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Article: Posterior cerebral artery dissection after excessive caffeine consumption in a teenager.

Staikoglou, Nikolaos / Polanagnostaki, Aspasia / Lamprou, Viktoria / Chartampilas, Evangelos / Pavlou, Evangelos / Tegos, Thomas / Finitsis, Stephanos

Radiology case reports

2022 Volume 17, Issue 6, Page(s) 2081–2084

Abstract: Arterial ischemic stroke is a rare but significant cause of neurological deficits in childhood. Even though there is a variety of risk factors, identifying the etiology can sometimes be a hard diagnostic challenge. Arteriopathies in general, and more ... ...

Abstract	Arterial ischemic stroke is a rare but significant cause of neurological deficits in childhood. Even though there is a variety of risk factors, identifying the etiology can sometimes be a hard diagnostic challenge. Arteriopathies in general, and more specifically, arterial dissection is one of the uncommon pathologies that can cause incidents of pediatric stroke. We report a rare case of a young adolescent with posterior cerebral artery dissection after excessive consumption of caffeine, contained in energy drinks, only hours before the onset of neurological symptoms. A complete neuroimaging evaluation (MRI, intracranial US and digital subtraction angiography) at the admission and during the follow-ups supported the diagnosis of arterial dissection possibly caused by caffeine overconsumption.
Language	English
Publishing date	2022-04-12
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2022.02.035
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Article ; Online: Efficacy of antiepileptic drugs in the era of pharmacogenomics: A focus on childhood.

Gogou, Maria / Pavlou, Evangelos

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2019 Volume 23, Issue 5, Page(s) 674–684

Abstract: Background: In recent years advances in the field of pharmacogenomics have expanded the concept for more individualized treatments. Our aim is to provide literature data about the relationship between genetic polymorphisms and efficacy of antiepileptic ... ...

Abstract	Background: In recent years advances in the field of pharmacogenomics have expanded the concept for more individualized treatments. Our aim is to provide literature data about the relationship between genetic polymorphisms and efficacy of antiepileptic drugs in children. Methods: Pubmed was used as the main medical database source. Only original research papers were considered. No year-of-publication restriction was placed. Quality of evidence was assessed according to American Academy of Neurology guidelines. Results: A total of 12 cross-sectional and case-control studies fulfilled our selection criteria. ABCB1 gene was associated with drug responsiveness in 2 out of 6 studies and ABCC2 gene in 1 out of 1 studies. SCN1A gene was also associated with seizure control in 4 out of 5 studies. Cytochrome P450 genes were found to significantly affect drug responsiveness in 2 out of 4 studies, while polymorphisms of uridinediphosphateglucuronosyltransferaseUGT2B7 gene predisposed to drug-resistance in 1 out of 2 studies. Conclusion: Variability in genes coding for sodium channels, drug transporters and cytochrome P450 enzymes can have a significant impact on response to antiepileptic drugs. Larger prospective studies with better stratification of samples are needed to shed light on these associations.
MeSH term(s)	Anticonvulsants/therapeutic use ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Drug Resistance/genetics ; Epilepsy/drug therapy ; Female ; Humans ; Male ; Pharmacogenetics ; Pharmacogenomic Variants/genetics ; Prospective Studies
Chemical Substances	Anticonvulsants
Language	English
Publishing date	2019-06-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2019.06.004
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Serum Neuron-Specific Enolase as a Biomarker of Neonatal Brain Injury-New Perspectives for the Identification of Preterm Neonates at High Risk for Severe Intraventricular Hemorrhage.

Metallinou, Dimitra / Karampas, Grigorios / Pavlou, Maria-Loukia / Louma, Maria-Ioanna / Mantzou, Aimilia / Sarantaki, Antigoni / Nanou, Christina / Gourounti, Kleanthi / Tzeli, Maria / Pantelaki, Nikoletta / Tzamakos, Evangelos / Boutsikou, Theodora / Lykeridou, Aikaterini / Iacovidou, Nicoletta

Biomolecules

2024 Volume 14, Issue 4

Abstract: Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron- ...

Abstract	Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in preterm neonates (<34 weeks) that later developed brain injury in the form of either periventricular leukomalacia (PVL) or intraventricular hemorrhage (IVH) during their hospitalization. Participants were recruited from one neonatal intensive care unit, and on the basis of birth weight and gestational age, we matched each case (
MeSH term(s)	Humans ; Phosphopyruvate Hydratase/blood ; Infant, Newborn ; Biomarkers/blood ; Infant, Premature/blood ; Male ; Female ; Case-Control Studies ; Prospective Studies ; Brain Injuries/blood ; Brain Injuries/diagnosis ; Leukomalacia, Periventricular/blood ; Leukomalacia, Periventricular/diagnostic imaging ; Cerebral Hemorrhage/blood ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/diagnosis ; Cerebral Intraventricular Hemorrhage/blood ; Cerebral Intraventricular Hemorrhage/diagnostic imaging ; Gestational Age ; Prognosis
Chemical Substances	Phosphopyruvate Hydratase (EC 4.2.1.11) ; Biomarkers ; ENO2 protein, human (EC 4.2.1.11)
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14040434
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Article ; Online: Sleep and prematurity: sleep outcomes in preterm children and influencing factors.

