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  1. Article ; Online: Stylocarotid syndrome causing middle cerebral artery infarction.

    Ramadan, Shadi M

    The journal of the Royal College of Physicians of Edinburgh

    2022  Volume 51, Issue 4, Page(s) 380–381

    Abstract: Stylocarotid syndrome is a variant of Eagle's syndrome that depicts elongation of styloid process or calcification of stylohyoid ligament causing compression of external or internal carotid arteries. Because of this compression, several neurological ... ...

    Abstract Stylocarotid syndrome is a variant of Eagle's syndrome that depicts elongation of styloid process or calcification of stylohyoid ligament causing compression of external or internal carotid arteries. Because of this compression, several neurological presentations could occur ranging from transient ischaemic attacks to carotid dissection and devastating ischaemic stroke. It is a rare cause of stroke that many physicians are not familiar with, yet it can be readily diagnosed by computed tomography angiography (CTA). Styloidectomy remains the definitive treatment for stylocarotid syndrome, however conservative treatment can be attempted in certain patients.
    MeSH term(s) Brain Ischemia ; Humans ; Infarction, Middle Cerebral Artery ; Ossification, Heterotopic ; Stroke ; Temporal Bone/diagnostic imaging
    Language English
    Publishing date 2022-01-26
    Publishing country Scotland
    Document type Case Reports
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.4997/JRCPE.2021.414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnostic challenges of focal neurological deficits during an acute take-Is this vascular?: Clinical hints, pearls and pitfalls.

    Ramadan, Shadi M / Rayessa, Rayessa / Esisi, Bernard

    Clinical medicine (London, England)

    2024  Volume 24, Issue 2, Page(s) 100037

    Abstract: Stroke and TIAs are amongst the common neurological presentations encountered by specialists and non-specialist health care providers. Despite the advances of neuroimaging techniques, clinicians are frequently faced with diagnostic challenges on ... ...

    Abstract Stroke and TIAs are amongst the common neurological presentations encountered by specialists and non-specialist health care providers. Despite the advances of neuroimaging techniques, clinicians are frequently faced with diagnostic challenges on evaluation of patients with suspected stroke. In this review, we discuss the characteristic features of cerebrovascular diseases and how to identify them. We also aim to provide a resource for non-stroke specialist clinicians to help them to correctly identify the symptoms and signs of disorders that may masquerade as stroke such as migraine, seizure, and functional disorder, and at the same time we explore how we can identify strokes that present atypically.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.1016/j.clinme.2024.100037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A retrospective audit of out-of-hours mechanical thrombectomy of anterior circulation large vessel occlusion in a UK tertiary centre.

    Ramadan, Shadi M / Esisi, Bernard

    Clinical medicine (London, England)

    2023  Volume 23, Issue 5, Page(s) 491–494

    Abstract: Mechanical thrombectomy (MT) is indicated for patients with acute ischemic stroke resulting from large vessel occlusion (LVO). At Hull Royal Infirmary (HRI), the MT service is available from 08:00 h to 16:00 h, Monday to Friday. Consequently, many ... ...

    Abstract Mechanical thrombectomy (MT) is indicated for patients with acute ischemic stroke resulting from large vessel occlusion (LVO). At Hull Royal Infirmary (HRI), the MT service is available from 08:00 h to 16:00 h, Monday to Friday. Consequently, many patients who present outside of those times are denied a chance of having this treatment. The objective of this audit was to detect the percentage of patients who had presented out of hours and managed to have MT and to identify why the remaining proportion of patients did not receive this treatment. A total of 35 patients with anterior circulation LVO who presented out of hours and on weekends were included in this audit. Of these, only six patients (17%) received MT. Selection of those patients was favoured by their early-morning presentation shortly before the opening of the MT service at 08:00 h. Thus, a substantial number of patients presenting with LVO out of hours were not considered for MT. This could be attributed to inadequate communication between staff. Initiation of an in-hospital protocol could facilitate communication between stroke physicians and neuroradiologists and provide a pathway for consideration of such patients for late-window MT.
    MeSH term(s) Humans ; Thrombectomy/adverse effects ; Thrombectomy/methods ; Retrospective Studies ; Ischemic Stroke/etiology ; Treatment Outcome ; Stroke/etiology ; After-Hours Care ; United Kingdom ; Brain Ischemia/etiology
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2022-0395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An interesting case of small vessel pathology following coronavirus infection.

    Ramadan, Shadi M / Kasfiki, Eirini V / Kelly, Ciaran Wp / Ali, Irshad

    BMJ case reports

    2020  Volume 13, Issue 9

    Abstract: Vasculitis is a descriptive term for a wide variety of conditions characterised by inflammation of the blood vessels that may occur as a primary process or secondary to an underlying disease. Occlusive vasculopathy is a different clinical entity ... ...

