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Article ; Online: Lack of antiviral activity of ivermectin against foot-and-mouth disease virus serotype O in BALB/c mice.

Arshad, Sheeza / Raza, Sohail / Rafique, Rehan / Altaf, Imran / Sattar, Adeel

2023 Volume 182, Page(s) 106245

Abstract: Ivermectin is an FDA approved drug and showed in vitro antiviral activity against different serotypes of Foot-and-mouth disease virus (FMDV). We here assessed the effect of ivermectin in 12 day old female BALB/c mice infected with ... ...

Abstract	Ivermectin is an FDA approved drug and showed in vitro antiviral activity against different serotypes of Foot-and-mouth disease virus (FMDV). We here assessed the effect of ivermectin in 12 day old female BALB/c mice infected with 50LD
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106245
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Article: Synergistic antibacterial activity of carvacrol loaded chitosan nanoparticles with Topoisomerase inhibitors and genotoxicity evaluation.

Akhlaq, Amina / Ashraf, Muhammad / Ovais Omer, Muhammad / Altaf, Imran

Saudi journal of biological sciences

2023 Volume 30, Issue 9, Page(s) 103765

Abstract: The increasing prevalence of antibiotic resistant bacteria is a significant healthcare crisis with substantial socioeconomic impact on global community. The development of new antibiotics is both costly and time-consuming prompting the exploration of ... ...

Abstract	The increasing prevalence of antibiotic resistant bacteria is a significant healthcare crisis with substantial socioeconomic impact on global community. The development of new antibiotics is both costly and time-consuming prompting the exploration of alternative solutions such as nanotechnology which represents opportunities for targeted drug delivery and reduced MIC. However, concerns have arisen regarding genotoxic effects of nanoparticles on human health necessitating an evaluation of nanoparticle induced DNA damage. This study aimed to investigate the antibacterial potential of already prepared, characterized chitosan nanoparticles loaded with carvacrol and their potential synergism with Topoisomerase II inhibitors against
Language	English
Publishing date	2023-08-06
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2023.103765
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Article: Preparation of purified vaccine from local isolate of foot and mouth disease virus and its immune response in bovine calves.

Razak, Abdul / Altaf, Imran / Ahmad Anjum, Aftab / Raza Awan, Ali

Saudi journal of biological sciences

2023 Volume 30, Issue 7, Page(s) 103709

Abstract: Foot and Mouth Disease (FMD) is globally pandemic which badly affect the economics of livestock based countries like Pakistan. There are different types of Foot and Mouth Disease Virus (FMDV) among these types O is most prevalent in Pakistan. Recently ... ...

Abstract	Foot and Mouth Disease (FMD) is globally pandemic which badly affect the economics of livestock based countries like Pakistan. There are different types of Foot and Mouth Disease Virus (FMDV) among these types O is most prevalent in Pakistan. Recently Pakistan is producing approximately fifteen million doses of non-purified FMD vaccine against the demand of 160 million doses annually. More over the Pakistan is still striving for the development and optimization of concentration as well as purification of FMDV. The present project was designed to develop the technology for the purification of FMDV indigenously. The locally isolated and adapted FMDV type O virus was propagated on adherent culture of BHK-21cells to get final volume of virus one liter. This virus suspension was concentrated by peggylation as well as ultra-filtration method. The purification and quantification of concentrated virus was done by size exclusion chromatography. The results showed that peggylation is better method of concentration up to 603.75 µg/ml with 82.80 % recovery rate than ultra-filtration with 43.90 % followed by chromatography for purification. The PD
Language	English
Publishing date	2023-06-16
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2023.103709
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Article ; Online: Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells.

Akhlaq, Amina / Ashraf, Muhammad / Omer, Muhammad Ovais / Altaf, Imran

ACS omega

2023 Volume 8, Issue 35, Page(s) 31826–31838

Abstract: Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted ... ...