Gogou, Maria / Haidopoulou, Katerina / Pavlou, Evangelos

World journal of pediatrics : WJP

2019 Volume 15, Issue 3, Page(s) 209–218

Abstract: Background: Sleep undergoes changes from birth to adulthood, while sleep disorders are associated with various cognitive deficiencies in childhood. In parallel, prematurity is known to predispose to poor neurodevelopmental outcomes. Our aim is to ... ...

Abstract	Background: Sleep undergoes changes from birth to adulthood, while sleep disorders are associated with various cognitive deficiencies in childhood. In parallel, prematurity is known to predispose to poor neurodevelopmental outcomes. Our aim is to provide literature data about factors influencing sleep in the premature infants and sleep outcomes in this population. Methods: A systematic review was conducted using a variety of health-related databases. Original research papers were considered and no year-of-publication restriction was placed. Results: In total, 22 articles fulfilled our selection criteria. Available studies present remarkable heterogeneity in terms of methodological design. Compared to full term, premature infants exhibit significant differences in sleep structure, which mainly include differences in electroencephalographic spectral values, in total sleep time and in arousal threshold. Furthermore, prematurity seems to be a risk factor of sleep breathing disorders in childhood and adolescence. Data about the effect of methylxanthines and the environment of neonatal intensive care unit is controversial. With regard to the impact of prematurity-related sleep disorders on future neurodevelopment, available research papers are generally few. Conclusions: The alterations in sleep patterns are an outcome of prematurity (immaturity of nervous system) as well as of postnatal factors and comorbidities. Sleep problems in this population of infants seems to be a missing piece of the puzzle of impaired neurodevelopment. Future studies should focus on interventions to improve sleep hygiene and limit neurodevelopmental problems.
MeSH term(s)	Electroencephalography ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/etiology ; Nervous System Diseases/etiology ; Risk Factors ; Sleep Wake Disorders/etiology
Language	English
Publishing date	2019-03-04
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-019-00240-8
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Zs.A 6309: Show issues

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Article ; Online: Therapies that are available and under development for Duchenne muscular dystrophy: What about lung function?

Gogou, Maria / Pavlou, Evangelos / Haidopoulou, Katerina

Pediatric pulmonology

2019 Volume 55, Issue 2, Page(s) 300–315

Abstract: Background: Respiratory failure is the principal source of morbidity and mortality among patients with Duchenne muscular dystrophy exerting a negative influence on their total quality of life. The aim of this review is to provide systematically current ... ...

Abstract	Background: Respiratory failure is the principal source of morbidity and mortality among patients with Duchenne muscular dystrophy exerting a negative influence on their total quality of life. The aim of this review is to provide systematically current literature evidence about the effects of different treatment options (available or under development) for Duchenne muscular dystrophy on the pulmonary function of these patients. Methods: A comprehensive search was undertaken using multiple health-related databases, while two independent reviewers assessed the eligibility of studies. A third person addressed any disagreements between reviewers. The quality of the methodology of the included studies was also assessed. Results: A total of 19 original research papers (nine evaluating the role of steroids, six idebenone, three eteplirsen, one stem-cell therapy, and one ataluren) were found to fulfill our selection criteria with the majority of them (14 of 19) being prospective studies, not always including a control group. Endpoints mainly used in these studies were values of pulmonary function tests. Current and under development treatments proved to be safe and no significant adverse events were reported. A beneficial impact on pulmonary function was described by authors in the majority of these studies. The principal effect was slowing of lung disease progress, as expressed by spirometric values. However, the risk of bias was introduced in many of the above studies, while high heterogeneity in terms of treatment protocols and outcome measures limits the comparability of the results. Conclusion: Glucocorticoids remain the best-studied pharmacologic therapy for Duchenne muscular dystrophy and very likely delay the expected decline in lung function. With regard to new therapeutic agents, initial study results are encouraging. However, larger clinical trials are needed that minimize the risk of study bias, optimize the comparability of treatment groups, examine clinically meaningful pulmonary outcome measures, and include long-term follow up.
MeSH term(s)	Glucocorticoids/therapeutic use ; Humans ; Lung/physiopathology ; Male ; Morpholinos ; Muscular Dystrophy, Duchenne/therapy ; Prospective Studies ; Quality of Life ; Respiratory Function Tests ; Ubiquinone/analogs & derivatives
Chemical Substances	Glucocorticoids ; Morpholinos ; Ubiquinone (1339-63-5) ; eteplirsen (AIW6036FAS) ; idebenone (HB6PN45W4J)
Language	English
Publishing date	2019-12-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24605
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Zs.A 2143: Show issues

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Article ; Online: Is the prevalence of thyroid disease higher in children receiving antiepileptic medication? A systematic review and meta-analysis.

