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  1. Article ; Online: Enhancing LOD determination in gas chromatography: Validating the Hubaux-Vos method for gas concentration measurement.

    Kim, Hyeong Rae / Kim, Sunwoo / Jung, Jinsang / Lee, Hwan / Ho, Keon / Kim, Byeongmoon / Oh, Sanghyub

    Journal of chromatography. A

    2024  Volume 1720, Page(s) 464764

    Abstract: The limit of detection (LOD) is a crucial measure in analytical methods, representing the smallest amount of a substance that can be distinguished from background noise. In the realm of gas chromatography (GC), however, determining LOD can be quite ... ...

    Abstract The limit of detection (LOD) is a crucial measure in analytical methods, representing the smallest amount of a substance that can be distinguished from background noise. In the realm of gas chromatography (GC), however, determining LOD can be quite subjective, leading to significant variability among researchers. In this study, we validate the Hubaux-Vos method, an International Standards Organization(ISO)-approved approach for determining LOD in gas concentration measurements, using a GC equipped with a discharge ionization detector (DID) and a dynamic dilution system. We employ a gas mixture certified reference material (CRM) of CO, CH
    MeSH term(s) Limit of Detection ; Chromatography, Gas/methods ; Calibration ; Reference Standards ; Indicator Dilution Techniques
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2024.464764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Earlobe Reconstruction Using Two Opposed Periauricular Dermal Pedicled Flap.

    Ryu, Hyeong Rae / Lee, Da Woon / Kim, Jun Hyuk

    The Journal of craniofacial surgery

    2022  Volume 34, Issue 2, Page(s) 721–722

    Abstract: There are several flap techniques of earlobe reconstruction. The ideal method should be a 1-stage procedure that is simple, has fewer complications, and has excellent esthetic outcomes with a proper earlobe texture and volume. We report a case of a 45- ... ...

    Abstract There are several flap techniques of earlobe reconstruction. The ideal method should be a 1-stage procedure that is simple, has fewer complications, and has excellent esthetic outcomes with a proper earlobe texture and volume. We report a case of a 45-year-old man presented with skin and soft tissue defect of right ear lobule. He underwent composite graft using 2×1 cm sized stump. Two weeks later, total necrosis of graft site was observed. After that, he underwent 2 opposed periauricular dermal pedicled flap. Each flap caudally based periauricular flaps were elevated and consisted of redundant fat tissue. These flaps were sutured like sandwich and the donor sites were closured by primary repair. There was no complication as flap congestion or hematoma. After 6 months, the patient was satisfied esthetically and there was no need of additional surgical procedure. We introduce new technique of earlobe reconstruction named 2 opposed periauricular flap. This method affords reconstruction of large sized and full-thickness earlobe defect in a simple, easy manner. It provides proper texture and volume as normal earlobe. Also, it is 1-stage method not requiring skin graft or debulking procedure. Therefore, if plastic surgeon reconstructs a large defect of earlobe, our technique can be thought of as one good option.
    MeSH term(s) Male ; Humans ; Middle Aged ; Esthetics, Dental ; Surgical Flaps ; Skin Transplantation/methods ; Ear Auricle ; Transplants
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000008899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High air flow-rate electrostatic sampler for the rapid monitoring of airborne coronavirus and influenza viruses.

    Kim, Hyeong Rae / An, Sanggwon / Hwang, Jungho

    Journal of hazardous materials

    2021  Volume 412, Page(s) 125219

    Abstract: Capturing virus aerosols in a small volume of liquid is essential when monitoring airborne viruses. As such, aerosol-to-hydrosol enrichment is required to produce a detectable viral sample for real-time quantitative reverse transcription polymerase chain ...