Abstract	Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted therapeutics. Nanoparticles are suitable substitutes to circumvent multidrug resistance for the targeted treatment of cancer. The current study was aimed to investigate the anticancer effect of carvacrol-loaded chitosan nanoparticles with topoisomerase inhibitors. The average size of carvacrol-loaded chitosan nanoparticles was found to be 80 nm with 24.7 mV ζ-potential, and maximum absorbance was observed at 275 nm. Among all drug combinations, the carvacrol nanoparticles with the doxorubicin combination group exerted greater dose-dependent growth inhibition of both MCF-7 and HeLa cells as compared to single carvacrol nanoparticles and doxorubicin. Combination index values of carvacrol nanoparticles and the doxorubicin combination group showed a strong synergistic effect as they were found to be between 0.2 and 0.4, 0.31 for MCF-7 and 0.34 for HeLa cells. The carvacrol nanoparticles in combination with doxorubicin on MCF-7 cells reduced the dose 16.32-fold for carvacrol nanoparticles and 4.09-fold for doxorubicin at 6.23 μg/mL IC
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03337
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Article ; Online: Synergistic antibacterial activity of carvacrol loaded chitosan nanoparticles with Topoisomerase inhibitors and genotoxicity evaluation

Amina Akhlaq / Muhammad Ashraf / Muhammad Ovais Omer / Imran Altaf

Saudi Journal of Biological Sciences, Vol 30, Iss 9, Pp 103765- (2023)

2023

Abstract	The increasing prevalence of antibiotic resistant bacteria is a significant healthcare crisis with substantial socioeconomic impact on global community. The development of new antibiotics is both costly and time-consuming prompting the exploration of alternative solutions such as nanotechnology which represents opportunities for targeted drug delivery and reduced MIC. However, concerns have arisen regarding genotoxic effects of nanoparticles on human health necessitating an evaluation of nanoparticle induced DNA damage.This study aimed to investigate the antibacterial potential of already prepared, characterized chitosan nanoparticles loaded with carvacrol and their potential synergism with Topoisomerase II inhibitors against S. aureus, E. coli and S. typhi using agar well diffusion, microdilution and checkerboard method. Genotoxicity was assessed through comet assay.Results showed that both alone and drug combinations of varying concentrations exhibited greater zones of inhibition at higher concentrations. Carvacrol nanoparticles combined with ciprofloxacin and doxorubicin significantly reduced MIC compared to the drugs used alone. The MIC50 values for ciprofloxacin were 35.8 µg/ml, 48.74 µg/ml, 35.57 µg/ml while doxorubicin showed MIC50 values of 20.79 µg/ml, 34.35 µg/ml, 25.32 µg/ml against S. aureus, E. coli and S. typhi respectively. The FICI of ciprofloxacin and doxorubicin with carvacrol nanoparticles found ≤ 0.5 Such as 0.44, 0.44,0.48 for ciprofloxacin and 0.45, 0.45, 0.46 for doxorubicin against S. aureus, E. coli and S. typhi respectively revealed the synergistic effect. The analysis of comet assay output images showed alteration of DNA at high concentrations.Our results suggested that carvacrol nanoparticles in combination with Topoisomerase inhibitors may prevent and control the emergence of resistant bacteria with reduced dose.
Keywords	Antibacterial effect ; MIC ; Topoisomerase inhibitors ; Carvacrol nanoparticles ; Genotoxicity ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation of purified vaccine from local isolate of foot and mouth disease virus and its immune response in bovine calves

Abdul Razak / Imran Altaf / Aftab Ahmad Anjum / Ali Raza Awan

Saudi Journal of Biological Sciences, Vol 30, Iss 7, Pp 103709- (2023)