Ilia, Tatiani Soultana / Dragoumi, Pinelopi / Papanikolopoulou, Stavroula / Goulis, Dimitrios G / Pavlou, Evangelos / Zafeiriou, Dimitrios

Seizure

2021 Volume 94, Page(s) 117–125

Abstract: Purpose: Antiseizure medications (ASM) have long been examined for their potential to induce thyroid dysfunction. The aim of this systematic review and meta-analysis was to assess the prevalence of thyroid disease in children up to 16 years receiving ... ...

Abstract	Purpose: Antiseizure medications (ASM) have long been examined for their potential to induce thyroid dysfunction. The aim of this systematic review and meta-analysis was to assess the prevalence of thyroid disease in children up to 16 years receiving monotherapy with valproate (VPA), carbamazepine (CBZ) and levetiracetam (LEV). Methods: PubMed/MEDLINE, Cochrane/CENTRAL databases and the gray literature were searched to identify observational studies providing the prevalence of thyroid dysfunction in the target population under VPA, CBZ, or LEV monotherapy schemes. The results were pooled using a random-effects model, and additional subgroup analyses were performed for the three ASM groups. Results: Fifteen and thirteen studies met inclusion criteria for the qualitative and the quantitative analysis, respectively, with a total of 945 pediatric patients with prevalence data. Only VPA and CBZ were associated with thyroid dysfunction. The overall prevalence of thyroid abnormality was higher in children receiving ASM [odds ratio (OR) 6.82, 95% confidence interval (CI) 3.96-11.75]. In the subgroup analysis, the prevalence of biochemical thyroid abnormality with increased TSH was higher in the VPA (OR 9.54, 95%CI 5.25-17.34) and the CBZ group (OR 4.08, 95%CI 1.84-9.04) compared with controls. Conclusion: This study confirms the higher prevalence of biochemical thyroid abnormality in children under VPA and CBZ monotherapy, whereas no such evidence is present for LEV. In children with a predisposition for thyroid disease, LEV should be considered over VPA and CBZ, if appropriate for seizure type and epilepsy syndrome. More studies are needed to reach a consensus on monitoring and management of thyroid dysfunction in children receiving ASM therapy.
MeSH term(s)	Anticonvulsants/adverse effects ; Carbamazepine/adverse effects ; Child ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Humans ; Levetiracetam/adverse effects ; Prevalence ; Thyroid Diseases/chemically induced ; Thyroid Diseases/epidemiology ; Valproic Acid/adverse effects
Chemical Substances	Anticonvulsants ; Carbamazepine (33CM23913M) ; Levetiracetam (44YRR34555) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2021-11-24
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2021.11.010
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Zs.A 3573: Show issues

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Article ; Online: Sleep Disturbances in Children with Rolandic Epilepsy.

Gogou, Maria / Haidopoulou, Katerina / Eboriadou, Maria / Pavlou, Evangelos

Neuropediatrics

2017 Volume 48, Issue 1, Page(s) 30–35

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Epilepsy, Rolandic/complications ; Female ; Hemoglobins/metabolism ; Humans ; Male ; Polysomnography ; Sleep Wake Disorders/etiology
Chemical Substances	Hemoglobins
Language	English
Publishing date	2017-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0036-1593611
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Article ; Online: Posterior cerebral artery dissection after excessive caffeine consumption in a teenager

Nikolaos Staikoglou, MD / Aspasia Polanagnostaki, MD / Viktoria Lamprou, MD / Evangelos Chartampilas, MD / Evangelos Pavlou, MD, PhD / Thomas Tegos, MD, PhD / Stephanos Finitsis, MD, PhD

Radiology Case Reports, Vol 17, Iss 6, Pp 2081-

2022 Volume 2084

Abstract	Arterial ischemic stroke is a rare but significant cause of neurological deficits in childhood. Even though there is a variety of risk factors, identifying the etiology can sometimes be a hard diagnostic challenge. Arteriopathies in general, and more specifically, arterial dissection is one of the uncommon pathologies that can cause incidents of pediatric stroke. We report a rare case of a young adolescent with posterior cerebral artery dissection after excessive consumption of caffeine, contained in energy drinks, only hours before the onset of neurological symptoms. A complete neuroimaging evaluation (MRI, intracranial US and digital subtraction angiography) at the admission and during the follow-ups supported the diagnosis of arterial dissection possibly caused by caffeine overconsumption.
Keywords	Dissection ; Posterior cerebral artery ; Pediatric stroke ; Caffeine ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Charcot-Marie-Tooth 1A concurrent with anaplastic ependymoma in a toddler: when an acute event unmasks a chronic condition.

