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  1. Article: Editorial: Role of epigenetics in environmental pollution associated diseases.

    He, Xiang / Liu, Jiliu / Li, Guoping

    Frontiers in genetics

    2023  Volume 14, Page(s) 1266714

    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1266714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium.

    Li, Yuan / Zhang, Meilin / Zhang, Shengnan / Yang, Guoping

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 1

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010125
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  3. Article ; Online: Pulling the trigger: Noncoding RNAs in white adipose tissue browning.

    Liang, Dehuan / Li, Guoping

    Reviews in endocrine & metabolic disorders

    2023  Volume 25, Issue 2, Page(s) 399–420

    Abstract: White adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat ... ...

    Abstract White adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various levels. Recent studies have shed light on the involvement of ncRNAs in adipose tissue development, differentiation, and function. In this review, we aim to summarize the current understanding of ncRNAs in adipose biology, with a focus on their role and intricate mechanisms in WAT browning. Also, we discuss the potential applications and challenges of ncRNA-based therapies for overweight and its metabolic disorders, so as to combat the obesity epidemic in the future.
    MeSH term(s) Animals ; Humans ; Adipose Tissue, White/metabolism ; Obesity/genetics ; Obesity/metabolism ; Adipose Tissue, Brown/metabolism ; Adipocytes/metabolism ; Adiposity ; RNA, Untranslated/genetics ; Thermogenesis/genetics ; Energy Metabolism/genetics ; Mammals
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2023-12-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-023-09866-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6069: Show issues Location:
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  4. Article ; Online: Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization.

    Wang, Junyi / Li, Guoping / Wu, Min

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 387

    MeSH term(s) Animals ; RNA ; Cephalopoda/genetics ; Cephalopoda/metabolism ; RNA, Messenger/genetics
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01632-z
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  5. Article ; Online: RNA methylation into m

    Lin, Ping / Li, Guoping / Wu, Min

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 78

    MeSH term(s) Methylation ; T-Lymphocytes/metabolism ; RNA/metabolism ; Methyltransferases/genetics
    Chemical Substances RNA (63231-63-0) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01360-4
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  6. Article ; Online: Dissolving self to protect community: cGAS ubiquitin-like mechanism for bacteria to fight against phages.

    Wang, Junyi / Li, Guoping / Wu, Min

    Science bulletin

    2023  Volume 68, Issue 19, Page(s) 2132–2134

    MeSH term(s) Bacteriophages ; Nucleotidyltransferases ; Bacteria ; Ubiquitins
    Chemical Substances Nucleotidyltransferases (EC 2.7.7.-) ; Ubiquitins
    Language English
    Publishing date 2023-08-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.08.029
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  7. Article: A retrospective study of the efficacy and safety of levofloxacin in children with severe infection.

    Junqi, Zhang / Jie, Cai / Jinglin, Wang / Jinmiao, Lu / Guoping, Lu / Yi, Wang / Zhiping, Li

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1381742

    Abstract: Objectives: Levofloxacin is widely used because of its broad-spectrum antimicrobial activity and convenient dosing schedule. However, the relevance of its use in children remains to be investigated. The purpose of this study is to investigate the ... ...

    Abstract Objectives: Levofloxacin is widely used because of its broad-spectrum antimicrobial activity and convenient dosing schedule. However, the relevance of its use in children remains to be investigated. The purpose of this study is to investigate the efficacy and safety of levofloxacin use in children with severe infections.
    Methods: We conducted a retrospective observational study of patients <18 years of age who received levofloxacin intravenously in the Pediatric Intensive Care Unit (PICU) of our hospital during the period between 2021 and 2022. Patient demographics, course characteristics, clinical effectiveness, and adverse event correlations were extracted through a retrospective tabular review.
    Results: We included 25 patients treated with 28 courses of levofloxacin. The mean age of these children treated with levofloxacin was 4.41 years. Conversion of pathogenic microbiological test results to negative after levofloxacin treatment was detected in 11 courses (39.29%). A decrease in inflammatory markers, white blood cell or C-reactive protein counts, was detected in 18 courses (64.29%). A total of 57 adverse events occurred during the treatment period, of which 21 were possibly related to levofloxacin and no adverse events were probably related to levofloxacin.
    Conclusion: The effectiveness of levofloxacin use in children with serious infections is promising, especially for the treatment of multidrug-resistant bacteria. Adverse events occurring during the initiation of levofloxacin therapy in children are reported to be relatively common, but in this study, only a small percentage of them were possibly related to levofloxacin, and none of them were highly possibly related to levofloxacin.
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1381742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Research progress on immunological properties of ESAT-6 secreted by Mycobacterium tuberculosis and its role in new vaccines].

    Li, Yujie / Yu, Haiyan / Yang, Yuting / Yang, Guoping

    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

    2024  Volume 40, Issue 1, Page(s) 89–94

    Abstract: Early secreted antigenic target of 6 kDa protein (ESAT-6) is the major virulence factor of Mycobacterium tuberculosis (MTB), which can resist the clearance of MTB in bodies by inhibiting macrophage phagocytosis and autophagy reaction, thus impeding the ... ...

    Abstract Early secreted antigenic target of 6 kDa protein (ESAT-6) is the major virulence factor of Mycobacterium tuberculosis (MTB), which can resist the clearance of MTB in bodies by inhibiting macrophage phagocytosis and autophagy reaction, thus impeding the immune defense function of the body against MTB infection. In addition, ESAT-6-induced apoptosis of macrophage and massive necrosis of innate immune cells can foster MTB proliferation and colonization, leading to systemic MTB infection. Moreover, ESAT-6 hampers the protective immune response of Th1 cells, reducing the secretion of pro-inflammatory cytokines and contributing to immune dysfunction, thus accelerating the course of MTB infection. During the process, the high immunogenicity of ESAT-6 can be leveraged as a dominant antigen in the development of new TB vaccines, making it a promising candidate with broad prospects for further development.
    MeSH term(s) Humans ; Mycobacterium tuberculosis ; Vaccines ; Cytokines ; Apoptosis ; Autophagy ; Sepsis
    Chemical Substances Vaccines ; Cytokines
    Language Chinese
    Publishing date 2024-01-21
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-8738
    ISSN 1007-8738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on 'Intelligent cataract surgery supervision and evaluation via deep learning'.

    Kuang, Guoping / Li, Ying / Hou, Pan

    International journal of surgery (London, England)

    2023  Volume 109, Issue 6, Page(s) 1804–1805

    MeSH term(s) Humans ; Deep Learning ; Cataract Extraction ; Cataract
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000419
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Mechanism of photocatalytic CO

    Zhang, Ya-Qiong / Zhang, Yu / Zeng, Guoping / Liao, Rong-Zhen / Li, Man

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 2, Page(s) 684–698

    Abstract: The tetradentate PNNP-type ... ...

    Abstract The tetradentate PNNP-type Ir
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03329e
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