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Article: Successful repositioning of the subcutaneous implantable cardioverter-defibrillator lead to avoid inappropriate shock.

Fukunaga, Hiroshi / Inoue, Kanki / Sekiguchi, Yukio / Nitta, Junichi / Isobe, Mitsuaki

2023 Volume 39, Issue 1, Page(s) 74–77

Language	English
Publishing date	2023-01-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2696593-8
ISSN	1883-2148 ; 1880-4276
ISSN (online)	1883-2148
ISSN	1880-4276
DOI	10.1002/joa3.12805
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Glomerular hyperfiltration and hypertrophy: an evaluation of maximum values in pathological indicators to discriminate "diseased" from "normal".

Kataoka, Hiroshi / Nitta, Kosaku / Hoshino, Junichi

Frontiers in medicine

2023 Volume 10, Page(s) 1179834

Abstract: The success of sodium-glucose cotransporter 2 inhibitors and bariatric surgery in patients with chronic kidney disease has highlighted the importance of glomerular hyperfiltration and hypertrophy in the progression of kidney disease. Sustained glomerular ...

Abstract	The success of sodium-glucose cotransporter 2 inhibitors and bariatric surgery in patients with chronic kidney disease has highlighted the importance of glomerular hyperfiltration and hypertrophy in the progression of kidney disease. Sustained glomerular hyperfiltration and hypertrophy can lead to glomerular injury and progressive kidney damage. This article explores the relationship between obesity and chronic kidney disease, focusing on the roles of glomerular hyperfiltration and hypertrophy as hallmarks of obesity-related kidney disease. The pathological mechanisms underlying this association include adipose tissue inflammation, dyslipidemia, insulin resistance, chronic systemic inflammation, oxidative stress, and overactivation of the sympathetic nervous system, as well as the renin-angiotensin aldosterone system. This article explains how glomerular hyperfiltration results from increased renal blood flow and intraglomerular hypertension, inducing mechanical stress on the filtration barrier and post-filtration structures. Injured glomeruli increase in size before sclerosing and collapsing. Therefore, using extreme values, such as the maximal glomerular diameter, could improve the understanding of the data distribution and allow for better kidney failure predictions. This review provides important insights into the mechanisms underlying glomerular hyperfiltration and hypertrophy and highlights the need for further research using glomerular size, including maximum glomerular profile, calculated using needle biopsy specimens.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1179834
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Article ; Online: Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation.

Muro, Ryunosuke / Narita, Tomoya / Nitta, Takeshi / Takayanagi, Hiroshi

Frontiers in immunology

2023 Volume 13, Page(s) 1045881

Abstract: The γδT cells that produce IL-17 (γδT17 cells) play a key role in various pathophysiologic processes in host defense and homeostasis. The development of γδT cells in the thymus requires γδT cell receptor (γδTCR) signaling mediated by the spleen tyrosine ... ...

Abstract	The γδT cells that produce IL-17 (γδT17 cells) play a key role in various pathophysiologic processes in host defense and homeostasis. The development of γδT cells in the thymus requires γδT cell receptor (γδTCR) signaling mediated by the spleen tyrosine kinase (Syk) family proteins, Syk and Zap70. Here, we show a critical role of Syk in the early phase of γδT cell development using mice deficient for Syk specifically in lymphoid lineage cells (Syk-conditional knockout (cKO) mice). The development of γδT cells in the Syk-cKO mice was arrested at the precursor stage where the expression of Rag genes and αβT-lineage-associated genes were retained, indicating that Syk is required for γδT-cell lineage commitment. Loss of Syk in γδT cells weakened TCR signal-induced phosphorylation of Erk and Akt, which is mandatory for the thymic development of γδT17 cells. Syk-cKO mice exhibited a loss of γδT17 cells in the thymus as well as throughout the body, and thereby are protected from γδT17-dependent psoriasis-like skin inflammation. Collectively, our results indicate that Syk is a key player in the lineage commitment of γδT cells and the priming of γδT17 cell differentiation.
MeSH term(s)	Animals ; Mice ; Syk Kinase/genetics ; Signal Transduction ; Cell Differentiation/genetics ; Thymus Gland ; Cell Lineage
Chemical Substances	Syk Kinase (EC 2.7.10.2)
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1045881
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Article: Visceral fat and attribute-based medicine in chronic kidney disease.

Kataoka, Hiroshi / Nitta, Kosaku / Hoshino, Junichi

Frontiers in endocrinology

2023 Volume 14, Page(s) 1097596

Abstract: Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, ... ...

