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  1. Article ; Online: Photodermatitis caused by torasemide.

    Haeberle, Michael / Karle, Christoph A

    Contact dermatitis

    2020  Volume 84, Issue 1, Page(s) 53–54

    MeSH term(s) Aged ; Antihypertensive Agents/adverse effects ; Diuretics/adverse effects ; Drug Therapy, Combination ; Female ; Heart Failure/complications ; Heart Failure/drug therapy ; Humans ; Hydrochlorothiazide/adverse effects ; Hydrochlorothiazide/chemistry ; Lymphedema/drug therapy ; Lymphedema/etiology ; Molecular Structure ; Photosensitivity Disorders/chemically induced ; Torsemide/adverse effects ; Torsemide/chemistry
    Chemical Substances Antihypertensive Agents ; Diuretics ; Hydrochlorothiazide (0J48LPH2TH) ; Torsemide (W31X2H97FB)
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/cod.13665
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  2. Article ; Online: A multiplex PCR strategy to screen for known mutations in families with sudden cardiac death burden.

    Duong, Giang / Helms, Thomas M / Karle, Christoph A

    Journal of biological methods

    2017  Volume 4, Issue 3, Page(s) e78

    Abstract: Ventricular tachyarrythmia occurring in ischemic heart disease, dilated/hypertrophic cardiomyopathies or rare monogenic mutations of cardiac ion channels or associated proteins belong to the most frequent causes of sudden cardiac death (SCD). In further ... ...

    Abstract Ventricular tachyarrythmia occurring in ischemic heart disease, dilated/hypertrophic cardiomyopathies or rare monogenic mutations of cardiac ion channels or associated proteins belong to the most frequent causes of sudden cardiac death (SCD). In further decades, next generation sequencing and bioinformatic analysis will become the gold standard of SCD risk stratification. At the moment, Sanger-sequencing is still obligatory in genetic diagnosis. A multiplex polymerase chain reaction (PCR) assay detecting eight SCD mutations in one reaction-tube was developed. To test the general validity of the assay, it was used with 12 patients, who had one or two of the eight mutations (LMNA, p.V256V; SCN5A, p.R1583C; RYR2, p.G1885E; MYH7, V606M; DSG2, p.T335A; KCNJ8, p.S422L; MYBPC, p.E441K; TNNT2, A38V). Thereafter, we tested the multiplex assay in a real diagnostic environment within a high risk family of several past SCD cases. This method allows efficient discrimination of multiple mutations by allele-specific PCR with standard PCR conditions. It relies on obtaining a PCR product specific to the mutation or wildtype-using primers that have the 3'end base complementary to the DNA template site,
    Language English
    Publishing date 2017-07-03
    Publishing country United States
    Document type Journal Article
    ISSN 2326-9901
    ISSN (online) 2326-9901
    DOI 10.14440/jbm.2017.181
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  3. Article ; Online: Herzinsuffizienzversorgung in einer digitalisierten Zukunft : Ein Diskurs zu ressourcenschonenden Strukturen und selbstbestimmten Patienten.

    Helms, Thomas M / Köpnick, Anne / Leber, Alexander / Zugck, Christian / Steen, Henning / Karle, Christoph / Remppis, Andrew / Zippel-Schultz, Bettina

    Der Internist

    2021  Volume 62, Issue 11, Page(s) 1180–1190

    Abstract: Digital health solutions, applications of artificial intelligence (AI) and new technologies, such as cardiac magnetic resonance imaging and cardiac human genetics are currently being validated in cardiac healthcare pathways. They show promising ... ...

    Title translation Heart failure care in a digitalized future : A discourse on resource-sparing structures and self-determined patients.
    Abstract Digital health solutions, applications of artificial intelligence (AI) and new technologies, such as cardiac magnetic resonance imaging and cardiac human genetics are currently being validated in cardiac healthcare pathways. They show promising approaches for improving existing healthcare structures in the future by strengthening the focus on predictive, preventive and personalized medicine. In addition, the accompanying use of digital health applications will become increasingly more important in the future healthcare, especially in patients with chronic diseases. In this article, the authors describe a case of chronic heart failure (HF) as an example to provide an overview of how digitalized healthcare can be efficiently designed across sectors and disciplines in the future. Moreover, the importance of a self-determined patient management for the treatment process itself is underlined. Since HF is frequently accompanied by various comorbidities during the course of the disease that are often recognized only after a delay, the necessity for a timely simultaneous and preventive treatment of multiple comorbidities in cardiovascular diseases is emphasized. Against this background the currently separately applied disease management programs (DMP) are critically questioned. The development of a holistic DMP encompassing all indications for the treatment of chronic diseases may pave the way to a more efficient medical care system.
    MeSH term(s) Artificial Intelligence ; Delivery of Health Care ; Forecasting ; Heart ; Heart Failure/diagnosis ; Heart Failure/therapy ; Humans
    Language German
    Publishing date 2021-10-14
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01173-z
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  4. Article ; Online: Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries.