    Abstract Capturing virus aerosols in a small volume of liquid is essential when monitoring airborne viruses. As such, aerosol-to-hydrosol enrichment is required to produce a detectable viral sample for real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. To meet this requirement, the efficient and non-destructive collection of airborne virus particles is needed, while the incoming air flow rate should be sufficiently high to quickly collect a large number of virus particles. To achieve this, we introduced a high air flow-rate electrostatic sampler (HAFES) that collected virus aerosols (human coronavirus 229E, influenza A virus subtypes H1N1 and H3N2, and bacteriophage MS2) in a continuously flowing liquid. Viral collection efficiency was evaluated using aerosol particle counts, while viral recovery rates were assessed using real-time qRT-PCR and plaque assays. An air sampling period of 20 min was sufficient to produce a sample suitable for use in real-time qRT-PCR in a viral epidemic scenario.
    MeSH term(s) Aerosols ; Air Microbiology ; Coronavirus/genetics ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H3N2 Subtype ; Static Electricity
    Chemical Substances Aerosols
    Language English
    Publishing date 2021-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2021.125219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aerosol-to-Hydrosol Sampling and Simultaneous Enrichment of Airborne Bacteria For Rapid Biosensing.

    Kim, Hyeong Rae / An, Sanggwon / Hwang, Jungho

    ACS sensors

    2020  Volume 5, Issue 9, Page(s) 2763–2771

    Abstract: Rapid monitoring of biological particulate matter (Bio-PM, bioaerosols) requires an enrichment technique for concentrating the Bio-PM dispersed in the air into a small volume of liquid. In this study, an electrostatic air sampler is employed to capture ... ...

    Abstract Rapid monitoring of biological particulate matter (Bio-PM, bioaerosols) requires an enrichment technique for concentrating the Bio-PM dispersed in the air into a small volume of liquid. In this study, an electrostatic air sampler is employed to capture aerosolized test bacteria in a carrier liquid (aerosol-to-hydrosol (ATH) enrichment). Simultaneously, the captured bacteria are carried into a fluid channel for hydrosol-to-hydrosol (HTH) enrichment with Concanavalin A coated magnetic particles (CMPs). The ATH enrichment capacity of the air sampler was evaluated with an aerosol particle counter for the following test bacteria:
    MeSH term(s) Aerosols ; Air Microbiology ; Bacteria ; Environmental Monitoring ; Particulate Matter/analysis
    Chemical Substances Aerosols ; Particulate Matter
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.0c00555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: RCS Estimation of Singly Curved Dielectric Shell Structure with PMCHWT Method and Experimental Verification.

    Im, Hyeong-Rae / Kim, Woobin / Noh, Yeong-Hoon / Hong, Ic-Pyo / Yook, Jong-Gwan

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 3

    Abstract: In this paper, a numerical algorithm for the electromagnetic scattering analysis of singly curved dielectric structures, which can be applied to a canopy of fighter aircraft, is presented with experimental verification. At first, the Poggio-Miller-Chang- ... ...

    Abstract In this paper, a numerical algorithm for the electromagnetic scattering analysis of singly curved dielectric structures, which can be applied to a canopy of fighter aircraft, is presented with experimental verification. At first, the Poggio-Miller-Chang-Harrington-Wu-Tsai (PMCHWT) method is used as a MoM-based solution for the electromagnetic scattering of a dielectric material. Its formulation was generated with the EFIE formulation in a multi-region condition. The PMCHWT algorithm is implemented with C++ code, and the accuracy is verified by calculating the bistatic RCS of some canonical structures with conductive or dielectric materials. RCS measurement under quasi-anechoic condition is presented with its procedure and calibration method. The monostatic RCS results of a specially modeled singly curved dielectric structures are obtained analytically with the PMCHWT, as well as experimentally, revealing excellent agreement.
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22030734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Feasibility Study of Federated Learning on the Distributed Research Network of OMOP Common Data Model.

    Lee, Geun Hyeong / Park, Jonggul / Kim, Jihyeong / Kim, Yeesuk / Choi, Byungjin / Park, Rae Woong / Rhee, Sang Youl / Shin, Soo-Yong

    Healthcare informatics research

    2023  Volume 29, Issue 2, Page(s) 168–173

    Abstract: Objectives: Since protecting patients' privacy is a major concern in clinical research, there has been a growing need for privacy-preserving data analysis platforms. For this purpose, a federated learning (FL) method based on the Observational Medical ... ...