Gogou, Maria / Pavlidou, Efterpi / Pavlou, Evangelos / Papageorgiou, Theodotis / Tragiannidis, Athanasios / Giannopoulos, Andreas / Hatzipantelis, Emmanuel

The Turkish journal of pediatrics

2020 Volume 61, Issue 3, Page(s) 428–430

Abstract: Gogou M, Pavlidou E, Pavlou E, Papageorgiou T, Tragiannidis A, Giannopoulos A, Hatzipantelis E ...

Abstract	Gogou M, Pavlidou E, Pavlou E, Papageorgiou T, Tragiannidis A, Giannopoulos A, Hatzipantelis E. Charcot-Marie -Tooth 1A concurrent with anaplastic ependymoma in a toddler: when an acute event unmasks a chronic condition. Turk J Pediatr 2019; 61: 428-430. We report a 14-month-old toddler admitted to the Pediatric Oncology Department after surgical resection of supratentorial anaplastic ependymoma. The child was treated with International Society of Pediatric Oncology Ependymoma II 2015 chemotherapy protocol (vincristine, carboplatin, cisplatin, cyclophosphamide and methotrexate). At the end of the first cycle the child presented with symptoms such as unsteadiness and ataxic gait along with decreased motor and sensory action potentials of the limbs. As the father of the child was diagnosed with Charcot-Marie-Tooth 1A disease, a genetic analysis of the PMP22 gene was performed confirming the diagnosis of Charcot- Marie-Tooth 1A in the child, too. This case gently reminds the possibility of vincristine-induced neurotoxicity and underscores the significance of an appropriate neurological assessment before vincristine initiation.
MeSH term(s)	Acute Disease ; Charcot-Marie-Tooth Disease/complications ; Charcot-Marie-Tooth Disease/diagnosis ; Charcot-Marie-Tooth Disease/genetics ; Chronic Disease ; DNA Mutational Analysis ; Diagnosis, Differential ; Ependymoma/complications ; Ependymoma/diagnosis ; Ependymoma/genetics ; Female ; Humans ; Infant ; Mutation ; Myelin Proteins/genetics ; Myelin Proteins/metabolism
Chemical Substances	Myelin Proteins ; PMP22 protein, human
Language	English
Publishing date	2020-01-09
Publishing country	Turkey
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2019.03.017
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Article ; Online: Wounded healers during the COVID-19 syndemic: Compassion fatigue and compassion satisfaction among nursing care providers in Greece.

Missouridou, Evdokia / Mangoulia, Polyxeni / Pavlou, Vassiliki / Kritsotakis, Emmanouel / Stefanou, Evangelia / Bibou, Polyxeni / Kelesi, Martha / Fradelos, Evangelos C

Perspectives in psychiatric care

2021 Volume 58, Issue 4, Page(s) 1421–1432

Abstract: Purpose: The aim of this study was to investigate compassion fatigue (CF) and compassion satisfaction (CS) in nursing care providers in COVID-19 units.: Methods: A mixed-method study with 105 nurses.: Results: 23% of participants reported high CF ... ...

Abstract	Purpose: The aim of this study was to investigate compassion fatigue (CF) and compassion satisfaction (CS) in nursing care providers in COVID-19 units. Methods: A mixed-method study with 105 nurses. Results: 23% of participants reported high CF risk while 77% expressed high to moderate potential for CS. Adequate preparation/education, clear and accountable leadership, and team sharing of feelings, experiences, and responsibilities during the transition in the COVID-19 unit helped participants to deal with overwhelming anxiety which if unattended could bring about frustration and long-lasting feelings of powerlessness. Practical implications: In the face of the present and future pandemics, there is a clear need to prepare healthcare organizations and nursing care providers to cope with the emotional content of public health emergencies while protecting themselves and avoid absorbing unmanageable emotions.
MeSH term(s)	Humans ; Compassion Fatigue/psychology ; Empathy ; Personal Satisfaction ; COVID-19 ; Syndemic ; Burnout, Professional/psychology ; Greece ; Quality of Life ; Job Satisfaction ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	391097-0
ISSN	1744-6163 ; 0031-5990
ISSN (online)	1744-6163
ISSN	0031-5990
DOI	10.1111/ppc.12946
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