    Karle, Weronika / Becker, Samuel / Stenzel, Philipp / Knosalla, Christoph / Siegel, Günter / Baum, Oliver / Zakrzewicz, Andreas / Berkholz, Janine

    Clinical science (London, England : 1979)

    2021  Volume 135, Issue 7, Page(s) 887–905

    Abstract: Promyelocytic leukemia protein (PML) is a constitutive component of PML nuclear bodies (PML-NBs), which function as stress-regulated SUMOylation factories. Since PML can also act as a regulator of the inflammatory and fibroproliferative responses ... ...

    Abstract Promyelocytic leukemia protein (PML) is a constitutive component of PML nuclear bodies (PML-NBs), which function as stress-regulated SUMOylation factories. Since PML can also act as a regulator of the inflammatory and fibroproliferative responses characteristic of atherosclerosis, we investigated whether PML is implicated in this disease. Immunoblotting, ELISA and immunohistochemistry showed a stronger expression of PML in segments of human atherosclerotic coronary arteries and sections compared with non-atherosclerotic ones. In particular, PML was concentrated in PML-NBs from α-smooth muscle actin (α-SMA)-immunoreactive cells in plaque areas. To identify possible functional consequences of PML-accumulation in this cell type, differentiated human coronary artery smooth muscle cells (dHCASMCs) were transfected with a vector containing the intact PML-gene. These PML-transfected dHCASMCs showed higher levels of small ubiquitin-like modifier (SUMO)-1-dependent SUMOylated proteins, but lower levels of markers for smooth muscle cell (SMC) differentiation and revealed more proliferation and migration activities than dHCASMCs transfected with the vector lacking a specific gene insert or with the vector containing a mutated PML-gene coding for a PML-form without SUMOylation activity. When dHCASMCs were incubated with different cytokines, higher PML-levels were observed only after interferon γ (IFN-γ) stimulation, while the expression of differentiation markers was lower. However, these phenotypic changes were not observed in dHCASMCs treated with small interfering RNA (siRNA) suppressing PML-expression prior to IFN-γ stimulation. Taken together, our results imply that PML is a previously unknown functional factor in the molecular cascades associated with the pathogenesis of atherosclerosis and is positioned in vascular SMCs (VSMCs) between upstream IFN-γ activation and downstream SUMOylation.
    MeSH term(s) Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Coronary Vessels/metabolism ; Female ; Humans ; Interferon-gamma ; Male ; Myocytes, Smooth Muscle/pathology ; Peptide Fragments ; Phenotype ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Promyelocytic Leukemia Protein/genetics ; Promyelocytic Leukemia Protein/metabolism ; Sumoylation
    Chemical Substances Peptide Fragments ; Promyelocytic Leukemia Protein ; interferon gamma (1-39) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20201399
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  5. Book: Facharztausbildung in Großbritannien

    Karle, Peter / Wigfield, Christopher

    Berufseinstieg und Karriere-Optionen

    1997  

    Author's details Peter Karle ; Christoph Wigfield
    Keywords Specialties, Medical / education / Great Britain ; Career Mobility / Great Britain ; Großbritannien ; Arzt ; Medizinische Ausbildung ; Deutsche ; Ärztliche Weiterbildung
    Subject Deutscher ; Deutscher Mann ; Arzt ; Medizin ; Heilberuf ; Gesundheitswesen ; Gesundheitsberuf ; Medizinischer Beruf ; Mediziner ; Ärzte
    Language German
    Size 290 S.
    Publisher Antilla, Medizin-Verl
    Publishing place Berlin
    Document type Book
    HBZ-ID HT008091876
    ISBN 3-929891-10-7 ; 978-3-929891-10-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 A 1260 order for loan Magazin

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  6. Article ; Online: Recurrent necrotizing cellulitis, multi-organ autoimmune disease and humoral immunodeficiency due to a novel NFKB1 frameshift mutation.

