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  1. Book: Clinical psychiatry

    Sher, Leo

    (Medical clinics of North America ; volume 107, number 1 (January 2023))

    2023  

    Author's details editor Leo Sher
    Series title Medical clinics of North America ; volume 107, number 1 (January 2023)
    Collection
    Language English
    Size xviii, 197 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021695573
    ISBN 978-0-323-96065-6 ; 0-323-96065-0
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Patient deaths by suicide significantly affect clinicians.

    Sher, Leo

    Evidence-based nursing

    2023  Volume 26, Issue 3, Page(s) 124

    MeSH term(s) Humans ; Suicide ; Suicide Prevention
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1425988-6
    ISSN 1468-9618 ; 1367-6539
    ISSN (online) 1468-9618
    ISSN 1367-6539
    DOI 10.1136/ebnurs-2022-103669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is it possible to find reliable biomarkers to diagnose suicide risk?

    Sher, Leo

    Acta neuropsychiatrica

    2023  Volume 35, Issue 3, Page(s) 186–187

    MeSH term(s) Humans ; Suicide ; Suicide Prevention ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1017/neu.2023.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Depression and suicide in patients with diabetes.

    Sher, Leo

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2023  Volume 45, Issue 1, Page(s) 84

    MeSH term(s) Humans ; Depression ; Suicide ; Diabetes Mellitus ; Risk Factors
    Language English
    Publishing date 2023-03-13
    Publishing country Brazil
    Document type Letter
    ZDB-ID 2024119-7
    ISSN 1809-452X ; 1809-452X
    ISSN (online) 1809-452X
    ISSN 1809-452X
    DOI 10.47626/1516-4446-2022-2680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Phylogeography of lions (Panthera leo ssp.) reveals three distinct taxa and a late Pleistocene reduction in genetic diversity.

    Barnett, Ross / Shapiro, Beth / Barnes, Ian / Ho, Simon Y W / Burger, Joachim / Yamaguchi, Nobuyuki / Higham, Thomas F G / Wheeler, H Todd / Rosendahl, Wilfried / Sher, Andrei V / Sotnikova, Marina / Kuznetsova, Tatiana / Baryshnikov, Gennady F / Martin, Larry D / Harington, C Richard / Burns, James A / Cooper, Alan

    Molecular ecology

    2009  Volume 18, Issue 8, Page(s) 1668–1677

    Abstract: ... revealed three distinct clusters: (i) modern lions, Panthera leo; (ii) extinct Pleistocene cave lions ...

    Abstract Lions were the most widespread carnivores in the late Pleistocene, ranging from southern Africa to the southern USA, but little is known about the evolutionary relationships among these Pleistocene populations or the dynamics that led to their extinction. Using ancient DNA techniques, we obtained mitochondrial sequences from 52 individuals sampled across the present and former range of lions. Phylogenetic analysis revealed three distinct clusters: (i) modern lions, Panthera leo; (ii) extinct Pleistocene cave lions, which formed a homogeneous population extending from Europe across Beringia (Siberia, Alaska and western Canada); and (iii) extinct American lions, which formed a separate population south of the Pleistocene ice sheets. The American lion appears to have become genetically isolated around 340 000 years ago, despite the apparent lack of significant barriers to gene flow with Beringian populations through much of the late Pleistocene. We found potential evidence of a severe population bottleneck in the cave lion during the previous interstadial, sometime after 48 000 years, adding to evidence from bison, mammoths, horses and brown bears that megafaunal populations underwent major genetic alterations throughout the last interstadial, potentially presaging the processes involved in the subsequent end-Pleistocene mass extinctions.
    MeSH term(s) Animals ; DNA, Mitochondrial/genetics ; Evolution, Molecular ; Fossils ; Genetic Variation ; Genetics, Population ; Geography ; Lions/classification ; Lions/genetics ; Phylogeny ; Sequence Analysis, DNA ; Species Specificity
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2009-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/j.1365-294X.2009.04134.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Testosterone and Suicidal Behavior in Bipolar Disorder.

    Sher, Leo

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Bipolar disorder is associated with suicidal behavior. The risk of suicide for individuals with bipolar disorder is up to 20-30 times larger than that of the general population. Considerable evidence suggests that testosterone may play a role in the ... ...

    Abstract Bipolar disorder is associated with suicidal behavior. The risk of suicide for individuals with bipolar disorder is up to 20-30 times larger than that of the general population. Considerable evidence suggests that testosterone may play a role in the pathophysiology of suicidal behavior in both men and women with bipolar disorder and other psychiatric conditions. Testosterone has complex effects on psychological traits. It affects mood and behavior, including interactions with other people. Testosterone regulates pro-active and re-active aspects of aggression. Probably, both high and low levels of testosterone may contribute to the neurobiology of suicide in various patient populations. The effects of endogenous and exogenous testosterone on suicidality in patients with bipolar disorder need further investigation. The aim of this commentary article is to provide a commentary on the author's work on the topic, summarize the literature on testosterone, bipolar disorder, and suicide, and encourage future research on this poorly studied topic.
    MeSH term(s) Male ; Humans ; Female ; Bipolar Disorder/psychology ; Suicidal Ideation ; Testosterone ; Risk Factors ; Suicide/psychology
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20032502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Suicide in individuals with no psychiatric disorders-what makes you vulnerable?

