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Article ; Online: Special issue in honor of Professor De-Quan Yu.

Yu, Shi-Shan

Journal of Asian natural products research

2024 Volume 26, Issue 1, Page(s) 1–3

Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Editorial
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2024.2313889
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Book ; Online: Idealized simulations of Mei-yu rainfall in Taiwan under uniform southwesterly flow using a cloud-resolving model

Wang, Chung-Chieh / Chuang, Pi-Yu / Chen, Shi-Ting / Lee, Dong-In / Tsuboki, Kazuhisa

eISSN: 1684-9981

2022

Abstract: ... and the role of the complex topography in Taiwan during the Mei-yu season without the influence ...

Abstract	In this study, idealized cloud-resolving simulations are performed for horizontally uniform and steady southwesterly flow at fixed direction–speed combinations to investigate rainfall characteristics and the role of the complex topography in Taiwan during the Mei-yu season without the influence of a front or other disturbances. Eight directions (180 to 285 ∘ , every 15 ∘ ) and eight speeds (5 to 22.5 m s −1 , every 2.5 m s −1 ) are considered, and near-surface relative humidity is also altered (from 55 %–100 %) in a subset of these tests to further examine the effects of moisture content, yielding a total 109 experiments each having a integration length of 50 h . Three rainfall regimes that correspond to different ranges of the wet Froude number ( Fr w ) are identified from the idealized simulations (with a grid size of 2 km ). The low- Fr w regime ( Fr w ≤ ∼ 0.3) is where the island circulation from thermodynamic effects is the main driver of rainfall in local afternoon. The lower the wind speed and Fr w are, the more widespread the rainfall is, as well as its amount. On the other hand, the high- Fr w regime ( Fr w ≥ ∼ 0.4) occurs when the flow of at least 12.5 m s −1 impinges on Taiwan terrain at a large angle (not parallel). This favors the flow-over scenario, and topographic rainfall production becomes dominant through mechanical uplift of unstable air. In this scenario, the faster and wetter the flow is, the heavier the rainfall on the windward slopes is, and maximum amounts typically occur at wind directions from 240–255 ∘ . Between the two regimes above, a third, mixed regime also exists. The idealized results are discussed for their applicability to the real atmosphere.
Subject code	333 ; 511
Language	English
Publishing date	2022-06-02
Publishing country	de
Document type	Book ; Online
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Article ; Online: Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl

Li, Hou-Gang / You, Peng-Tao / Xia, Yu / Cai, Yu / Tu, Yi-Jun / Wang, Meng-Heng / Song, Wan-Ci / Quan, Tai-Min / Ren, Hui-Ying / Liu, Yan-Wen / Dan, Han-Xiong / Xu, Shi-Qing

Current medical science

2020 Volume 40, Issue 3, Page(s) 539–547

Abstract: Yu Gan Long (YGL) is a Chinese traditional herbal formula which has been reported to attenuate ...

Abstract	Yu Gan Long (YGL) is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor (TGF-β) in the previous study. But the mechanisms associated with platelet-derived growth factor (PDGF)-BB remain obscure. In this study, we further investigated the mechanism of YGL reducing carbon tetrachloride (CCl
MeSH term(s)	Animals ; Carbon Tetrachloride/pharmacology ; Cytokines/metabolism ; Disease Models, Animal ; Down-Regulation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Janus Kinase 1/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; MAP Kinase Signaling System/drug effects ; Male ; Medicine, Chinese Traditional/methods ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
Chemical Substances	Cytokines ; Drugs, Chinese Herbal ; STAT3 Transcription Factor ; Carbon Tetrachloride (CL2T97X0V0) ; Janus Kinase 1 (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-07-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-020-2211-3
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Article: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model.

Wang, Lu / Zhu, Wenxiang / Sun, Rui / Liu, Jing / Ma, Qihong / Zhang, Binbin / Shi, Yuanyuan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7753508

Abstract: ... side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases ...

