Abstract The contribution of T cell responses to immunity against respiratory syncytial virus (RSV) is not fully defined, but this is an important issue for vaccine design. Recent studies demonstrating RSV-induced pulmonary T cell suppression suggest that RSV may have evolved strategies to escape T cell immunity. Here we evaluated potential consequences of RSV-mediated immunosuppression for protective memory T cell responses in vivo. Surprisingly, we found strong ex vivo cytolytic activity and interferon production of pulmonary RSV-specific CD8(+) T cells both in the acute and the memory phase of primary murine RSV infection. More significantly, T cell memory made an important contribution to immunity against RSV independent of antibodies. Thus, RSV-primed mice were protected against challenge with RSV-recombinant vaccinia viruses, which can be controlled by RSV-specific T cells, but not by RSV-specific antibodies. In conclusion, RSV does not appear to impair acute and protective memory T cell responses induced by a primary infection. These findings further support that induction of T cell immunity should be a relevant goal for RSV vaccines.
    MeSH term(s) Animals ; Bronchoalveolar Lavage Fluid ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/secretion ; Cytotoxicity, Immunologic ; Female ; Immunization ; Immunologic Memory/immunology ; Interferon-gamma/secretion ; Lung/immunology ; Lung/pathology ; Lung/virology ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Ovary/virology ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses/physiology ; Specific Pathogen-Free Organisms ; T-Lymphocyte Subsets/immunology ; Time Factors ; Vaccines, Synthetic/immunology ; Vaccinia virus ; Viral Vaccines/immunology ; Virus Replication
    Chemical Substances Vaccines, Synthetic ; Viral Vaccines ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2002-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/1521-4141(200209)32:9<2562::AID-IMMU2562>3.0.CO;2-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Heinz Werner: His Life, Ideas, and Contributions to Developmental Psychology in the First Half of the 20th Century.

    Ostler, Teresa

    The Journal of genetic psychology

    2016  Volume 177, Issue 6, Page(s) 231–243

    Abstract: The author provides an overview of Heinz Werner's life and contributions to the field of developmental psychology during the first half of the 20th century. She focuses on his early work in Vienna and Munich as well as his tenure at the Psychological ... ...

    Abstract The author provides an overview of Heinz Werner's life and contributions to the field of developmental psychology during the first half of the 20th century. She focuses on his early work in Vienna and Munich as well as his tenure at the Psychological Institute in Hamburg, up through the time when he became a named Professor in Psychology at Clark University. Recognized as one of the founders of developmental psychology, Heinz Werner worked in the areas of perceptual development, comparative psychology, and symbol formation. Versatile in rigorous experimental methodologies, and in observational and phenomenological methodologies, Werner's approach to development stood in contrast to other approaches of development, both past and current. For Werner, development was a heuristic, a way of looking at processes in a variety of domains, including ontogeny, phylogeny, microgenesis, biology, developmental psychopathology, neuropsychology, and comparative psychology. Werner viewed development as proceeding from a state of relative globality and lack of differentiation to a state of increasing differentiation, articulation, and hierarchical integration, but he also stressed that individuals can function at different developmental levels under different times and conditions. Werner's holistic, organismic, comparative, and contextual approach to development transcended interdisciplinary boundaries, allowing him to study the interrelatedness between thought, language, feeling, perception, and culture.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3133-1
    ISSN 1940-0896 ; 0022-1325
    ISSN (online) 1940-0896
    ISSN 0022-1325
    DOI 10.1080/00221325.2016.1245520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.

    Ostler, T / Hussell, T / Surh, C D / Openshaw, P / Ehl, S

    European journal of immunology

    2001  Volume 31, Issue 9, Page(s) 2574–2582

    Abstract: ... T cells, but only 2-3% of CD8(+) T cells in the draining lymph node secreted interferon-gamma in response ... to a single peptide. Surprisingly, the percentage of virus-specific T cells in the lung remained at these high ... levels long after the acute infection. Pulmonary memory T cells were further studied in a sensitive ...

    Abstract In mice acutely infected with respiratory syncytial virus (RSV), more than 20% of pulmonary CD8(+) T cells, but only 2-3% of CD8(+) T cells in the draining lymph node secreted interferon-gamma in response to a single peptide. Surprisingly, the percentage of virus-specific T cells in the lung remained at these high levels long after the acute infection. Pulmonary memory T cells were further studied in a sensitive adoptive transfer system, which allows visualizing polyclonal CD4(+) and CD8(+) virus-specific memory T cell responses. Fifty days after infection, persisting RSV-specific pulmonary T cells remained CD69(hi) CD62L(lo), but had returned to a resting memory state according to functional criteria. In the absence of neutralizing antibodies reinfection first induced cell division among virus-specific memory T cells 3 days after infection predominantly in the local lymph node. However, divided cells then rapidly accumulated in the lung without significantly increasing in the lymph node. These results suggest rapid export of reactivated cells from the lymph node to the target organ. Thus, although memory T cells can be maintained in the infected organ after a localized virus infection, amplification of a recall response appears to be most effective in organized lymphoid tissue.
    MeSH term(s) Adoptive Transfer ; Animals ; Antigens, Viral/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/transplantation ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/transplantation ; Cells, Cultured ; Immunologic Memory ; Interferon-gamma/biosynthesis ; Kinetics ; Lung/immunology ; Lung Diseases/immunology ; Lung Diseases/virology ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Viruses/immunology
    Chemical Substances Antigens, Viral ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2001-08-14
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/1521-4141(200109)31:9<2574::aid-immu2574>3.0.co;2-v
    Database MEDical Literature Analysis and Retrieval System OnLINE

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