Abstract	Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including systemic inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system. Moreover, an increase in adipose tissue directly and indirectly affects the kidneys by increasing renal sodium reabsorption, causing glomerular hyperfiltration and hypertrophy, which leads to increased proteinuria and kidney fibrosis/dysfunction. Although the interest in the adverse effects of obesity on renal diseases has grown exponentially in recent years, the relationship between obesity and renal prognosis remains controversial. This may be attributed to the long clinical course of obesity, numerous obesity-related metabolic complications, and patients' attributes. Multiple individual attributes influencing the pathophysiology of fat accumulation make it difficult to understand obesity. In such cases, it may be effective to elucidate the pathophysiology by conducting research tailored to individual attributes from the perspective of attribute-based medicine/personalized medicine. We consider the appropriate use of clinical indicators necessary, according to attributes such as chronic kidney disease stage, level of visceral adipose tissue accumulation, age, and sex. Selecting treatments and clinical indicators based on individual attributes will allow for advancements in the clinical management of patients with obesity and chronic kidney disease. In the clinical setting of obesity-related nephropathy, it is first necessary to accumulate attribute-based studies resulting from the accurate evaluation of visceral fat accumulation to establish evidence for promoting personalized medicine.
MeSH term(s)	Humans ; Intra-Abdominal Fat/metabolism ; Obesity/metabolism ; Metabolic Syndrome/metabolism ; Kidney/metabolism ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1097596
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Article: Intravascular Large B-Cell Lymphoma in Acute Hypoxic Respiratory Failure.

Yanagisawa, Kei / Kameyama, Akiko / Miyama, Hiroshi / Mori, Koutarou / Hattori, Masao / Imamura, Hiroshi / Nitta, Kenichi

Case reports in critical care

2023 Volume 2023, Page(s) 9192396

Abstract: Intravascular large B-cell lymphoma, an extranodal large B-cell lymphoma, is a rare hematological malignancy with only a few reports of lung involvement. We report a case of intravascular large B-cell lymphoma with acute hypoxic respiratory failure and ... ...

Abstract	Intravascular large B-cell lymphoma, an extranodal large B-cell lymphoma, is a rare hematological malignancy with only a few reports of lung involvement. We report a case of intravascular large B-cell lymphoma with acute hypoxic respiratory failure and interstitial lung disease diagnosed via random skin biopsies. A 54-year-old woman presented with fever, cough, and dyspnea. Computed tomography imaging revealed findings concerning interstitial lung disease. The patient's respiratory status worsened despite the treatment with antibiotics and steroids. Generalized edema and thrombocytopenia also developed. Intravascular large B-cell lymphoma was clinically suspected and ultimately diagnosed by skin biopsy, although she had no apparent skin lesions. The patient's condition considerably improved after chemotherapy. Intravascular large B-cell lymphoma should be considered in patients with acute respiratory failure and interstitial lung lesions.
Language	English
Publishing date	2023-08-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2927720-6
ISSN	2090-6439 ; 2090-6420
ISSN (online)	2090-6439
ISSN	2090-6420
DOI	10.1155/2023/9192396
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Article ; Online: Non-Epithelial Thymic Stromal Cells: Unsung Heroes in Thymus Organogenesis and T Cell Development.

Nitta, Takeshi / Takayanagi, Hiroshi

Frontiers in immunology

2021 Volume 11, Page(s) 620894

Abstract: The stromal microenvironment in the thymus is essential for generating a functional T cell repertoire. Thymic epithelial cells (TECs) are numerically and phenotypically one of the most prominent stromal cell types in the thymus, and have been recognized ... ...

Abstract	The stromal microenvironment in the thymus is essential for generating a functional T cell repertoire. Thymic epithelial cells (TECs) are numerically and phenotypically one of the most prominent stromal cell types in the thymus, and have been recognized as one of most unusual cell types in the body by virtue of their unique functions in the course of the positive and negative selection of developing T cells. In addition to TECs, there are other stromal cell types of mesenchymal origin, such as fibroblasts and endothelial cells. These mesenchymal stromal cells are not only components of the parenchymal and vascular architecture, but also have a pivotal role in controlling TEC development, although their functions have been less extensively explored than TECs. Here, we review both the historical studies on and recent advances in our understanding of the contribution of such non-TEC stromal cells to thymic organogenesis and T cell development. In particular, we highlight the recently discovered functional effect of thymic fibroblasts on T cell repertoire selection.
MeSH term(s)	Animals ; Cellular Microenvironment ; Endothelial Cells/cytology ; Epithelial Cells/cytology ; Fibroblasts/cytology ; Humans ; Lymphopoiesis ; Mammals ; Mesoderm/cytology ; Mice ; Mice, Inbred C57BL ; Organogenesis ; Stromal Cells/cytology ; T-Lymphocytes/cytology ; Thymus Gland/blood supply ; Thymus Gland/cytology ; Thymus Gland/embryology ; Thymus Gland/growth & development
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.620894
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Article ; Online: Visceral fat and attribute-based medicine in chronic kidney disease