    Abstract Objectives: Since protecting patients' privacy is a major concern in clinical research, there has been a growing need for privacy-preserving data analysis platforms. For this purpose, a federated learning (FL) method based on the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) was implemented, and its feasibility was demonstrated.
    Methods: We implemented an FL platform on FeederNet, which is a distributed clinical data analysis platform based on the OMOP CDM in Korea. We trained it through an artificial neural network (ANN) using data from patients who received steroid prescriptions or injections, with the aim of predicting the occurrence of side effects depending on the prescribed dose. The ANN was trained using the FL platform with the OMOP CDMs of Kyung Hee University Medical Center (KHMC) and Ajou University Hospital (AUH).
    Results: The area under the receiver operating characteristic curves (AUROCs) for predicting bone fracture, osteonecrosis, and osteoporosis using only data from each hospital were 0.8426, 0.6920, and 0.7727 for KHMC and 0.7891, 0.7049, and 0.7544 for AUH, respectively. In contrast, when using FL, the corresponding AUROCs were 0.8260, 0.7001, and 0.7928 for KHMC and 0.7912, 0.8076, and 0.7441 for AUH, respectively. In particular, FL led to a 14% improvement in performance for osteonecrosis at AUH.
    Conclusions: FL can be performed with the OMOP CDM, and FL often shows better performance than using only a single institution's data. Therefore, research using OMOP CDM has been expanded from statistical analysis to machine learning so that researchers can conduct more diverse research.
    Language English
    Publishing date 2023-04-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2619923-3
    ISSN 2093-369X ; 2093-3681
    ISSN (online) 2093-369X
    ISSN 2093-3681
    DOI 10.4258/hir.2023.29.2.168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Feasibility Study of Federated Learning on the Distributed Research Network of OMOP Common Data Model

    Geun Hyeong Lee / Jonggul Park / Jihyeong Kim / Yeesuk Kim / Byungjin Choi / Rae Woong Park / Sang Youl Rhee / Soo-Yong Shin

    Healthcare Informatics Research, Vol 29, Iss 2, Pp 168-

    2023  Volume 173

    Abstract: Objectives Since protecting patients’ privacy is a major concern in clinical research, there has been a growing need for privacy-preserving data analysis platforms. For this purpose, a federated learning (FL) method based on the Observational Medical ... ...

    Abstract Objectives Since protecting patients’ privacy is a major concern in clinical research, there has been a growing need for privacy-preserving data analysis platforms. For this purpose, a federated learning (FL) method based on the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) was implemented, and its feasibility was demonstrated. Methods We implemented an FL platform on FeederNet, which is a distributed clinical data analysis platform based on the OMOP CDM in Korea. We trained it through an artificial neural network (ANN) using data from patients who received steroid prescriptions or injections, with the aim of predicting the occurrence of side effects depending on the prescribed dose. The ANN was trained using the FL platform with the OMOP CDMs of Kyung Hee University Medical Center (KHMC) and Ajou University Hospital (AUH). Results The area under the receiver operating characteristic curves (AUROCs) for predicting bone fracture, osteonecrosis, and osteoporosis using only data from each hospital were 0.8426, 0.6920, and 0.7727 for KHMC and 0.7891, 0.7049, and 0.7544 for AUH, respectively. In contrast, when using FL, the corresponding AUROCs were 0.8260, 0.7001, and 0.7928 for KHMC and 0.7912, 0.8076, and 0.7441 for AUH, respectively. In particular, FL led to a 14% improvement in performance for osteonecrosis at AUH. Conclusions FL can be performed with the OMOP CDM, and FL often shows better performance than using only a single institution’s data. Therefore, research using OMOP CDM has been expanded from statistical analysis to machine learning so that researchers can conduct more diverse research.
    Keywords machine learning ; deep learning ; distributed systems ; privacy ; common data element ; Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 006
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher The Korean Society of Medical Informatics
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: One-stage reconstruction of full-thickness alar defects with a folded nasolabial island flap.

    Lee, Da Woon / Ryu, Hyeong Rae / Choi, Hwan Jun / Kim, Jun Hyuk

    Archives of craniofacial surgery

    2021  Volume 22, Issue 6, Page(s) 296–302

    Abstract: Background: The reconstruction of large full-thickness alar defects requires complex surgical procedures that are usually performed in two stages, with concomitant disadvantages in terms of patient trauma, surgical risk, and cost. This study presents a ... ...