2023

Abstract	Foot and Mouth Disease (FMD) is globally pandemic which badly affect the economics of livestock based countries like Pakistan. There are different types of Foot and Mouth Disease Virus (FMDV) among these types O is most prevalent in Pakistan. Recently Pakistan is producing approximately fifteen million doses of non-purified FMD vaccine against the demand of 160 million doses annually. More over the Pakistan is still striving for the development and optimization of concentration as well as purification of FMDV. The present project was designed to develop the technology for the purification of FMDV indigenously. The locally isolated and adapted FMDV type O virus was propagated on adherent culture of BHK-21cells to get final volume of virus one liter. This virus suspension was concentrated by peggylation as well as ultra-filtration method. The purification and quantification of concentrated virus was done by size exclusion chromatography. The results showed that peggylation is better method of concentration up to 603.75 µg/ml with 82.80 % recovery rate than ultra-filtration with 43.90 % followed by chromatography for purification. The PD50 was calculated in bovines at 24, 12, 6, 3 and 1.5 µg of FMDV Ag/dose and it revealed that antigen load of 1.98 µg is the dose, where the 50 % of inoculated animals showed the protective antibody level based upon percent inhibition through antibody detecting ELISA. According to the British pharmacopeia, the vaccine should contain 3PD50 which found equivalent to our findings about 6 µg/dose. The group of animal injected with 6/dose (3.23PD50) showed protective titer up to 20th week post priming.
Keywords	Baby Hamster Kidney Fibroblast Cells ; Virus concentration ; Vaccine preparation ; Size exclusion chromatography ; Potency testing ; Vaccine evaluation ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of commonly used transition metals in total synthesis of indole alkaloids

Abdul Hannan Khan / Sawaira Altaf / Nasir Rasool / Adeel Mubarik / Matloob Ahmad / Syed Adnan Ali Shah / Syahrul Imran / Majed A. Bajaber

Arabian Journal of Chemistry, Vol 17, Iss 2, Pp 105523- (2024)

2024

Abstract: This Paper reviews the most recent advances in synthesizing indole alkaloids using transition metal-catalyzed methods. The essential class of natural substances known as indole alkaloids has several biological effects, including anti-inflammatory, anti- ... ...

Abstract	This Paper reviews the most recent advances in synthesizing indole alkaloids using transition metal-catalyzed methods. The essential class of natural substances known as indole alkaloids has several biological effects, including anti-inflammatory, anti-cancer, and anti-bacterial properties. Although there are numerous known natural sources of indole alkaloids, due to their scarcity and complexity, total synthesis has emerged as a promising technique of manufacture. Transition metal-catalyzed methods have become efficient tools for synthesizing indole alkaloids due to their high selectivity and efficiency. The various metal-catalyzed reactions that are used to synthesize indole alkaloids are discussed in this paper, including cross-coupling, cycloaddition, and oxidative cyclization reactions in last five years.
Keywords	Indole ; Alkaloids ; Transition metals ; Natural product ; Biological activities ; Chemistry ; QD1-999
Language	English
Publishing date	2024-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Association of sleep-wake pattern with cognitive performance and academic achievement in young adults.

Altaf, Shafaq / Aftab, Anam / Khan, Komal Fayyaz / Anwar, Farah / Imran, Abeeha / Syed, Maira

JPMA. The Journal of the Pakistan Medical Association

2022 Volume 72, Issue 7, Page(s) 1325–1329

Abstract: Objective: To determine the association of sleep wake pattern with cognitive performance and academic achievement in young adults.: Method: It was a cross sectional study conducted in March 2019 after approval from the Institutional Review Board & ... ...