Hiroshi Kataoka / Kosaku Nitta / Junichi Hoshino

Frontiers in Endocrinology, Vol

2023 Volume 14

Abstract	Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including systemic inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system. Moreover, an increase in adipose tissue directly and indirectly affects the kidneys by increasing renal sodium reabsorption, causing glomerular hyperfiltration and hypertrophy, which leads to increased proteinuria and kidney fibrosis/dysfunction. Although the interest in the adverse effects of obesity on renal diseases has grown exponentially in recent years, the relationship between obesity and renal prognosis remains controversial. This may be attributed to the long clinical course of obesity, numerous obesity-related metabolic complications, and patients’ attributes. Multiple individual attributes influencing the pathophysiology of fat accumulation make it difficult to understand obesity. In such cases, it may be effective to elucidate the pathophysiology by conducting research tailored to individual attributes from the perspective of attribute-based medicine/personalized medicine. We consider the appropriate use of clinical indicators necessary, according to attributes such as chronic kidney disease stage, level of visceral adipose tissue accumulation, age, and sex. Selecting treatments and clinical indicators based on individual attributes will allow for advancements in the clinical management of patients with obesity and chronic kidney disease. In the clinical setting of obesity-related nephropathy, it is first necessary to accumulate attribute-based studies resulting from the accurate evaluation of visceral fat accumulation to establish evidence for promoting personalized medicine.
Keywords	visceral fat ; patient-centered medicine ; sex difference ; personalized medicine ; obesity ; precision medicine ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610 ; 616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Glomerular hyperfiltration and hypertrophy

Hiroshi Kataoka / Kosaku Nitta / Junichi Hoshino

Frontiers in Medicine, Vol

an evaluation of maximum values in pathological indicators to discriminate “diseased” from “normal”

2023 Volume 10

Abstract	The success of sodium-glucose cotransporter 2 inhibitors and bariatric surgery in patients with chronic kidney disease has highlighted the importance of glomerular hyperfiltration and hypertrophy in the progression of kidney disease. Sustained glomerular hyperfiltration and hypertrophy can lead to glomerular injury and progressive kidney damage. This article explores the relationship between obesity and chronic kidney disease, focusing on the roles of glomerular hyperfiltration and hypertrophy as hallmarks of obesity-related kidney disease. The pathological mechanisms underlying this association include adipose tissue inflammation, dyslipidemia, insulin resistance, chronic systemic inflammation, oxidative stress, and overactivation of the sympathetic nervous system, as well as the renin-angiotensin aldosterone system. This article explains how glomerular hyperfiltration results from increased renal blood flow and intraglomerular hypertension, inducing mechanical stress on the filtration barrier and post-filtration structures. Injured glomeruli increase in size before sclerosing and collapsing. Therefore, using extreme values, such as the maximal glomerular diameter, could improve the understanding of the data distribution and allow for better kidney failure predictions. This review provides important insights into the mechanisms underlying glomerular hyperfiltration and hypertrophy and highlights the need for further research using glomerular size, including maximum glomerular profile, calculated using needle biopsy specimens.
Keywords	chronic kidney disease ; glomerular hyperfiltration ; glomerular hypertrophy ; obesity ; sodium-glucose cotransporter 2 inhibitors ; visceral fat ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influences of hair dyeing on the distribution shapes of zolpidem and methoxyphenamine in hair.

Shima, Noriaki / Nitta, Atsushi / Sasaki, Keiko / Katagi, Munehiro / Sato, Takako / Nishioka, Hiroshi

Forensic science international

2024 Volume 357, Page(s) 111990

Abstract: In order to investigate the influences of hair dyeing on the distribution shapes of drugs in hair, different hair dyeing processes ("semi-permanent coloring without bleaching" and "permanent coloring with bleaching") were performed in vitro on black hair ...

