LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 98

Search options

  1. Article ; Online: Vascular Insulin Resistance and Free Fatty Acids: The Micro-Macro Circulation Nexus.

    Muniyappa, Ranganath

    The Journal of clinical endocrinology and metabolism

    2024  

    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Disentangling Dual Threats: Premature Coronary Artery Disease and Early-Onset Type 2 Diabetes Mellitus in South Asians.

    Muniyappa, Ranganath / Narayanappa, Satish Babu K

    Journal of the Endocrine Society

    2023  Volume 8, Issue 1, Page(s) bvad167

    Abstract: South Asian individuals (SAs) face heightened risks of premature coronary artery disease (CAD) and early-onset type 2 diabetes mellitus (T2DM), with grave health, societal, and economic implications due to the region's dense population. Both conditions, ... ...

    Abstract South Asian individuals (SAs) face heightened risks of premature coronary artery disease (CAD) and early-onset type 2 diabetes mellitus (T2DM), with grave health, societal, and economic implications due to the region's dense population. Both conditions, influenced by cardiometabolic risk factors such as insulin resistance, hypertension, and central adiposity, manifest earlier and with unique thresholds in SAs. Epidemiological, demographic, nutritional, environmental, sociocultural, and economic transitions in SA have exacerbated the twin epidemic. The coupling of premature CAD and T2DM arises from increased obesity due to limited adipose storage, early-life undernutrition, distinct fat thresholds, reduced muscle mass, and a predisposition for hepatic fat accumulation from certain dietary choices cumulatively precipitating a decline in insulin sensitivity. As T2DM ensues, the β-cell adaptive responses are suboptimal, precipitating a transition from compensatory hyperinsulinemia to β-cell decompensation, underscoring a reduced functional β-cell reserve in SAs. This review delves into the interplay of these mechanisms and highlights a prediabetes endotype tied to elevated vascular risk. Deciphering these mechanistic interconnections promises to refine stratification paradigms, surpassing extant risk-prediction strategies.
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvad167
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Diabetes, Obesity, and Risk Prediction of Severe COVID-19.

    Muniyappa, Ranganath / Wilkins, Kenneth J

    The Journal of clinical endocrinology and metabolism

    2020  Volume 105, Issue 10

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Humans ; Mexico ; Obesity ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa442
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: COVID-19 pandemic, coronaviruses, and diabetes mellitus.

    Muniyappa, Ranganath / Gubbi, Sriram

    American journal of physiology. Endocrinology and metabolism

    2020  Volume 318, Issue 5, Page(s) E736–E741

    Abstract: The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity ... ...

    Abstract The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.
    MeSH term(s) Animals ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Diabetes Mellitus/immunology ; Diabetes Mellitus/mortality ; Host Microbial Interactions/immunology ; Humans ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Risk Assessment ; SARS-CoV-2 ; Uncertainty ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00124.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action.

    Ha, Joon / Muniyappa, Ranganath / Sherman, Arthur S / Quon, Michael J

    Frontiers in physiology

    2021  Volume 12, Page(s) 601894

    Abstract: We address a problem with the Bergman-Cobelli Minimal Model, which has been used for 40 years to ... ...

    Abstract We address a problem with the Bergman-Cobelli Minimal Model, which has been used for 40 years to estimate
    Language English
    Publishing date 2021-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.601894
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Glucosamine and osteoarthritis: time to quit?

    Muniyappa, Ranganath

    Diabetes/metabolism research and reviews

    2011  Volume 27, Issue 3, Page(s) 233–234

    MeSH term(s) Administration, Oral ; Glucosamine/therapeutic use ; Glucose/metabolism ; Glycosaminoglycans/biosynthesis ; Humans ; Insulin Resistance/physiology ; Osteoarthritis/drug therapy
    Chemical Substances Glycosaminoglycans ; Glucose (IY9XDZ35W2) ; Glucosamine (N08U5BOQ1K)
    Language English
    Publishing date 2011-03
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1470192-3
    ISSN 1520-7560 ; 1520-7552
    ISSN (online) 1520-7560
    ISSN 1520-7552
    DOI 10.1002/dmrr.1179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: Impact of selective insulin resistance on cardiovascular risk reduction strategies

    Muniyappa, Ranganath

    (Contemporary clinical medicine, great teachers ; Annual John Laws Decker memorial lecture ; 12th)

    2015  

    Abstract: CIT): Contemporary Clinical Medicine: Great Teachers Twelfth Annual John Laws Decker Memorial Lecture: Impact of Selective Insulin Resistance on Cardiovascular Risk Reduction ... ...

    Institution National Institutes of Health (U.S.),
    Author's details Ranganath Muniyappa
    Series title Contemporary clinical medicine, great teachers
    Annual John Laws Decker memorial lecture ; 12th
    Abstract (CIT): Contemporary Clinical Medicine: Great Teachers Twelfth Annual John Laws Decker Memorial Lecture: Impact of Selective Insulin Resistance on Cardiovascular Risk Reduction Strategies
    MeSH term(s) Cardiovascular Diseases/etiology ; Diabetes Mellitus/etiology ; Insulin Resistance ; Risk Factors
    Language English
    Size 1 online resource (1 streaming video file (56 min.)) :, color, sound.
    Document type Book
    Note Closed-captioned.
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: COVID-19 pandemic, coronaviruses, and diabetes mellitus

    Muniyappa, Ranganath / Gubbi, Sriram

    Am J Physiol Endocrinol Metab

    Abstract: The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity ... ...

    Abstract The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension, and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #23168
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course.

    Bansal, Rashika / Gubbi, Sriram / Muniyappa, Ranganath

    Endocrinology

    2020  Volume 161, Issue 10

    Abstract: The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Individuals with metabolic syndrome are at increased risk for poor disease outcomes and mortality ... ...

    Abstract The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Individuals with metabolic syndrome are at increased risk for poor disease outcomes and mortality from COVID-19. The pathophysiologic mechanisms for these observations have not been fully elucidated. A critical interaction between SARS-CoV-2 and the angiotensin-converting enzyme 2 (ACE2) facilitates viral entry into the host cell. ACE2 is expressed in pancreatic islets, vascular endothelium, and adipose tissue, and the SARS-CoV-2 -ACE2 interaction in these tissues, along with other factors, governs the spectrum and the severity of clinical manifestations among COVID-19 patients with metabolic syndrome. Moreover, the pro-inflammatory milieu observed in patients with metabolic syndrome may contribute toward COVID-19-mediated host immune dysregulation, including suboptimal immune responses, hyperinflammation, microvascular dysfunction, and thrombosis. This review describes the spectrum of clinical features, the likely pathophysiologic mechanisms, and potential implications for the management of metabolic syndrome in COVID-19 patients.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Endocrine System/metabolism ; Endocrine System/physiopathology ; Humans ; Immune System/immunology ; Immune System/physiopathology ; Metabolic Syndrome/immunology ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/physiopathology ; Microvessels/physiopathology ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/immunology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqaa112
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top