Abstract	Background: Pulmonary fibrosis (PF) is a devastating lung disease, resulting in gas exchange dysfunction until death. The two drugs approved by the FDA, pirfenidone and nintedanib, have obvious side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases. The potential effects and the underlying mechanism of WYJ against PF are unclear. Purpose: Employing network pharmacology, molecular docking, and in vivo and in vitro experiments to explore the potential effects and underlying mechanisms of WYJ in the treatment of PF. Methods: Ultra-high pressure liquid chromatography combined with linear ion trap-orbital tandem mass spectrometry (UHPLC-LTQ-orbital trap) was used to identify compounds of WYJ. We got PF-related targets and WYJ compounds-related targets from public databases and further completed critical targets exploration, network construction, and pathway analysis by network pharmacology. Molecular docking predicted binding activity of WYJ compounds and critical targets. Based on the above results, in vivo and in vitro experiments validated the potential effects and mechanisms of WYJ against PF. Results: 23 major compositions of WYJ were identified based on UHPLC-LTQ-Orbitrap. According to the results of network pharmacology, STAT3, SRC, IL6, MAPK1, AKT1, EGFR, MAPK8, MAPK14, and IL1B are critical therapeutic targets. Molecular docking results showed that most of the compounds have good binding activities with critical targets. The results of in vivo and in vitro experiments showed that WYJ alleviated the process of fibrosis by targeting MAPK and STAT3 pathways. Conclusion: Network pharmacology, molecular docking, and in vivo and in vitro experiments showed the potential effects and mechanisms of WYJ against PF, which provides a theoretical basis for the treatment of WYJ with PF.
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7753508
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Article: Metabolomics Response to Drought Stress in Morus alba L. Variety Yu-711

Ackah, Michael / Shi, Yisu / Wu, Mengmeng / Wang, Lei / Guo, Peng / Guo, Liangliang / Jin, Xin / Li, Shaocong / Zhang, Qiaonan / Qiu, Changyu / Lin, Qiang / Zhao, Weiguo

Plants. 2021 Aug. 09, v. 10, no. 8

2021

Abstract: ... approach, the effect of drought stress on mulberry Yu-711 metabolic balance was examined ... For this objective, Yu-711 leaves were subjected to two weeks of drought stress treatment and control ...

Abstract	Mulberry is an economically significant crop for the sericulture industry worldwide. Stresses such as drought exposure have a significant influence on plant survival. Because metabolome directly reflects plant physiological condition, performing a global metabolomic analysis is one technique to examine this influence. Using a liquid chromatography-mass spectrometry (LC-MS) technique based on an untargeted metabolomic approach, the effect of drought stress on mulberry Yu-711 metabolic balance was examined. For this objective, Yu-711 leaves were subjected to two weeks of drought stress treatment and control without drought stress. Numerous differentially accumulated metabolic components in response to drought stress treatment were revealed by multivariate and univariate statistical analysis. Drought stress treatment (EG) revealed a more differentiated metabolite response than the control (CK). We found that the levels of total lipids, galactolipids, and phospholipids (PC, PA, PE) were significantly altered, producing 48% of the total differentially expressed metabolites. Fatty acyls components were the most abundant lipids expressed and decreased considerably by 73.6%. On the other hand, the prenol lipids class of lipids increased in drought leaves. Other classes of metabolites, including polyphenols (flavonoids and cinnamic acid), organic acid (amino acids), carbohydrates, benzenoids, and organoheterocyclic, had a dynamic trend in response to the drought stress. However, their levels under drought stress decreased significantly compared to the control. These findings give an overview for the understanding of global plant metabolic changes in defense mechanisms by revealing the mulberry plant metabolic profile through differentially accumulated compounds.
Keywords	Morus alba ; cinnamic acid ; drought ; flavonoids ; galactolipids ; industry ; liquid chromatography ; mass spectrometry ; metabolites ; metabolome ; metabolomics ; mulberries ; phospholipids ; polyphenols ; sericulture ; statistical analysis ; water stress
Language	English
Dates of publication	2021-0809
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10081636
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Compound Chai Jin Jie Yu Tablets, Acts as An Antidepressant by Promoting Synaptic Function in the Hippocampal Neurons

Li Zi-Rong / Han Yuan-Shan / Wu Meng-Yao / Liu Jian / Jin Shi / Zhang Xi / Wang Yu-Hong

Digital Chinese Medicine, Vol 3, Iss 2, Pp 80-

2020 Volume 95

Abstract: Objective: To investigate the effectiveness of compound Chai Jin Jie Yu Tablets (CJJYT ...