    Bergbreiter, Astrid / Jaeger, Teresa / Karle, Antje / Bitzinger, Diane / Ettl, Tobias / Spanier, Gerrit / Jägle, Herbert / Neu, Reiner / Söder, Yorick / Evert, Matthias / Reichert, Torsten E / Berneburg, Mark / Brochhausen, Christoph / Schreml, Julia / Fliegauf, Manfred / Salzer, Ulrich / Redel, Andreas / Schreml, Stephan

    European journal of medical genetics

    2021  Volume 64, Issue 3, Page(s) 104144

    Abstract: Background: Mutations in NFKB1(nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) are associated with a variety of clinical symptoms, including lymphadenopathy, splenomegaly, hepatomegaly, autoimmune haemolytic anaemia, arthralgia, ... ...

    Abstract Background: Mutations in NFKB1(nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) are associated with a variety of clinical symptoms, including lymphadenopathy, splenomegaly, hepatomegaly, autoimmune haemolytic anaemia, arthralgia, recurrent respiratory tract infections and post-operative necrotizing cellulitis.
    Case presentation: We describe a case of a 47-year-old man, who presented with deep necrotizing cellulitis after incision of a submucous abscess by a dentist. Surgical intervention led to a massive progress. Pyoderma gangraenosum (PG) was diagnosed clinically and confirmed histopathologically. High dose corticosteroids and intravenous immunoglobulins (IVIG) improved wound healing dramatically. Until now, immune mediated inflammation events not only affected the skin, but also multiple inner organs, i.e. the heart, lungs and gut. Sequencing of all coding exons of NFKB1 revealed a heterozygous 1bp deletion in exon 23 predicting a frameshift starting at codon Ala891 and resulting in a subsequent stop codon at position 6 in the new reading frame: NM_003998.4: c.2671del; p.(Ala891Glnfs*6) Acute episodes were always successfully treated with corticosteroids, IVIG and concomitant antibiotics. To prevent further exacerbations, the patient receives IVIG once a month, low-dose corticosteroids and methotrexate.
    Conclusion: This is the first case of a patient with recurrent necrotizing cellulitis and immune mediated multi-organ involvement (heart, lungs, intestine) carrying the novel frameshift mutation c.2671del (p.Ala891Glnfs*6) in NFKB1 effectively treated with IVIG, low-dose corticosteroids and methotrexate.
    MeSH term(s) Autoimmune Diseases/diagnosis ; Autoimmune Diseases/genetics ; Cellulitis/diagnosis ; Cellulitis/genetics ; Frameshift Mutation ; Humans ; Male ; Middle Aged ; NF-kappa B p50 Subunit/genetics ; Primary Immunodeficiency Diseases/diagnosis ; Primary Immunodeficiency Diseases/genetics ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/genetics ; Syndrome
    Chemical Substances NF-kappa B p50 Subunit ; NFKB1 protein, human
    Language English
    Publishing date 2021-01-22
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2184135-4
    ISSN 1878-0849 ; 1769-7212
    ISSN (online) 1878-0849
    ISSN 1769-7212
    DOI 10.1016/j.ejmg.2021.104144
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  7. Article ; Online: Strukturmerkmale und Voraussetzungen zur ambulanten Implantation von implantierbaren Defibrillatoren, Geräten zur kardialen Resynchronisation und Ereignisrekordern.

    Helms, Thomas M / Bosch, Ralph / Hansen, Claudius / Willhöft, Cord / Zippel-Schultz, Bettina / Karle, Christoph / Schwab, Jörg Otto

    Herzschrittmachertherapie & Elektrophysiologie

    2021  Volume 32, Issue 2, Page(s) 227–235

    Abstract: The possibility of outpatient implantation of defibrillators, devices for cardiac resynchronization, and event recorders (collectively called cardiac implantable electronic devices, CIEDs) is becoming increasingly important. In Germany, only a few ... ...

    Title translation Structural requirements and prerequisites for outpatient implantation of defibrillators, devices for cardiac resynchronization and event recorders.
    Abstract The possibility of outpatient implantation of defibrillators, devices for cardiac resynchronization, and event recorders (collectively called cardiac implantable electronic devices, CIEDs) is becoming increasingly important. In Germany, only a few options for outpatient implantation are currently realized. Furthermore, there is a lack of uniform, recognized, and binding quality criteria. This article provides insight into the current contract constellations for outpatient surgery and defines a first, holistic quality concept for outpatient implantations of CIEDs. The present works aims to initiate a discourse in the specialist society in order to define a coordinated, binding quality concept. Then, this should serve as the basis for future outpatient implantation services, enabling comparability and to contribute long-term evidence.
    MeSH term(s) Cardiac Resynchronization Therapy ; Cardiac Resynchronization Therapy Devices ; Defibrillators, Implantable ; Germany ; Humans ; Outpatients ; Pacemaker, Artificial
    Language German
    Publishing date 2021-05-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1082953-2
    ISSN 1435-1544 ; 0938-7412
    ISSN (online) 1435-1544
    ISSN 0938-7412
    DOI 10.1007/s00399-021-00764-5
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  8. Article ; Online: Role of plasma membrane-associated AKAPs for the regulation of cardiac I