    Abstract Vasculitis is a descriptive term for a wide variety of conditions characterised by inflammation of the blood vessels that may occur as a primary process or secondary to an underlying disease. Occlusive vasculopathy is a different clinical entity characterised by skin changes and ulceration of the lower extremities because of thrombosis of the small vessels of the dermis and is usually associated with pre-thrombotic conditions. Both conditions can be confirmed or excluded by skin biopsy. We report the case of a 63-year-old woman presenting with upper and lower respiratory tract symptoms followed by a vasculitic rash on both legs. The patient underwent extensive radiological and laboratory investigations that were negative apart from positive coronavirus OC43. A biopsy of the skin was performed. Considering the clinical presentation and the investigations performed, the diagnosis of small vessel vasculopathy following coronavirus OC43 has been suggested by the authors.
    MeSH term(s) COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Vascular Diseases/virology
    Keywords covid19
    Language English
    Publishing date 2020-09-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-237407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Quorum Sensing Inhibiting Activity of Streptomyces coelicoflavus Isolated from Soil.

    Hassan, Ramadan / Shaaban, Mona I / Abdel Bar, Fatma M / El-Mahdy, Areej M / Shokralla, Shadi

    Frontiers in microbiology

    2016  Volume 7, Page(s) 659

    Abstract: Quorum sensing (QS) systems communicate bacterial population and stimulate microbial pathogenesis through signaling molecules. Inhibition of QS signals potentially suppresses microbial infections. Antimicrobial properties of Streptomyces have been ... ...

    Abstract Quorum sensing (QS) systems communicate bacterial population and stimulate microbial pathogenesis through signaling molecules. Inhibition of QS signals potentially suppresses microbial infections. Antimicrobial properties of Streptomyces have been extensively studied, however, less is known about quorum sensing inhibitory (QSI) activities of Streptomyces. This study explored the QSI potential of Streptomyces isolated from soil. Sixty-five bacterial isolates were purified from soil samples with morphological characteristics of Streptomyces. The three isolates: S6, S12, and S17, exhibited QSI effect by screening with the reporter, Chromobacterium violaceum. Isolate S17 was identified as Streptomyces coelicoflavus by sequencing of the hypervariable regions (V1-V6) of 16S rRNA and was assigned gene bank number KJ855087. The QSI effect of the cell-free supernatant of isolate S17 was not abolished by proteinase K indicating the non-enzymatic activity of QSI components of S17. Three major compounds were isolated and identified, using spectroscopic techniques (1D, 2D NMR, and Mass spectrometry), as behenic acid (docosanoic acid), borrelidin, and 1H-pyrrole-2-carboxylic acid. 1H-pyrrole-2-carboxylic acid inhibited QS and related virulence factors of Pseudomonas aeruginosa PAO1 including; elastase, protease, and pyocyanin without affecting Pseudomonas viability. At the molecular level, 1H-pyrrole-2-carboxylic acid suppressed the expression of QS genes (lasI, lasR, lasA, lasB, rhlI, rhlR, pqsA, and pqsR). Moreover, QSI activity of S17 was assessed under different growth conditions and ISP2 medium supplemented with glucose 0.4% w/v and adjusted at pH 7, showed the highest QSI action. In conclusion, 1H-pyrrole-2-carboxylic acid, one of the major metabolites of Streptomyces isolate S17, inhibited QS and virulence determinants of P. aeruginosa PAO1. The findings of the study open the scope to exploit the in vivo efficacy of this active molecule as anti-pathogenic and anti-virulence of P. aeruginosa.
    Language English
    Publishing date 2016-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2016.00659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 associated Mucormycosis among ICU patients: risk factors, control, and challenges.

    Abd El-Baky, Rehab Mahmoud / Shady, Esraa R / Yahia, Ramadan / Ahmed, Fatma Y / Ramadan, Mohamed / Ahmed, Hala Rady / Al-Kadmy, Israa M S / Ramadan, Yasmin N / Hetta, Helal F

    AMB Express

    2023  Volume 13, Issue 1, Page(s) 99

    Abstract: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is still difficult to be controlled. The spread of this virus and the emergence of new variants are considered a great challenge worldwide. Disturbance in infection control ... ...

    Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is still difficult to be controlled. The spread of this virus and the emergence of new variants are considered a great challenge worldwide. Disturbance in infection control guidelines implementation, use of steroids, antibiotics, hospital crowdedness, and repeated use of oxygen masks during the management of critically ill COVID-19 patients lead to an increase in the rate of opportunistic infections. So, patients need to fight both the virus with its different variants and opportunistic pathogens including bacteria and fungi especially patients with diabetes mellitus, malignancy, or those who undergo hemodialysis and receive deferoxamine. During the pandemic, many cases of Mucormycosis associated with COVID-19 infection were observed in many countries. In this review, we discuss risk factors that increase the chance of infection by opportunistic pathogens, especially fungal pathogens, recent challenges, and control measures.
    Language English
    Publishing date 2023-09-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2621432-5
    ISSN 2191-0855
    ISSN 2191-0855
    DOI 10.1186/s13568-023-01599-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Characterization, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities of green synthesized silver nanoparticles using

    Khodeer, Dina M / Nasr, Ali M / Swidan, Shady A / Shabayek, Sarah / Khinkar, Roaa M / Aldurdunji, Mohammed M / Ramadan, Maryam A / Badr, Jihan M

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1078061

    Abstract: Introduction: Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion all over the world. It is becoming an epidemic disease adding a major burden to the health care system, particularly in developing countries.: Methods: The ...

    Abstract Introduction: Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion all over the world. It is becoming an epidemic disease adding a major burden to the health care system, particularly in developing countries.
    Methods: The plant under investigation in the current study
    Results and discussion: The results showed a decrease in body fat, obesity, an improvement in lipid profiles, normalization of hyperglycemia, insulin resistance, and hyperinsulinemia, and an improvement in liver tissue structure and function. However, the results obtained from AgNPs for both extract and the pure gallic acid were better in most measured parameters. Additionally, the activity of both the crude extract of the plant and its AgNPs were evaluated against a number of gram-positive, gram-negative bacteria and fungi. Although the activity of the crude extract ranged from moderate to weak or even non-active, the AgNPs of the plant extract clearly enhanced the antimicrobial activity. AgNPs of the extract demonstrated remarkable activity, especially against the Gram-negative pathogens
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1078061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of the anti-infective potential of the seed endophytic fungi of Corchorus olitorius through metabolomics and molecular docking approach.

    Ahmed, Arwa Mortada / Ibrahim, Ayman M / Yahia, Ramadan / Shady, Nourhan Hisham / Mahmoud, Basma Khalaf / Abdelmohsen, Usama Ramadan / Fouad, Mostafa A

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 355

    Abstract: Background: Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae), followed by ... ...

    Abstract Background: Endophytic fungi are very rich sources of natural antibacterial and antifungal compounds. The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae), followed by antimicrobial screening against various bacterial and fungal strains.
    Results: Seven endophytic fungal strains belonging to different three genera were isolated, including Penicillium, Fusarium, and Aspergillus. The seven isolated endophytic strains revealed selective noticeable activity against Escherichia coli (ATCC25922) with varied IC
    Conclusion: These results will expand the knowledge of endophytes and provide us with new approaches to face the global antibiotic resistance problem and the future production of undiscovered compounds different from the antibiotics classes.
    MeSH term(s) Corchorus/microbiology ; Molecular Docking Simulation ; Escherichia coli ; Microbial Sensitivity Tests ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/metabolism ; Fungi ; Anti-Bacterial Agents/metabolism ; Aspergillus ; Seeds/microbiology
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03092-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The anti-infective potential of the endophytic fungi associated with

    Hassan, Hind Ashraf / Abdelhafez, Omnia Hesham / Shady, Nourhan Hisham / Yahia, Ramadan / Mohamed, Nada M / Rateb, Mostafa E / Akil, Lina / Khadra, Ibrahim / Glaeser, Stefanie P / Kämpfer, Peter / Abdelmohsen, Usama Ramadan / El-Katatny, Mo'men Hamed

    Natural product research

    2023  Volume 37, Issue 23, Page(s) 4063–4068

    Abstract: Endophytic fungi are known to be a rich source of anti-infective drugs. In our study, ...

    Abstract Endophytic fungi are known to be a rich source of anti-infective drugs. In our study,
    MeSH term(s) Onions ; Phylogeny ; Molecular Docking Simulation ; Anti-Infective Agents/pharmacology ; Fungi ; Candida albicans ; Endophytes
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2167204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Network Pharmacological Analysis of the Red Sea Sponge

    Abou-Taleb, Heba A / Sayed, Ahmed M / Refaat, Hesham / Alsenani, Faisal / Alaaeldin, Eman / Mokhtar, Fatma A / Abdelmohsen, Usama Ramadan / Shady, Nourhan Hisham

    Marine drugs

    2022  Volume 20, Issue 10

    Abstract: In this study, the LC-HRMS-assisted chemical profiling ... ...

    Abstract In this study, the LC-HRMS-assisted chemical profiling of
    MeSH term(s) Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Caco-2 Cells ; Complex Mixtures ; Indian Ocean ; Liposomes ; Proteoglycans ; Porifera
    Chemical Substances Antineoplastic Agents ; Complex Mixtures ; Liposomes ; Proteoglycans
    Language English
    Publishing date 2022-10-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20100628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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