Abstract	In order to investigate the influences of hair dyeing on the distribution shapes of drugs in hair, different hair dyeing processes ("semi-permanent coloring without bleaching" and "permanent coloring with bleaching") were performed in vitro on black hair specimens collected from two subjects (Asians) who took a single dose of zolpidem (ZP, 10 mg of ZP tartrate) or methoxyphenamine (MOP, 50 mg of MOP hydrochloride). Under the following three different dyeing conditions, (1) semi-permanent coloring, (2) permanent coloring (once), (3) permanent coloring (twice), drug distributions in single hair specimens were investigated using a 2-mm segmental analysis by liquid chromatography-tandem mass spectrometry. Distribution shapes of drugs changed significantly only under the permanent coloring (twice) condition, resulting in reduced peak concentration and extended distribution width. There was, however, no significant difference in the amounts of drugs in hair between non-treated and dyed specimens, suggesting the drugs hardly leaked out of hair or were only slightly degraded during dyeing. In addition, while assuming contact with aqueous environment such as daily hair washing after dyeing, dyed hair specimens were individually immersed in ultrapure water for 20 hours, then the outflow of drugs in ultrapure water as well as the distribution shapes of drugs remaining in hair were determined. The drug outflow after permanent coloring (once and twice) was significantly larger than those after semi-permanent coloring, and the outflow ratios, [outflow]/([outflow] + [amount remaining in hair]), ranged over 9.8-24% (n = 3) for ZP and 68-71% (n = 3) for MOP after permanent coloring (once), and 54-72% (n = 3) for ZP and 86-91% (n = 3) for MOP after permanent coloring (twice). The distribution shapes of drugs after 20 h of immersion tended to flatten as outflow ratios increased, resulting in no change in the shapes after semi-permanent coloring, and complete collapse of their shapes after permanent coloring (twice). Thus, the present results indicated that hair dyeing involving bleaching and subsequent contact with aqueous environment after dyeing could significantly influence distribution shapes of drugs in hair.
MeSH term(s)	Humans ; Zolpidem/analysis ; Substance Abuse Detection/methods ; Hair/chemistry ; Water/analysis ; Methamphetamine/analogs & derivatives
Chemical Substances	Zolpidem (7K383OQI23) ; methoxyphenamine (J3Z5SRI26Z) ; Water (059QF0KO0R) ; Methamphetamine (44RAL3456C)
Language	English
Publishing date	2024-03-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2024.111990
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Article ; Online: [Outline of the Japan Environment and Children's Study and the Framework of Genome Analysis].

Nitta, Hiroshi

Nihon eiseigaku zasshi. Japanese journal of hygiene

2016 Volume 71, Issue 1, Page(s) 91–93

Abstract: The goal of the Japan Environment and Children's Study (JECS) is to improve the health and welfare of children and to contribute to better risk management of chemical substances in the environment. The study will examine hypotheses related to ... ...

Abstract	The goal of the Japan Environment and Children's Study (JECS) is to improve the health and welfare of children and to contribute to better risk management of chemical substances in the environment. The study will examine hypotheses related to reproduction, congenital anomalies, neuropsychiatric development, immunity, metabolism and endocrine system. The hypotheses will be tested for indicative outcomes in combination with exposure to chemicals, as well as confounders and modulators, such as chemical, physical, genetic, social and lifestyle-related factors. A total of 100,000 pregnant women associated with the selected study locations were recruited during the first three years starting January 2011. Their children will be followed up until the age of 13 years. The main study (nationwide survey) will include all participants recruited in all regional centres. Substudies will be conducted on randomly selected individuals from among all the participants. In the main and substudies, blood, urine, hair and breast milk samples will be collected from mothers. Blood, hair, and urine samples as well as umbilical cord blood at delivery will be collected from the children. Blood samples will also be collected from fathers. Each specimen will be analysed for specific chemical substances. In addition, genetic background will be evaluated. The collected blood samples for genetic assessments will be stored at the national centre. The detailed assessment procedures will be reviewed for approval by IRBs.
MeSH term(s)	Child ; Child, Preschool ; Environmental Pollutants/analysis ; Female ; Genome, Human ; Humans ; Infant ; Male
Chemical Substances	Environmental Pollutants
Language	Japanese
Publishing date	2016
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604089-5
ISSN	1882-6482 ; 0021-5082
ISSN (online)	1882-6482
ISSN	0021-5082
DOI	10.1265/jjh.71.91
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