    Sher, Leo

    QJM : monthly journal of the Association of Physicians

    2023  

    Abstract: Globally, hundreds of thousands of people die by suicide every year. Suicides are usually associated with psychiatric illness. However, considerable evidence suggests that a significant number of individuals who die by suicide do not have diagnosable ... ...

    Abstract Globally, hundreds of thousands of people die by suicide every year. Suicides are usually associated with psychiatric illness. However, considerable evidence suggests that a significant number of individuals who die by suicide do not have diagnosable psychiatric disorders. The goal of this article is to attract attention to an overlooked issue of suicide in persons with no psychiatric disorders and to discuss some aspects of this issue. Research on identification and prevention of suicidal behavior in people with no psychiatric disorders is very limited. The available data indicates that suicides in individuals without psychiatric disorders are related to life stressors, lack of social support, and certain personality traits such as impulsivity. Suicide risk may be increased in military veterans with no psychiatric disorders. Many physical disorders, especially conditions associated with pain increase suicide risk in individuals with no diagnosable psychiatric disorders. Developmental, genetic, and physical factors may play a role in the psychobiology of suicide in people with no psychiatric conditions. Promoting resilience may reduce suicide risk in the general population. Clinicians who work with medical or surgical patients need to have sufficient training in suicide prevention. Possibly, shifting some suicide prevention resources from individuals who are regarded as high-risk suicide patients to the general population may reduce suicide rates. Public education and better awareness about suicide may reduce suicide deaths among people with no psychiatric disorders.
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The uncounted casualties of war: suicide in combat veterans.

    Sher, Leo

    QJM : monthly journal of the Association of Physicians

    2023  Volume 117, Issue 3, Page(s) 163–167

    Abstract: Military conflicts are ubiquitous. There are a lot of combat veterans around the world. Suicidality in combat veterans is a large and important issue. In this article, the author discusses some aspects of this issue. The combat environment is ... ...

    Abstract Military conflicts are ubiquitous. There are a lot of combat veterans around the world. Suicidality in combat veterans is a large and important issue. In this article, the author discusses some aspects of this issue. The combat environment is characterized by violence, physical strains, separation from loved ones and other hardships. Combat deployment may lead to multiple emotional, cognitive, psychosomatic symptoms, suicidal ideation and behavior. Pre-deployment, deployment and post-deployment adversities may increase suicide risk in combat veterans. The act of killing in combat is a stressor which may raise suicide risk. Combat-related injuries are associated with increased suicide risk. Post-deployment difficulties of reintegrating into civilian life may lead to depression and suicidality. Studies suggest that suicidal behavior in combat veterans may have a neurobiological basis. Prevention of suicide among combat veterans should include pre-deployment screening to exclude individuals with psychiatric disorders; psychological support and prevention of harassment and/or abuse during deployment; psychosocial support after deployment; diagnosing and treating psychiatric and medical disorders including neurological disorders; frequent suicide screening; education of mental and non-mental health clinicians, war veterans, their families and friends regarding signs/symptoms of suicidality; and restriction of access to lethal means. We need to study the specific psychobiology of combat veterans to understand how to develop effective suicide prevention interventions for this population.
    MeSH term(s) Humans ; Veterans/psychology ; Suicide/psychology ; Suicidal Ideation ; Military Personnel/psychology ; Mental Disorders
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Suicide in diabetes: an important but underappreciated problem.

    Sher, Leo

    Molecular psychiatry

    2022  Volume 27, Issue 7, Page(s) 2916–2917

    MeSH term(s) Diabetes Mellitus/epidemiology ; Humans ; Suicide ; Suicide, Attempted
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01573-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Testosterone and Suicidal Behavior in Bipolar Disorder

    Leo Sher

    International Journal of Environmental Research and Public Health, Vol 20, Iss 2502, p

    2023  Volume 2502

    Abstract: Bipolar disorder is associated with suicidal behavior. The risk of suicide for individuals with bipolar disorder is up to 20–30 times larger than that of the general population. Considerable evidence suggests that testosterone may play a role in the ... ...

    Abstract Bipolar disorder is associated with suicidal behavior. The risk of suicide for individuals with bipolar disorder is up to 20–30 times larger than that of the general population. Considerable evidence suggests that testosterone may play a role in the pathophysiology of suicidal behavior in both men and women with bipolar disorder and other psychiatric conditions. Testosterone has complex effects on psychological traits. It affects mood and behavior, including interactions with other people. Testosterone regulates pro-active and re-active aspects of aggression. Probably, both high and low levels of testosterone may contribute to the neurobiology of suicide in various patient populations. The effects of endogenous and exogenous testosterone on suicidality in patients with bipolar disorder need further investigation. The aim of this commentary article is to provide a commentary on the author’s work on the topic, summarize the literature on testosterone, bipolar disorder, and suicide, and encourage future research on this poorly studied topic.
    Keywords testosterone ; suicide ; bipolar disorder ; mental health ; public health ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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