Abstract	Objective: To investigate the effectiveness of compound Chai Jin Jie Yu Tablets (CJJYT) in ameliorating cognitive impairment associated with depression and its potential mechanism of action. Methods: In vitro experiments, the hippocampus was isolated from the whole brain of the fetal rat and cultured into hippocampal neuron cells. 50 μM corticosterone (CORT) was added to each group 18 h before the experiment for modeling depression, with the exception of the control group. After modeling, the blank serum group was added with 10% blank serum, the CJJYT group and the venlafaxine group were added with the corresponding 10% drug-containing serum, and the control group and the model group were added with equal volumes of culture medium. The intracellular Ca2+ mean fluorescence intensity, miniature excitatory postsynaptic current (mEPSC) current amplitude, and frequency of different hippocampal neurons were evaluated as indicators of synaptic function in the hippocampal neurons. In addition, the expression of synaptic plasticity related proteins, synaptophysin-α (SYN-α), N-methyl-D-aspartate receptor 2A (NR2A), N-methyl-D- aspartate receptor 2B (NR2B), post synaptic density 95 protein (PSD-95), calcium/calmodulin dependent protein kinaseⅡ (CaMKⅡ) and synaptic associated protein (SynGAP) were detected in the hippocampal neurons by immunofluorescence staining and high content analysis (HCA) system. Then, reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the mRNA expression levels of SYN-α, NR2A, NR2B, PSD- 95, CaMKⅡ and SynGAP. For in vivo experiments, except for those in the blank control group, all rats were treated within a single cage for chronic unpredictable stress-induced depression modeling and subjected to corresponding drug interventions. Behavioral tests were used to detect depressive behavior and determine learning, memory and other cognitive abilities, whereas enzyme-linked immunosorbent assay (ELISA) was used to detect the CORT levels. Golgi-Cox staining was used to observe ...
Keywords	Compound Chai Jin Jie Yu Tablets (CJJYT) ; Depression ; SYN-α/NR ; Synaptic plasticity ; Cognition ; Medicine ; R ; Other systems of medicine ; RZ201-999
Subject code	571
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jie-Yu Pill, A Proprietary Herbal Medicine, Ameliorates Mood Disorder-Like Behavior and Cognitive Impairment in Estrogen-Deprived Mice Exposed to Chronic Unpredictable Mild Stress: Implication for a Potential Therapy of Menopause Syndrome.

Zhou, Xi-Dan / Yang, Xin-Jing / Zheng, Yu / Qin, Zong-Shi / Sha, Wei / Chen, Gang / Zhang, Zhang-Jin

Frontiers in psychiatry

2020 Volume 11, Page(s) 579995

Abstract: Jie-Yu Pill (JYP) is a proprietary herbal medicine initially developed to treat menstrual ...

Abstract	Jie-Yu Pill (JYP) is a proprietary herbal medicine initially developed to treat menstrual mood disorders. This study sought to determine whether JYP could alleviate menopausal psychiatric symptoms in ovariectomized (OVX) mice, an animal model of estrogen deprivation, exposed to chronic unpredictable mild stress (CUMS) and the underlying mechanisms in comparison with estrogen therapy. The OVX+CUMS mice were treated with 0.3 mg/kg estradiol (E
Language	English
Publishing date	2020-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2020.579995
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Article ; Online: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model

Lu Wang / Wenxiang Zhu / Rui Sun / Jing Liu / Qihong Ma / Binbin Zhang / Yuanyuan Shi

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: ... side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases ...

Abstract	Background. Pulmonary fibrosis (PF) is a devastating lung disease, resulting in gas exchange dysfunction until death. The two drugs approved by the FDA, pirfenidone and nintedanib, have obvious side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases. The potential effects and the underlying mechanism of WYJ against PF are unclear. Purpose. Employing network pharmacology, molecular docking, and in vivo and in vitro experiments to explore the potential effects and underlying mechanisms of WYJ in the treatment of PF. Methods. Ultra-high pressure liquid chromatography combined with linear ion trap-orbital tandem mass spectrometry (UHPLC-LTQ-orbital trap) was used to identify compounds of WYJ. We got PF-related targets and WYJ compounds-related targets from public databases and further completed critical targets exploration, network construction, and pathway analysis by network pharmacology. Molecular docking predicted binding activity of WYJ compounds and critical targets. Based on the above results, in vivo and in vitro experiments validated the potential effects and mechanisms of WYJ against PF. Results. 23 major compositions of WYJ were identified based on UHPLC-LTQ-Orbitrap. According to the results of network pharmacology, STAT3, SRC, IL6, MAPK1, AKT1, EGFR, MAPK8, MAPK14, and IL1B are critical therapeutic targets. Molecular docking results showed that most of the compounds have good binding activities with critical targets. The results of in vivo and in vitro experiments showed that WYJ alleviated the process of fibrosis by targeting MAPK and STAT3 pathways. Conclusion. Network pharmacology, molecular docking, and in vivo and in vitro experiments showed the potential effects and mechanisms of WYJ against PF, which provides a theoretical basis for the treatment of WYJ with PF.
Keywords	Other systems of medicine ; RZ201-999
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure.