Abstract	Objective: To determine the association of sleep wake pattern with cognitive performance and academic achievement in young adults. Method: It was a cross sectional study conducted in March 2019 after approval from the Institutional Review Board & Ethics Committee of the study setting on February 28, 2019. Total sample of the study was 189 calculated by using Rao software. Inclusion criteria was healthy young adults of age 18 to 24 years from Doctor of Physical Therapy department of Shifa Tameer-e-Millat University, Dar-ul-Shifa campus, Islamabad. Exclusion criteria included all those students who were married, diagnosed with psychological disorder and were taking any sedatives. Data was collected through three questionnaires named Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ) and Montreal Cognitive Assessment (MOCA) in addition to inquiry regarding GPA of latest exam. Results: A total sample was 236 students with a mean age of 20.94±1.58 years with range 18-24 years. The sample comprised of males n=24 (10.2%) and females n=212(89.8%). Mean GPA was 3.10±0.53. MOCA showed that 70(29.66%) students had mild cognitive impairment, 166(70.34%) were students with normal cognition. The results obtained by applying independent T-test showed a significant difference of cognition between high and low achievers (p-value: 0.029<0.05. Students who scored high were definite morning types. Conclusions: There is a significant association between cognitive performance and academic achievement with high achievers being definite morning types.
MeSH term(s)	Academic Success ; Adolescent ; Adult ; Circadian Rhythm ; Cognition ; Cross-Sectional Studies ; Female ; Humans ; Hypnotics and Sedatives ; Male ; Sleep ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2022-09-07
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.2087
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Article ; Online: DrunkChain: Blockchain-Based IoT System for Preventing Drunk Driving-Related Traffic Accidents.

Farooq, Hamza / Altaf, Ayesha / Iqbal, Faiza / Galán, Juan Castanedo / Aray, Daniel Gavilanes / Ashraf, Imran

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 12

Abstract: Traffic accidents present significant risks to human life, leading to a high number of fatalities and injuries. According to the World Health Organization's 2022 worldwide status report on road safety, there were 27,582 deaths linked to traffic-related ... ...

Abstract	Traffic accidents present significant risks to human life, leading to a high number of fatalities and injuries. According to the World Health Organization's 2022 worldwide status report on road safety, there were 27,582 deaths linked to traffic-related events, including 4448 fatalities at the collision scenes. Drunk driving is one of the leading causes contributing to the rising count of deadly accidents. Current methods to assess driver alcohol consumption are vulnerable to network risks, such as data corruption, identity theft, and man-in-the-middle attacks. In addition, these systems are subject to security restrictions that have been largely overlooked in earlier research focused on driver information. This study intends to develop a platform that combines the Internet of Things (IoT) with blockchain technology in order to address these concerns and improve the security of user data. In this work, we present a device- and blockchain-based dashboard solution for a centralized police monitoring account. The equipment is responsible for determining the driver's impairment level by monitoring the driver's blood alcohol concentration (BAC) and the stability of the vehicle. At predetermined times, integrated blockchain transactions are executed, transmitting data straight to the central police account. This eliminates the need for a central server, ensuring the immutability of data and the existence of blockchain transactions that are independent of any central authority. Our system delivers scalability, compatibility, and faster execution times by adopting this approach. Through comparative research, we have identified a significant increase in the need for security measures in relevant scenarios, highlighting the importance of our suggested model.
MeSH term(s)	Humans ; Accidents, Traffic/prevention & control ; Blockchain ; Driving Under the Influence ; Internet of Things ; Blood Alcohol Content
Chemical Substances	Blood Alcohol Content
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23125388
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Article ; Online: Laparoscopic Roux-en-Y fistula tract jejunostomy for disconnected pancreatic duct syndrome associated pancreaticocutaneous fistula following laparoscopic infracolic necrosectomy.

Latif, Javed / Mountjoy, Poppy / Bandlamudi, Nanda / Thurley, Peter / Bhatti, Imran / Awan, Altaf

HPB : the official journal of the International Hepato Pancreato Biliary Association

2023 Volume 26, Issue 2, Page(s) 310–312

MeSH term(s)	Humans ; Jejunostomy/adverse effects ; Fistula ; Pancreatic Ducts ; Anastomosis, Roux-en-Y/adverse effects ; Laparoscopy/adverse effects
Language	English
Publishing date	2023-10-14
Publishing country	England
Document type	Letter
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2023.10.013
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