    Seyler, Claudia / Scherer, Daniel / Köpple, Christoph / Kulzer, Martin / Korkmaz, Sevil / Xynogalos, Panagiotis / Thomas, Dierk / Kaya, Ziya / Scholz, Eberhard / Backs, Johannes / Karle, Christoph / Katus, Hugo A / Zitron, Edgar

    Naunyn-Schmiedeberg's archives of pharmacology

    2017  Volume 390, Issue 5, Page(s) 493–503

    Abstract: The cardiac ... ...

    Abstract The cardiac I
    MeSH term(s) A Kinase Anchor Proteins/antagonists & inhibitors ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; CHO Cells ; Cell Membrane/drug effects ; Cell Membrane/enzymology ; Cricetulus ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Enzyme Activation ; Enzyme Activators/pharmacology ; HEK293 Cells ; Humans ; Immunoprecipitation ; Ion Channel Gating ; Membrane Potentials ; Microinjections ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Patch-Clamp Techniques ; Peptides/pharmacology ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Protein Binding ; Rats ; Transfection ; Xenopus
    Chemical Substances A Kinase Anchor Proteins ; Adaptor Proteins, Signal Transducing ; Akap5 protein, rat ; Akap7 protein, rat ; Enzyme Activators ; KCNJ2 protein, rat ; Kir2.2 channel ; Peptides ; Potassium Channels, Inwardly Rectifying ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
    Language English
    Publishing date 2017-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-017-1344-9
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  9. Article: An ion channel 'addicted' to ether, alcohol and cocaine: the HERG potassium channel.

    Karle, Christoph A / Kiehn, Johann

    Cardiovascular research

    2002  Volume 53, Issue 1, Page(s) 6–8

    MeSH term(s) Arrhythmias, Cardiac/metabolism ; Cocaine/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Ethanol/metabolism ; Ether/metabolism ; Humans ; Membrane Potentials/physiology ; Myocardium/metabolism ; Potassium Channel Blockers/metabolism ; Potassium Channels, Inwardly Rectifying/metabolism
    Chemical Substances Potassium Channel Blockers ; Potassium Channels, Inwardly Rectifying ; Ether (0F5N573A2Y) ; Ethanol (3K9958V90M) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2002-01
    Publishing country England
    Document type Comment ; Editorial ; Review
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1016/s0008-6363(01)00518-1
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  10. Article ; Online: Cardiovascular ion channels as a molecular target of flavonoids.

    Scholz, Eberhard P / Zitron, Edgar / Katus, Hugo A / Karle, Christoph A

    Cardiovascular therapeutics

    2010  Volume 28, Issue 4, Page(s) e46–52

    Abstract: Flavonoids are a class of naturally occurring polyphenols abundant in edibles and beverages of plant origin. Epidemiological studies consistently associate high flavonoid intake with a reduced risk for the development of cardiovascular diseases. So far ... ...

    Abstract Flavonoids are a class of naturally occurring polyphenols abundant in edibles and beverages of plant origin. Epidemiological studies consistently associate high flavonoid intake with a reduced risk for the development of cardiovascular diseases. So far these beneficial effects have been mainly attributed to nonspecific antioxidant and antiinflammatory properties. However, there is an increasing body of evidence that flavonoids specifically target molecular structures including cardiovascular ion channels. Playing a pivotal role in the regulation of vascular tone and cardiac electric activity, ion channels represent a major target for the induction of antihypertensive and cardioprotective effects. Thus, pharmacological properties of flavonoids on cardiovascular ion channels, ion currents and tissue preparations are being increasingly addressed in experimental studies. Whereas it has become clear that cardiovascular ion channels represent an important molecular target of flavonoids, the published data have not yet been systematically reviewed.
    MeSH term(s) Animals ; Cardiovascular Agents/pharmacology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Cardiovascular System/drug effects ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Dietary Supplements ; Flavonoids/pharmacology ; Humans ; Ion Channels/drug effects ; Ion Channels/metabolism ; Ion Transport ; Membrane Potentials
    Chemical Substances Cardiovascular Agents ; Flavonoids ; Ion Channels
    Language English
    Publishing date 2010-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2428378-2
    ISSN 1755-5922 ; 1755-5914
    ISSN (online) 1755-5922
    ISSN 1755-5914
    DOI 10.1111/j.1755-5922.2010.00212.x
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