Qiu, Hua / Mao, Dewen / Tang, Nong / Long, Fuli / Zhang, Rongzhen / Wang, Minggang / Shi, Qinglan / Li, Jiahuan / Jiang, Qin / Chen, Yueqiao / Wang, Xiufeng

Drug design, development and therapy

2019 Volume 13, Page(s) 589–600

Abstract: Objectives: Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines ...

Abstract	Objectives: Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines with known therapeutic effect in treating acute liver failure (ALF). The aim of this study was to investigate the amelioration efficacy of JDHY in lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF in rat and explore the possible molecular mechanism underlying the therapeutic efficacy. Materials and methods: The efficacy of JDHY was determined by assessing hepatic pathology and function in LPS and D-GalN challenged Wistar rat. We also evaluated the effect of JDHY on LPS-induced Kupffer cells by measuring inflammatory cytokines and determining the phenotypic function. By means of bioinformatics analysis of liver tissue and validation in Kupffer cells, we identified possible pathways involved in the pharmacologic action of mechanism of JDHY. Results: JDHY could attenuate LPS-induced liver injury in rat by inhibiting apoptosis and increasing hepatic activity. In vitro study showed that JDHY could decrease the production of proinflammatory cytokines (tumor necrosis factor-α, IL6, and interferon-γ), increase anti-inflammatory cytokines (IL10, IL13), and promote cell survival and proliferation, possibly due to inhibition of IκB/nuclear factor-κB (NF-κB) signaling pathway and expression of CD14 and CXCL2, which was consistent with the findings from bioinformatics analysis. Conclusion: Our results revealed that JDHY protected against LPS-induced liver damage both in vitro and in vivo, by inhibiting the NF-κB-mediated inflammatory pathway, indicating its potential function to treat liver diseases.
MeSH term(s)	Animals ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Galactosamine/pharmacology ; Lipopolysaccharides/pharmacology ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/pathology ; Liver Failure, Acute/prevention & control ; Male ; Medicine, Chinese Traditional ; Rats ; Rats, Wistar
Chemical Substances	Drugs, Chinese Herbal ; Lipopolysaccharides ; Galactosamine (7535-00-4)
Language	English
Publishing date	2019-02-11
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S180969
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Article ; Online: Simultaneous determination of sulfur compounds from the sulfur pathway in rat plasma by liquid chromatography tandem mass spectrometry: application to the study of the effect of Shao Fu Zhu Yu decoction.

Zhang, Yue / Kang, An / Deng, Haishan / Shi, Le / Su, Shulan / Yu, Li / Xie, Tong / Shan, Jinjun / Wen, Hongmei / Chi, Yumei / Han, Shuying / Su, Ruilin / Song, Yilin / Chen, Xi / Shaikh, Armaan Basheer

Analytical and bioanalytical chemistry

2018 Volume 410, Issue 16, Page(s) 3743–3755

Abstract: A sensitive, accurate, and time-saving approach was developed for the simultaneous quantification of eight sulfur compounds in the sulfur pathway, which could reflect the status of an organism, including oxidative stress, signal transduction, enzyme ... ...

Abstract	A sensitive, accurate, and time-saving approach was developed for the simultaneous quantification of eight sulfur compounds in the sulfur pathway, which could reflect the status of an organism, including oxidative stress, signal transduction, enzyme reaction, and so on. In order to overcome the instability of highly reactive sulfhydryl compounds, N-ethylmaleimide derivatization was adopted to effectively protect sulfhydryl-containing samples. Using isotope-labeled glutathione (GSH-
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Chromatography, High Pressure Liquid/methods ; Drug Evaluation, Preclinical/methods ; Drugs, Chinese Herbal/pharmacology ; Female ; Limit of Detection ; Metabolic Networks and Pathways/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Sulfur Compounds/blood ; Sulfur Compounds/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Antioxidants ; Drugs, Chinese Herbal ; Shao-Fu-Zhu-Yu ; Sulfur Compounds
Language	English
Publishing date	2018-06
Publishing country	Germany
Document type	Journal Article ; Validation Studies
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-018-1038-2
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