    Abstract Background: The reconstruction of large full-thickness alar defects requires complex surgical procedures that are usually performed in two stages, with concomitant disadvantages in terms of patient trauma, surgical risk, and cost. This study presents a functional folded nasolabial island flap (FNIF) that can be used to repair large-sized full-thickness alar defects in a straightforward manner.
    Methods: This retrospective study included seven patients who received a FNIF for a full-thickness alar defect between January 2007 and December 2020. The FNIF is different from the conventional nasolabial flap in that it is folded and twisted to achieve nostril reconstruction with a satisfactory three-dimensional mucosal lining in a single stage. The cosmetic and functional results of FNIF were evaluated by both patients and physicians.
    Results: The age ranged from 51 to 82 years (mean, 65.6 years). The causes of the defects were squamous cell carcinoma, basal cell carcinoma, and trigeminal trophic syndrome. The nostril lining did not collapse, there was no hypertrophic scarring, and air movement through the nostrils on the flap side was normal. Overall, FNIF produced excellent aesthetic and functional outcomes, with minimal patient discomfort. There were no postoperative complications.
    Conclusion: Compared with existing reconstruction methods for large full-thickness alar defects, FNIF can easily achieve aesthetic and functional success in a single-stage procedure. It provides satisfactory results for both the patient and the surgeon.
    Language English
    Publishing date 2021-12-20
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800630-6
    ISSN 2287-5603 ; 2287-1152
    ISSN (online) 2287-5603
    ISSN 2287-1152
    DOI 10.7181/acfs.2021.00339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Increased survivability of coronavirus and H1N1 influenza virus under electrostatic aerosol-to-hydrosol sampling.

    Piri, Amin / Kim, Hyeong Rae / Park, Dae Hoon / Hwang, Jungho

    Journal of hazardous materials

    2021  Volume 413, Page(s) 125417

    Abstract: Airborne virus susceptibility is an underlying cause of severe respiratory diseases, raising pandemic alerts worldwide. Following the first reports of the novel severe acute respiratory syndrome coronavirus-2 in 2019 and its rapid spread worldwide and ... ...

    Abstract Airborne virus susceptibility is an underlying cause of severe respiratory diseases, raising pandemic alerts worldwide. Following the first reports of the novel severe acute respiratory syndrome coronavirus-2 in 2019 and its rapid spread worldwide and the outbreak of a new highly variable strain of influenza A virus (H1N1) in 2009, developing quick, accurate monitoring and diagnostic approaches for emerging infections is considered critical. Efficient air sampling of coronaviruses and the H1N1 virus allows swift, real-time identification, triggering early adjuvant interventions. Electrostatic precipitation is an efficient method for sampling bio-aerosols as hydrosols; however, sampling conditions critically impact this method. Corona discharge ionizes surrounding air, generating reactive oxygen species (ROS), which may impair virus structural components, leading to RNA and/or protein damage and preventing virus detection. Herein, ascorbic acid (AA) dissolved in phosphate-buffered saline (PBS) was used as the sampling solution of an electrostatic sampler to counteract virus particle impairment, increasing virus survivability throughout sampling. The findings of this study indicate that the use of PBS+AA is effective in reducing the ROS damage of viral RNA by 95%, viral protein by 45% and virus yield by 60%.
    MeSH term(s) Aerosols ; COVID-19 ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2 ; Static Electricity
    Chemical Substances Aerosols
    Language English
    Publishing date 2021-02-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2021.125417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Stereoselective Synthesis of Highly Functionalized 5- and 6-Membered Aminocyclitols Starting with a Readily Available 2-Azetidinone.

    Achary, Raghavendra / Kim, Hyeong Rae / Lee, Hyeon-Kyu

    The Journal of organic chemistry

    2019  Volume 84, Issue 7, Page(s) 4263–4272

    Abstract: Stereoselective transformations of 4-vinyl-2-azetidinone derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1-N bond cleavage and Ru-catalyzed ring- ... ...

    Abstract Stereoselective transformations of 4-vinyl-2-azetidinone derivative 4 into a variety of highly functionalized 6- and 5-membered carbocyclic compounds 7 and 9 were carried out using sequences involving sequential C1-N bond cleavage and Ru-catalyzed ring-closing metathesis. The derived carbocycles were further transformed into polyhydroxylated 6- and 5-membered aminocyclitols.
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.9b00239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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